28 found
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  1.  42
    Building Simulations From the Ground Up: Modeling and Theory in Systems Biology.Miles MacLeod & Nancy J. Nersessian - 2013 - Philosophy of Science 80 (4):533-556.
  2.  28
    Coupling Simulation and Experiment: The Bimodal Strategy in Integrative Systems Biology.Miles MacLeod & Nancy J. Nersessian - 2013 - Studies in History and Philosophy of Science Part C: Studies in History and Philosophy of Biological and Biomedical Sciences 44 (4):572-584.
    The importation of computational methods into biology is generating novel methodological strategies for managing complexity which philosophers are only just starting to explore and elaborate. This paper aims to enrich our understanding of methodology in integrative systems biology, which is developing novel epistemic and cognitive strategies for managing complex problem-solving tasks. We illustrate this through developing a case study of a bimodal researcher from our ethnographic investigation of two systems biology research labs. The researcher constructed models of metabolic and cell-signaling (...)
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  3.  10
    Interdisciplinary Problem- Solving: Emerging Modes in Integrative Systems Biology.Miles MacLeod & Nancy J. Nersessian - 2016 - European Journal for Philosophy of Science 6 (3):401-418.
    Integrative systems biology is an emerging field that attempts to integrate computation, applied mathematics, engineering concepts and methods, and biological experimentation in order to model large-scale complex biochemical networks. The field is thus an important contemporary instance of an interdisciplinary approach to solving complex problems. Interdisciplinary science is a recent topic in the philosophy of science. Determining what is philosophically important and distinct about interdisciplinary practices requires detailed accounts of problem-solving practices that attempt to understand how specific practices address the (...)
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  4.  11
    Modeling complexity: cognitive constraints and computational model-building in integrative systems biology.Miles MacLeod & Nancy J. Nersessian - 2018 - History and Philosophy of the Life Sciences 40 (1):17.
    Modern integrative systems biology defines itself by the complexity of the problems it takes on through computational modeling and simulation. However in integrative systems biology computers do not solve problems alone. Problem solving depends as ever on human cognitive resources. Current philosophical accounts hint at their importance, but it remains to be understood what roles human cognition plays in computational modeling. In this paper we focus on practices through which modelers in systems biology use computational simulation and other tools to (...)
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  5.  61
    Natural Kinds in Philosophy and in the Life Sciences: Scholastic Twilight or New Dawn? [REVIEW]Miles MacLeod & Thomas A. C. Reydon - 2013 - Biological Theory 7 (2):89-99.
    This article, which is intended both as a position paper in the philosophical debate on natural kinds and as the guest editorial to this thematic issue, takes up the challenge posed by Ian Hacking in his paper, “Natural Kinds: Rosy Dawn, Scholastic Twilight.” Whereas a straightforward interpretation of that paper suggests that according to Hacking the concept of natural kinds should be abandoned, both in the philosophy of science and in philosophy more generally, we suggest that an alternative and less (...)
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  6.  21
    What Makes Interdisciplinarity Difficult? Some Consequences of Domain Specificity in Interdisciplinary Practice.Miles MacLeod - 2018 - Synthese 195 (2):697-720.
    Research on interdisciplinary science has for the most part concentrated on the institutional obstacles that discourage or hamper interdisciplinary work, with the expectation that interdisciplinary interaction can be improved through institutional reform strategies such as through reform of peer review systems. However institutional obstacles are not the only ones that confront interdisciplinary work. The design of policy strategies would benefit from more detailed investigation into the particular cognitive constraints, including the methodological and conceptual barriers, which also confront attempts to work (...)
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  7.  6
    Coupling Simulation and Experiment: The Bimodal Strategy in Integrative Systems Biology.Miles MacLeod & Nancy J. Nersessian - 2013 - Studies in History and Philosophy of Science Part C 44 (4a):572-584.
    The importation of computational methods into biology is generating novel methodological strategies for managing complexity which philosophers are only just starting to explore and elaborate. This paper aims to enrich our understanding of methodology in integrative systems biology, which is developing novel epistemic and cognitive strategies for managing complex problem-solving tasks. We illustrate this through developing a case study of a bimodal researcher from our ethnographic investigation of two systems biology research labs. The researcher constructed models of metabolic and cell-signaling (...)
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  8. Applying the Causal Theory of Reference to Intentional Concepts.John Michael & Miles MacLeod - 2013 - Philosophy of Science 80 (2):212-230.
    We argue that many recent philosophical discussions about the reference of everyday concepts of intentional states have implicitly been predicated on descriptive theories of reference. To rectify this, we attempt to demonstrate how a causal theory can be applied to intentional concepts. Specifically, we argue that some phenomena in early social de- velopment ðe.g., mimicry, gaze following, and emotional contagionÞ can serve as refer- ence fixers that enable children to track others’ intentional states and, thus, to refer to those states. (...)
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  9.  25
    Modeling Systems-Level Dynamics: Understanding Without Mechanistic Explanation in Integrative Systems Biology.Miles MacLeod & Nancy J. Nersessian - 2015 - Studies in History and Philosophy of Science Part C: Studies in History and Philosophy of Biological and Biomedical Sciences 49:1-11.
  10.  13
    The Creative Industry of Integrative Systems Biology.Miles MacLeod & Nancy J. Nersessian - 2013 - Mind and Society 12 (1):35-48.
    Integrative systems biology is among the most innovative fields of contemporary science, bringing together scientists from a range of diverse backgrounds and disciplines to tackle biological complexity through computational and mathematical modeling. The result is a plethora of problem-solving techniques, theoretical perspectives, lab-structures and organizations, and identity labels that have made it difficult for commentators to pin down precisely what systems biology is, philosophically or sociologically. In this paper, through the ethnographic investigation of two ISB laboratories, we explore the particular (...)
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  11.  33
    Limitations of Natural Kind Talk in the Life Sciences: Homology and Other Cases. [REVIEW]Miles MacLeod - 2013 - Biological Theory 7 (2):109-120.
    The aim of this article is to detail some reservations against the beliefs, claims, or presuppositions that current essentialist natural kind concepts (including homeostatic property cluster kinds) model grouping practices in the life sciences accurately and generally. Such concepts fit reasoning into particular preconceived epistemic and semantic patterns. The ability of these patterns to fit scientific practice is often argued in support of homeostatic property cluster accounts, yet there are reasons to think that in the life sciences kind concepts exhibit (...)
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  12.  23
    Heuristic Approaches to Models and Modeling in Systems Biology.Miles MacLeod - 2016 - Biology and Philosophy 31 (3):353-372.
    Prediction and control sufficient for reliable medical and other interventions are prominent aims of modeling in systems biology. The short-term attainment of these goals has played a strong role in projecting the importance and value of the field. In this paper I identify the standard models must meet to achieve these objectives as predictive robustness—predictive reliability over large domains. Drawing on the results of an ethnographic investigation and various studies in the systems biology literature, I explore four current obstacles to (...)
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  13.  2
    In Silico Modeling: The Human Factor.Marta Bertolaso & Miles MacLeod - 2016 - Humana Mente 9 (30).
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  14.  18
    What Does Interdisciplinarity Look Like in Practice: Mapping Interdisciplinarity and its Limits in the Environmental Sciences.Miles MacLeod & Michiru Nagatsu - 2018 - Studies in History and Philosophy of Science Part A 67:74-84.
    In this paper we take a close look at current interdisciplinary modeling practices in the environmental sciences, and suggest that closer attention needs to be paid to the nature of scientific practices when investigating and planning interdisciplinarity. While interdisciplinarity is often portrayed as a medium of novel and transformative methodological work, current modeling strategies in the environmental sciences are conservative, avoiding methodological conflict, while confining interdisciplinary interactions to a relatively small set of pre-existing modeling frameworks and strategies (a process we (...)
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  15.  10
    Model-Based Inferences in Modeling of Complex Systems.Miles MacLeod - forthcoming - Topoi:1-11.
    Modelers are tackling ever more complex systems with the aid of computation. Model-based inferences can play a key role in their ability to handle complexity and produce reliable or informative models. We study here the role of model-based inference in the modern field of computational systems biology. We illustrate how these inferences operate and analyze the material and theoretical bases or conditions underlying their effectiveness. Our investigation reiterates the significance and centrality of model-based reasoning in day-to-day problem-solving practices, and the (...)
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  16. 1. Really Statistical Explanations and Genetic Drift Really Statistical Explanations and Genetic Drift (Pp. 169-188).Marc Lange, Peter Vickers, John Michael, Miles MacLeod, Alexander R. Pruss, David John Baker, Clark Glymour & Simon Fitzpatrick - 2013 - Philosophy of Science 80 (2).
  17.  24
    The Epistemology-Only Approach to Natural Kinds: A Reply to Thomas Reydon.Miles Macleod - 2010 - In F. Stadler, D. Dieks, W. Gonzales, S. Hartmann, T. Uebel & M. Weber (eds.), The Present Situation in the Philosophy of Science. Springer. pp. 189--194.
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  18.  23
    Interdisciplinarity in Action: Philosophy of Science Perspectives.Uskali Mäki & Miles MacLeod - 2016 - European Journal for Philosophy of Science 6 (3):323-326.
    Interdisciplinarity has become a dominant research policy imperative1 – exercised by European Research Council and other funding agencies at different scales – and a substantial topic in science studies fields outside philosophy of science, including science education, research management (particularly team management) and scientometrics. Philosophers of science have only recently begun to dedicate more attention to this feature of contemporary science. The present collection of studies aspires to promote this line of philosophical inquiry in terms of case studies on various (...)
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  19.  58
    The Present Situation in the Philosophy of Science: Opening Conference of the Esf-Research Networking Programme “the Philosophy of Science in a European Perspective” (University of Vienna, December 18–20, 2008). [REVIEW]Friedrich Stadler, Donata Romizi & Miles MacLeod - 2009 - Journal for General Philosophy of Science / Zeitschrift für Allgemeine Wissenschaftstheorie 40 (1):129 - 136.
  20.  22
    Rethinking Scientific Concepts for Research Contexts: The Case of the Classical Gene.Miles MacLeod - 2012 - In Uljana Feest & Friedrich Steinle (eds.), Scientific Concepts and Investigative Practice. De Gruyter. pp. 3--47.
  21.  20
    Modernizing Philosophy of Science for the Philosopher and Student Alike.Miles MacLeod - 2015 - Metascience 24 (3):507-510.
    Philosophy of science is a rapidly evolving and increasingly inclusive academic field. It is one of the most dynamic branches of philosophy. However, for the most part, philosophy of science has been taught historically by recounting and tracing through discussions and debates from the early to late twentieth century. Great texts of positivism, instrumentalism, demarcation, falsification, paradigm shifts, realism, observation and so on are handed out to students and critically assessed. There is something rather puzzling about this way of teaching (...)
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  22.  15
    How to Compare Homology Concepts: Class Reasoning About Evolution and Morphology in Phylogenetics and Developmental Biology.Miles MacLeod - 2011 - Biological Theory 6 (2):141-153.
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  23.  15
    Meeting Disciplinary Boundaries: Towards a More Inclusive Philosophy of the Life Sciences.Pierre-Olivier Méthot, Miles MacLeod, Susanne Bauer, Fridolin Gross & Antonine Nicoglou - 2010 - Biological Theory (3):292-294.
  24.  16
    Following Through on Naturalistic Approaches to Natural Kinds.Miles MacLeod - 2014 - Metascience 23 (2):335-338.
    Large-scale book-length treatises on natural kinds are rather few compared to the amount of discussion on the subject and not since Brian Ellis’ Scientific Essentialism perhaps has anyone attempted to build a philosophical “world view” around a theory of natural kinds. Most discussion about natural kinds of the last decade has restricted itself to specific issues, such as the species debate or chemical kinds, or, as in the case of LaPorte (2009), the semantic practices surrounding kind concepts and conceptual change. (...)
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  25.  12
    Perhaps Essentialism is Not so Essential: At Least Not for Natural Kinds. [REVIEW]Miles MacLeod - 2013 - Metascience 22 (2):293-296.
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  26.  6
    The Present Situation in the Philosophy of Science: Opening Conference of the ESF-Research Networking Programme “The Philosophy of Science in a European Perspective”.Friedrich Stadler, Donata Romizi & Miles MacLeod - 2009 - Journal for General Philosophy of Science / Zeitschrift für Allgemeine Wissenschaftstheorie 40 (1):129-136.
  27.  4
    Meeting Disciplinary Boundaries: Towards a More Inclusive Philosophy of the Life Sciences.Antonine Nicoglou, Fridolin Gross, Susanne Bauer, Miles MacLeod & Pierre-Olivier Méthot - 2010 - Biological Theory 5 (3):292-294.
  28. A Piecewise Aggregation of Philosophers’ and Biologists’ Perspectives.Werner Callebaut, Martin Schlumpp, Julia Lang, Christoph Frischer, Stephan Handschuh, Miles MacLeod & Isabella Sarto-Jackson - 2016 - Biological Theory 11 (1):1-10.
    Re-Engineering Philosophy for Limited Beings is about new approaches to many of the big topics in philosophy of science today, but with a very different take. To begin with, we are urged to reject the received Cartesian-Laplacean myths: Descartes’ certainty and Laplace’s computational omniscience. Instead, Wimsatt re-engineers a philosophy for human beings with all their cognitive limitations. His approaches find their starting point in the actual practices of scientists themselves, which he strongly identifies with engineering practices as the source of (...)
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