Order:
  1.  34
    Lifespan Profiles of Alzheimer's Disease-Associated Genes and Products in Monkeys and Mice.R. Dosunmu, J. Wu, L. Adwan, B. Maloney, M. R. Basha, C. A. McPherson, G. J. Harry, D. C. Rice, N. H. Zawia & D. K. Lahiri - 2009 - J Alzheimers Dis 18:211-30.
    Alzheimer's disease is characterized by plaques of amyloid-beta peptide, cleaved from amyloid-beta protein precursor . Our hypothesis is that lifespan profiles of AD-associated mRNA and protein levels in monkeys would differ from mice and that differential lifespan expression profiles would be useful to understand human AD pathogenesis. We compared profiles of AbetaPP mRNA, AbetaPP protein, and Abeta levels in rodents and primates. We also tracked a transcriptional regulator of the AbetaPP gene, specificity protein 1 , and the beta amyloid precursor (...)
    Direct download (5 more)  
     
    Export citation  
     
    Bookmark   2 citations  
  2.  39
    Alzheimer's Disease -Like Pathology in Aged Monkeys After Infantile Exposure to Environmental Metal Lead : Evidence for a Developmental Origin and Environmental Link for AD.J. Wu, M. R. Basha, B. Brock, D. P. Cox, F. Cardozo-Pelaez, C. A. McPherson, J. Harry, D. C. Rice, B. Maloney, D. Chen, D. K. Lahiri & N. H. Zawia - 2008 - J Neurosci 28:3-9.
    The sporadic nature of Alzheimer's disease argues for an environmental link that may drive AD pathogenesis; however, the triggering factors and the period of their action are unknown. Recent studies in rodents have shown that exposure to lead during brain development predetermined the expression and regulation of the amyloid precursor protein and its amyloidogenic beta-amyloid product in old age. Here, we report that the expression of AD-related genes [APP, BACE1 ] as well as their transcriptional regulator were elevated in aged (...)
    Direct download (2 more)  
     
    Export citation  
     
    Bookmark   2 citations  
  3.  10
    Exposure to Lead and the Developmental Origin of Oxidative DNA Damage in the Aging Brain.C. M. Bolin, R. Basha, D. Cox, N. H. Zawia, B. Maloney, D. K. Lahiri & F. Cardozo-Pelaez - 2006 - Faseb J 20:788-90.
    Oxidative damage to DNA has been associated with neurodegenerative diseases. Developmental exposure to lead has been shown to elevate the Alzheimer's disease related beta-amyloid peptide , which is known to generate reactive oxygen species in the aging brain. This study measures the lifetime cerebral 8-hydroxy-2'-deoxyguanosine levels and the activity of the DNA repair enzyme 8-oxoguanine DNA glycosylase in rats developmentally exposed to Pb. Oxo8dG was transiently modulated early in life , but was later elevated 20 months after exposure to Pb (...)
    Direct download (2 more)  
     
    Export citation  
     
    Bookmark   2 citations  
  4.  13
    Co-Localization and Distribution of Cerebral APP and SP1 and its Relationship to Amyloidogenesis.B. Brock, R. Basha, K. DiPalma, A. Anderson, G. J. Harry, D. C. Rice, B. Maloney, D. K. Lahiri & N. H. Zawia - 2008 - J Alzheimers Dis 13:71-80.
    Alzheimer's disease is characterized by amyloid-beta peptide -loaded plaques in the brain. Abeta is a cleavage fragment of amyloid-beta protein precursor and over production of APP may lead to amyloidogenesis. The regulatory region of the APP gene contains consensus sites recognized by the transcription factor, specificity protein 1 , which has been shown to be required for the regulation of APP and Abeta. To understand the role of SP1 in APP biogenesis, herein we have characterized the relative distribution and localization (...)
    Direct download  
     
    Export citation  
     
    Bookmark   1 citation