BackgroundIn the Canadian Alliance for Healthy Hearts and Minds (CAHHM) cohort, participants underwent magnetic resonance imaging (MRI) of the brain, heart, and abdomen, that generated incidental findings (IFs). The approach to managing these unexpected results remain a complex issue. Our objectives were to describe the CAHHM policy for the management of IFs, to understand the impact of disclosing IFs to healthy research participants, and to reflect on the ethical obligations of researchers in future MRI studies.MethodsBetween 2013 and 2019, 8252 participants (...) (mean age 58 ± 9 years, 54% women) were recruited with a follow-up questionnaire administered to 909 participants (40% response rate) at 1-year. The CAHHM policy followed a restricted approach, whereby routine feedback on IFs was not provided. Only IFs of severe structural abnormalities were reported.ResultsSevere structural abnormalities occurred in 8.3% (95% confidence interval 7.7–8.9%) of participants, with the highest proportions found in the brain (4.2%) and abdomen (3.1%). The majority of participants (97%) informed of an IF reported no change in quality of life, with 3% of participants reporting that the knowledge of an IF negatively impacted their quality of life. Furthermore, 50% reported increased stress in learning about an IF, and in 95%, the discovery of an IF did not adversely impact his/her life insurance policy. Most participants (90%) would enrol in the study again and perceived the MRI scan to be beneficial, regardless of whether they were informed of IFs. While the implications of a restricted approach to IF management was perceived to be mostly positive, a degree of diagnostic misconception was present amongst participants, indicating the importance of a more thorough consent process to support participant autonomy.ConclusionThe management of IFs from research MRI scans remain a challenging issue, as participants may experience stress and a reduced quality of life when IFs are disclosed. The restricted approach to IF management in CAHHM demonstrated a fair fulfillment of the overarching ethical principles of respect for autonomy, concern for wellbeing, and justice. The approach outlined in the CAHHM policy may serve as a framework for future research studies.Clinical trial registrationhttps://clinicaltrials.gov/ct2/show/nct02220582. (shrink)

Volume 18, Issue 5, October 2019, Page 475-486.

The question to be discussed in this paper can be put in simple terms: at what date were the collections of scholia on classical Greek authors compiled? Scholars have given two conflicting answers. The first was put forward by J. W. White in his edition of the scholia to Aristophanes' Birds. Developing an opinion of Dindorf, he suggested that the archetype of the scholia was a large parchment codex of the fourth or fifth century, which contained in the margins a (...) commentary drawn from several sources. A very similar view has been expressed about the scholia to Apollonius Rhodius and Pindar. (shrink)

Movido no sólo por haber experimentado intensas ilusiones a lo largo de su vida, sino por su propia vocación teórica, y, una vez puesto a la tarea, por los sorprendentes hallazgos, en primer lugar, de que la palabra ilusión -«tan general, de tan larga historia, de tan claro linaje latino, común a tantas lenguas»- es algo privado del hispanohablante, y en segundo, de la casi absoluta ignorancia acerca de esta emoción, J. Marías aborda en este libro un insólito y fascinante (...) recorrido por este «secreto de la lengua española». A partir de aquí, y a través de sus distintos capítulos, Marías analiza con su indiscutible sabiduría las relaciones del término, y aquello que designa, con la imaginación, el tiempo, el deseo, la vocación, el amor y, por último, con la presencia y la ausencia del propio objeto de la ilusión. (shrink)

Morocco; Andalusia (Spain); intellectual life; philosophy; history.

ʻAyyānī, Yaḥyá ibn Ḥumaydān, ca. 12th century; Muslim scholars; Yemen; views on Islamic philosophy.

The restoration of "forgotten" names to the bosom of our culture is a natural and necessary accompaniment of the political freedom beginning to make its way in our country. Free and continuous creativity is being reunited with the reader, the listener, and the participant, who had been tragically alienated from it. Our half-knowledge, intellectual arbitrariness, and opportunism are becoming clearer, more acute, and more shameful. All this is an inevitable accompaniment of one of the most prestigious and, it would seem, (...) least labor consuming trends in contemporary publishing and journal policy. The publication of texts of Russian philosophers has marked journals as different in character and mission as Novyi mir, Voprosy filosofii, Literaturnaia ucheba, Druzhba narodov, Volga, and many others. In most cases they are more or less well known works reprinted from the YMCA Press, equipped with prefaces—some better, some worse—and devoid of any sort of real intellectual commentary. (shrink)