The aim of synthetic biology is to rationally design devices, systems, and organisms with desired innovative and useful functions (Slusarczyk, Lin, and Weiss 2012). To achieve this aim, synthetic biology uses a concept similar to engineering sciences: well-characterized and standardized modular biological building blocks are reassembled in a systematic and rational manner to generate complex devices and systems with a predicted function. In the past, molecular biological research in combination with intense work in new research areas like systems biology and (...) functional genomics revealed a large inventory of multifaceted modular biological parts that are now in the toolboxes of synthetic biologists. Due to .. (shrink)

Supervenient libertarianism maintains that indeterminism may exist at a supervening agency level, consistent with determinism at a subvening physical level. It seems as if this approach has the potential to break the longstanding deadlock in the free will debate, since it concedes to the traditional incompatibilist that agents can only do otherwise if they can do so in their actual circumstances, holding the past and the laws constant, while nonetheless arguing that this ability is compatible with physical determinism. However, we (...) argue that supervenient libertarianism faces some serious problems, and that it fails to break us free from this deadlock within the free will debate. (shrink)

Justified by spectacular achievements facilitated through applied deep learning methodology, the “Everything is possible” view dominates this new hour in the “boom and bust” curve of AI performance. The optimistic view collides head on with the “It is not possible”—ascertainments often originating in a skewed understanding of both AI and medicine. The meaning of the conflicting views can be assessed only by addressing the nature of medicine. Specifically: Which part of medicine, if any, can and should be entrusted to AI—now (...) or at some moment in the future? AI or not, medicine should incorporate the anticipation perspective in providing care. (shrink)

It is a long-standing puzzle why predicates like believe embed declarative but not interrogative complements and why predicates like wonder embed interrogative but not declarative complements. This paper shows how the selectional restrictions of a range of predicates can be derived from semantic assumptions that can be independently motivated.

While philosophers have worried about mental causation for centuries, worries about the causal relevance of conscious phenomena are also increasingly featuring in neuroscientific literature. Neuroscientists have regarded the threat of epiphenomenalism as interesting primarily because they have supposed that it entails free will scepticism. However, the steps that get us from a premise about the causal irrelevance of conscious phenomena to a conclusion about free will are not entirely clear. In fact, if we examine popular philosophical accounts of free will, (...) we find, for the most part, nothing to suggest that free will is inconsistent with the presence of unconscious neural precursors to choices. It is only if we adopt highly non-naturalistic assumptions about the mind (e.g. if we embrace Cartesian dualism and locate free choice in the non-physical realm) that it seems plausible to suppose that the neuroscientific data generates a threat to free will. (shrink)

The Druze movement originated at the beginning of the eleventh century and developed out of the Ismā'īlī faction of Shī'ī Islām. Founded by the Ismā'īlī Ḥamza ibn 'Alī, the Tawḥīd is a philosophical and spiritual path that incorporates the fundamentals of Islam, Christianity, and Judaism referred to in the Qur'ān, together with the ancient philosophies of Pythagoras, Plato, Aristotle, Plotinus, and others. It is a synthesis and a unification of the most contradictory thoughts, a synthesis that leads to the real (...) Tawḥīd or "third course".The specificity of the Tawḥīd consists in establishing a bridge between monotheism and non-dualism. To say that God is One does not merely mean... (shrink)

Proponents of modern Frankfurt-Style Counterexamples generally accept that we cannot construct successful FSCs in which there are no alternative possibilities present. But they maintain that we can construct successful FSCs in which there are no morally significant alternatives present and that such examples succeed in breaking any conceptual link between alternative possibilities and free will. I argue that it is not possible to construct an FSC that succeeds even in this weaker sense. In cases where any alternatives are clearly insignificant, (...) it does not appear at all obvious that the agent can be held responsible. Present popular FSCs include alternatives that are ambiguous in their significance, and when the examples are sharpened to remove this ambiguity, they lose their force. Moreover, the proponent of such examples faces a problem: We can easily construct scenarios in which any alternatives are obviously insignificant, and in such scenarios, we are not intuitively inclined to suppose the agent is responsible. The proponent of new FSCs must therefore distinguish any alternatives she includes from the sorts included in these scenarios. The difference must now be such that this helps to make it seem intuitively likely that the agent is responsible where the agent otherwise would not appear responsible, and these alternatives are irrelevant to any judgment about whether the agent is responsible. I maintain that it is impossible to achieve both of these goals at once. (shrink)

Pereboom has formulated a Frankfurt-style counterexample in which an agent is alleged to be responsible despite the fact that there are only non-robust alternatives present (Pereboom, Moral responsibility and alternative possibilities: essays on the importance of alternative possibilities, 2003; Phil Explor 12(2):109–118, 2009). I support Widerker’s objection to Pereboom’s Tax Evasion 2 example (Widerker, J Phil 103(4):163–187, 2006) (which rests on the worry that the agent in this example is derivatively culpable as opposed to directly responsible) against Pereboom’s recent counterarguments (...) to this objection (Pereboom 2009). Building on work by Moya (J Phil 104:475–486, 2007; Critica 43(128):3–26, 2011) and Widerker (Widerker 2006), I argue that there is good reason to measure the robustness of alternatives in terms of comparative, rather than non-comparative likelihood of exemption, where the important factor for blame is whether the agent is “doing her reasonable best” to avoid blameworthy behaviour. I maintain that an agent only ever appears responsible when alternatives are robust in this sense. In Pereboom’s examples, both Tax Evasion 2, and his more recent version, Tax Evasion 3 (Pereboom 2009), I maintain the robustness of the alternatives, so understood, is unclear. We can clear up any ambiguity by sharpening the examples, and the result is that the agent appears responsible when the alternatives are made clearly robust, and does not appear responsible when alternatives appear clearly non-robust. The comparative nature of our judgements about blame, I maintain helps to explain the continuing appeal of the “leeway-incompatibilist” viewpoint. (shrink)

In the mid-2000s, rising gas prices, political instability, pollution, and fossil fuel depletion brought renewable domestic energy production onto the policy agenda. Biofuels, or fuels made from plant materials, came to be seen as America’s hope for energy security, environmental conservation, and rural economic revitalization. Yet even as the actual environmental, economic, and energy contributions of a biofuels boom remained debatable, support for biofuels swelled and became a prominent driver of not only US energy policy but of US farm policy (...) as well. This paper asks why biofuels became such a powerful force in farm policy debates, and draws on policy windows theory and discourse analysis to analyze biofuels’ contributions to the passage of the 2008 farm bill. It finds that budgetary and political factors combined with a particular set of patriotic biofuels-oriented discourses to carry energy policy debates into farm policy. It also comments on the implications of biofuels policies for conservation and sustainable land use in 2008 and beyond. (shrink)

While philosophers have worried about mental causation for centuries, worries about the causal relevance of conscious phenomena are also increasingly featuring in neuroscientific literature. Neuroscientists have regarded the threat of epiphenomenalism as interesting primarily because they have supposed that it entails free will scepticism. However, the steps that get us from a premise about the causal irrelevance of conscious phenomena to a conclusion about free will are not entirely clear. In fact, if we examine popular philosophical accounts of free will, (...) we find, for the most part, nothing to suggest that free will is inconsistent with the presence of unconscious neural precursors to choices. It is only if we adopt highly non-naturalistic assumptions about the mind that it seems plausible to suppose that the neuroscientific data generates a threat to free will. (shrink)

I examine Manuel Vargas's revisionist justification for continuing with our responsibility-characteristic practices in the absence of basic desert. I query his claim that this justification need not depend on how we settle questions about the content of morality, arguing that it requires us to reject the Kantian principle that prohibits treating anyone merely as a means. I maintain that any convincing argument against this principle would have to be driven by concerns that arise within the sphere of moral theory itself, (...) whereas Vargas's argument draws solely on concerns about the expensive metaphysics involved in a libertarian conception of freedom. I argue that this amounts not just to changing the concept of free will by stipulation, but also to changing our moral principles by stipulation. (shrink)

Controversies in food and agriculture abound, with many portrayed as conflicts between polarized viewpoints. Framing such controversies as dichotomies, however, can at times obscure what might be a plurality of views and potential common ground on the subject. We used Q methodology to explore stakeholders’ views about pesticide safety, agricultural worker exposure, and human health concerns in the tree fruit industry of central Washington State. Using a purposive sample of English and Spanish-speaking agricultural workers, industry representatives, state agencies, educators, and (...) advocates, participants sorted 45 statements on pesticide use and perceived human safety risks in the tree fruit industry in 2011. We used PQMethod 2.33 statistical software program to identify viewpoints, based on differences between how participants sorted the statements. The results revealed three distinct viewpoints among 38 sorters that explained 52 percent of the variance. The viewpoints included the: skeptics who expressed concern over the environmental and human health impacts of pesticide use; acceptors who acknowledged inherent risks for using pesticides but saw the risks as known, small and manageable; and incrementalists who prioritized opportunities to introduce human capital and technological improvements to increase agricultural worker safety. We then brought representatives with these different viewpoints together to analyze the results of the Q study, and to brainstorm mutually acceptable improvements to health and safety in tree fruit orchards. In describing and analyzing this case study, we argue that Q methodology can serve as one potentially effective tool for collaborative work, in this case facilitating a process of orchard safety improvements despite perceived stakeholder polarization. (shrink)

In this paper I explore a neglected discussion of vagueness put forward by Wittgenstein in his Philosophical Grammar (1932–34). In this work, unlike Philosophical Investigations (1953), Wittgenstein not only discusses the venerable Sorites paradox but provides a novel conception of vagueness using an analogy with coin tossing and converging intervals. As he sees it, the problematic picture of vagueness arises because we conflate aspects of the functioning of vague concepts with those of non-vague ones. Thus, while we accept that vague (...) concepts have no sharp cut-off points (are boundaryless), we nevertheless retain the idea that we can progress towards the penumbra the way we progress towards the cut-off points of non-vague concepts. As a potential remedy, Wittgenstein's analogy with coin tossing and converging intervals replaces this picture and provides an understanding of the functioning of vague concepts in which no notion of a progression arises. (shrink)

Recent feminist criticism suggests that Hegel’s account of Antigone in the Phenomenology of Spirit is antithetical to feminism on two key counts: first, Hegel does not develop an authentic political representation of women’s agency and participation in the community, and second, he does not provide a model for a genuinely ethical order especially where relations between men and women are concerned. Patricia Jagentowicz Mills and Luce Irigaray are two feminist thinkers who have expressed these positions. They both take issue with (...) Hegel’s interpretation of Antigone’s actions, although each for different reasons. Mills argues that Hegel misrepresents the experience of women in the Greek community, symbolized by Antigone, as not self-conscious, unreflective, and incapable of enduring ethical conflict. The main reason for this mistaken identity, according to Mills, stems from Hegel’s beliefs that human law and man are ethically superior to divine law and woman, and that the former can legitimately rule over, indeed dominate, the latter. Irigaray asserts that the phallogocentric power of the masculine in Hegel’s text almost completely eliminates the possibility of an authentic feminine individual and action. According to this view, an autonomous feminine understanding of purpose and action is rendered impossible by the feminine’s very masculinization at the outset. At issue here is whether Antigone can indeed be understood as an ethical actor when she acts on behalf of the family and/or whether she can be understood as an ethical actor who represents the community. The conclusions drawn from these interpretations have been that, for Hegel, women are not genuine political actors, on the one hand, because their association with the family disqualifies them as such, and on the other hand, because their actions are constituted by consciousness which is masculine, and also instrumentalized for the masculine. (shrink)

Business ethics should be taught in business schools as an integrated part of core curricula in MBA programs with a dual focus on both analytical frameworks and their applications to the business disciplines. To overcome the reluctance of many faculty to handle ethical issues, a critical mass of faculty must develop suitable materials, educate their peers in its use, and take the lead by introducing it in their own courses and on senior management programs.

The claim that theoretical foundations are historically contingent does not draw the same intensity of fire as it did one or especially two decades ago. The aftermath of debates on the political boundaries created by foundations allows for a deeper exploration of the foundations of feminist theory. This article re-examines the (anti)-Hegelian foundations of the feminist standpoint put forward by Nancy Hartsock and argues that the Hegelian subject of the early Phenomenology of Spirit resists gender codification in its experience of (...) ongoing rediscovery and fallibility in knowing. The subject against which the feminist self was constituted does not fit the masculinity thought to be natural. Hegel’s master-slave dialectic and phenomenological subject reveal contradictions that cannot be resolved by an opposing feminist standpoint, and may provide resources that resist the rigid gender categories upon which the standpoint depends. Key Words: abstract masculinity • feminist standpoint • feminist theory • foundations • Nancy Hartsock • Hegel • master-slave dialectic • subjectivity. (shrink)

This article provides an analysis of moral emotions from an attributional point of view, guided by the metaphors of man as a naïve scientist and as a moral judge. The theoretical analysis focuses on three concepts: The distinction between the actor and the observer, the functional quality of moral emotions, and the perceived controllability of the causes of events. Moral emotions are identified. A classification of these moral emotions is suggested and the empirical evidence briefly summarized. In discussing our results, (...) we identify unresolved issues awaiting further analyses and research. (shrink)

Many historical studies have been devoted to the French school of molecular biology, in particular to the work of Jacques Monod on adaptive enzymes. By focusing on Francois Jacob's studies on lysogeny between 1950 and 1960, we intend to redress the imbalance of historiography, as well as proposing a more fruitful point of view for understanding the relative importance of international contacts and local traditions in the genesis of the operon model.Elie Wollman and Jacob's work on temperate bacteriophages rendered respectable (...) a system that had been considered an artefact for more than two decades. They did this firstly by modelling their studies on those of the US phage group and secondly by basing these studies on a complex vision of the relations between bacteria and bacteriophages. The interaction between bacteria and temperate bacteriophages was considered ab initio as a biochemical process, the mechanisms of which would eventually be characterized. It was also considered as a ''normal'' phenomenon that could be used as a model to understand the process of differentiation, as well as the role of viruses in diseases and cancer. The temperate bacteriophage was a model system that was far more epistemologically open and, for this reason, in a sense more productive than the virulent phage studied by the US phage group. (shrink)

Pregnancy is thought to be a metabolically very expensive endeavor, yet investigations have produced inconsistent results concerning the responsiveness of human birth weight to maternal nutritional stress or nutritional intervention. These findings have led some researchers to conclude that fetal growth is strongly buffered against fluctuations in maternal energy balance, making the fetus in effect a “nearly perfect parasite.” This buffering would appear to be a reasonable adaptive response given the high risk of morbidity and mortality associated with low birth (...) weight. However, a life-history approach leads to the prediction that maternal investment strategies in pregnancy should be geared toward maximizing lifetime reproductive success rather than simply the success of the current pregnancy, and by extension that maternal investment strategies should vary with reproductive value. The physiology of human pregnancy in fact appears to include a number of mechanisms that protect maternal energy resources from diversion to the fetus and preserve them for future reproductive events. These mechanisms include adjustment of blood flow to the uterus and perhaps minor adjustments in gestation length, although evidence for the latter is scant. Suggestions are made for ways of investigating these maternal options. (shrink)

The Flemish government considers well-being of pupils as an important output indicator for the quality of education. The education inspectorate needed an instrument to measure this well-being in a school context, an instrument that should also be a basis for actions plans aimed at enhancing pupils' well-being. The development of this instrument is described in this article. A total of 342 pupils were interviewed. The material from these interviews was used for construction of—mainly Likert-type—items for a questionnaire. A pilot version (...) of the questionnaire was examined by experts and tested with a random sample of 306 pupils. The experimental version was tried out on a random sample of 2054 pupils. This resulted in a questionnaire with four consistent scales and thirteen subscales. Significant differences between schools were found. Atmosphere at school, contacts with teachers, involvement in class and at school, school regulations and infrastructure were among the best predictors. (shrink)

This study examines how the use of self‐ and peer‐assessment within a girls‐only biology class can support students’ motivation. The study took place over 22 weeks in a rural comprehensive school, and the participants were girls between 15 and 16 years of age. Data included questionnaires, semi‐structured interviews, notes from lesson observations and video‐transcripts of peer‐assessment episodes. Data analysis suggests that girls’ motivation may be supported, both by being taught in a single‐sex group and by employing assessment for learning techniques. (...) However, such benefits were not ubiquitous and may have been negated by examination anxiety, inadequate time to adapt to assessment for learning strategies, limited negative effects of single‐sex teaching on learning, the way in which the single‐sex class was created and some girls’ resilient conceptions of science being a masculine subject. (shrink)

This study focuses on the profile of principals who seem to be able to shape the school culture to best encourage teaching and learning. Data from a representative sample of primary schools (N = 46) were collected through questionnaires for principals and for teachers (N = 700) and semi?structured interviews with the principals. Functioning, well?being and personal characteristics of the principal, structural and cultural characteristics of school, and organisational context are examined. Compared to their opposites, principals in schools with cultures (...) stimulating professional development, combine (1) type A, achievement?oriented behaviour, (2) transformational leadership, (3) a preference for tasks related to education matters and people management and (4) effective time management allowing them to devote most of their time to their preferred role and task component. (shrink)

In this paper I present the philosophical backdrop to Russell's 1923 "Vagueness" paper. I argue that his view of vagueness in 1923 is the result of a rise in the importance of symbolism in his thinking coupled with a new interest in psychology. I show how these new interests are related to concerns he had with his theory of judgment as well as his logicist project. I attend to the two major complaints against his view of vagueness: that all language (...) is vague and his purported conflation of vagueness with generality. I lastly show how Russell's view is distinct from modern approaches to vagueness in so far as he is not concerned with truth-value gaps but instead sees vagueness as applying primarily to what is cognitive and as a transitory position between ignorance and knowledge. (shrink)

A large number of feminist philosophers and social critics accept that Simone de Beauvoir's conception of transcendence in The Second Sex relies on masculinist ontology. In contrast with feminist interpretations that see Beauvoir claiming the success of masculinist ontology, this article argues that transcendence as masculinist ontology does not succeed in The Second Sex because it requires a relation of domination, something contrary to its own definition of freedom-producing relations. The Second Sex obliquely reveals this failure, but Beauvoir does not (...) ruminate upon it. Instead, Beauvoir turns to imagine freedom-producing gender relations in the future where the body and consciousness are already emancipated from constitutive domination. This is a future that resonates with G. W. F. Hegel's `Stoic Consciousness'. The significance of this finding is that the location of freedom neither resides in the intertwinement of the male body and consciousness previously argued to be the case, for Beauvoir, nor does it reside in the intertwinement of the female body and consciousness. Rather, freedom resides in the intertwinement of male and female bodies and consciousness where domination is already absent, that is, a place outside of history. Thus, the conclusion of The Second Sex can be read as a consolation and an escape from the inescapable limits of the present. (shrink)

Open Science policies encourage researchers to disclose a wide range of outputs from their work, thus codifying openness as a specific set of research practices and guidelines that can be interpreted and applied consistently across disciplines and geographical settings. In this paper, we argue that this “one-size-fits-all” view of openness sidesteps key questions about the forms, implications, and goals of openness for research practice. We propose instead to interpret openness as a dynamic and highly situated mode of valuing the research (...) process and its outputs, which encompasses economic as well as scientific, cultural, political, ethical, and social considerations. This interpretation creates a critical space for moving beyond the economic definitions of value embedded in the contemporary biosciences landscape and Open Science policies, and examining the diversity of interests and commitments that affect research practices in the life sciences. To illustrate these claims, we use three case studies that highlight the challenges surrounding decisions about how––and how best––to make things open. These cases, drawn from ethnographic engagement with Open Science debates and semistructured interviews carried out with UK-based biologists and bioinformaticians between 2013 and 2014, show how the enactment of openness reveals judgments about what constitutes a legitimate intellectual contribution, for whom, and with what implications. (shrink)

Incompatibilism is often accused of incoherence because it introduces randomness in support of freedom. I argue that the sort of randomness that's thought to be detrimental to freedom results not from denying causal determinism, so much as denying what we might call ‘rational determinism’: denying that agents' actions are determined by their reasons for acting. Compatibilists argue that introducing the ability to decide differently allows agents to make choices that are irrational, and this undermines rather than furthering freedom. I maintain (...) that this argument neglects scenarios in which reasons are in conflict with one another. In such scenarios, we can preserve rationality without claiming that the agent's choices are rationally determined. (shrink)

The current assumptions of knowledge acquisition brought about the crisis in the reproducibility of experiments. A complementary perspective should account for the specific causality characteristic of life by integrating past, present, and future. A “second Cartesian revolution,” informed by and in awareness of anticipatory processes, should result in scientific methods that transcend the theology of determinism and reductionism. In our days, science, itself an expression of anticipatory activity, makes possible alternative understandings of reality and its dynamics. For this purpose, the (...) study advances G-complexity for defining and comparing decidable and undecidable knowledge. AI and related computational expressions of knowledge could benefit from the awareness of what distinguishes the dynamics of life from any other expressions of change. (shrink)