The understanding of locomotion in neurological disorders requires technologies for quantitative gait analysis. Numerous modalities are available today to objectively capture spatiotemporal gait and postural control features. Nevertheless, many obstacles prevent the application of these technologies to their full potential in neurological research and especially clinical practice. These include the required expert knowledge, time for data collection, and missing standards for data analysis and reporting. Here, we provide a technological review of wearable and vision-based portable motion analysis tools (...) that emerged in the last decade with recent applications in neurological disorders such as Parkinson's disease and Multiple Sclerosis. The goal is to enable the reader to understand the available technologies with their individual strengths and limitations in order to make an informed decision for own investigations and clinical applications. We foresee that ongoing developments toward user-friendly automated devices will allow for closed-loop applications, long-term monitoring, and telemedical consulting in real-life environments. (shrink)

Language is a spontaneously evolved emergent adaptation, not a formal computational system. Its structure does not derive from either innate or social instruction but rather self-organization and selection. Its quasi-universal features emerge from the interactions among semiotic constraints, neural processing limitations, and social transmission dynamics. The neurological processing of sentence structure is more analogous to embryonic differentiation than to algorithmic computation. The biological basis of this unprecedented adaptation is not located in some unique neurologieal structure nor the result of (...) any single mutation, but is vested in the synergistic interaction of numerous coevolved neurological biases and social dynamics. (shrink)

During the nineteenth century, neuroanatomical knowledge and the clinical practice of treating mental illnesses develop at the same time. Some practitioners of mental medicine try to combine the clinical practice of treating mental diseases with neuroanatomical knowledge using the idea of cerebral localisations. This point of view is advocated by Gall and the field of phrenology. But there is no obvious success of such a localisationist project before Broca and Wernicke’s works on aphasia. This discovery will provoke a revival of (...) the desire to localise the cerebral zones involved in mental diseases. However, the cerebral localisation project progressively decreases during the end of the nineteenth century while neurological clinical practice emerges. Moreover, neurological clinical practice aims to localise anatomical lesions through clinical examination. From a philosophy of science point of view, this segment of history brings into question the relation between a scientific object (the cerebral localisation of zones involved in diseases) and a scientific subject (psychiatry and neurology). It stresses how a scientific project can migrate from one subject to another. (shrink)

This article examines the imagination by way of various studies in cognitive science. It opens by examining the neural correlates of bodily metaphors. It assumes a basic knowledge of metaphor studies, or the primary finding that has emerged from this field: that large swathes of human conceptualization are structured by bodily relations. I examine the neural correlates of metaphor, concentrating on the relation between the sensory motor cortices and linguistic conceptualization. This discussion, however, leaves many questions unanswered. If it is (...) the case that the sensory motor cortices are appropriated in language acquisition, how does this process occur at the neural level? What neural preconditions exist such that this appropriation is possible? It is with these questions in mind that I will turn my attention to studies of neural plasticity, degeneracy and the mirror neuron activation. Whereas some scholarship in philosophy and cognitive neuroscience has aimed to identify the neurological correlates of consciousness, examining plasticity, degeneracy and activation shifts the discussion away from a study of correlates toward an exploration of the neurological dynamics of thought. This shift seems appropriate if we are to examine the processes of the “imagination.”. (shrink)

Page has done connectionist researchers a valuable service in this target article. He points out that connectionist models using localized representations often work as well or better than models using distributed representations. I point out that models using distributed representations are difficult to understand and often lack parsimony and plausibility. In conclusion, I give an example – the case of the missing fundamental in music – that can easily be explained by a model using localist representations but can be explained (...) only with great difficulty and implausibility by a model using distributed representations. (shrink)

Written by leading theorists and empirical researchers, this book presents new ways of addressing the old question: Why did religion first emerge and then continue to evolve in all human societies? The authors of the book--each with a different background across the social sciences and humanities -- assimilate conceptual leads and empirical findings from anthropology, evolutionary biology, evolutionary sociology, neurology, primate behavioral studies, explanations of human interaction and group dynamics, and a wide range of religious scholarship to construct a deeper (...) and more powerful explanation of the origins and subsequent evolutionary development of religions than can be currently found in what is now vast literature. While explaining religion has been a central question in many disciplines for a long time, this book draws upon a much wider array of literatures to develop a robust and cross-disciplinary analysis of religion. The book remains true to its subtitle by emphasizing an array of both biological and sociocultural forms of selection dynamics that are fundamental to explaining religion as a universal institution in human societies. In addition to Darwinian selection, which can explain the biology and neurology of religion, the book outlines a set of four additional types of sociocultural natural selection that can explain fill out the explanation of why religion first emerged as an institutional system in human societies, and why it has continued to evolve over the last 200,000 years of societal evolution. These sociocultural forms of natural selection are labeled by the names of the early sociologists who first emphasized them; and these can be seen as a necessary supplement to the type of natural selection theorized by Charles Darwin. Explanations of religion that remain in the shadow cast by Darwin's great insights will, it is argued, remain narrow and incomplete when explaining a robust sociocultural phenomena like religion. (shrink)

Spanish culture has recently shown interest about Neuroethics, a new line of research and reflection. It can be said that two general, and somewhat opposing, perspectives are currently being developed in Spain about neuroethics-related topics. One originates from the neuroscientific field and the other from the philosophical field. We will see, throughout this article, that the Spanish authors, who I am going to select here, deal with very diverse neuroethical topics and that they analyse them from different intellectual assumptions. However, (...) I consider that there is one constant concern, which emerges extensively or briefly in each one of the books that I am going to present. I am referring to the problem of freedom. Spanish neuroscientists, in general, stress and accept the new determinism that emanates from recent research about the brain, whilst those who engage in the study of philosophy usually point in their texts to the limitations of empirical research that purport to "demonstrate" the new neurological determinism. I will dedicate the last section, which is more extensive in length, to the work that I consider the most valuable, at least until the present day, and whose title is Neuroética y Neuropolítica (Tecnos, Madrid, 2011). Professor Adela Cortina (chair of Moral Philosophy at Valencia University and member of the Spanish Royal Academy of Moral and Political Science) is its author. But, firstly, I am going to refer to the works written by neuroscientists, and then to those written by philosophers. This will enable us to obtain a global view of the neuroethics models that are being constructed in Spain. (shrink)

This non-article explores the limitations of applying brain science in “higher” disciplines. Many brain scientists believe that it is only a matter of time that everything human will be accounted for by the findings of brain science. Michael Polányi in the nineteen-sixties and recently Michael Gazzaniga argued against such determinism. They say that while “lower-level” processes constrain “higher-level” ones, they cannot determine them. The human mind is an emergent process, and it cannot be predicted from brain structure anymore than traffic (...) can be predicted from the structure of a car. I claim that in many instances, the application of brain science in psychology and literary studies merely re-states in brain-language what has already been said in psychology-language or literature-language. It can, however, be fruitfully applied when it refutes prevalent erroneous assumptions or resolves certain incongruities in the domain of “higher” disciplines. (shrink)

This non-article explores the limitations of applying brain science in “higher” disciplines. Many brain scientists believe that it is only a matter of time that everything human will be accounted for by the findings of brain science. Michael Polányi in the nineteen-sixties and recently Michael Gazzaniga argued against such determinism. They say that while “lower-level” processes constrain “higher-level” ones, they cannot determine them. The human mind is an emergent process, and it cannot be predicted from brain structure anymore than traffic (...) can be predicted from the structure of a car. I claim that in many instances, the application of brain science in psychology and literary studies merely re-states in brain-language what has already been said in psychology-language or literature-language. It can, however, be fruitfully applied when it refutes prevalent erroneous assumptions or resolves certain incongruities in the domain of “higher” disciplines. (shrink)

A review essay of three recent publications that focus in different ways on the evolution­ary basis of religion. Asma focuses on the ways in which “religion” energizes the emotional needs of humans. Torrey pays close attention to the evolutionary stages of brain development that are necessary for the emergence of religious concepts and the attitudes that accompany them. Finally, Turner et al. develop a complex theory of different types of selection that they regard as necessary in order to account for (...) the institu­tionalization of religion: they think that biological natural selection, even though building human capacities, is insufficient to explain the sociological facts about religion. (shrink)

À partir des années 1980 eut lieu une véritable révolution dans la connaissance du phénomène neurologique de la synesthésie, qui s’est accompagnée d’une révolution culturelle avec l’apparition de témoignages personnels de synesthètes. Cette représentation littéraire et plastique des perceptions synesthésiques fait partie du mouvement contemporain de représentations autobiographiques de différentes conditions neurologiques. Carol Steen, Patricia Lynne Duffy et Marcia Smilack sont des acteurs pionniers de la représentation des perceptions synesthésiques. From the 1980s, a revolution took place in the knowledge of (...) the neurological phenomenon of synesthesia, which has been accompanied by a cultural revolution with the emergence of personal accounts of synesthetes. Autobiographical representation—literary or plastic—of synesthetic perceptions belongs to the contemporary movement of autobiographical representations of various neurological conditions. Carol Steen, Patricia Lynne Duffy and Marcia Smilack are pioneers involved in representation of synesthetic perceptions. (shrink)

We present a theory of human artistic experience and the neural mechanisms that mediate it. Any theory of art has to ideally have three components. The logic of art: whether there are universal rules or principles; The evolutionary rationale: why did these rules evolve and why do they have the form that they do; What is the brain circuitry involved? Our paper begins with a quest for artistic universals and proposes a list of ‘Eight laws of artistic experience’ -- a (...) set of heuristics that artists either consciously or unconsciously deploy to optimally titillate the visual areas of the brain. One of these principles is a psychological phenomenon called the peak shift effect: If a rat is rewarded for discriminating a rectangle from a square, it will respond even more vigorously to a rectangle that is longer and skinnier that the prototype. We suggest that this principle explains not only caricatures, but many other aspects of art. Example: An evocative sketch of a female nude may be one which selectively accentuates those feminine form-attributes that allow one to discriminate it from a male figure; a Boucher, a Van Gogh, or a Monet may be a caricature in ‘colour space’ rather than form space. Even abstract art may employ ‘supernormal’ stimuli to excite form areas in the brain more strongly than natural stimuli. Second, we suggest that grouping is a very basic principle. The different extrastriate visual areas may have evolved specifically to extract correlations in different domains , and discovering and linking multiple features into unitary clusters -- objects -- is facilitated and reinforced by direct connections from these areas to limbic structures. In general, when object-like entities are partially discerned at any stage in the visual hierarchy, messages are sent back to earlier stages to alert them to certain locations or features in order to look for additional evidence for the object . Finally, given constraints on allocation of attentional resources, art is most appealing if it produces heightened activity in a single dimension rather than redundant activation of multiple modules. This idea may help explain the effectiveness of outline drawings and sketches, the savant syndrome in autists, and the sudden emergence of artistic talent in fronto-temporal dementia. In addition to these three basic principles we propose five others, constituting a total of ‘eight laws of aesthetic experience’. (shrink)

Transcranial direct current stimulation (tDCS) is a brain stimulation technique known for its relative safety and minimal invasiveness. tDCS has demonstrated efficacy as a potential treatment for certain neurological disorders, such as Parkinson’s disease, and has been shown to enhance a range of cognitive abilities under certain contexts. As a result, this technique has captured the interest of both the research community and the public at large. However, efforts to gather information about the effects of tDCS on the brain (...) are still in their infancy, leading to concerns about informed consent as it pertains to the possible risks associated with tDCS treatment. The ability to purchase tDCS equipment in the form of commercial, direct-to-consumer devices, generates even more cause for ethical concern, given the unknowns surrounding this technology and its potential broader societal impact. Previous research has touched on the many ethical issues raised by the emergence of this technology, including under what circumstances its use is justifiable and appropriate. In this paper, we survey recent normative and empirical works pertaining to the ethics of tDCS with the goal of summarizing the current state of ethical debate surrounding its use in the contexts of both therapy and cognitive enhancement, with a particular emphasis on the latter. Our analysis of the collected research finds that issues pertaining to user safety are paramount within existing scholarship; that tDCS use in children is an emerging area of concern entailing special considerations; and that regulatory bodies and legal agencies have struggled to implement appropriate, impactful regulation pertaining to tDCS and related technologies in order to balance public welfare against individual autonomy. This analysis will facilitate future efforts to develop bioethical approaches to tDCS by highlighting the ethical dimensions of tDCS prioritized in existing literature and identifying areas where further ethical consideration is needed. (shrink)

Our aim was to describe Chinese nurses' experiences of workplace distress and ethical dilemmas on a neurological ward. Qualitative interviews were performed with 20 nurses. On using latent content analysis, themes emerged in four content areas: ethical dilemmas, workplace distress, quality of nursing and managing distress. The ethical dilemmas were: (1) conflicting views on optimal treatment and nursing; (2) treatment choice meeting with financial constraints; and (3) misalignment of nursing responsibilities, competence and available resources. The patients' relatives lacked respect (...) for the nurses' skills. Other dilemmas could be traced to the transition from a planned to a market economy, resulting in an excessive workload and treatment withdrawal for financial reasons. Lack of resources was perceived as an obstacle to proper patient care in addition to hospital organization, decreasing the quality of nursing, and increasing moral and workplace distress. The nurses managed mainly by striving for competence, which gave them hope for the future. (shrink)

Extensive scholarship has described the historical and ethical imperatives shaping the emergence of the brain death criteria in the 1960s and 1970s. This essay explores the longer intellectual history that shaped theories of neurological consciousness from the late-nineteenth century to that period, and argues that a significant transformation occurred in the elaboration of those theories in the 1960s and after, the period when various disturbances of consciousness were discovered or thoroughly elaborated. Numerous historical conditions can be identified and attributed (...) to the production of the new theories that emerged from that period-on, not least in the broader social and cultural transformations that occurred with decolonialization, pro-democracy movements, and civil and disability rights advocacy, all contexts which exerted pressures on the institutions and professions of medicine. In this telling, the discovery of the locked-in patient is thus the exploration of a transformed vision of medical patients – one that moved them from a liminal indefinite space into a firmly grounded epistemological existence – in a backdrop in which medical professionals in particular and society in general was beginning to see the body differently. With this new vision, came a relational theory of consciousness to, a reading of a body and it signs, that shifted consciousness from an internally-derived state into a relationally-constructed object. The ontology of consciousness, whatever it was, thereby became entangled with the social condition of consciousness, one that bridged the worlds of close relationship with the social movements and anxieties about personhood that emanated out of that fraught period. (shrink)

Does exploration of the gut microbiota–brain axis expand our understanding of what it means to be human? Recognition and conceptualization of a gut microbiota–brain axis challenges our study of the nervous system. Here, integrating gut microbiota–brain research into the metaorganism model is proposed. The metaorganism—an expanded, dynamic unit comprising the host and commensal organisms—asserts a radical blurring between man and microbe. The metaorganism nervous system interacts with the exterior world through microbial‐colored lenses. Ongoing studies have reported that gut microbes contribute (...) to brain function and pathologies, even shaping higher neurological functions. How will continued collaborative efforts (e.g., between neurobiology and microbiology), including partnerships with the arts (e.g., philosophy), contribute to the knowledge of microbe‐to‐mind interactions? While this is not a systemic review, this nascent field is briefly described, highlighting ongoing challenges and recommendations for emerging gut microbiota–brain research. Also see the video abstract here https://youtu.be/lP9gOW8StXg. (shrink)

The purpose of this paper is to explore the merits of the idea that dynamical systems theory (also known as chaos theory) provides a model of the mind that can vindicate the language of thought (LOT). I investigate the nature of emergent structure in dynamical systems to assess its compatibility with causally efficacious syntactic structure in the brain. I will argue that anyone who is committed to the idea that the brain's functioning depends on emergent features of dynamical systems should (...) have serious reservations about the LOT. First, dynamical systems theory casts doubt on one of the strongest motives for believing in the LOT: principle P, the doctrine that structure found in an effect must also be found in its cause. Second, chaotic emergence is a double-edged sword. Its tendency to cleave the psychological from the neurological undermines foundations for belief in the existence of causally efficacious representations. Overall, a dynamic conception of the brain sways us away from realist conclusions about the causal powers of representations with constituent structure. (shrink)

Recent years have seen a rapid growth in neuroscientific research, and an expansion beyond basic research to incorporate elements of the arts, humanities and social sciences. It has been suggested that the neurosciences will bring about major transformations in the understanding of ourselves, our culture and our society. In academia one finds debates within psychology, philosophy and literature about the implications of developments within the neurosciences, and the emerging fields of educational neuroscience, neuro-economics, and neuro-aesthetics also bear witness to a (...) 'neurological turn' which is currently taking place. Neuroscience and Critique is a ground-breaking edited collection which reflects on the impact of neuroscience in contemporary social science and the humanities. It is the first book to consider possibilities for a critique of the theories, practices, and implications of contemporary neuroscience. Bringing together leading scholars from several disciplines, the contributors draw upon a range of perspectives, including cognitive neuroscience, critical philosophy, psychoanalysis, and feminism, and also critically examine several key ideas in contemporary neuroscience, including: The idea of "neural personhood" Theories of emotion in affective neuroscience Empathy, intersubjectivity and the notion of "embodied simulation" The concept of an "emo-rational" actor within neuro-economics. The volume will stimulate further debate in the emerging field of interdisciplinary studies in neuroscience, and will appeal to researchers and advanced students in a range of disciplines including critical psychology, philosophy, and critical studies. (shrink)

This set reprints eight rare volumes, covering the origins of neurology from 1803, the time when the brain was first identified as being the centre of the mind, to 1906. It includes a new introduction and the essential works of Bell, Gall, Mueller and Ferrier.

Drawing on two years of ethnographic fieldwork in Egypt focused on organ transplantation, this paper examines the ways in which the “scientific” criteria of determining death in terms of brain function are contested by Egyptian doctors. Whereas in North American medical practice, the death of the “person” is associated with the cessation of brain function, in Egypt, any sign of biological life is evidence of the persistence, even if fleeting, of the soul. I argue that this difference does not exemplify (...) an irresolvable culture clash but points to an unsettling aspect of cadaveric organ procurement that has emerged wherever organ transplantation is practiced. Further, I argue that a misdiagnosis of the problem, as one about “religious extremism” or a “civilizational clash,” has obfuscated unresolved concerns about fairness, access, and justice within Egyptian medical spheres. This misdiagnosis has led to the suspension of a cadaveric procurement program for over 30 years, despite Egypt’s pioneering efforts in kidney transplantation. (shrink)

Language is a spontaneously evolved emergent adaptation, not a formal computational system. Its structure does not derive from either innate or social instruction but rather self-organization and selection. Its quasi-universal features emerge from the interactions among semiotic constraints, neural processing limitations, and social transmission dynamics. The neurological processing of sentence structure is more analogous to embryonic differentiation than to algorithmic computation. The biological basis of this unprecedented adaptation is not located in some unique neurologieal structure nor the result of (...) any single mutation, but is vested in the synergistic interaction of numerous coevolved neurological biases and social dynamics. (shrink)

Language is a spontaneously evolved emergent adaptation, not a formal computational system. Its structure does not derive from either innate or social instruction but rather self-organization and selection. Its quasi-universal features emerge from the interactions among semiotic constraints, neural processing limitations, and social transmission dynamics. The neurological processing of sentence structure is more analogous to embryonic differentiation than to algorithmic computation. The biological basis of this unprecedented adaptation is not located in some unique neurologieal structure nor the result of (...) any single mutation, but is vested in the synergistic interaction of numerous coevolved neurological biases and social dynamics. (shrink)

According to property-emergentism, consciousness is an emergent property of certain aggregate neurological constructions, whereas substance-emergentism maintains that the emergence of consciousness depends on the emergence of mental substance or soul. In this article, we presented some arguments supporting substance-emergentism by analysing various properties of consciousness, including the first-person perspective, referral state, qualia, being active, causative, non-atomic, interpretative, inferential and inventive. We also explored the impossibility of representing big images on the small monitor and the incapacity of physical entities being (...) conscious because of their intrinsic multiplicity, absence and deficiency. These arguments, which apply the philosophy of Mulla Sadra, could be considered by philosophers of mind and religion, as well as theologians who follow some religious beliefs such as the afterlife on existence and survival of the soul. Also, we attempted to respond to property-emergentists' objections to substance-emergentism.CONTRIBUTION: This research contributes to prove and accept the emergence of the immaterial soul after the stages of natural evolution of the body. It uses the basics of emergentism, including natural evolution, to link science and religion in believing the existence of the immaterial soul. Demonstrating the immaterial reality of human existence provides the ground for theological issues such as afterlife and religious morality. (shrink)

In this article I will attempt to refute the claim that the mind is a radically emergent feature of the brain. First, the inter-related concepts of emergence, reducibility and constraint are considered, particularly as these ideas relate to hierarchical biological systems. The implications of radical emergence theories of the mind such as the one posited by Roger Sperry, are explored. I then argue that the failure of Sperry's model is based on the notion that consciousness arises as a radically emergent (...) feature ‘at the top command’ of a non-nested neurological hierarchy. An alternative model, one that avoids the dualism inherent in radical emergence theories, is offered in which the brain is described as producing a nested hierarchy of meaning and purpose that has no ‘top’ or ‘summit’. Finally, I will argue there remains a non-reducible aspect of consciousness that does not depend upon radical emergence theory, but rather on the mutual irreducibility of the subjective and objective points of view. This irreducible aspect of consciousness can be understood as the non-mysterious result of brain evolution and normal neural functioning. (shrink)

Weaknesses in Roger Sperry's "Defense of Mentalism" that appeared in the Spring issue of JMB are described. Sperry's clarification of his mentalist position still appears to lack a plausible mechanism of interaction. The wheel rolling down hill analogy is described as "a ghost in the subcircuitry." Neurological Positivism's energetic mechanism of brain-mind interaction is summarized. The relatioship of systems theory to reductionism is described briefly in terms of NP.

One of the central tenets of Christian theology is the denial of self for the benefit of another. However, many views on the evolution of altruism presume that natural selection inevitably leads to a self-seeking human nature and that altruism is merely a façade to cover underlying selfish motives. I argue that human altruism is an emergent characteristic that cannot be reduced to any one particular evolutionary explanation. The evolutionary processes at work in the formation of human nature are not (...) necessarily in conflict with the possibility of altruism; rather, aspects of human nature are uniquely directed toward the care and concern of others. The relationship between altruism, human nature, and evolution can be reimagined by adopting an emergent view of the hierarchy of science and a theological worldview that emphasizes self-renunciation. The investigation of altruism necessitates an approach that analyzes several aspects of altruistic behavior at different levels in the hierarchy of sciences. This research includes the study of evolutionary adaptations, neurological systems, cognitive functions, behavioral traits, and cultural influences. No one level is able to offer a full explanation, but each piece adds a unique dimension to a much larger puzzle. (shrink)

We estimate that 208,000 deep brain stimulation (DBS) devices have been implanted to address neurological and neuropsychiatric disorders worldwide. DBS Think Tank presenters pooled data and determined that DBS expanded in its scope and has been applied to multiple brain disorders in an effort to modulate neural circuitry. The DBS Think Tank was founded in 2012 providing a space where clinicians, engineers, researchers from industry and academia discuss current and emerging DBS technologies and logistical and ethical issues facing the (...) field. The emphasis is on cutting edge research and collaboration aimed to advance the DBS field. The Eighth Annual DBS Think Tank was held virtually on September 1 and 2, 2020 (Zoom Video Communications) due to restrictions related to the COVID-19 pandemic. The meeting focused on advances in: (1) optogenetics as a tool for comprehending neurobiology of diseases and on optogenetically-inspired DBS, (2) cutting edge of emerging DBS technologies, (3) ethical issues affecting DBS research and access to care, (4) neuromodulatory approaches for depression, (5) advancing novel hardware, software and imaging methodologies, (6) use of neurophysiological signals in adaptive neurostimulation, and (7) use of more advanced technologies to improve DBS clinical outcomes. There were 178 attendees who participated in a DBS Think Tank survey, which revealed the expansion of DBS into several indications such as obesity, post-traumatic stress disorder, addiction and Alzheimer’s disease. This proceedings summarizes the advances discussed at the Eighth Annual DBS Think Tank. (shrink)

Medical, scientific and societal progress has been such that, in a universalist humanist perspective such as the WHO’s, it has become an ethical imperative for the primary endpoints in evidence based health care research to be expressed in e.g. Quality Adjusted Life Years (QALYs). The classical endpoints of discrete health‐related functions and duration of survival are increasingly perceived as unacceptably reductionistic. The major problem in ‘felicitometrics’ is the measurement of the ‘quality’ term in QALYs. That the mental, physical and social (...) domains, each containing many dimensions and items, all contribute to QOL is uncontroversial. What is controversial, is the weight of the different dimensions in overall QOL. It has been shown to be very different between different patient populations. In human individuals, assuredly complex systems, the many dimensions and items of QOL observably interact, probably sometimes also in chaotic ways. In these conditions, the weights of isolated items in individuals become for all practical purposes meaningless. Therefore, the much used multi‐item questionnaires at best describe, but do not evaluate QOL, neither in individuals, nor in populations. For example, allergic patients treated with cetirizine scored better than those a placebo on all dimensions of the SF‐36, a standard QOL questionnaire. Here there is no serious doubt that the treatment improved QOL, because it is highly unlikely that any important dimension on which the patient groups would have scored otherwise is missing in the SF‐36. However, whether piracetam treatment of acute stroke, which improved the surrogate endpoints neurological and functional scores, also improved QOL is plausible, but will be proven only when comprehensive QOL measurement will have been done. And suppose in randomised populations of end‐stage metastatic solid cancer patients, one would compare palliative last‐line chemotherapy with only palliative care, and one would, as can be expected, find no significant differences in average survival, and chemotherapy superior for the mental domain, but inferior for the physical comfort domain: we would not know which treatment, on aggregate, would be the better. The problem is that QOL is an individual and emergent construct, the resultant of a great many intractions, and of a different order than its contributing components. Overall QOL can therefore best be captured only as the Gestalt of a global self‐assessment. Just as people in everyday life, while acting under uncertainty, make global assessments all the time, so they can seriously answer the serious question: ‘How have you been?’ A solemn, practical, non peer‐relativistic, non‐cultural, experiential, and well tolerated way to obtain such responses is Anamnestic Comparative Self Assessment (ACSA), in which the subjects' memories of the best and the worst times in their life experience define their individual scale of QOL. ACSA is thus both exquisitely idiosyncratic, and yet can in a universalist humanistic perspective be considered generic. Using both a multi‐item questionnaire and a global assessment allows by one logistic regression, to estimate the weights of the dimensions and items in populations, and thus identify those whose improvement would most contribute to the QOL of the greatest number. A combined approach to measurement of QOL is necessary to maximise the utility of QOL interventions. (shrink)

Possible measurement and testability weaknesses in Sperry's mind-supervenient emergent interactionism "argument by analogy" model are described. An alternative brain-supervenient interactionism that addresses the weaknesses of Sperry's mind-brain model is presented. The alternative model, Neurological Positivism - a systems-theoretical evolutionary epistemology - proposes that the measurable energy quality of the algorithmic organization of the Darwinian brain supervenes that of cultural mental models and thus downwardly influences the brain circuitry patterns that underlie them. Brain and mind are defined in interrelated energy (...) terms within the context of the self-referential maximum-power principle. The equivalence of maximum-power principle energy hierarchies to chaotic/fractal dynamical designs is described. The production of mental models through reflective thinking is defined as an emergent dimension of energetic self-referencing by the brain operating in accordance with the maximum-power principle. It is concluded that within the context of NP the brain-mind relationship constitutes an "uneven" central state energy identity, with brain supervenient, when brain-mind relative energy qualities are taken into account. (shrink)

A growing number of technologies are currently being developed to improve and distribute thinking and decision-making. Rapid progress in brain-to-brain interfacing and swarming technologies promises to transform how we think about collective and collaborative cognitive tasks across domains, ranging from research to entertainment, and from therapeutics to military applications. As these tools continue to improve, we are prompted to monitor how they may affect our society on a broader level, but also how they may reshape our fundamental understanding of agency, (...) responsibility, and other key concepts of our moral landscape.In this paper we take a closer look at this class of technologies – Technologies for Collective Minds – to see not only how their implementation may react with commonly held moral values, but also how they challenge our underlying concepts of what constitutes collective or individual agency. We argue that prominent contemporary frameworks for understanding collective agency and responsibility are insufficient in terms of accurately describing the relationships enabled by Technologies for Collective Minds, and that they therefore risk obstructing ethical analysis of the implementation of these technologies in society. We propose a more multidimensional approach to better understand this set of technologies, and to facilitate future research on the ethics of Technologies for Collective Minds. (shrink)

Dual aspect theory has conceptual advantages over alternative mind-body notions, but difficulties of its own. The nature of the underlying psychophysical ground, for one, remains problematic either in terms of the principle of complementarity or if mind and matter are taken to be aspects of something like energy, movement, or information. Moreover, for a dual aspect theory to be plausible it should avoid the four perils of all mind-body theories: epiphenomenalism, reductionism, gross panpsychism, and the problems of emergence. An alternative (...) dual aspect theory, patterned process theory, is introduced and defended in neurological and individuality terms. The concept is grounded in a brain model of hierarchies wherein consciousness is conceived to be a cognitive aspect of the highest emergent brain inter-module activity, which is situated in the context of a living organism coping with a changing environment. The notion of individuals as psychophysical units unfolding as patterned processes is shown to constitute an integrative approach to brain, consciousness, and behavior that can avoid the conceptual perils and meet the ontological requirements of dual aspect reality and thereby advance the foundations of an integrative mind-body science. (shrink)

Severe Traumatic Brain Injury (TBI) remains a major cause of death and disability afflicting mostly young adult males and elderly people, resulting in high economic costs to society. Therapeutic approaches focus on reducing the risk on secondary brain injury. Specific ethical issues pertaining in clinical testing of pharmacological neuroprotective agents in TBI include the emergency nature of the research, the incapacity of the patients to informed consent before inclusion, short therapeutic time windows, and a risk-benefit ratio based on concept (...) that in relation to the severity of the trauma, significant adverse side effects may be acceptable for possible beneficial treatments. Randomized controlled phase III trials investigating the safety and efficacy of agents in TBI with promising benefit, conducted in acute emergency situations with short therapeutic time windows, should allow randomization under deferred consent or waiver of consent. Making progress in knowledge of treatment in acute neurological and other intensive care conditions is only possible if national regulations and legislations allow waiver of consent or deferred consent for clinical trials. (shrink)

The aetio-pathogenetic sequences and the physio-pathological patterns of diabetes, emphysema, cholera, circulatory shock and thrombosis have been analysed with respect to an evolutionary interpretation. The diseases, although reflecting alterations of processes that can always be described in physico-chemical language, occur only at the level of biological systems which reflects the decodification of genomic project: the teleonomic projects that have been developed during evolution. The concepts of evolutionary emergence and of downward causation have been used to discuss the relationship between the (...) molecular events responsible for the initiation of the disease, and the subsequent events responsible for the aetio-pathogenesis, for the systemic disarrangement and for the additional alterations of tissues and cells independent of the initial molecular events. In diabetes the systemic disarrangement, glycosuria and hyperglycemia, reflect the evolutionary emergence of the processes regulating carbohydrate metabolism, whereas the cardiovascular and neurological alterations are effects of the systemic disarrangement by a mechanism of downward causation. The complexity of the aetio-pathogenesis and of the physio-pathological patterns of diseases is due to the generation of information during the evolution of multi-hierarchical entities. The evolutionary epistemology approach is useful to explain the behaviour of complex systems. (shrink)

Possible measurement and testability weaknesses in Sperry's mind-supervenient emergent interactionism "argument by analogy" model are described. An alternative brain-supervenient interactionism that addresses the weaknesses of Sperry's mind-brain model is presented. The alternative model, Neurological Positivism - a systems-theoretical evolutionary epistemology - proposes that the measurable energy quality of the algorithmic organization of the Darwinian brain supervenes that of cultural mental models and thus downwardly influences the brain circuitry patterns that underlie them. Brain and mind are defined in interrelated energy (...) terms within the context of the self-referential maximum-power principle. The equivalence of maximum-power principle energy hierarchies to chaotic/fractal dynamical designs is described. The production of mental models through reflective thinking is defined as an emergent dimension of energetic self-referencing by the brain operating in accordance with the maximum-power principle. It is concluded that within the context of NP the brain-mind relationship constitutes an "uneven" central state energy identity, with brain supervenient, when brain-mind relative energy qualities are taken into account. (shrink)

In an adaptive clinical trial , key trial characteristics may be altered during the course of the trial according to predefined rules in response to information that accumulates within the trial itself. In addition to having distinguishing scientific features, adaptive trials also may involve ethical considerations that differ from more traditional randomized trials. Better understanding of clinical trial experts’ views about the ethical aspects of adaptive designs could assist those planning ACTs. Our aim was to elucidate the opinions of clinical (...) trial experts regarding their beliefs about ethical aspects of ACTs. (shrink)

The recent emergence of reprogramming technologies to convert brain cell types or epigenetically alter neurons and neural progenitors in vivo and in situ hold significant promises in brain repair and neuronal aging reversal. However, given the significant epigenetic and transcriptomic changes to components of the existing neuronal cells and network, we question if these reprogramming technology might inadvertently alter or erase memory engrams, conceivably resulting in changes in narrative identity or personality. We suggest that the nature of these alterations might (...) be less predictable compared to memory and personality changes known to be associated with diseases, drugs or brain stimulation therapies. While research in applying reprogramming technologies to neurological ailments and aging should continue, more targeted analyses should be put in place in animal experiments to gauge the severity and degree of memory alterations, and appropriate risk and benefit analyses should be conducted before these technologies move into human trials. (shrink)

This paper considers the impact which developments in neuroscience seem likely to have on our inherited, intuitive psychology ? the system of beliefs called ?folk psychology? by enthusiasts for its elimination. The paper argues that while closer relations between a developing genuinely scientific cognitive psychology and a burgeoning neurological understanding are to be welcomed, physiology will not reduce psychology, and the concepts belonging to intuitive psychology will be transformed and enriched, but not discredited or discarded, when psychology, in its (...) cognitive form, emerges as a science with genuine explanatory power. The analogy between belief and desire, on one hand, and witches and phlogiston, on the other, is rejected. So is the parallel between folk psychology and folk physics. We face the choice, on Churchland's principles, between the rejection of historical, literary, and moral culture, and accepting a dualism in human thought which despairs of a comprehensively naturalistic vision of ourselves. (shrink)

Emerging data indicates the prevalence and increased use of pharmaceutical enhancements by young medical professionals. As pharmaceutical enhancements advance and become more readily available, it is imperative to consider their impact on medical professionals. If pharmaceutical enhancements augment a person’s neurological capacities to higher functioning levels, and in some situations having higher functioning levels of focus and concentration could improve patient care, then might medical professionals have a responsibility to enhance? In this paper, I suggest medical professionals may have (...) a responsibility to use pharmaceutical enhancements. In some situations, having higher functioning levels of focus and concentration is conducive to providing the best possible care to a patient. In these circumstances medical professionals should use pharmaceutical cognitive enhancements. I conclude by examining the limitations and implications of this responsibility in the practice of medicine and areas for future research. (shrink)

Clinical neuroethics and neuroskepticism are recent entrants to the vocabulary of neuroethics. Clinical neuroethics has been used to distinguish problems of clinical relevance arising from developments in brain science from problems arising in neuroscience research proper. Neuroskepticism has been proposed as a counterweight to claims about the value and likely implications of developments in neuroscience. These two emergent streams of thought intersect within the practice of neurology. Neurologists face many traditional problems in bioethics, like end of life care in the (...) persistent vegetative state, determination of capacity in progressive dementia, and requests for assisted suicide in cognition-preserving neurodegenerative disease (like amyotrophic lateral sclerosis). Neurologists also look to be at the forefront of downstream clinical applications of neuroscience, like pharmacological enhancement of mental life. At the same time, the practice of neurology, concerned primarily with the structure, function, and treatment of the nervous system, has historically fostered a kind of skeptical attitude toward its own subject matter. Not all problems that appear primarily neurological are primarily neurological. This disciplinary skepticism is generally clinical in orientation and limited in scope. The rise of interest in clinical neuroethics and in neuroskepticsim generally suggests a possible broader application. The clinical skepticism of neurology provides impetus for thinking about the appropriate role for skepticism in clinical areas of neuroethics. After a brief review of neuroskepticism and clinical neuroethics, a taxonomy of clinical neuroskepticism is offered and reasons why a stronger rather than weaker form of clinical neuroskepticism is currently warranted. (shrink)

The long standing reign of psychology as the privileged partner of education has, arguably, now been superseded by the neurosciences. Given that this helped to drive the emergent field of neuroeducation, it is crucial to ask what changes in education, if anything does in fact change, when the hitherto hegemonic psychologising discourse is substituted for a neurological one. The primary contention of this paper is that with the neuro-turn a process of “neurologisation” has also been initiated, which can be (...) analysed by taking into account its genealogical predecessor, psychologisation. In doing so, I argue, one ultimately discerns a primordial incompatibility between education and neuroscience, one that can be traced back to the fundamental and problematic reflexivity of modern subjectivity itself, which the discipline of psychology was never able to wholly resolve. From here, I proceed with the argument that while the eagerness of the psy-sciences to embrace neuroscience testifies to how much psychology needs neurology, the neurosciences are structurally incapable of disconnecting from the paradigms of the psy-sciences. Following on from this proposition, other strong/weak factors are brought into the equation: strong/weak nature, strong/weak culture, strong/weak subjectivity and, most pertinently, strong/weak education. Finally, the critical question becomes: if education in itself needs to take recourse to both the psy-sciences and the neurosciences, then how can we begin to account for the fact that these sciences invariably end up becoming captured within educational discourses themselves; that is, the fact that teachers, parents, and pupils themselves are taught the key insights of neuropsychology. (shrink)

Direct neurological and especially imaging-driven investigations into the structures essential to naturally occurring cognitive systems in their development and operation have motivated broadening interest in the potential for artificial consciousness modeled on these systems. This first paper in a series of three begins with a brief review of Boltuc’s (2009) “brain-based” thesis on the prospect of artificial consciousness, focusing on his formulation of h-consciousness. We then explore some of the implications of brain research on the structure of consciousness, finding (...) limitations in biological approaches to the study of consciousness. Looking past these limitations, we introduce research in artificial consciousness designed to test for the emergence of consciousness, a phenomenon beyond the purview of the study of existing biological systems. (shrink)

In the article author analyses the extent to which it is possible to regard the Aristotelian conception of the soul as actually necessary and applicable for modern neuroscience. The framework in which this objective is going to be accomplished is provided by the idea of the coexistence of the “manifest” and “scientific” images of the world and persons, as introduced by Wilfrid Sellars. In subsequent sections, author initially formulates an answer to the questions of what it is that Aristotle sought (...) to explain with his conception of soul as formal cause, and how this notion could be portrayed in terms drawn from contemporary neurological science. It is author’s intention to show that no other concepts—be they the Cartesian “mind” or a Chalmers-style “self”—come anywhere close to matching the breadth of scope of Aristotelian “soul”. At the same time, though, analysis carried out here do not intend to undertake any kind of defence of the soul as a spiritual entity of the sort popular where religious faith is concerned, namely as an entity separable from the body, immortal, and inimitably tied to God. Then, in the second major part of the article, author analyses the extent to which the Aristotelian conception of the soul can be thought of as involving criteria of the sort that we encounter in the contemporary theory of strong emergence. According to the author the theory of strong emergence has, as a heuristic theory, quite general predictive and explanatory power as regards the field of human thought and behaviour. (shrink)

This article outlines the emergence of ABA (Applied Behaviour Analysis) in the mid-20th century, and the current popularity of ABA in the anglophone world. I draw on the work of earlier historians to highlight the role of Ole Ivar Lovaas, the most influential practitioner of ABA. I argue that reception of his initial work was mainly positive, despite concerns regarding its efficacy and use of physical aversives. Lovaas’ work, however, was only cautiously accepted by medical practitioners until he published results (...) in 1987. Many accepted the results as validation of Lovaas’ research, though both his methods and broader understanding of autism had shifted considerably since his early work in the 1960s. The article analyses the controversies surrounding ABA since the early 1990s, considering in particular criticisms made by autistic people in the ‘neurodiversity movement’. As with earlier critics, some condemn the use of painful aversives, exemplified in the campaign against the use of shock therapy at the Judge Rotenberg Center. Unlike earlier, non-autistic critics, however, many in this movement reject the ideological goals of ABA, considering autism a harmless neurological difference rather than a pathology. They argue that eliminating benign autistic behaviour through ABA is impermissible, owing to the individual psychological harm and the wider societal impact. Finally, I compare the claims made by the neurodiversity movement with those made by similar 20th- and 21st-century social movements. (shrink)

In the historical context of a crisis in biological psychiatry, psychedelic drugs paired with psychotherapy are globally re-emerging in research clinics as a potential transdiagnostic therapy for treating mood disorders, addictions, and other forms of psychological distress. The treatments are poised to soon shift from clinical trials to widespread service delivery in places like Australia, North America, and Europe, which has prompted ethical questions by social scientists and bioethicists. Taking a broader view, we argue that the ethics of psychedelic therapy (...) concerns not simply how psychotherapies are different when paired with psychedelic drugs, but how psychedelic therapies shape and are shaped by different values, norms, and metaphysical commitments. Drawing from the published literature and interviews with seven psychedelic therapists working in clinical trials in the United States, Germany, Switzerland, and Australia, this article opens the black box of the treatments to consider the values and informal debates currently animating the therapies. Considering questions of patient autonomy, mechanisms of therapeutic action, and which therapies are best suited to pair with psychedelic substances, we examine the ethics of psychedelic therapy as an emergent form of life. To bring this form of life out in fuller relief, we conclude by comparing and contrasting it with ayahuasca use in Amazonian shamanism. (shrink)