Cancers rely on multiple, heterogeneous processes at different scales, pertaining to many biomedical fields. Therefore, understanding cancer is necessarily an interdisciplinary task that requires placing specialised experimental and clinical research into a broader conceptual, theoretical, and methodological framework. Without such a framework, oncology will collect piecemeal results, with scant dialogue between the different scientific communities studying cancer. We argue that one important way forward in service of a more successful dialogue is through greater integration of applied sciences (experimental and clinical) (...) with conceptual and theoretical approaches, informed by philosophical methods. By way of illustration, we explore six central themes: (i) the role of mutations in cancer; (ii) the clonal evolution of cancer cells; (iii) the relationship between cancer and multicellularity; (iv) the tumour microenvironment; (v) the immune system; and (vi) stem cells. In each case, we examine open questions in the scientific literature through a philosophical methodology and show the benefit of such a synergy for the scientific and medical understanding of cancer. (shrink)

This site has been developed by the Center for Mental Health Services to "promote the development of healthy behaviors, competence, and resilience in school-aged children and youth," in the hopes of reducing violence in schools. Included is information about model programs and links to resources on topics such as safe and drug free schools, emergency services, and the influence of the media.

Toute guerre se remporte avec des hommes et des munitions, y compris celle des idées. Aujourd'hui l'histoire, la politique, l'économie, la culture, le droit sont des champs de bataille. À nous d'y triompher de la pensée unique. Beaucoup ont déjà pris la plume, tels Jean Sévillia, Philippe de Villiers ou Mathieu Bock-Côté. Mais à cette aventure intellectuelle, le droit reste étranger. Chose curieuse, au regard de son immixtion dans nos vies, réglées comme des horloges suisses par ses rouages. Mal interprété, (...) il regorge d'idées fausses, parfois sciemment entretenues par nos législateurs à des fins politiques. Remettre le droit à l'endroit? C'est l'objet insolite de cet ouvrage. Les hommes naissent-ils réellement libres et égaux en droit? Nos élus nous coûtent-ils trop cher? La naissance d'un étranger en France le rend-elle nécessairement français? Le droit européen est-il vraiment supérieur au droit national? Trente questions pour y voir clair et combattre les idées reçues. (shrink)

Open and shut -- Thinking about technology -- The problem with technology -- Evil and the empire of good -- Hall of mirrors -- Our faith -- Thinking past technology -- Living among things -- Less is more.

Le présent article se propose de mettre en lumière non seulement la critique platonicienne de la poésie telle qu’elle se déploie dans les livres II, III et X de la République, mais aussi - et surtout - la lecture qu’en fait le néoplatonicien Proclus dans son vaste Commentaire sur la République. Le principal enjeu de cette lecture est le lien entre le mythe et l’éducation. Nous verrons d’abord comment Platon s’emploie à lier ces deux éléments, puis comment Proclus cherche pour (...) sa part à relativiser ce lien, au point où mythe et éducation en viennent, sinon à s’exclure mutuellement, du moins à n’entretenir qu’un faible commerce. (shrink)

Taste as Experience puts the pleasure of food at the center of human experience. It shows how the sense of taste informs our preferences for and relationship to nature, pushes us toward ethical practices of consumption, and impresses upon us the importance of aesthetics. Eating is often dismissed as a necessary aspect of survival, and our personal enjoyment of food is considered a quirk. Nicola Perullo sees food as the only portion of the world we take in on a (...) daily basis, constituting our first and most significant encounter with the earth. Perullo has long observed people's food practices and has listened to their food experiences. He draws on years of research to explain the complex meanings behind our food choices and the thinking that accompanies our gustatory actions. He also considers our indifference toward food as a force influencing us as much as engagement. For Perullo, taste is value and wisdom. It cannot be reduced to mere chemical or cultural factors but embodies the quality and quantity of our earthly experience. (shrink)

Previous research suggests that social anxiety symptoms are maintained and intensified by inflexible emotion regulation (ER). Therefore, we examined whether trait-level social anxiety moderates ER flexibility operationalised at both between-person (covariation between variability in emotional intensity and variability in strategy use across occasions) and within-person (associations between emotional intensity and strategy use on a given day) levels. In a sample of healthy college-aged adults (N = 185, Mage = 21.89), we examined overall and emotion-specific intensities (shame, guilt, anxiety, anger, sadness) (...) and regulatory strategies (i.e. experiential avoidance, expressive suppression, and rumination) in response to each day’s most emotionally intense event over 6 days. During the study period, we found a positive association between variability in emotional intensity and variability of experiential avoidance in individuals with lower, rather than higher, levels of trait social anxiety after controlling for key covariates (i.e. gender, personality traits, and stress exposure). However, we did not find evidence for the moderating role of trait social anxiety in ER flexibility assessed at within-person levels. Our findings highlight the need to delineate dynamic ER flexibility across everyday events. (shrink)

This paper studies the capture of organisms and materials in soil construction – a branch of ecological engineering dedicated to making soil in order to compensate for soil degradation. This approach takes all organisms to be ‘ecosystem engineers’, and often refers to earthworms as ‘collaborators’ in making soil. I examine the claim that such a convocation of worms amounts to a redistribution of agency and the underlying assumption that form-taking is the shaping of raw matter according to pre-existing forms. Drawing (...) on processual anthropology, I question the distinction between living and material components of soils, and between growing and making. I elaborate on soil scientists’ description of soil growth as pedogenesis in order to propose a view in which soil materials, along with organisms, participate in soil’s transformative and generative fluxes. I envisage the process as a concrescence, an experimentation that brings humans, worms, and soil materials together in new ways. (shrink)

De part en part traversé par le mythe, le Commentaire sur la République du Néoplatonicien Proclus accorde forcément une attention soutenue au symbole. Cet article se propose de mettre en lumière deux types de symbolisme que l’on trouve dans ce Commentaire. Le premier, «non imitatif», reconfigure significativement l’héritage des Formes intelligibles platoniciennes; le second, tiré des Oracles chaldaïques, consiste en une «intériorisation» du symbole. Les deux symbolismes se rejoignent en ce qu’ils impliquent une sympathie profonde entre toutes choses, et présupposent (...) la communication préalable des symboles tant dans la genèse que dans l’interprétation du mythe inspiré. (shrink)

In the historical context of a crisis in biological psychiatry, psychedelic drugs paired with psychotherapy are globally re-emerging in research clinics as a potential transdiagnostic therapy for treating mood disorders, addictions, and other forms of psychological distress. The treatments are poised to soon shift from clinical trials to widespread service delivery in places like Australia, North America, and Europe, which has prompted ethical questions by social scientists and bioethicists. Taking a broader view, we argue that the ethics of psychedelic therapy (...) concerns not simply how psychotherapies are different when paired with psychedelic drugs, but how psychedelic therapies shape and are shaped by different values, norms, and metaphysical commitments. Drawing from the published literature and interviews with seven psychedelic therapists working in clinical trials in the United States, Germany, Switzerland, and Australia, this article opens the black box of the treatments to consider the values and informal debates currently animating the therapies. Considering questions of patient autonomy, mechanisms of therapeutic action, and which therapies are best suited to pair with psychedelic substances, we examine the ethics of psychedelic therapy as an emergent form of life. To bring this form of life out in fuller relief, we conclude by comparing and contrasting it with ayahuasca use in Amazonian shamanism. (shrink)

Certitudes et incertitudes du déterminisme.--La crise de l'esprit.--Le drame.--La tour de Babel.--Le crépuscule.--L'aube.

This paper aims to show that the COVID-19 pandemic has amplified existing barriers to healthcare in England for ethnic minority and migrant women. These barriers include those embedded within the i...

Methexiology is not a particular theory, but rather a general philosophical orientation. Therefore, in Methexiology: Philosophical Theology and Theological Philosophy for the Deification of Humanity, Nicolas Laos elucidates the significance of methexiology for the study of ontology, epistemology, ethics, philosophical psychology, theory of justice, philosophy of history, and philosophy of religion. Laos argues that, faced with the modern and the postmodern crises of meaning, we need a new myth, a new spiritual formula, for the resacralization of humanity and the cosmos, (...) without restoring defunct totems, without using tales as "cheap" substitutes for the lack of a life-giving myth, and without negating history. In his Methexiology, Laos studies the "genealogy" of the modern and the postmodern crises of meaning, and, based on his new interpretation of classical Greek philosophy and Hesychasm, proposes methexiology as a way of overcoming the crises of meaning and as a way of resacralizing humanity and the cosmos through a new metaphysically grounded humanism. (shrink)

1. L'oeuvre musicale et son écoute -- 2. Le monde-musique et son solfège -- 3. Le musicien et son intellectualité musicale -- 4. Les raisonances du monde-musique ; postlude d'Alain Badiou.

Trente et un penseurs, parmi lesquels Jacques Derrida, Françoise Héritier, Edgar Morin, Jean-Luc Nancy, Michel Onfray ou encore Jacques Rancière, pour comprendre les errements et les raisons d'espérer d'une planète convulsée. Dix-neuf entretiens et débats avec les intellectuels les plus engagés dans la réflexion sur le temps présent dressent un état des lieux des questions qui taraudent notre modernité. Issu du Théâtre des idées, cycle de rencontres intellectuelles du Festival d'Avignon (2004-2012), ces dialogues singuliers s'attachent à faire vivre l'esprit critique, (...) cette faculté de juger, de soumettre la réalité sociale, artistique ou politique au tamis du jugement argumenté, qu'il soit sérieux ou ironique, virulent ou tempéré. De très actuelles "résistances intellectuelles" qui esquissent ce que pourrait être un service public des idées, c'est-à-dire un accès direct, libre et partagé à l'intellectualité. (shrink)

Sometimes physicians lie to third-party payers in order to grant their patients treatment they would otherwise not receive. This strategy, commonly known as gaming the system, is generally condemned for three reasons. First, it may hurt the patient for the sake of whom gaming was intended. Second, it may hurt other patients. Third, it offends contractual and distributive justice. Hence, gaming is considered to be immoral behavior. This article is an attempt to show that, on the contrary, gaming may sometimes (...) be a physician's duty. Under specific circumstances, gaming may be necessary from the viewpoint of the internal morality of medicine. Moreover, the objections against gaming are examples of what we call the idealistic fallacy, that is, the fallacy of passing judgments in a nonideal world according to ideal standards. Hence, the objections are inconclusive. Gaming is sometimes justified, and may even be required in the name of beneficence. (shrink)

Dans son dernier cours au Collège de France, Michel Foucault nous parle d'un oubli, plus fondamental à ses yeux que le fameux "oubli de l'être", ou plus précisément d'une négligence ; une négligence dont la philosophie est responsable, ce qui est d'autant plus paradoxal qu'il concerne précisément la vie philosophique. "Je voudrais, en tout cas, suggérer simplement que s'il est vrai que la question de l'être a bien été ce que la philosophie occidentale a oublié et dont l'oubli a rendu (...) possible la métaphysique, peut-être aussi la question de la vie philosophique n'a-t-elle pas cessé d'être, je ne dirais pas oubliée, mais négligée ; elle n'a pas cessé d'apparaître comme en trop par rapport à la philosophie, à la pratique philosophique, à un discours de plus en plus indexé au modèle scientifique" Cette négligence a une histoire. Car le problème de la vie philosophique a été posé dans toute sa radicalité dans l'Antiquité ; il n'était pas complètement oublié à l'époque moderne, comme en témoigne l'oeuvre de Spinoza ; mais à partir du moment "où la philosophie est devenue un métier de professeur, c'est-à-dire au début du XIXème siècle", elle a évacué du champ des problèmes pertinents, des problèmes "sérieux", cela même qui pourtant lui avait donné son horizon et sa raison d'être : la possibilité de définir une vie philosophique, c'est-à-dire une vie juste, une vie bonne, une "vraie vie". (shrink)

Die Utopien sind tot, es leben die Utopien. In diesem Buch wird die Utopie sozialer Gerechtigkeit entwickelt. INhaltlich besteht es in dem Dreischritt, (1) aus im Alltag von jedermann hin und wieder geauSSerten situativen Urteilen das gemeinsame Grundverstandnis von Gerechtigkeit zu destillieren, (2) anhand dieses Gelanders die bedeutendsten zeitgenossischen Theoretiker sozialer Gerechtigkeit akribisch zu lesen und in konstruktiver Absicht zu kritisieren, um (3) in ersten Ansatzen eine gerechtere Zukunftsgesellschaft zu skizzieren, deren quer zu tradierten Ideologien liegendes System sich ethischer Sozialismus (...) nennen lieSSe. (shrink)

Une modernité indigène: Ruptures et innovations dans les théories politiques japonaise du xviiie siècle, by Olivier Ansart, is a thoughtful, elegantly written book that offers valuable insights into Japanese political thought in an era that culminated in the Meiji Restoration. Despite the specific characteristics of the rigid centralized feudal structure of Tokugawa society, Ansart argues, political ideas generally associated with the advent of “modernity” in the West were generated indigenously in a context in which knowledge of the West was limited (...) primarily to science and technology.The main focus of the book is the thought of Kaiho Seiryō.1 Seiryō was inspired by two schools of thought that... (shrink)

This book advances a new interpretation of Hart's penal philosophy. Positioning itself in opposition to current interpretations, the book argues that Hart does not defend a mixed theory of punishment, nor a rule-utilitarian theory of punishment, nor a liberal form of utilitarianism, nor a goal and constraint approach. Rather, it is argued, his penal philosophy is based on his moral pluralism, which comprises two aspects: value pluralism and pluralism with respect to forms of moral reason. It is held that this (...) means, on the one hand, that criminal law has an irreducible complexity due to the compromises it makes to accommodate competing values, and on the other hand, that there need not be one single justification of punishment. This original interpretation is not based only on Hart's key volume on the subject Punishment and Responsibility, but on a careful reading of his complete works. The book will be a valuable resource for academics and researchers interested in Hart's philosophy, the philosophy of law and criminal law. (shrink)