Ontologies are being developed throughout the biomedical sciences to address standardization, integration, classification and reasoning needs against the background of an increasingly data-driven research paradigm. In particular, ontologies facilitate the translation of basic research into benefits for the patient by making research results more discoverable and by facilitating knowledge transfer across disciplinary boundaries. Addressing and adequately treating mental illness is one of our most pressing public health challenges. Primary research across multiple disciplines such as psychology, psychiatry, biology, neuroscience and pharmacology (...) needs to be integrated in order to promote a more comprehensive understanding of underlying processes and mechanisms, and this need for integration only becomes more pressing with our increase in understanding of differences among individuals and populations at the molecular level concerning susceptibility to specific illnesses. Substance addiction is a particularly relevant public health challenge in the developed world, affecting a substantial percentage of the population, often co-morbid with other illnesses such as mood disorders. Currently, however, there is no straightforward automated method to combine data of relevance to the study of substance addiction across multiple disciplines and populations. In this contribution, we describe a framework of interlinked, interoperable bio-ontologies for the annotation of primary research data relating to substance addiction, and discuss how this framework enables easy integration of results across disciplinary boundaries. We describe entities and relationships relevant for the description of addiction within the Mental Functioning Ontology, Chemical Entities of Biological Interest Ontology, Protein Ontology, Gene Ontology and the Neuroscience Information Framework ontologies. (shrink)
Throughout the biological and biomedical sciences there is a growing need for, prescriptive ‘minimum information’ (MI) checklists specifying the key information to include when reporting experimental results are beginning to find favor with experimentalists, analysts, publishers and funders alike. Such checklists aim to ensure that methods, data, analyses and results are described to a level sufficient to support the unambiguous interpretation, sophisticated search, reanalysis and experimental corroboration and reuse of data sets, facilitating the extraction of maximum value from data sets (...) them. However, such ‘minimum information’ MI checklists are usually developed independently by groups working within representatives of particular biologically- or technologically-delineated domains. Consequently, an overview of the full range of checklists can be difficult to establish without intensive searching, and even tracking thetheir individual evolution of single checklists may be a non-trivial exercise. Checklists are also inevitably partially redundant when measured one against another, and where they overlap is far from straightforward. Furthermore, conflicts in scope and arbitrary decisions on wording and sub-structuring make integration difficult. This presents inhibit their use in combination. Overall, these issues present significant difficulties for the users of checklists, especially those in areas such as systems biology, who routinely combine information from multiple biological domains and technology platforms. To address all of the above, we present MIBBI (Minimum Information for Biological and Biomedical Investigations); a web-based communal resource for such checklists, designed to act as a ‘one-stop shop’ for those exploring the range of extant checklist projects, and to foster collaborative, integrative development and ultimately promote gradual integration of checklists. (shrink)
Dans On What Matters Parfit défénd un objectivisme moral sur lequel il espère que les philosophes finiront par converger. Au cœur de cet espoir sont des vérités normatives irréductibles telles que l’affirmation que la souffrance est intrinsèquement mauvaise. Parfit se demande si Nietzsche menace son édifice et lui consacre un chapitre entier chapeautant la discussion du désaccord moral et de la convergence, et conclut que Nietzsche soit n’est pas en vrai désaccord, soit ne raisonne pas dans des conditions satisfaisantes. Je (...) mets ici à l’épreuve la prédiction de convergence de Parfit et montre que Nietzsche pose une menace encore plus sérieuse que ne le prétend Parfit. Je montre que l’idée que la souffrance peut être bonne est intelligible, cohérente et plus complexe que la lecture de Parfit ne le révèle. (shrink)
Il s’agit ici de présenter une version raffinée du libéralisme de la peur de Judith Shklar : le libéralisme de la prudence. Après en avoir brièvement présenté les grandes lignes et les principales faiblesses, j’esquisse les contours du libéralisme de la prudence et montre comment il réalise, mieux que libéralisme de la peur, le programme minimaliste poursuivi par Shklar. Je montre ensuite comment le libéralisme de la prudence nous permet de sortir du dilemme libéral posé par la tradition postrawlsienne : (...) justifier le libéralisme sur des bases morales, au risque de le priver de neutralité, ou le justifier sur des bases réalistes hobbesiennes, au risque d’en faire l’otage des rapports de force changeants. Enfin, j’examine comme le principal défaut apparent du libéralisme de la prudence – à savoir son ascétisme programmatique – est en fait son principal mérite. (shrink)
After reviewing the literature on current knowledge about consciousness in humans, we present a state-of-the art discussion on consciousness and related key concepts in animals. Obviously much fewer publications are available on non-human species than on humans, most of them relating to laboratory or wild animal species, and only few to livestock species. Human consciousness is by definition subjective and private. Animal consciousness is usually assessed through behavioural performance. Behaviour involves a wide array of cognitive processes that have to be (...) assessed separately using specific experimental protocols. Accordingly, several processes indicative of the presence of consciousness are discussed: perception and cognition, awareness of the bodily-self, self-related knowledge of the environment (including social environment). When available, specific examples are given in livestock species. Next, we review the existing evidence regarding neuronal correlates of consciousness, and emphasize the difficulty of linking aspects of consciousness to specific neural structures across the phyla because high-level cognitive abilities may have evolved independently along evolution. Several mammalian brain structures (cortex and midbrain) are involved in the manifestations of consciousness, while the equivalent functional structures for birds and fishes would likely be the pallium/tectum and midbrain. Caution is required before excluding consciousness in species not having the same brain structures as the mammalian ones as different neural architectures may mediate comparable processes. Finally, specific neurophysiological mechanisms appear to be strongly linked to the emergence of consciousness, namely neural synchrony and neural feedback. Considering the limited amount of data available and the few animal species studied so far, we conclude that different manifestations of consciousness can be observed in animals but that further refinement is still needed to characterize their level and content in each species. Further research is required to clarify these issues, especially in livestock species. (shrink)
Ce livre apporte un nouvel eclairage sur ce qu'il conviendrait d'appeler les commencements de la phenomenologie en France et donc, plus particulierement, sur la ...
Les « collectifs en ligne » proposent un modèle original qui cherche à rendre compatible d'une part la production de quasi-unanimités avec l'exigence de ne pas perdre de temps dans la production de consensus, d'autre part l'intérêt pour la discussion argumentée avec la mise en oeuvre de techniques de délibération et de vote. L'article explore le fonctionnement de ces communautés virtuelles, en faisant l'hypothèse qu'elles construisent un modèle souverainiste de délibération.The "online group" . Propose an original model that seeks to (...) make it compatible with a production share of almost unanimities with the requirement not to lose time in the production of consensus, On the other hand the interest in reasoned discussion with the technical implementation of deliberation and vote. The article explores how these virtual communities, assuming they construct a model of deliberation sovereignty. (shrink)
The importance of the Treatise on equations by Sharaf al-Dīn al-Ṭūsī has been brought to our attention by R. Rashed, who underlined the analytical aspects of this essentially algebraic work. Following Rashed, this article concentrates on one of these analytical concepts, namely the maximum of a polynomial expression f of degree 3. The purpose is to clarify the techniques that led al-Ṭūsī, when computing the maximum of f, to systematically display algebraic equations equivalent to f = 0. By demonstrating that (...) al-Ṭūsī's essentially algebraic proofs were also based on analytical procedures, we show that the presence of these equations was not fortuitous, but resulted from a correct understanding of the maximum of f. The accompanying geometrical representations were primarily for illustration. L'importance du Traité des équations de Sharaf al-Dīn al-Ṭūsī, a été mise en évidence par les travaux de R. Rashed, qui ont souligné les aspects analytiques de cette œuvre essentiellement algébrique. Parmi les notions analytiques qui figurent dans le Traité d'al-Ṭūsī, nous évoquerons uniquement celle du maximum d'une expression polynomiale du 3 e degré, f. La présente étude pourrait apporter une contribution à une problématique posée par R. Rashed: élucider les moyens et les techniques qui, lors du calcul du maximum, auraient conduit al-Ṭūsī à mettre systématiquement en valeur des équations équivalentes à fʹ = 0. Notre étude confirme que la présence de telles expressions n'est pas fortuite; elle découle d'une conception correcte du maximum de f. À cet effet, nous montrons que si les démonstrations utilisées par al-Ṭūsī sont essentiellement algébriques, elles s'appuient sur des procédés analytiques; les représentations géométriques qui les accompagnent constituent surtout des moyens de visualisation. (shrink)
Despite intensive exegetical work, Plato’s description of dialectic in the Sophist still raises many questions. Through a close reading of this passage that contextualizes it in the general organisation of the Sophist, this paper provides answers to these questions. After presenting the difficult text, I contend that the “vowel-kinds” are necessary conditions for the blending of kinds. Then, I interpret the “cause of divisions” mentioned by the Stranger as the kinds responsible of the dichotomous division in the first half of (...) the dialogue. In the next part, I show that 235d5-e2 does not describe a procedure of “meta-divison” as some commentators have it, but that it describes the method of division itself. Finally, I connect the difficulty and the obscurity of the passage to the fact that dialectic is the supreme science and I explain why dialectic is the science of free men. (shrink)
Les abréviations qu’on rencontre dans les textes français médiévaux ont été décrites par les paléographes et les philologues dans la perspective pratique de leur résolution. Elles peuvent par ailleurs être décrites de manière systématique à l’intérieur du système graphique envisagé dans son ensemble. La modélisation qui découle de cette description permet de critiquer les pratiques d’édition traditionnelles et modernes. Il est ainsi possible de sélectionner la solution de transcription la plus appropriée, en combinant et en modifiant légèrement un ensemble de (...) conventions standards formulées par la Text Encoding Initiative (TEI). (shrink)
An intellectual and cultural movement advocating a radical enhancement of human performance via technoscientific and biomedical advances, transhumanism has grown in notoriety in recent years. Grouping engineers, philosophers, sociologists, and entrepreneurs, the movement and its ideals of enhanced humans have a strong social resonance, be it doping in sport, the use of smart drugs, or the biomedical battle against aging. This article sheds theoretical and critical light on transhumanism through the lens of human perfectibility. It particularly aims to show how (...) the movement marks a significant reversal of the humanist conception of human perfectibility inherited from the Enlightenment. Far from working for the social and political emancipation of humans and the human condition, transhumanism is emblematic of a depoliticized conception of human perfectibility focused on the technoscientific adaptation of the human being. Transhumanism thus marks a major rupture with the modern democratic project of autonomy. (shrink)
François Duchesneau | : Nicolas de Béguelin, philosophe et scientifique, membre de l’Académie de Berlin, entreprit de concilier des thèses contrastées sur les fondements de la philosophie de la nature, qui semblaient suggérer une antinomie irréductible entre les principes leibniziens-wolffiens et les principes newtoniens. Dans une série de mémoires consacrés à ce projet, il tente d’établir qu’une philosophie expérimentale reste incertaine de ses hypothèses, si elle ne les confronte aux réquisits qu’imposent certains des principes architectoniques dérivant du principe de (...) la raison suffisante. Au coeur de l’argument figure une analyse visant à rattacher le concept de loi de la nature à la catégorie des vérités contingentes. Illustration en est fournie par la « déduction » des lois fondamentales de la mécanique : celles-ci ne sauraient être réduites à des propositions abstraites relevant de la seule nécessité géométrique. C’est en se fondant sur le réquisit de l’harmonie universelle que Béguelin propose des hypothèses sur l’intégration de forces motrices, intégration qui serait sous-jacente à l’inertie des corps, et sur l’espace comme ordre de coexistence des corps qui dépendrait de l’interrelation entre des éléments monadiques. | : Nicolas de Béguelin, philosopher and scientist and a member of the Berlin Academy, undertook to conciliate such conflicting views concerning the foundations of natural philosophy as seemed to suggest an irreducible antinomy between the Leibnizian-Wolffian and the Newtonian principles. In a series of memoirs, he argued that experimental philosophy would remain unsettled about the validity of its hypotheses as long as it failed to check them against requisites arising from architectonic principles and their source in sufficient reason. At the heart of his argument, one finds an analysis of the relationship that holds between laws of nature and contingent truths. Case studies were provided relative to the “deduction” of the fundamental laws of mechanics : these should be in no way equated with abstract statements featuring geometrical necessity. Relying on the requisites of universal harmony, Beguelin framed up hypotheses concerning the integration of motive forces underpinning inertia, as well as concerning space as an order of coexistent bodies that would depend on the interrelation between monadic elements. (shrink)
Lukács avait 86 ans, il était atteint d’une maladie grave, un cancer du poumon, les forces commençaient à l’abandonner au point qu’il n’arrivait plus à lire et à corriger le manuscrit de son dernier travail philosophique, les Prolégomènes à une ontologie de l’être social, achevé en automne 1970, lorsqu’il a accepté la sollicitation des..
Edition du ms. K 861 découvert à la Bibliothèque humaniste de Sélestat, dans lequel Beatus Rhenanus, étudiant alsacien de Jacques Lefèvre d’Etaples et de Charles de Bovelles de 1503 à 1505, rapporte un propos de ce dernier, réunit un ensemble de citations de Nicolas de Cues, et transcrit un opuscule inédit de 62 propositions Sapiens est qui se fecit hominem, que l’on peut attribuer à Bovelles.
In Résolution des quatre principaux problèmes d’architecture then in Cours d’architecture, the architect–mathematician Nicolas-François Blondel addresses one of the most famous architectural problems of all times, that of the reduction in columns. The interest of the text lies in the variety of subjects that are linked to this issue. The text is a response to the challenge launched by Curabelle in 1664 under the name Étrenne à tous les architectes; Blondel mathematicizes the problem in the “style of the Ancients”; (...) The problem is reformulated and solved through the continuous drawing of the curve; Blondel refutes the uniqueness of the curve by enumerating a variety of solutions. This exuberance responds to an intention that does not coincide with the state of the art of mathematics at the end of the seventeenth century, nor with the taste for geometry of the Ancients, nor with any pedagogical project. This feature is explained by Blondel’s plan to found architecture on scientific bases. The reasons for his failure are analysed. (shrink)
