New concepts may prove necessary to profit from the avalanche of sequence data on the genome, transcriptome, proteome and interactome and to relate this information to cell physiology. Here, we focus on the concept of large activity-based structures, or hyperstructures, in which a variety of types of molecules are brought together to perform a function. We review the evidence for the existence of hyperstructures responsible for the initiation of DNA replication, the sequestration of newly replicated origins of replication, cell division (...) and for metabolism. The processes responsible for hyperstructure formation include changes in enzyme affinities due to metabolite-induction, lipid-protein affinities, elevated local concentrations of proteins and their binding sites on DNA and RNA, and transertion. Experimental techniques exist that can be used to study hyperstructures and we review some of the ones less familiar to biologists. Finally, we speculate on how a variety of in silico approaches involving cellular automata and multi-agent systems could be combined to develop new concepts in the form of an Integrated cell (I-cell) which would undergo selection for growth and survival in a world of artificial microbiology. (shrink)
Son habituelle dénomination de Logique de Port-Royal, cet Art de Penser d’Antoine Arnauld et Pierre Nicole la mérite tout à fait, et cela en dépit d’un usage et d’un impact dépassant largement et profondément les limites jansénistes.Les deux auteurs, oeuvrant au sein d’un milieu où la théologie et la spiritualité comptaient plus que la philosophie proprement dite, voulaient, pour ainsi dire, enseigner cette dernière, même après la fermeture des « Petites Écoles » de Port-Royal, à leur « parti », (...) selon leur « parti », et aussi, c’est évident, par les canaux de l’augustinisme et du cartésianisme, à tout le public.Bien juger et comprendre, non seulement bien raisonner, exhorter à l’expression sobre et claire, inculquer et conduire, dans cette optique, une polyvalence intellectuelle aussi mesurée qu’ouverte, voilà la continuation et le couronnement de l’oeuvre accomplie par les « Messieurs » de Port-Royal, qui ont formé un Racine, préludant au développement du célèbre « Classicisme » et au sage perfectionnement du fameux « honnête homme » du XVIIe siècle. L’Art de Penser c’est d’ailleurs, à la différence de la Renaissance trop « subtile » et profane du XVIe siècle contestée par Arnauld et Nicole, un « renouveau » relatif à une logique dynamique, à la fois rigoureuse, équilibrée et riche de réalistes perspectives, fruit, en quelque sorte, d’une culture jansénisante où les exigences d’un christianisme sévère s’allient à un sens de la liberté individuelle fécond, et fécondant dans le domaine des idées. (shrink)
_Thinking for Clinicians_ provides analysts of all orientations with the tools and context for working critically within psychoanalytic theory and practice. It does this through detailed chapters on some of the philosophers whose work is especially relevant for contemporary theory and clinical writing: Emmanuel Levinas, Martin Buber, Ludwig Wittgenstein, Maurice Merleau-Ponty, and Hans-Georg Gadamer. Orange presents the historical background for their ideas, along with clinical vignettes to help contextualize their theories, further grounding them in real-world experience. With a hermeneutic (...) sensibility firmly in mind, _Thinking for Clinicians_ rewards as it challenges and will be a valuable reference for clinicians who seek a better understanding of the philosophical bases of contemporary psychoanalytic theory. (shrink)
Nourishing the Inner Life of Clinicians and Humanitarians: The Ethical Turn in Psychoanalysis, demonstrates the demanding, clinical and humanitarian work that psychotherapists often undertake with fragile and devastated people, those degraded by violence and discrimination. In spite of this, Donna M. Orange argues that there is more to human nature than a relentlessly negative view. Drawing on psychoanalytic and philosophical resources, as well as stories from history and literature, she explores ethical narratives that ground hope in human goodness and (...) shows how these voices, personal to each analyst, can become sources of courage, warning and support, of prophetic challenge and humility which can inform and guide their work. Over the course of a lifetime, the sources change, with new ones emerging into importance, others receding into the background. Donna Orange uses examples from ancient Rome, from twentieth century Europe, from South Africa, and from nineteenth century Russia. She shows how not only can their words and examples, like those of our personal mentors, inspire and warn us; but they also show us the daily discipline of spiritual self-care, although these examples rely heavily on the discipline of spiritual reading, other practitioners will find inspiration in music, visual arts, or elsewhere and replenish the resources regularly. Nourishing the Inner Life of Clinicians and Humanitarians will help psychoanalysts to develop a language with which to converse about ethics and the responsibility of the therapist/analyst. This is an exceptional contribution highly suitable for practitioners and students of psychoanalysis and psychotherapy. Donna M. Orange teaches, consults, and offers study groups for psychoanalysts and gestalt therapists. She seeks to integrate contemporary psychoanalysis with radically relational ethics. Recent books are _Thinking for Clinicians: Philosophical Resources for Contemporary Psychoanalysis and the Humanistic Psychotherapies _, and _The Suffering Stranger: Hermeneutics for Everyday Clinical Practice_, both from Routledge. (shrink)
What is hermeneutics? -- The suffering stranger and the hermeneutics of trust -- Sandor Ferenczi : the analyst of last resort and the hermeneutics of trauma -- Frieda Fromm-Reichmann : incommunicable loneliness -- D.W. Winnicott : humanitarian without sentimentality -- Heinz Kohut : glimpsing the hidden suffering -- Bernard Brandchaft : liberating the incarcerated spirit.
In its infancy the British Association for the Advancement of Science derived a good deal of its inspiration from the writings of Francis Bacon. But the pursuit of Baconian policies brought with it attendant dangers which critics from Charles Dickens to the Times were not slow to magnify. Although the situation was further complicated by the sensitiveness of institutional Christianity at the start of Victoria's reign, some of the hazards which the Association endured had to be accepted simply as consequences (...) of the attempt to provide a secure platform for British science. (shrink)
This paper proposes a conceptual framework for understanding the implementation process of a complex intervention concerned with professional role change. The proposed framework holds that the intervention must address three interacting systems (socio-cultural, educational and disciplinary) through which a health professional role is evolved. Each system is operationalized by four dimensions (values, methods, actors and targets). As for the implementation, the framework posits that it can be analyzed, by depicting the barriers and facilitators located within the dimensions of the three (...) interacting systems and within the intervention involved in the process through using the “menu of constructs” approach suggested by the Consolidated Framework for Implementation Research (CFIR). The implications of this framework, on theoretical research and practical levels, are reviewed. (shrink)
_ Source: _Volume 56, Issue 1-2, pp 83 - 125 Aristotelian cosmology implies the plurality of celestial motion for the process of generation and corruption in the sublunar world. In order to investigate the structure of the cosmos and the degree of dependence of the sublunar on the supralunar region, medieval Latin commentators on Aristotle explored the consequences of the cessation of celestial motion. This paper analyses the position of some philosophers of the fourteenth-century Parisian school, namely Nicole Oresme, (...) John Buridan and Albert of Saxony. (shrink)
La notion de « commerce d’amour-propre » telle qu’elle a été élaborée par Pierre Nicole constitue-t-elle une sorte de préfiguration de l’utilitarisme moderne ? Il est commun de le penser. Mais c’est peut-être là faire trop peu de cas du soubassement théologique augustinien de la doctrine de Nicole. Pour analyser le problème, il convient de confronter la pensée de Nicole à celles de Pascal, de Hobbes et de saint Augustin lui-même.
Saunders and van Brakel question whether the special status of red, green, yellow, and blue in our perceptual organization is anything more than a shadow cast by the English language. I suggest that it is more than this. We can hardly imagine treating lime, purple, orange, and teal as unique hues, and the reason does not lie in special training. To settle the issue, I suggest some lines for psychological experiment and anthropological investigation.