Cancer is a singular cellular state, the emergence of which destabilises the homeostasis reached through the evolution to multicellularity. We present the idea that the onset of the cellular disobedience to the metazoan functional and structural architecture, known as the cancer phenotype, is triggered by changes in the cell's external environment that occur with ageing: what ensues is a breach of the social contract of multicellular life characteristic of metazoans. By integrating old ideas with new evidence, we propose that with (...) ageing the environmental information that maintains a multicellular organisation is eroded, rewiring internal processes of the cell, and resulting in an internal shift towards an ancestral condition resulting in the pseudo‐multicellular cancer phenotype. Once that phenotype emerges, a new local social contract is built, different from the homeostatic one, leading to tumour formation and the foundation of a novel local ecosystem. (shrink)

Schelling est le moins connu des " grands " philosophes : c'est que, sans doute, dans l'œuvre qu'il nous propose, il n'y a rien justement à connaître, aucun sens ultime et autonome qui puisse désormais se représenter, se résumer pour lui-même, se diffuser dans une quelconque postérité - rien d'autre que l'œuvre elle-même et le travail toujours recommencé de son impossible perfection. Pendant soixante années, de 1794 à 1854, qui sont les plus riches peut-être (parce que les dernières) de l'histoire (...) de la philosophie, une pensée a cherché à se clore, à se comprendre, à s'arrêter, sans cesser de se voir rouverte par l'effondrement (le retournement) des structures où elle avait cru s'équilibrer. Il a semblé à l'auteur de cette étude que ces ruines successives finissaient par présenter un tracé signifiant, comme si le véritable " système " de Schelling s'écrivait peu à peu, hors de la vue du philosophe, dans un autre espace qui est celui de l'histoire même de son œuvre, jusqu'au moment où, dans sa " dernière philosophie ", tout le passé contradictoire se récapitule et redevient contemporain au sein d'une construction qui se présente elle-même comme dédoublée et interminable. On trouvera ici l'histoire de cette formation, de ce destin que Schelling a patiemment enduré sans jamais chercher à l'interrompre de manière prématurée, et qui fait de lui une figure proprement exemplaire. Grâce à cette œuvre en effet, où la pensée apparaît perpétuellement replongée dans la profondeur parfois désespérante de son travail, il devient possible d'approcher d'un peu plus près " l'acte et le lieu " de la philosophie, partout ailleurs masqués par la perfection superficielle de son résultat ; par là même, au-delà de l'individu Schelling, c'est une question plus vaste qui se trouve posée - la question : Qu'est-ce qu'une œuvre philosophique? (shrink)

Avant de quitter cet ouvrage, le dernier, sans doute, que nous proposerons au public, nous voudrions aussi remercier les lecteurs et les auditeurs qui, depuis plus d'un demi-siècle, ont bien voulu nous conserver leur attention et dont certains sont devenus des amis. Peut-être auront-ils remarqué, à travers tous ces textes, une orientation, d'abord tâtonnante, puis de plus en plus consciente vers une étoile unique que nous appelons Singularité. À défaut d'autre mérite, cette aimantation donne à notre humble vie un axe (...) et une certaine cohérence. Et nunc dimittis servum tuum, Domine."."--Page 4 of cover. (shrink)

Schelling est le moins connu des " grands " philosophes : c'est que, sans doute, dans l'œuvre qu'il nous propose, il n'y a rien justement à connaître, aucun sens ultime et autonome qui puisse désormais se représenter, se résumer pour lui-même, se diffuser dans une quelconque postérité - rien d'autre que l'œuvre elle-même et le travail toujours recommencé de son impossible perfection. Pendant soixante années, de 1794 à 1854, qui sont les plus riches peut-être (parce que les dernières) de l'histoire (...) de la philosophie, une pensée a cherché à se clore, à se comprendre, à s'arrêter, sans cesser de se voir rouverte par l'effondrement (le retournement) des structures où elle avait cru s'équilibrer. Il a semblé à l'auteur de cette étude que ces ruines successives finissaient par présenter un tracé signifiant, comme si le véritable " système " de Schelling s'écrivait peu à peu, hors de la vue du philosophe, dans un autre espace qui est celui de l'histoire même de son œuvre, jusqu'au moment où, dans sa " dernière philosophie ", tout le passé contradictoire se récapitule et redevient contemporain au sein d'une construction qui se présente elle-même comme dédoublée et interminable. On trouvera ici l'histoire de cette formation, de ce destin que Schelling a patiemment enduré sans jamais chercher à l'interrompre de manière prématurée, et qui fait de lui une figure proprement exemplaire. Grâce à cette œuvre en effet, où la pensée apparaît perpétuellement replongée dans la profondeur parfois désespérante de son travail, il devient possible d'approcher d'un peu plus près " l'acte et le lieu " de la philosophie, partout ailleurs masqués par la perfection superficielle de son résultat ; par là même, au-delà de l'individu Schelling, c'est une question plus vaste qui se trouve posée - la question : Qu'est-ce qu'une œuvre philosophique? (shrink)

The incredible achievements of modern scientific theories lead most of us to embrace scientific realism: the view that our best theories offer us at least roughly accurate descriptions of otherwise inaccessible parts of the world like genes, atoms, and the big bang. In Exceeding Our Grasp, Stanford argues that careful attention to the history of scientific investigation invites a challenge to this view that is not well represented in contemporary debates about the nature of the scientific enterprise. The historical record (...) of scientific inquiry, Stanford suggests, is characterized by what he calls the problem of unconceived alternatives. Past scientists have routinely failed even to conceive of alternatives to their own theories and lines of theoretical investigation, alternatives that were both well-confirmed by the evidence available at the time and sufficiently serious as to be ultimately accepted by later scientific communities. Stanford supports this claim with a detailed investigation of the mid-to-late 19th century theories of inheritance and generation proposed in turn by Charles Darwin, Francis Galton, and August Weismann. He goes on to argue that this historical pattern strongly suggests that there are equally well-confirmed and scientifically serious alternatives to our own best theories that remain currently unconceived. Moreover, this challenge is more serious than those rooted in either the so-called pessimistic induction or the underdetermination of theories by evidence, in part because existing realist responses to these latter challenges offer no relief from the problem of unconceived alternatives itself. Stanford concludes by investigating what positive account of the spectacularly successful edifice of modern theoretical science remains open to us if we accept that our best scientific theories are powerful conceptual tools for accomplishing our practical goals, but abandon the view that the descriptions of the world around us that they offer are therefore even probably or approximately true. (shrink)

The place of the emotions among the passions -- The analytic of the emotions I -- The analytic of the emotions II -- The dialectic of the emotions -- Pride, arrogance, and humility -- Shame, embarrassment, and guilt -- Envy -- Jealousy -- Anger -- Love -- Friendship -- Sympathy and empathy.

The concept of normal is so familiar that it can be hard to imagine contemporary life without it. Yet the term entered everyday speech only in the mid-twentieth century. Before that, it was solely a scientific term used primarily in medicine to refer to a general state of health and the orderly function of organs. But beginning in the middle of the twentieth century, normal broke out of scientific usage, becoming less precise and coming to mean a balanced condition to (...) be maintained and an ideal to be achieved. In Normality, Peter Cryle and Elizabeth Stephens offer an intellectual and cultural history of what it means to be normal. They explore the history of how communities settle on any one definition of the norm, along the way analyzing a fascinating series of case studies in fields as remote as anatomy, statistics, criminal anthropology, sociology, and eugenics. Cryle and Stephens argue that since the idea of normality is so central to contemporary disability, gender, race, and sexuality studies, scholars in these fields must first have a better understanding of the context for normality. This pioneering book moves beyond binaries to explore for the first time what it does—and doesn’t—mean to be normal. (shrink)

Jean-François Marquet est Professeur de philosophie émérite à l'université de Paris-Sorbonne. Eminent historien de la métaphysique, de Parménide à Heidegger, il a aussi consacré ses recherches à la relation de la philosophie avec l'art et la littérature, la mystique et la gnose chrétienne. Il invite ici le lecteur à jouer le jeu de la parole, en considérant certaines questions décisives d'un cheminement dont le sens le plus profond est sans doute celui d'une méditation de la singularité, où se noue (...) le dialogue des voix ou des personnes (Je-Tu-Il), triade constitutive de toute vie singulière. Si la pensée s'origine dans une parole en énigme et si l'achèvement de la philosophie la conduit à se déployer dans un espace où oeuvres et visions du monde se correspondent en étant contemporaines, comme en un vitrail, c'est à la récapitulation de cette histoire que l'interprète convie enfin son lecteur. (shrink)

Profesor responsable del laboratorio de química para estudiantes de 15 y 18 años, Javier Lavalle ofrece regalos para seducir a jóvenes hasta que, extorsionado por un periodista, el profesor se ve obligado a renunciar y abandonar la ciudad de Guanajuato para emigrar a la Ciudad de México. Con un despliegue de un estilo directo y preciso, ajeno a prejuicios, Después de todo de José Ceballos Maldonado, es una de las obras emblemáticas de la narrativa homosexual del siglo pasado.

Papers presented at a conference within the scope of Ecole doctorale de philosophie de l'Universite de Paris-Sorbonne (Paris IV) on Nov. 18-19, 1994.

Cet article étudie la question du fanatisme dans la philosophie de Hegel en examinant successivement : 1 / la genèse du concept de « fanatisme » de Luther à l’époque des Lumières ; 2 / la place initiale du fanatisme dans la dialectique hégélienne de la volonté libre ; 3 / ses figures religieuses et politiques ; 4 / les solutions hégéliennes au problème du fanatisme. Contrairement aux Lumières qui voyaient dans le fanatisme une pathologie de la raison et un (...) phénomène exclusivement religieux, Hegel le conçoit comme une forme possible de la liberté humaine ayant une signification autant politique que religieuse : la liberté du vide, la négativité abstraite qui ne s’affirme que par la destruction de l’ordre éthique.This paper address the issue of the fanaticism in Hegel’s philosophy, by examining successively : 1 / the genesis of the concept of « fanaticism » from Luther to the Age of Enlightenment ; 2 / the initial situation of the fanaticism in the Hegelian dialectic of free will ; 3 / its religious and political forms ; 4 /Hegel solution to the problem of fanaticism. Unlike the Enlightenment philosophers, who conceived fanaticism as a pathology of reason that could only arise in religion, Hegel considers it as a possible form of human freedom, loaded with a religious and political meaning : the fanaticism is the empty freedom, the abstract negativity that may only be assessed through the destruction of the ethical world. (shrink)

On sait que pour Cuvier la totalite d'un organisme vivant peut etre reconnue par chaque fragment de chacune de ses parties, ce qui permet, a partir d'un seul element, de restituer un exemplaire d'une espece aujourd'hui disparue. Les etudes reunies dans ce volume ont une intention analogue: partir a chaque fois d'une question determinee et restituer dans son ensemble la secrete architecture d'une oeuvre philosophique (ici a l'interieur du domaine allemand, de Kant a Heidegger). Travail, si l'on veut, de paleontologie (...) philosophique, mais au terme duquel les differentes pensees abordees peuvent sembler se restituer les unes aux autres, comme si elles procedaient toutes d'un unique philosophe tentant, par differentes voies, de resoudre une unique question: celle, precisement, de l'Unique. C'est a nous, interprete ou lecteur, qu'incombe aujourd'hui la responsabilite de sa fragile survie. (shrink)

Originally published in 1957, The Uniqueness of the Individual is a collection of 9 essays published from the ten years preceding publication. The essays deal with some of the central problems of biology. These are among the questions put and answered from the standpoint of modern experimental biology. What is ageing and how is it measured? What theories have been held to account for it, and with what success? Did ageing evolve, and if so how? Is Lamarckism and adequate explanation (...) of evolutionary process? Does evolution sometimes go wrong? Do human beings evolve in a way peculiar to themselves? Other essays touch upon the problems of scientific method and of growth and transformation. This book will be of interest to natural historians, evolutionists and anthropologists. (shrink)

An Interdisciplinary Approach to Cognitive Modelling presents a new approach to cognition that challenges long-held views. It systematically develops a broad-based framework to model cognition, which is mathematically equivalent to the emerging 'quantum-like modelling' of the human mind. The book argues that a satisfactory physical and philosophical basis of such an approach is missing, a particular issue being the application of quantization to the mind for which there is no empirical evidence as yet. In response to this issue, the book (...) adopts a COM (classical optical modelling) approach, broad-based but mathematically equivalent to quantum-like modelling while avoiding its problematic features. It presents a philosophically informed and empirically motivated mathematical model of cognition, mainly concerning decision making processes. It also deals with applications to different areas of the social sciences. It will be of interest to scholars and research students interested in the mathematical modelling of cognition and decision making, and also interdisciplinary researchers interested in broader issues of cognition. (shrink)

This study concerns the ideas of one particular philosopher, Henri Bergson, whose views of time, intuition, and creativity have had a significant impact on art, literature, and the humanities, both in his time and in our own. Although it is generally recognized that Bergson's ideas have significantly impacted the arts and the humanities, it has not been recognized how they have also had a creative influence on the sciences as well. Nor has it been realized that this was one of (...) his most basic contentions. Bergson's conception of intuition--his fundamental insight into reality--was not limited to fugitive insights into human existence. By realizing previously unsuspected possibilities for research and discovery, his endeavors were also meant to make possible new advances in the sciences. If it enabled his cousin by marriage, Marcel Proust, to explore human memory in depth, it also inspired psychologists like Daniel Schachter to use Bergson's ideas to make real contributions to contemporary memory science. If his notion of creative evolution brought many thinkers to a belief in human creative freedom, it brought others (notably Alexis Carrel and Pierre Lecomte de Noüy) to a scientific study of biological time. Among his successful speculations was the theory of the Big Bang cosmology. 'Getting Bergson Straight' shows many points at which Bergson's ideas anticipated future developments in the sciences. This was seen clearly by the Nobel Prize-winning physicist Luis de Broglie who viewed Bergson's physics as presaging quantum physics. Thus, the text is well situated for arts, humanities, social science, and natural science classrooms studying creative thinking and/or intellectual history. (shrink)

Profoundly important ethical and political controversies turn on the question of whether biological life is an essential aspect of a human person, or only an extrinsic instrument. Lee and George argue that human beings are physical, animal organisms - albeit essentially rational and free - and examine the implications of this understanding of human beings for some of the most controversial issues in contemporary ethics and politics. The authors argue that human beings are animal organisms and that their personal identity (...) across time consists in the persistence of the animal organisms they are; they also argue that human beings are essentially rational and free and that there is a radical difference between human beings and other animals; criticize hedonism and hedonistic drug-taking; present detailed defenses of the prolife positions on abortion and euthanasia; and defend the traditional moral position on marriage and sexual acts. (shrink)

Do the ethical features of an artwork bear on its aesthetic value? This movie endorses misogyny, that song is a civil rights anthem, the clay constituting this statue was extracted with underpaid labor—are facts like these the proper bases for aesthetic evaluation? I argue that this debate has suffered from a false presupposition: that if the answer is yes (for at least some such ethical features), such considerations feature as pro tanto contributions to an artwork's overall aesthetic value, i.e., as (...) merits or flaws which make something have more or less overall aesthetic value. As the case of ethically laden, aesthetic evaluation makes clear, however, good aesthetic judgement is irreducibly multi-dimensional, e.g., "the movie has an engaging soundtrack, tasteful camera work, and takes a misogynistically prurient perspective on its female lead.'' Such a "non-summative" judgement refuses to reduce those various dimensions of aesthetic value to a single aggregate aesthetic evaluation, like "it's a 6/10" or "it's a pretty good movie!" I defend both the modest claim that such non-summative evaluations are not mistaken and the extremist claim that summative (i.e., unidimensional) aesthetic evaluation is defective by considering other domains of normative assessment in which summing seems inappropriate, notably including evaluations of people's character. (shrink)

This practical and essential text, co-authored by an engineer and an ethicist, covers ethical dilemmas that any engineer might encounter on the job, emphasizing the responsibility of a practicing engineer to act in an ethical manner. To illustrate the complexities involved, the authors present characters who encounter situations that test the engineering code of ethics. The dialogue between the characters highlights different perspectives of each dilemma. As they proceed through the book, students see how the code of ethics can help (...) in decision making, as well as the implications of various decisions. The philosophical theory that supports the ethical situations encountered is presented as boxed material following each section. Important Notice: Media content referenced within the product description or the product text may not be available in the ebook version. (shrink)

In worlds that lack life, there is no value. For all that, there is no mystery about 'the existence of values in a world of facts'. The world does not consist of facts, rather true descriptions of the world consist of statements of fact. It is as much a fact concerning the world that there are things that are of value to living things, that human beings value things and possess valuable characteristics, perform valuable deeds, stand in valuable relationships to (...) others, as it is a fact that there is life on earth. (shrink)

A critical note on Christopher Bartel and Jack M. C. Kwong, ‘Pluralism, Eliminativism, and the Definition of Art’, Estetika 58 (2021): 100–113. Art pluralism is the view that there is no single, correct account of what art is. Instead, art is understood through a plurality of art concepts and with considerations that are different for particular arts. Although avowed pluralists have retained the word ‘art’ in their discussions, it is natural to ask whether the considerations that motivate pluralism should lead (...) us to abandon art talk altogether; that is, should pluralism lead to eliminativism? This paper addresses arguments both for and against this move. We ultimately argue that pluralism allows one to retain the word ‘art’, if one wants it, but only in a loose, conversational sense. The upshot of pluralism is that talk of art in general cannot be asked to do theoretical and philosophical work. (shrink)

" In a book that seeks to shift the ground of debate within theory of knowledge, William P. Alston finds that the century-lo.

In lieu of an abstract, here is a brief excerpt of the content:Burma’s Healthcare Under Fire: My Experience as an Exiled Medical ProfessionalP. P. KyawI used to work as a medical doctor in a less developed state than many big cities in Burma1 that experienced prolonged civil wars and current similar atrocities decades before the urban areas of the country experienced them. Before everything started, I was responsible for the medical management of the most vulnerable communities and had been struggling (...) with pandemic-related medical activities. Those were the happiest years of my life. I was with one of the best international organizations, where every effort I made was directly delivered to the patients with no unnecessary paperwork. The system was efficient, my colleagues were supportive, and I had a good work-life balance. I supported my family and whoever needed temporary financial support, played music weekly, met good friends who I hung out with every weekend, and [End Page 164] found hobbies like gardening and crocheting. I was content and happy. I even postponed my plans to get registered as a doctor in the Western world.Before moving to this beautiful ethnic state in 2019, I previously worked as a government medical doctor in Yangon, the capital. As much as I loved working in those civilian hospitals, I could not support myself with a monthly pay of $100-$150 USD. It was a hard decision to leave the service because it meant I could not pursue the medical specialty that I had always longed for and had to leave like-minded supportive colleagues. In Myanmar, unless you are a civil servant, you cannot pursue further clinical specialties. However, after leaving the government’s service to work in humanitarian medical assistance in hard-to-reach areas of Burma, I learned that life is still beautiful outside my comfort zone, until February 2021 when the coup began. Democratically elected members of the country’s ruling party were overthrown by the military, which then bestowed power in a military junta.I expected the election prior to the coup in November 2020 to be an uphill battle for Burma, but nothing more. I was still in denial when I first heard the news from one of the town’s NGO staff. The person had to travel on a motorbike to inform everyone that the junta had staged the coup. No telephone or internet was working at that time. My colleagues and I cried in our office, saying, “We are so young, and the future is still ahead. I don’t think this is going to last long. Maybe it will be over in a few days or, at most, a few weeks.” Once the peaceful protests started nationwide, my friends and I provided medical cover for the protesters, initially for minor medical problems such as low sugar, low blood pressure, injuries from accidental minor slips and falls, etc. Never in my life had I imagined that I would be taking care of bullet wounds and people injured by live rounds. While learning about gunshot wounds in forensic medicine, I thought, “Oh, this is not going to be very useful because Burma is not America, and I am not going there.” Then suddenly, it became too real and more useful than I would’ve liked it to be.I always think back to one especially bloody day when many people in the town were shot with live rounds. We assisted many patients. Usually, we would go around with the protest groups until they were over in the late afternoon. The protesters were always peaceful. There were no riots, no harmful acts, or vandalism. Only when the protesters were cruelly dispersed with tear gas, high-pressure pumps, rubber bullets, and live rounds (to the head) did they decide to defend themselves while still making their voices heard. The only defenses people had to counteract the live rounds were things like metal covers, firecrackers, and slingshots.One afternoon in March 2021, my team and I took an early break for lunch—unaware that some people would lose their lives that afternoon. We followed the local protests through Facebook Live while having lunch and started to hear firecracker sounds. A few seconds later, we knew... (shrink)