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  1.  15
    Humanised Models of Cancer in Molecular Medicine: The Experimental Control of Disanalogy.Paolo Maugeri & Alessandro Blasimme - 2011 - History and Philosophy of the Life Sciences 33 (4).
    This paper explores the epistemology of extrapolation from model organisms to humans in molecular medicine. We take into account two common views on the issue, the homology view and the disanalogy view. In response to both interpretations, we argue that the foundational basis of extrapolations cannot simply be provided by homology and that relevant disanalogies can, thanks to the techniques of molecular biology, be experimentally controlled and exploited to allow useful and reliable extrapolations. The case of "humanised mice" in the (...)
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  2.  35
    What Mechanisms Can’T Do: Explanatory Frameworks and the Function of the P53 Gene in Molecular Oncology.Alessandro Blasimme, Paolo Maugeri & Pierre-Luc Germain - 2013 - Studies in History and Philosophy of Science Part C: Studies in History and Philosophy of Biological and Biomedical Sciences 44 (3):374-384.
    What has been called the new mechanistic philosophy conceives of mechanisms as the main providers of biological explanation. We draw on the characterization of the p53 gene in molecular oncology, to show that explaining a biological phenomenon implies instead a dynamic interaction between the mechanistic level—rendered at the appropriate degree of ontological resolution—and far more general explanatory tools that perform a fundamental epistemic role in the provision of biological explanations. We call such tools “explanatory frameworks”. They are called frameworks to (...)
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    Genetic Enhancement in Sports: The Role of Reason and Private Rationalities in the Public Arena.Silvia Camporesi & Paolo Maugeri - 2011 - Cambridge Quarterly of Healthcare Ethics 20 (2):248-257.
    Reviews of philosophical books run the risk of being either excessively and unconstructively critical or superficially praiseworthy. To avoid both these risks, we test the approach outlined by Häyry in his book Rationality and the Genetic Challenge: Making People Better? by applying it to an eighth genetic challenge, namely, a variation of the genetic enhancement challenge discussed by Häyry as it applies to sports. We assess whether genetic enhancement in sports should be conceived as an eighth wonder or an eighth (...)
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    What Autonomy for Telecare? An Externalist Approach.Luca Chiapperino, Marco Annoni, Paolo Maugeri & Giuseppe Schiavone - 2012 - American Journal of Bioethics 12 (9):55-57.
    The American Journal of Bioethics, Volume 12, Issue 9, Page 55-57, September 2012.
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