The 2013 Rostock Symposium on Systems Biology and Bioinformatics in Aging Research was again dedicated to dissecting the aging process using in silico means. A particular focus was on ontologies, as these are a key technology to systematically integrate heterogeneous information about the aging process. Related topics were databases and data integration. Other talks tackled modeling issues and applications, the latter including talks focussed on marker development and cellular stress as well as on diseases, in particular on diseases of kidney (...) and skin. (shrink)

Over recent years, the research community has been increasingly using preprint servers to share manuscripts that are not yet peer-reviewed. Even if it enables quick dissemination of research findings, this practice raises several challenges in publication ethics and integrity. In particular, preprints have become an important source of information for stakeholders interested in COVID19 research developments, including traditional media, social media, and policy makers. Despite caveats about their nature, many users can still confuse pre-prints with peer-reviewed manuscripts. If unconfirmed but (...) already widely shared first-draft results later prove wrong or misinterpreted, it can be very difficult to “unlearn” what we thought was true. Complexity further increases if unconfirmed findings have been used to inform guidelines. To help achieve a balance between early access to research findings and its negative consequences, we formulated five recommendations: (a) consensus should be sought on a term clearer than ‘pre-print’, such as ‘Unrefereed manuscript’, “Manuscript awaiting peer review” or ‘’Non-reviewed manuscript”; (b) Caveats about unrefereed manuscripts should be prominent on their first page, and each page should include a red watermark stating ‘Caution—Not Peer Reviewed’; (c) pre-print authors should certify that their manuscript will be submitted to a peer-review journal, and should regularly update the manuscript status; (d) high level consultations should be convened, to formulate clear principles and policies for the publication and dissemination of non-peer reviewed research results; (e) in the longer term, an international initiative to certify servers that comply with good practices could be envisaged. (shrink)

Web-based platforms play an increasingly important role in managing and sharing research data of all types and sizes. This article presents a case study of the data storage, sharing, and management platform Figshare. We argue that such platforms are displacing and reconfiguring the infrastructure of norms, technologies, and institutions that underlies traditional scholarly communication. Using a theoretical framework that combines infrastructure studies with platform studies, we show that Figshare leverages the platform logic of core and complementary components to re-integrate a (...) presently splintered scholarly infrastructure. By means of this logic, platforms may provide the path to bring data inside a scholarly communication system still optimized mainly for text publications. Yet the platform strategy also risks turning over critical scientific functions to private firms whose longevity, openness, and corporate goals remain uncertain. It may amplify the existing trend of splintering infrastructures, with attendant effects on equity of service. (shrink)

The 1994 biography of Lenin by General Dmitri Volkogonov, the chairperson of President Yeltsin's commission for examining the Soviet archives, has been hailed as exposing Lenin's crimes. Volkogonov charges that Lenin's fanaticism caused him to order acts of inhuman cruelty; that he was an agent of the German government; that the October revolution was the coup of a minority; that Lenin was the originator of the idea of a one-party dictatorship; that he persecuted religious believers; and that he created the (...) totalitarian system that was perfected by Stalin. Volkogonov's evidence from archival and other sources is examined, and his charges are found to be unjustified. (shrink)

The cuticular surface of Drosophila is decorated by parallel arrays of polarized structures such as hairs and sensory bristles; for example, on the wing each cell produces a distally pointing hair. These patterns are termed [tissue polarity]. Several genes are known whose activity is essential for the development of normal tissue polarity. Mutations in these genes alter the orientation of the hair or bristle with respect to neighboring cells and the body as a whole. The phenotypes of mutations in these (...) genes allows them to be placed in three phenotypic groups. Based on their behavior in genetic mosaics, it has proved possible to determine that individual genes are required either for the generation of an intercellular polarity signal and/or the transduction of that signal to the cytoskeleton. (shrink)

We present an analysis of Szilard's one-molecule Maxwell's demon, including a detailed entropy accounting, that suggests a general theory of the entropy cost of information. It is shown that the entropy of the demon increases during the expansion step, due to the decoupling of the molecule from the measurement information. It is also shown that there is an entropy symmetry between the measurement and erasure steps, whereby the two steps additivelv share a constant entropy change, but the proportion that occurs (...) during each of the two steps is arbitrary. Therefore the measurement step may be accompanied by an entropy increase, a decrease, or no change at all, and likewise for the erasure step. Generalizing beyond the demon, decorrelation between a physical system and information about that system always causes an entropy increase in the joint system comprised of both the original system and the information. Decorrelation causes a net entropy increase in the universe unless, as in the Szilard demon, the information is used to decrease entropy elsewhere before the correlation is lost. Thus, information is thermodynamically costly precisely to the extent that it is not used to obtain work from the measured system. (shrink)

The director of Courage International talks about the work of the apostolate in addressing homosexuality according to the mind and heart of the Church, which he calls “one of the most demanding aspects of education, formation, and pastoral care today.” But it is also an opportunity to attend to the often acute and persistent wounds of those who need healing within what Pope Francis calls the “field hospital” of the Church. The author points out that the work of Courage is (...) not first about homosexuality but about what it means to be human. It is an invitation to consider the question of the fulfillment of the human heart according to God’s gracious plan. National Catholic Bioethics Quarterly 15.2 : 221–230. (shrink)

In 2004, Google embarked on a massive book digitization project. Forty library partners and billions of scanned pages later, Google Book Search has provided searchable text access to millions of books. While many details of Google’s conversion processes remain proprietary secret, here we piece together their general outlines by closely examining Google Book Search products, Google patents, and the entanglement of libraries and computer scientists in the longer history of digitization work. We argue that far from simply “scanning” books, Google’s (...) efforts may be characterized as algorithmic digitization, strongly shaped by an equation of digital access with full-text searchability. We explore the consequences of Google’s algorithmic digitization system for what end users ultimately do and do not see, placing these effects in the context of the multiple technical, material, and legal challenges surrounding Google Book Search. By approaching digitization primarily as a text extraction and indexing challenge—an effort to convert print books into electronically searchable data—GBS enacts one possible future for books, in which they are defined largely by their textual content. (shrink)

Faith-based, transformational development organizations infrequently utilize impact assessment tools as learning activities. The author argues that the real and significant barriers to program assessment can be managed if shared learning becomes a core value within the organization. By integrating Biblical teaching and program assessment activities with what it means to be a learning organization, the paper outlines a strategy for sharing valuable experiences about holistic development within and outside the faith-based development community.

There are 43 million forcibly displaced people in the world, and they are categorized along a spectrum ranging from legal issues to humanitarian concerns for protection. Despite the complex efforts to provide protection to all those in need, the issues remain blurred and many fall through the cracks. The understanding of forced displacement needs to include aspects of personhood, and the example in John 4:4—26 highlights the possibility of a collective approach to understanding forced displacement as one that is rooted (...) in the notion and importance of the person. (shrink)

"Since the end of the last century," Walter Benjamin wrote, "philosophy has made a series of attempts to lay hold of the 'true' experience as opposed to the kind that manifests itself in the standardized, denatured life of the civilized masses. It is customary to classify these efforts under the heading of a philosophy of life. Towering above this literature is Henri Bergson's early monumental work, Matter and Memory."Along with Husserl's Ideas and Heidegger's Being and Time, Bergson's work represents one (...) of the great twentieth-century investigations into perception and memory, movement and time, matter and mind. Arguably Bergson's most significant book, Matter and Memory is essential to an understanding of his philosophy and its legacy.This new edition includes an annotated bibliography prepared by Bruno Paradis.Henri Bergson was awarded the Nobel Prize in 1927. His works include Time and Free Will, An Introduction to Metaphysics, Creative Evolution, and The Creative Mind. (shrink)

Why do we have a brain? After all, it's a good deal of trouble. A brain is very expensive; a hefty percentage of our cardiac output goes towards its nourishment. A brain is fragile. If you cut off its groceries for even a few minutes, it's gone, taking the rest of us with it. Worst of all, it is highly likely that pain, fear, sadness and other undesirable states require a brain. None of these things are issues for our brainless (...) relatives, such as lichens or pond scum. On the other hand, a brain comes in handy sometimes. Its very useful at tax time. I find it particularly helpful when watching "Jeopardy" or when taking board examinations. But those are just special cases; in general, why bother with a brain? 2012 APA, all rights reserved). (shrink)

Family carers of individual’s living with Huntington’s Disease (HD) manage a distinct and unique series of difficulties arising from the complex nature of HD. This paper presents the validation of the definitive measure of quality of life for this group. The Huntington’s Disease Quality of Life Battery for carers (HDQoL-C) was expanded and then administered to an international sample of 1716 partners and family carers from 13 countries. In terms of the psychometric properties of the tool, exploratory analysis of half (...) of the sample, demonstrated good internal consistency and reliability. Some items on the full version did not meet psychometric thresholds and a short version (HDQoL-Cs) was developed based on more stringent criteria. Confirmatory Factor Analysis of the model structure showed a good fit for all Factors and, indicated that the HDQoL-C and HDQoL-Cs are psychometrically robust measures of quality of life. We found that carers who lived with and looked after their spouse/partner had reduced sense of coping, hope for the future and overall quality of life. Carers with children who were at risk, carried the gene or were symptomatic also had poorer quality of life outcomes. Findings indicated the HDQoL-C and HDQoL-Cs are valid in multiple languages and across varied cultures as measures of self-reported quality of life in family carers of individual’s living with HD. These psychometrically validated tools can aid and guide the implementation of therapeutic interventions to improve life quality in this population. (shrink)

This essay proposes a cultural and historical explanation for the American Military's fascination with computing. Three key elements of post-WWII US political culture — apocalyptic struggle with the USSR, subsuming all other conflicts: a long history of antimilitarist sentiment in American politics; and the rise of science-based military power — contributed to a sense of the world as a closed system accessible to American technological control. A developing scientific systems discourse, centrally including computer science and AI, was adopted for strategic (...) thinking and military technology. The Strategic Computing and Strategic Defense Initiatives are discussed as contemporary examples of this conjunction. (shrink)

The present study was designed to explore the relationship between self-reported dissociative experiences and performance in tasks eliciting right-hemisphere processing load. Thirty-four participants performed a vigilance task in two conditions: with task-irrelevant negative-arousing pictures and task-irrelevant neutral pictures. Dissociation was assessed with the Dissociative Experience Scale. Consistent with theories positing right-hemisphere deregulation in high non-clinical dissociators, dissociative experiences correlated with greater vigilance decrement only in the negative picture condition. As both the vigilance task and negative picture processing are right lateralized, (...) this result provides support for a right-hemisphere dysfunction in high dissociators, at least in negative conditions. (shrink)

That we owe duties to others is a commonplace, the subject of countless philosophical treatises and monographs. Morality is interpersonal and other-directed, many claim. But what of what we owe ourselves? In Duty to Self, Paul Schofield flips the paradigm of interpersonal morality by arguing that there are moral duties we owe ourselves, and that in light of this, philosophers need to significantly rethink many of their views about practical reason, moral psychology, politics, and moral emotions. -/- Among (...) these views is the idea that divisions within a person's life enable her to relate to herself second-personally--that is, as though she were relating to a distinct other person--in the way required by morality. Further, there exist political duties owed to the self, which the state may coerce persons to perform. This amounts to a novel argument for paternalistic law, which appeals to considerations of right, justice, and freedom in order to justify coercing a person for their own sake--a liberal justification for an idea typically thought to be deeply at odds with liberalism. -/- Schofield untangles how this view would impact various issues in applied ethics and political philosophy, for example, financial prudence and risk, the pursuit of the good life, and medical ethics. Duty to Self is essential for anyone working in moral and political philosophy or political theory. (shrink)