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Paul Ndebele [15]Paul M. Ndebele [1]
  1.  9
    Promoting Ethical Payments in Human Challenge Studies Conducted in LMICs: Are We Asking the Right Questions?Paul Ndebele & Adnan A. Hyder - 2021 - American Journal of Bioethics 21 (3):51-53.
    The paper by Lynch et al. raises interesting ethical questions regarding whether and how much SARS-CoV-2 Human Challenge Studies participants should be paid. We appreciate the timely e...
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  2. Evaluating institutional capacity for research ethics in Africa: a case study from Botswana. [REVIEW]Adnan A. Hyder, Waleed Zafar, Joseph Ali, Robert Ssekubugu, Paul Ndebele & Nancy Kass - 2013 - BMC Medical Ethics 14 (1):31.
    The increase in the volume of research conducted in Low and Middle Income Countries (LMIC), has brought a renewed international focus on processes for ethical conduct of research. Several programs have been initiated to strengthen the capacity for research ethics in LMIC. However, most such programs focus on individual training or development of ethics review committees. The objective of this paper is to present an approach to institutional capacity assessment in research ethics and application of this approach in the form (...)
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  3.  75
    Improving understanding of clinical trial procedures among low literacy populations: an intervention within a microbicide trial in Malawi. [REVIEW]Paul M. Ndebele, Douglas Wassenaar, Esther Munalula & Francis Masiye - 2012 - BMC Medical Ethics 13 (1):29-.
    Background The intervention reported in this paper was a follow up to an empirical study conducted in Malawi with the aim of assessing trial participants’ understanding of randomisation, double-blinding and placebo use. In the empirical study, the majority of respondents (61.1%; n= 124) obtained low scores (lower than 75%) on understanding of all three concepts under study. Based on these findings, an intervention based on a narrative which included all three concepts and their personal implications was designed. The narrative used (...)
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  4.  8
    Study participants incentives, compensation and reimbursement in resource-constrained settings.Takafira Mduluza, Nicholas Midzi, Donold Duruza & Paul Ndebele - 2013 - BMC Medical Ethics 14 (S1):S4.
    BackgroundEvery year, research specimens are shipped from one institution to another as well as across national boundaries. A significant proportion of specimens move from poor to rich countries. Concerns are always raised on the future usage of the stored specimens shipped to research insitutions from developing countries. Creating awareness of the processes is required in all sectors involved in biomedical research. To maintain fairness and respect in sharing biomedical specimens and reserch products requires safeguarding by Ethics Review Committees in both (...)
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  5.  18
    Ethical Issues in Health Systems Research in Low and Middle‐Income Countries.Paul Ndebele & Adnan A. Hyder - 2016 - Developing World Bioethics 16 (3):122-123.
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  6. Ethical Considerations for International Recruitment in COVID-19 Human Challenge Trials.Kaleem Ahmid, Abie Rohrig, Paul Ndebele, Zacharia Kafuko & Josh Morrison - manuscript
    Ongoing and anticipated COVID-19 human challenge studies in the UK may advance our understanding of COVID-19 and facilitate the licensure of safe, effective, and easily deployable next-generation COVID-19 vaccines and boosters. We argue that international volunteer recruitment for COVID-19 human challenge trials can help promote diversity in these trials and ensure a sufficient number of eligible volunteers, both of which will increase the benefits of challenge research. We explore the ethical ramifications of dealing with unfair background conditions of global vaccine (...)
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  7.  16
    To What did They Consent? Understanding Consent Among Low Literacy Participants in a Microbicide Feasibility Study in Mazabuka, Zambia.Esther Munalula-Nkandu, Paul Ndebele, Seter Siziya & J. C. Munthali - 2014 - Developing World Bioethics 15 (3):248-256.
    We conducted a study to review the consenting process in a vaginal Microbicide feasibility study conducted in Mazabuka, Zambia. Participants were drawn from those participating in the microbicide study. A questionnaire and focus group discussion were used to collect information on participants understanding of study aims, risks and benefits. Altogether, 200 participants took part in this study. The results of the study showed that while all participants signed or endorsed their thumbprints to the consent forms, full informed consent was not (...)
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  8.  13
    Putting a positive spin on ethics teaching.Marion G. Ben-Jacob, Nancy L. Jones, Robert W. Brock, Kathleen H. Moore, Paul Ndebele & Lehana Thabane - 2018 - International Journal of Ethics Education 3 (2):125-133.
    Scientific endeavor is the pursuit of knowledge with the aim of advancing the welfare of all human beings. This endeavor is built on the ideology of science; thus, society relies on the integrity of the practice of science and of scientists themselves. The responsible conduct of research is the essence of good science; however, many of the pedagogical approaches used to instill integrity in science accentuate the negative rather than exemplify ideal professionalism. This paper makes an argument for the inculcation (...)
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  9.  66
    Hiv/aids reduces the relevance of the principle of individual medical confidentiality among the bantu people of southern Africa.Paul Ndebele, Joseph Mfutso-Bengo & Francis Masiye - 2008 - Theoretical Medicine and Bioethics 29 (5):331-340.
    The principle of individual medical confidentiality is one of the moral principles that Africa inherited unquestioningly from the West as part of Western medicine. The HIV/AIDS pandemic in Southern Africa has reduced the relevance of the principle of individual medical confidentiality. Individual medical confidentiality has especially presented challenges for practitioners among the Bantu communities that are well known for their social inter-connectedness and the way they value their extended family relations. Individual confidentiality has raised several unforeseen problems for persons living (...)
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  10.  10
    Standards of Care in Global Health: Identifying the Right Question.Paul Ndebele - 2017 - Hastings Center Report 47 (5):28-29.
    Govind Persad and Ezekiel Emanuel's article “The Case for Resource Sensitivity: Why It Is Ethical to Provide Cheaper, Less Effective Treatments in Global Health,” in this issue of the Hastings Center Report, is a reminder of the debates around resources for health care that raged during the years immediately preceding and following the fifth revision of the Declaration of Helsinki, in 2000. In global health, it is a common expectation for rich countries to assist poor countries in resolving health challenges, (...)
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  11.  3
    The role of science granting councils in promoting ethics in research and innovation: strategies used by selected African SGCs in promoting ethics in research and innovation.Paul Ndebele, Zivai Nenguke, Tiwonge Mtande, Kachedwa Mike, Samba Corr, Matandika Limbanazo, Lillian Naigaga Mutengu, Jonathan Mba & Maurice Bolo - forthcoming - International Journal of Ethics Education:1-15.
    The Science Granting Councils Initiative (SGCI) in Africa aims to strengthen the capacities of selected science granting councils (SGCs) in sub-Saharan Africa in order to support research and evidence-based policies that will contribute to Africa’s economic and social development. As part of SGCI, a study was conducted in 2021 to investigate strategies that have been adopted by fifteen SGCs participating in SGCI in promoting ethical practice in research and innovation. Data collection for the study was mainly based on a data (...)
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  12. Establishment of a collaborative research ethics training program to prepare the next generation of ethics researchers in Mali.Seydou Doumbia, Heather E. Rosen, Nino Paichadze, Housseini Dolo, Djeneba Dabitao, Zana Lamissa Sanogo, Karim Traore, Bassirou Diarra, Yeya dit Sadio Sarro, Awa Keita, Seydou Samake, Cheick Oumar Tangara, Hamadoun Sangho, Samba Ibrahim Diop, Mahamadou Diakite, Adnan A. Hyder & Paul Ndebele - forthcoming - International Journal of Ethics Education:1-11.
    Background: Despite an increase in health research conducted in Africa, there are still inadequate human resources with research ethics training and lack of local long-term training opportunities in research ethics. A research ethics training program named United States-Mali Research Ethics Training Program (US-Mali RETP) was established through a partnership between the George Washington University Milken Institute School of Public Health (GWSPH), USA and University of Sciences, Techniques & Technologies of Bamako (USTTB), to address the critical need for improved bioethics training, (...)
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  13.  12
    Maintaining respect and fairness in the usage of stored shared specimens.Takafira Mduluza, Nicholas Midzi, Donold Duruza & Paul Ndebele - 2013 - BMC Medical Ethics 14 (S1):S7.
    BackgroundEvery year, research specimens are shipped from one institution to another as well as across national boundaries. A significant proportion of specimens move from poor to rich countries. Concerns are always raised on the future usage of the stored specimens shipped to research insitutions from developing countries. Creating awareness of the processes is required in all sectors involved in biomedical research. To maintain fairness and respect in sharing biomedical specimens and reserch products requires safeguarding by Ethics Review Committees in both (...)
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  14.  17
    Land-Locked Developing Countries and Their Infrastructural Challenges in Contributing to Global Ethics: A Zimbabwe Case Study.Nahal Haghbin, Sithembile Ruzario, Paul Ndebele & Teck Chuan Voo - 2017 - American Journal of Bioethics 17 (10):21-24.
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  15.  54
    Infant feeding and hiv in sub-Saharan Africa: What lies beneath the dilemma?Faith E. Fletcher, Paul Ndebele & Maureen C. Kelley - 2008 - Theoretical Medicine and Bioethics 29 (5):307-330.
    The debate over how to best guide HIV-infected mothers in resource-poor settings on infant feeding is more than two decades old. Globally, breastfeeding is responsible for approximately 300,000 HIV infections per year, while at the same time, UNICEF estimates that not breastfeeding (formula feeding with contaminated water) is responsible for 1.5 million child deaths per year. The largest burden of these infections and deaths occur in Sub-Saharan Africa. Using this region as an example of the burden faced more generally in (...)
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  16.  8
    Bold Societal Responses Are Needed in Tackling Serious Ethical Violations in Medicine.Adnan A. Hyder & Paul Ndebele - 2019 - American Journal of Bioethics 19 (1):44-46.
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