All eukaryotic cellular mRNAs, and most viral mRNAs, are blocked at their 5′ ends with a cap structure (m7GpppX, where × is any nucleotide). Poliovirus, along with a small number of other animal and plant viral mRNAs, does not contain a 5′ cap structure. Since the cap structure functions to facilitate ribosome binding to mRNA, translation of poliovirus must proceed by a cap‐independent mechanism. Consistent with this, recent studies have shown that ribosomes can bind to an internal region within the (...) long 5′ noncoding sequence of poliovirus RNA. Possible mechanisms for cap‐independent translation are discussed. Cap‐independent translation of poliovirus RNA is of major importance to the mechanism of shut‐off of host protein synthesis after infection. Moreover, it is likely to play a role in determining poliovirus neurovirulence and attenuation. (shrink)

X: The Problem of the Negro as a Problem for Thought offers an original account of the African American as an object of discourse, knowledge, and general social practice, conceiving the focus of such a concern -- with W.E.B. Du Bois -- as forms of social and historical problems on an epochal scale, above all the global-level "problem of the color line," as the mark of both historical limit and possibility.

The paper describes the author's experience in using the history of science in teaching physics to science teachers. lt was found that history becomes more useful to teachers when explicitly combined with 'investigative' experimentation, which, in turn. can benefit from various uses of the history of science.

This book presents detailed discussions from leading intercultural philosophers, arguing for and against the priority of immanence in Chinese thought and the validity of Western interpretations that attempt to import conceptions of transcendence. The authors pay close attention to contemporary debates generated from critical analysis of transcendence and immanence, including discussions of apophasis, critical theory, post-secular conceptions of society, phenomenological approaches to transcendence, possible-world models, and questions of practice and application. This book aims to explore alternative conceptions of transcendence that (...) either call the tradition in the West into question, or discover from within Western metaphysics a thoroughly dialectical way of thinking about immanence and transcendence. (shrink)

El objetivo de este trabajo es medir el efecto del feedback correctivo escrito directo en el incremento del aprendizaje y el uso correcto de las preposiciones por y para en español como segunda lengua. Dichas preposiciones se consideran como unas de las más complejas durante el proceso de aprendizaje teniendo en cuenta la frecuencia de errores cometidos en sus usos y la naturaleza sintáctico-semántica. Para ello se llevó a cabo un estudio cuasiexperimental con pretest, postest inmediato, postest diferido y grupo (...) control, aplicando sistemáticamente las estrategias de FC metalingüístico directo y no metalingüístico directo a nivel escrito. Los resultados han demostrado evidencia de los efectos positivos de estos feedbacks correctivos en el incremento del aprendizaje y uso correcto de estas estructuras preposicionales. The aim of this research is to evaluate the effectiveness of written direct corrective feedback on the learning improvement of prepositions “por and para” in Spanish as second language. These grammatical structures are considered among the most complex prepositions to acquire during the learning process, considering the frequency of errors in their use and their syntactic-semantic nature. In order to achieve this aim, a quasi-experimental study with a pretest, immediate posttest, delayed posttest and control group was conducted. In this context, we have systematically applied the strategies of written metalinguistic and non-metalinguistic direct corrective feedback on these prepositions errors. The results have shown the positive effects of the written corrective feedback on the acquisition of these prepositional structures. (shrink)

This paper discusses a way of introducing a scientific controversy, which emphasizes objective aspects of such issues as multiple theoretical interpretation of phenomena, choosing a theory, insistence on the chosen theory, and others. The goal is to give students a better insight into the workings of science and provide guidelines for building theories in their own research.

A reprint of the Schocken Books edition of 1961.

In _Annotations_ Nahum Dimitri Chandler offers a philosophical interpretation of W. E. B. Du Bois’s 1897 American Negro Academy address, “The Conservation of Races.” Chandler approaches Du Bois as a generative and original philosophical thinker-writer on the status and historical implication of matters of human difference, both the fact of and the very idea thereof. Chandler proposes both a close reading of Du Bois’s engagement of the concept of so-called race and a deep meditation on Du Bois’s conceptualization of (...) historicity in general. He elaborates on the way Du Bois’s thought in this address can give an account of the organization of the historicity that yields the emergence of something like the African American, at once with its own internal dimensions and yet also as an originary articulation of forces and possibilities that have world historical implications. Chandler refigures Du Bois’s thought as a vital theoretical resource for rethinking our concepts of differences among humans and, so too, our understanding of modern historicity itself. (shrink)

In _“Beyond This Narrow Now”_ Nahum Dimitri Chandler shows that the premises of W. E. B. Du Bois's thinking at the turn of the twentieth century stand as fundamental references for the whole itinerary of his thought. Opening with a distinct approach to the legacy of Du Bois, Chandler proceeds through a series of close readings of Du Bois's early essays, previously unpublished or seldom studied, with discrete annotations of _The Souls of Black Folk: Essays and Sketches_ of 1903, (...) elucidating and elaborating basic epistemological terms of his thought. With theoretical attention to how the African American stands as an example of possibility for Du Bois and renders problematic traditional ontological thought, Chandler also proposes that Du Bois's most well-known phrase—“the problem of the color line”—sustains more conceptual depth than has yet been understood, with pertinence for our accounts of modern systems of enslavement and imperial colonialism and the incipient moments of modern capitalization. Chandler's work exemplifies a more profound engagement with Du Bois, demonstrating that he must be re-read, appreciated, and studied anew as a philosophical writer and thinker contemporary to our time. (shrink)

Discussing theories at length, including their origin, development, and replacement by other theories, can help students in understanding of both objective and subjective aspects of the scientific process. Presenting theories in the form of- models helps in this undertaking, and the history of science provides a number of suitable models. The paper describes specific examples that have been used in in-service courses for science teachers.

On a trop souvent classé l’œuvre d’Ernest Renan dans le strict domaine de la linguistique ou dans l’histoire des religions, sans voir qu’elle reposait sur un fondement épistémologique original : l’acclimatation en France d’une lecture de la Critique de la faculté de juger de Kant. L’article étudie comment Renan élabore dans ses textes sur le langage publiés entre 1848 et 1855 une théorie de la connaissance qui se réalise au moyen d’une réflexion sur le langage. Le langage va donc opérer (...) comme un outil réflexif autour duquel s’ordonne le reste de son œuvre. (shrink)

The rest is commentary.--Faith and knowledge.--The dynamics of emancipation.

A sourcebook of post-biblical Jewish literature from the Second Commonwealth to modern times.

Bu makalede Spinoza’nın dil eleştirisinin ve çözümlemesinin tartışılması amaçlanmaktadır. Bilindiği gibi, Spinoza, İbranice hakkında yarım kalmış bir dilbilgisi kitabı kaleme almış olsa da, bugün dil felsefesi diye adlandırılan alanda bir yapıt vermiş değildir. Bununla birlikte, dil konusunun, anlama yetisinin düzeltilmesinin önemli ayaklarından biri olması ölçüsünde, Spinoza açısından, felsefi uslamlama için bir propedötik işlevi gördüğü söylenebilir. Hatta Spinoza’ya göre, kendisinden önce gelen bazı filozofların doğanın ortak düzenini ve zorunlu nedenselliğini kavrayamamış olmasının nedeni, tam da fikirlerin ve şeylerin bağlantı ve düzenlerini izlemek (...) yerine, doğayı açıklamak için dilsel kategorilere başvurmalarıdır. İşte bu yüzden, felsefenin ilk adımlarından biri dilin bedensel-imgelemsel doğasının aydınlatılması olmalıdır. Böylelikle dilin felsefi amaçlar doğrultusunda, yani upuygun fikirlerin iletilmesi için kullanmasına zemin hazırlanacaktır. Bu yazıda, Spinoza’nın geliştirdiği dil kuramının, dil olgusunun psikolojik-bilişsel açıdan çözümlemesi kadar, kendine-gönderimli kavramsal bir dilin geometrik düzende kurulmasını da içerdiği ileri sürülecektir. (shrink)

This essay offers an examination of Agamben's statement that there is an important ambiguity in Aristotle's Metaphysics Theta as to whether actuality or potentiality is primary. I argue that this ambiguity is significant because it exposes the ontological dimension of Agamben's paradox of sovereignty.

Aristotle claims in book 9 of the Metaphysics that potentiality is distinct from actuality yet also that potentiality exists only for the sake of actuality. This essay presents the relationship between potentiality’s existence and actuality’s priority as an aporia, where potentiality remains distinct from and exists in excess of actuality, even though it exists only as actuality. I claim that this aporia helps the early Heidegger of Being and Time to conclude, contrary to Aristotle, that potentiality stands higher than actuality.

Aristotle claims in book 9 of the Metaphysics that potentiality is distinct from actuality yet also that potentiality exists only for the sake of actuality. This essay presents the relationship between potentiality’s existence and actuality’s priority as an aporia, where potentiality remains distinct from and exists in excess of actuality, even though it exists only as actuality. I claim that this aporia helps the early Heidegger of Being and Time to conclude, contrary to Aristotle, that potentiality stands higher than actuality.

Robb Dunphy's new book, Hegel and the Problem of Beginning: Scepticism and Presuppositionlessness, is a serious piece of scholarship intended for advanced reade.

In Hegel's Ontology of Power: The Structure of Social Domination in Capitalism, Arash Abazari offers a highly original account of Hegel's Science of Logic as a book of political theory. Hegel's Logic is traditionally understood to be a systematic dialectical study of fundamental ontology; revising this tradition, Abazari says that Hegel's Logic ‘expresses the spirit of capitalism’ (p. 8). He claims that Hegel's Logic is an ontological treatise, which, at the same time, exposes the power structures and asymmetrical relations of (...) domination and acts as a precursor for Marx's and Adorno's subsequent critiques of capitalism. Although some readers might find this way of reading the Logic to require interpretation that goes beyond what is evident in the text, Abazari's book is nevertheless filled with persuasive arguments designed to help his reader unlock the political dimensions of the Logic. I will outline the trajectory of the book's chapters, underscore some of the book's insights, anticipate its readership, and also consider a criticism. (shrink)

The aim of this article is to contrast Hegelian insights about the secret with Derrida’s literary account of the secret in the story of Abraham. Derrida outlines two kinds of secret in “Literature in Secret,” one revealable and the other apophatic. I propose that the first kind of secret is Hegelian in nature because a productive concept of contradiction underlies it. On the other hand, the second kind of secret is Derridean because it withdraws from all revelation. Through an analysis (...) of the role of contradiction in Hegel’s Logic and Derrida’s distinction between revealable and unrevealable secrets, I aim to explore the logical and structural components of the concept of the secret. (shrink)

Aristotle's famous claim that human beings are animals with rationality has a subtle and complicated articulation in his doctrine of the mean. This paper offers textual analysis of Aristotle's discussion of the mean as a resource for coming to terms with the thesis that humans naturally deliberate over the essence of their nature. Unlike other animals who tend to act without deliberation and without mediation, human beings are the animals who are capable of giving an account of themselves. However, this (...) also means that human beings are the animals whose nature it is to give an account. This paper proposes that Aristotle's doctrine of the mean, as it is found in the Nicomachean Ethics, helps to explain this circular, and in some ways puzzling, tension between having a nature and giving an account of one's nature. (shrink)

In this volume, scholars draw deeply on negative theology in order to consider some of the oldest questions in the philosophy of religion that stand as persistent challenges to inquiry, comprehension, and expression. The chapters engage different philosophical methodologies, cross disciplinary boundaries, and draw on varied cultural traditions in the effort to demonstrate that apophaticism can be a positive resource for contemporary philosophy of religion.

Brown offers close textual analysis of Hegel’s theory of modality. It situates Hegel within historical and contemporary debates about metaphysics, bringing him into dialogue with Aristotle, Leibniz, Kant, Heidegger, and Agamben. It is of benefit to anyone interested in the history of possibility.

One of the most difficult tasks Hegel scholars and teachers of Hegel face is how to introduce his work in a clear way without reducing the complexity of his thought to a caricature. This issue comes about more often with Hegel than with most other philosophers because of the intricacies of his local arguments, the abstract style of his writing, and how often dialectical reasoning shifts the meaning of a given standpoint. It is a significant achievement for a commentator to (...) explain Hegel to a student audience in a way that is both lucid and yet does not succumb to typical myths such as Hegel the necessitarian, Hegel the thinker of thesis–antithesis–synthesis, or Hegel the ambitious systematizer. In his new book Hegel's Century: Alienation and Recognition in a Time of Revolution, Jon Stewart does an admirable job of introducing Hegel and the subsequent generations of intellectuals that followed Hegel without reducing their ideas. (shrink)

I highly recommend reading Gregory S. Moss’ Hegel's Foundation Free Metaphysics: The Logic of Singularity. In this detailed examination of Hegel's masterpiece.

In one of the most memorable statements of his work, Hegel underscores how hugely important the role of the subject is for the developmental course of the Pheno.