Possible systemic effects of general anesthetic agents on neural information processing are discussed in the context of the thalamocortical suppression hypothesis presented by Drs. Alkire, Haier, and Fallon (this issue) in their PET study of the anesthetized state. Accounts of the neural requisites of consciousness fall into two broad categories. Neuronal-specificity theories postulate that activity in particular neural populations is sufficient for conscious awareness, while process-coherence theories postulate that particular organizations of neural activity are sufficient. Accounts of anesthetic narcosis, on (...) the other hand, explain losses of consciousness in terms of neural signal-suppressions, transmission blocks, and the disruptions of signal interpretation. While signal-suppression may account for the actions of some anesthetic agents, the existence of anesthetics, such as choralose, that cause both loss of consciousness and elevated discharge rates, is problematic for a general theory of narcosis that is based purely on signal suppression and transmission-block. However, anesthetic agents also alter relative firing rates and temporal discharge patterns that may disrupt the coherence of neural signals and the functioning of the neural networks that interpret them. It is difficult at present, solely on the basis of regional brain metabolic rates, to test process-coherence hypotheses regarding organizational requisites for conscious awareness. While these pioneering PET studies have great merit as panoramic windows of mind-brain correlates, wider ranges of theory and empirical evidence need to be brought into the formulation of truly comprehensive theories of consciousness and anesthesia. (shrink)

A form of context-appropriate verificationism is proposed that distinguishes between scientific theories as evolving systems of ideas and operationally-specified, testable formal-empirical models. Theories undergo three stages : a formative, exploratory, heuristic phase of theory conception, a developmental phase of theory-pruning and refinement, and a mature, rigorous phase of testing specific, explicit models. The first phase depends on Feyerabendian open possibility, the second on theoretical plausibility and internal coherence, and the third on testability. Multiple perspectives produce variety necessary for theory formation, (...) whereas explicit agreement on evaluative criteria is essential for testing. Hertzian observer-mechanics of empirical-deductive scientific models are outlined that use semiotic operations of measurement/evaluation, computation, and physical action/construction. If models can be fully operationalized, then they can be intersubjectively verified irrespective of metaphysical, theoretical, value-, or culture-based disagreements. Verificationism can be expanded beyond simple predictive efficacy to incorporate testing for pragmatic, functional efficacy in engineering, medicine, and design contexts. Such a more open, pragmatist, operationalist, epistemically-constructivist perspective is suggested in which verification is contingent on the type of assertion, its intended purpose, degree and reliability of model-based evidence, and existence of alternate, competing predictive models. Suggestions for epistemological hygiene amidst the world-wide pandemic of misinformation and propaganda are offered. (shrink)