A thought-provoking meditation on food, family, identity, immigration, and, most of all, hospitality--at the table and beyond--that's part food memoir, part appeal for more authentic decency in our daily worlds, and in the world at large.

Fair trade is a new form of commercial partnership whereby actors in the North engage with actors in the South on a number of conditions, including setting a minimum price, a development bonus, and so on. But above all, fair trade organizations in the South are implementing mechanisms that more or less facilitate the empowerment of their members. This article analyzes the empowerment effects of two fair trade organizations in South India. It shows that while positive effects can be seen, (...) the prevailing social norms in India are extremely influential for women at the moment, so that women are putting all their hopes on their daughters through their education. (shrink)

Background Structured training in research integrity, research ethics and responsible conduct of research is one strategy to reduce research misconduct and strengthen reliability of and trust in scientific evidence. However, how researchers develop their sense of integrity is not fully understood. We examined the factors and circumstances that shape researchers’ understanding of research integrity. Methods This study draws insights from in-depth, semi-structured interviews with 33 researchers in the life sciences and medicine, representing three seniority levels across five research universities in (...) Switzerland. Results The results of this study indicate that early education, moral values inculcated by the family and participation in team sports were the earliest influences on notions of honesty, integrity and fairness among researchers. Researchers’ personality traits, including degree of ambition and internal moral compass, were perceived as critical in determining the importance they attributed to conducting research with high ethical standards. Positive and negative experiences in early research life also had a significant impact on their views regarding research integrity. Two thirds of the study participants had not received any formal training in research integrity. Their awareness of training opportunities at their institutions was also limited. Conclusion Age-appropriate development of honesty and integrity starts as early as primary education. Research integrity training should be offered from the bachelors level and continue throughout the entire professional life of researchers. Although these courses may not imbue researchers with integrity itself, they are essential to improving the research culture, reinforcing integrity norms, and discouraging researchers who lack personal integrity from engaging in research misconduct. (shrink)

The subject of this essay is NBIC convergence. NBIC convergence is a recurring trope that is dominated by the paradigm of integration of the sciences. It is largely influenced by the considerations of social and economic impact, and it assumes positivism in the name of technological progress. The culture of NBIC convergence, including NBIC discourses, is ensconced on the borders between modernity/ postmodernity, ambition/restraint, unity/fragmentation, and rational intellect/creativity. Both the rhetoric of ambition and visionary development, and its responding calls for (...) some level of restraint and caution, make contrasting assumptions that, however unintentionally, further polarize the debate concerning NBIC technologies. Those engaged in producing the culture, including scientists, engineers, and ethicists of convergence, consider the ramifications of these technologies for subjectivity and identity in ways that do not fully account for the diversity of human experience, or the ambiguity of human nature. NBIC convergence, such as artificial intelligence, is a “projection of the normative self, unaware of its own specificity;” in other words, that converging technologies offer negligible insight into human corporeality or experience and, in their theoretical frameworks, are hardly conscious of the necessity of effectively mobilizing the diversity within society and of social existence in bringing about nanotechnology’s “maximum benefit to humanity,” and are part and parcel of creating a “nanoself,” bereft of uniqueness. (shrink)

Priyanshu Prabal Upadhyaya, b. 1919, Sanskrit scholar; contributed articles on various aspects of Indic philosophy, Vedic and Sanskrit literature.

Transcription is a fundamental cellular process and the first step in gene regulation. Although RNA polymerase (RNAP) is highly processive, in growing cells the progression of transcription can be hindered by obstacles on the DNA template, such as damaged DNA. The authors recent findings highlight a trade‐off between transcription fidelity and DNA break repair. While a lot of work has focused on the interaction between transcription and nucleotide excision repair, less is known about how transcription influences the repair of DNA (...) breaks. The authors suggest that when the cell experiences stress from DNA breaks, the control of RNAP processivity affects the balance between preserving transcription integrity and DNA repair. Here, how the conflict between transcription and DNA double‐strand break (DSB) repair threatens the integrity of both RNA and DNA are discussed. In reviewing this field, the authors speculate on cellular paradigms where this equilibrium is well sustained, and instances where the maintenance of transcription fidelity is favored over genome stability. (shrink)

Der Gedanke, der sich in der modernen Idee der Autonomie verdichtet, ist ein doppelter: Die Figur der Autonomie enthält zugleich eine neue Auffassung von Normativität und eine eigene Konzeption von Freiheit. Dem Gedanken der Autonomie zufolge ist ein Gesetz, das wahrhaft normativ ist, eines, als dessen Urheber wir uns selbst betrachten können; und eine Freiheit, die im vollen Sinne wirklich ist, drückt sich in Gestalt eben solcher selbstgegebener Gesetze aus. Die Idee der Autonomie artikuliert so die Einsicht, dass man Freiheit (...) und Gesetz nicht durch ihre Entgegensetzung bestimmen kann, sondern durcheinander erläutern muss. Wirkliche Freiheit ist nicht Freiheit von Gesetzen, sondern Freiheit in Gesetzen; verbindliche Normen sind nicht das, was Freiheit äußerlich beschränkt, sondern das, was Freiheit innerlich verwirklicht. Die Idee der Autonomie, die für die moderne praktische Philosophie seit Rousseau und Kant grundlegend ist, zielt so darauf, Freiheit und Verbindlichkeit in einem Zuge zu artikulieren: durch die Form selbstgegebener Gesetze. Mit Beiträgen von Robert Brandom, Judith Butler, Thomas Khurana, Christoph Menke, Terry Pinkard und Sebastian Rödl. (shrink)

The aim of this paper is to analyze the attitudes and reactions of researchers towards an authorship claim made by a researcher in a position of authority who has not made any scientific contribution to a manuscript or helped to write it. This paper draws on semi-structured interviews conducted with 33 researchers at three seniority levels working in biomedicine and the life sciences in Switzerland. This manuscript focuses on the analysis of participants’ responses when presented with a vignette describing an (...) authorship assignment dilemma within a research group. The analysis indicates that researchers use a variety of explanations and arguments to justify inclusion of what guidelines would describe as honorary or guest authorship. Fuzzy parameters such as “substantial contribution” lead to varied interpretation and consequently convenient application of authorship guidelines in practice. Factors such as the culture of the research group, the values and practice shaped by the research leaders, the hierarchy and relative positions of power within research institutions, and the importance given to publications as the currency for academic success and growth tend to have a strong influence on authorship practice. Unjustified authorship assignment practices can be reduced to some extent by creating empowering research cultures where each researcher irrespective of his/her career stage feels empowered to confidently raise concerns without fearing adverse impact on their professional lives. However, individual researchers and research institutions currently have limited influence on established methods for evaluating academic success, which is primarily based on the number of high impact publications. (shrink)

The Ebola epidemic in Western Africa has highlighted issues related to weak health systems, the politics of drug and vaccine development and the need for transparent and ethical criteria for use of scarce local and global resources during public health emergency. In this paper we explore two key themes. First, we argue that independent of any use of experimental drugs or vaccine interventions, simultaneous implementation of proven public health principles, community engagement and culturally sensitive communication are critical as these measures (...) represent the most cost-effective and fair utilization of available resources. Second, we attempt to clarify the ethical issues related to use of scarce experimental drugs or vaccines and explore in detail the most critical ethical question related to Ebola drug or vaccine distribution in the current outbreak: who among those infected or at risk should be prioritized to receive any new experimental drugs or vaccines? We conclude that healthcare workers should be prioritised for these experimental interventions, for a variety of reasons. (shrink)

Der Gedanke, der sich in der modernen Idee der Autonomie verdichtet, ist ein doppelter: Die Figur der Autonomie enthält zugleich eine neue Auffassung von Normativität und eine eigene Konzeption von Freiheit. Dem Gedanken der Autonomie zufolge ist ein Gesetz, das wahrhaft normativ ist, eines, als dessen Urheber wir uns selbst betrachten können; und eine Freiheit, die im vollen Sinne wirklich ist, drückt sich in Gestalt eben solcher selbstgegebener Gesetze aus. Die Idee der Autonomie artikuliert so die Einsicht, dass man Freiheit (...) und Gesetz nicht durch ihre Entgegensetzung bestimmen kann, sondern durcheinander erläutern muss. Wirkliche Freiheit ist nicht Freiheit von Gesetzen, sondern Freiheit in Gesetzen; verbindliche Normen sind nicht das, was Freiheit äußerlich beschränkt, sondern das, was Freiheit innerlich verwirklicht. Die Idee der Autonomie, die für die moderne praktische Philosophie seit Rousseau und Kant grundlegend ist, zielt so darauf, Freiheit und Verbindlichkeit in einem Zuge zu artikulieren: durch die Form selbstgegebener Gesetze. -/- Mit Beiträgen von Robert Brandom, Judith Butler, Thomas Khurana, Christoph Menke, Terry Pinkard und Sebastian Rödl. (shrink)

Nanotechnology, which involves manipulation of matter on a ‘nano’ scale, is considered to be a key enabling technology. Medical applications of nanotechnology are expected to significantly improve disease diagnostic and therapeutic modalities and subsequently reduce health care costs. However, there is no consensus on the definition of nanotechnology or nanomedicine, and this stems from the underlying debate on defining ‘nano’. This paper aims to present the diversity in the definition of nanomedicine and its impact on the translation of basic science (...) research in nanotechnology into clinical applications. We present the insights obtained from exploratory qualitative interviews with 46 stakeholders involved in translational nanomedicine from Europe and North America. The definition of nanomedicine has implications for many aspects of translational research including: fund allocation, patents, drug regulatory review processes and approvals, ethical review processes, clinical trials and public acceptance. Given the interdisciplinary nature of the field and common interest in developing effective clinical applications, it is important to have honest and transparent communication about nanomedicine, its benefits and potential harm. A clear and consistent definition of nanomedicine would significantly facilitate trust among various stakeholders including the general public while minimizing the risk of miscommunication and undue fear of nanotechnology and nanomedicine. (shrink)

Von einem Leben der Freiheit zu sprechen hat eine doppelte Bedeutung. Auf der einen Seite legt diese Wendung nahe, dass schon dem Leben das Merkmal der Freiheit zukommt. Zum anderen deutet der Ausdruck darauf hin, dass die Freiheit ein ihr eigenes Leben besitzen mag. In diesem doppelten Genitiv wird so ein Übergang angedeutet von der Freiheit, die dem Leben als solchem zukommt, zu dem eigenen Leben, das die Freiheit führt. Inwiefern aber ist schon das Leben frei und inwiefern besitzt auch (...) die Freiheit immer noch ein Leben? Warum mag es unserem Verständnis der Freiheit und des Lebens dienen, ihren inneren Zusammenhang zu begreifen? Und in welchem Sinne genau sind Leben und Freiheit aufeinander zu beziehen? -/- Die folgenden Überlegungen werden drei aufeinander bezogene Weisen erläutern, in denen Freiheit und Leben in einem wesentlichen Zusammenhang stehen: (1) Freiheit ist ein Vermögen, das sich nur in lebenden Wesen herausbilden kann. (2) Um die Form der Freiheit zu verstehen, müssen wir die Form des Lebens verstehen. (3) Um die Wirklichkeit der Freiheit zu begreifen, müssen wir verstehen, inwiefern die Freiheit ein Leben eigener Art gewinnt. In diesem Sinne sind wir auf den Lebensbegriff verwiesen, um die Genese, die Form und die Wirklichkeit der Freiheit zu verstehen. Um diese drei Gedanken zu entwickeln, wendet sich dieses Buch zwei Autoren zu, die zwar als Philosophen der Freiheit geläufig sind, wohl aber kaum als »Lebensphilosophen« gelten können: Kant und Hegel. (shrink)

In diesem Buch verbindet Thomas Khurana eine innovative Neubeschreibung des zentralen Konzepts der Psychoanalyse mit wesentlichen Elementen neuerer Theorien des Sozialen. In drei originellen Studien zu Freud, Lacan und Luhmann wird die These vorgestellt, dass sich der Begriff des Unbewussten nur dann in seiner erschließenden Kraft entfalten kann, wenn das Unbewusste nicht mehr substantialistisch verstanden wird.

In 2006, the Indian Council of Medical Research (ICMR) published its ‘Ethical guidelines for Biomedical Research on human participants’. The intention was to translate international ethical standards into locally and culturally appropriate norms and values to help biomedical researchers in India to conduct ethical research and thereby safeguard the interest of human subjects. Unfortunately, it is apparent that the guideline is not fit for purpose. In addition to problems with the structure and clarity of the guidelines, there are several serious (...) omissions and contradictions in the recommendations. In this paper, we take a close look at the two key chapters and highlight some of the striking flaws in this important document. We conclude that ethics committees and national authorities should not lose sight of international ethical standards while incorporating local reality and cultural and social values, as focusing too much on the local context could compromise the safety of human subjects in biomedical research, particularly in India. (shrink)

As with other rights, such as liberty and organization, intellectual property (IP) rights are often overlooked or disregarded simply because they are intangible. Yet, IP rights are essential to the workings of our society, and upholding them means greater freedom to invent, create, and advance.

This article serves as a demonstration of how certain models of literary analysis, used to theorize and analyze fiction and narrative, can also be applied to scientific communication in such a manner as to promote the accessibility of science to the general public and a greater awareness of the methodology used in making scientific discovery. The approach of this article is based on the assumption that the principles of structuralism and semiotics can provide plausible explanations for the divide between the (...) reception of science and literature. We provide a semiotic analysis of a scientific article that has had significant impact in the field of molecular biology with profound medical implications. Furthermore, we show how the structural and semiotic characteristics of literary texts are also evident in the scientific papers, and we address how these characteristics can be applied to scientific prose in order to propose a model of scientific communication that reaches the public. By applying this theoretical framework to the analysis of both scientific and literary communication, we establish parallels between primary scientific texts and literary prose. (shrink)

Khurana distinguishes different ways in which Derrida’s deconstruction can be understood as an attempt at transforming the transcendental question. Derrida’s essay “Cogito and the History of Madness” might lead us to the assumption that Derrida’s primary interest lies in a move of radicalization: in identifying conditions that are even more fundamental or basic than the conditions of the acts of our theoretical and practical cognition that transcendental philosophy has highlighted. He suggests, however, that instead of a mere radicalization, Derrida’s (...) decisive move in the transformation of the transcendental question resides rather in complicating the way we understand these conditions of possibility: (i) in an attempt to reveal conditions of the possibility of a certain type of act as being simultaneously the conditions of the impossibility of the purity of this act (a project that is sometimes termed “quasi-transcendental”); and (ii) an attempt to complicate the distinction between empirical and transcendental conditions (an investigation that is sometimes called “ultra-transcendental”). (shrink)

The aim of this paper is to analyze the attitudes and reactions of researchers towards an authorship claim made by a researcher in a position of authority who has not made any scientific contribution to a manuscript or helped to write it. This paper draws on semi-structured interviews conducted with 33 researchers at three seniority levels working in biomedicine and the life sciences in Switzerland. This manuscript focuses on the analysis of participants’ responses when presented with a vignette describing an (...) authorship assignment dilemma within a research group. The analysis indicates that researchers use a variety of explanations and arguments to justify inclusion of what guidelines would describe as honorary or guest authorship. Fuzzy parameters such as “substantial contribution” lead to varied interpretation and consequently convenient application of authorship guidelines in practice. Factors such as the culture of the research group, the values and practice shaped by the research leaders, the hierarchy and relative positions of power within research institutions, and the importance given to publications as the currency for academic success and growth tend to have a strong influence on authorship practice. Unjustified authorship assignment practices can be reduced to some extent by creating empowering research cultures where each researcher irrespective of his/her career stage feels empowered to confidently raise concerns without fearing adverse impact on their professional lives. However, individual researchers and research institutions currently have limited influence on established methods for evaluating academic success, which is primarily based on the number of high impact publications. (shrink)

The aim of this paper is to analyze the attitudes and reactions of researchers towards an authorship claim made by a researcher in a position of authority who has not made any scientific contribution to a manuscript or helped to write it. This paper draws on semi-structured interviews conducted with 33 researchers at three seniority levels working in biomedicine and the life sciences in Switzerland. This manuscript focuses on the analysis of participants’ responses when presented with a vignette describing an (...) authorship assignment dilemma within a research group. The analysis indicates that researchers use a variety of explanations and arguments to justify inclusion of what guidelines would describe as honorary or guest authorship. Fuzzy parameters such as “substantial contribution” lead to varied interpretation and consequently convenient application of authorship guidelines in practice. Factors such as the culture of the research group, the values and practice shaped by the research leaders, the hierarchy and relative positions of power within research institutions, and the importance given to publications as the currency for academic success and growth tend to have a strong influence on authorship practice. Unjustified authorship assignment practices can be reduced to some extent by creating empowering research cultures where each researcher irrespective of his/her career stage feels empowered to confidently raise concerns without fearing adverse impact on their professional lives. However, individual researchers and research institutions currently have limited influence on established methods for evaluating academic success, which is primarily based on the number of high impact publications. (shrink)

In the imagery debate, a key question concerns the inherent spatial nature of mental images. What do we mean by spatial representation? We explore a new idea that suggests that motion is instrumental in the coding of visual space. How is the imagery debate informed by the representation of space being determined by visual motion?

For post-Kantian philosophy, “life” is a transitory concept that relates the realm of nature to the realm of freedom. From this vantage point, the living seems to have the double character of being both already and not yet free: Compared with the external necessity of dead nature, the living already seems to exhibit a basic type of spontaneity and normativity that on the other hand still has to be superseded on the path to the freedom and normativity of spirit. The (...) contributions in the third volume of the series Freedom and Law take their departure from Hegel in order to investigate the extent to which we need figures and concepts of the living to understand the genesis and structure of theoretical and practical self-determination. In these analyses, Hegel’s philosophy reveals itself as a thinking not restricted to a mere opposition between the determinations of life and the freedom of spirit, but rather conceives of a freedom that realizes itself in and through life: a freedom of life. (shrink)

»Latenz« bezeichnet als spezifischer Modus des Verborgenseins und der Wirksamkeit aus dem Verborgenen eine ebenso alte wie virulente Figur. Das Wirken des Begriffs selbst jedoch geschieht bezeichnenderweise oft fast unbemerkt und wie aus dem Verborgenen: Nicht nur sucht man vergebens nach einer umfassenden Theorie der Latenz, auch im Einzelnen sind detaillierte Klärungen zur Struktur oder Verwendungsweise der mit Latenz verbundenen Begrifflichkeit die Ausnahme. »Latenz« taucht vielmehr fast ausschließlich als operativer Begriff auf, der einen Teil seiner spezifischen Wirksamkeit womöglich gerade seinem (...) unthematisierten, ›latenten‹ Charakter verdankt – der Ovid’schen Devise entsprechend, dass die Kunstfertigkeit darin bestehe, die ihr eigene Technik zu verbergen: ars adeo latet arte sua. (shrink)

Der Gedanke, der im Folgenden artikuliert und entfaltet werden soll, besagt, dass Sinn und Gedächtnis in einem internen Zusammenhang stehen. Das heißt näherhin: Sinn ist gedächtnishaft, und Gedächtnis ist nur richtig zu verstehen, wenn es von der zeitlichen Tiefenstruktur des Sinns aus expliziert wird. Die Weise, in der dieser Gedanke ausgeführt und begründet werden soll, ist eine systematische Entwicklung in zwei Zügen: Zum einen gilt es, die basale und implizite Gedächtnishaftigkeit des Sinns zu charakterisieren; zum anderen werden Formen des expliziten (...) Gedächtnisses auf dieser Grundlage neu verstanden und als Reflexionsfiguren der Zeitlichkeit des Sinns ausgewiesen. Die Absicht, die ich dabei verfolge, ist eine doppelte: die irreduzible, in der jüngeren Sprachphilosophie auffällig ignorierte Zeitlichkeit des Sinns ins Licht zu setzen; die Bedeutung und den Wert von Formen des Gedächtnisses zu erschließen, die auch Teilen der jüngeren kulturwissenschaftlichen Diskussion als defizient oder irrelevant erscheinen. (shrink)

Corporate Governance (CG) issues have driven organisations to set their house right. There is a continual effort by organisations to build on a good framework of policies, not only as an undertaking enforced by a regulatory body, but also to sustain and win. However, these organisations are facing a dilemma in terms of their focus priority. Is it the composition of the board or is it the employee as the stakeholder that has high determining power to reach their goals. The (...) aim of this article is to build upon a structure of enablers of good governance. The paper utilises the Interpretive Structural Modelling (ISM) methodology to understand the mutual influence among the various enablers in such a fashion that the enablers having high driving power and dependency power can be identified. (shrink)

It is, by now, a well-established thesis that one major path that runs from Kant, through Fichte and Schelling, up to Hegel is defined by the conception of freedom as autonomy. It is less known and has been less frequently the object of study that from Kant to Hegel a new idea of life takes shape as well. Even less taken into account is the fact that these two paths from Kant to Hegel might be systematically intertwined. If the notion (...) of life in German Idealism is discussed at all, it has been discussed mostly in dealing with the philosophies of nature and biology of Kant and his successors. This framing is, of course, not wrong in itself; yet to my mind we can only fully account for the thought of what is living and the new interest that the idealist philosophies of nature actually deserve if we regard life as a practical notion. For the idealists, life is, as Fichte has it, an “analogue of freedom in nature,” and it describes the one form of object we can encounter in nature that possesses a kind of unity and organization that comes close to the unity and the organization of spirit. In various accounts of German Idealism, life is not only regarded as an analogue of a self-grounded order, but figures furthermore as a precondition of the actuality of freedom: It is in being alive that we might become free. How exactly this is so is of course not only a very complicated issue but also a contested one among Kant and his successors. In order to outline at least two basic approaches to relating ‘life’ and ‘autonomy,’ I would like to present a sketch of a reading of Kant, in whose works the analogy of life and autonomy first manifests itself, and of Hegel, who has to my mind most fully developed the potential of this constellation. (shrink)

In this chapter, I consider the relation of the three major spheres of ethical life that Hegel distinguishes – family, civil society, and the state – and analyse their contribution to the constitution of the "second nature" of objective spirit. Family and civil society are both analyzed by Hegel as ways of taking up and transforming our given nature such that a second ethical nature can be produced. Where the family helps bring forth such a second nature by means of (...) “education” (Erziehung), civil society does so by means of “cultural formation” (Bildung). As I show in sections (I) and (II), these processes are characterised by Hegel as steps of an actualization of freedom insofar they liberate us from our given nature without suppressing it and bring forth a second nature that gives freedom the consistency of living reality. However, while these processes constitute forms of liberation, they are at the same time forms of social subjection, involving discipline and normalization, the subjection to the will of another, and the adaption to the given necessities of the social world. Therefore, the completion of the process of liberation seems to require a third sphere that allows individuals to relate, collectively and politically, to the second nature thus produced. In order for the second nature of spirit to be a self-constitutive actualization of freedom, ethical life thus requires a specific political dimension that I turn to in section (III). While this political process is only possible on the basis of the republican infrastructures of family and civil society, it at the same time calls these infrastructures into question. Although Hegel himself does not develop this dimension properly, his conception of second nature points towards the desideratum of a politics of second nature. I will close the discussion of this political dimension in section (IV) by pointing out the general and diagnostic dimensions that such a politics of second nature can help us elaborate. (shrink)

In this introductory paper, I discuss the second-personal approach to ethics and the theory of recognition as two accounts of the fundamental sociality of the human form of life. The first section delineates the deep affinities between the two approaches. They both put a reciprocal social constellation front and center from which they derive the fundamental norms of moral and social life and a social conception of freedom. The second section discusses three points of contrast between the two approaches: The (...) accounts differ in that the second-personal approach opts for a narrower conception of recognition focusing on mutual moral accountability, whereas recognition theory suggests a broader conception including relations of love, respect, and esteem. Secondly, the accounts differ as to how they conceive of the interrelation of the I-thou and the I-We relationship. Finally, they differ with regard to the way they think of struggles for recognition. Whereas the second-personal approach suggests that we can understand struggles on the basis of a transcendental infrastructure of second-personal address, the theory of recognition considers norms of recognition as themselves constituted by dialectical social struggles. The paper closes with a reflection on the ways in which both approaches can help us understand the social vulnerability of the human form of life. (shrink)