Conventional and well-established guidelines for the ethical conduct of clinical research are necessary but not sufficient for addressing research dilemmas related to public health research. There is a particular need for a public health ethics framework when, in the face of an epidemic, research is urgently needed to promote the common good. While there is limited experience in the use of a public health ethics framework, the value and potential of such an approach is increasingly being appreciated. Here we use (...) two examples of adolescent women as potential candidates for participation in microbicide trials to illustrate how ethical decisions for public health research can be enhanced by drawing on both traditional research ethics guidance, and the emerging framework for public health ethics. (shrink)
Why eschew luxury? The traditional arguments for frugality typically focus on what is good for the individual. Some see frugality as morally valuable because it tends to be associated with other virtues such as wisdom, honesty, or sincerity. Some find the natural, uncluttered, focused character of a simple lifestyle aesthetically appealing. The most common argument, though, is that simple living is the surest route – some even say the only route – to happiness.
As the “Sacred Place”—meant as the new space for religions offered by the Internet—demands for continuous investigations on the encounter between traditional narratives and social practices, the rapid growth of Question and Answering websites asks for improving social research about the Authenticity of the religious feeling as well as their responsibility in the construction of a shared knowledge. In this background, the aim of this study is to investigate the role of Q&A websites as additional interpretative resources in accordance with (...) different religious forms of life. About 800 extracts—composed by questions and answers—from the religious pages of Stack Exchange were analyzed, in accordance with social discursive psychology, through bottom-up and top-down pathways. In relation to the different emerging questioners’ profiles, the rhetoric of “closeness” and “openness” reveal a dialectic trend of these websites in offering both supplementary and extending religious experiences. (shrink)
Drawing on recent developments in media entertainment research, this study examined the relationship between social question and answer websites use and users’ perceived enjoyment with the goal of expanding the line of research on the enjoyment of new and interactive forms of media entertainment. Special attention was paid to meaningfulness, self-presentation, and social presence, which were introduced as mediators. An online survey of users of a social Q&A website was carried out. Results indicated an indirect effect of social Q&A websites (...) usage on enjoyment through users’ meaningfulness, self-presentation success, and social presence. Theoretical implications and further directions were discussed in detail. (shrink)
BackgroundObtaining informed consent for participation in genomic research in low-income settings presents specific ethical issues requiring attention. These include the challenges that arise when providing information about unfamiliar and technical research methods, the implications of complicated infrastructure and data sharing requirements, and the potential consequences of future research with samples and data. This study investigated researchers’ and participants’ parents’ experiences of a consent process and understandings of a genome-wide association study of malaria involving children aged five and under in Mali. (...) It aimed to inform best practices in recruiting participants into genomic research.MethodsA qualitative rapid ethical assessment was undertaken. Fifty-five semi-structured interviews were conducted with the parents of research participants. An additional nine semi-structured interviews were conducted with senior research scientists, research assistants and with a member of an ethics committee. A focus group with five parents of research participants and direct observations of four consent processes were also conducted. French and translated English transcripts were descriptively and thematically coded using OpenCode software.ResultsParticipants’ parents in the MalariaGEN study had differing understandings of the causes of malaria, the rationale for collecting blood samples, the purposes of the study and the kinds of information the study would generate. Genomic aspects of the research, including the gene/environment interaction underlying susceptibility or resistance to severe malaria, proved particularly challenging to explain and understand.ConclusionsThis study identifies a number of areas to be addressed in the design of consent processes for genomic research, some of which require careful ethical analysis. These include determining how much information should be provided about differing aspects of the research and how best to promote understandings of genomic research. We conclude that it is important to build capacity in the design and conduct of effective and appropriate consent processes for genomic research in low and middle-income settings. Additionally, consideration should be given to the role of review committees and community consultation activities in protecting the interests of participants in genomic research. (shrink)
Arthur Norman Prior was born on 4 December 1914 in Masterton, New Zealand. He studied philosophy in the 1930s and was a significant, and often provocative, voice in theological debates until well into the 1950s. He became a lecturer in philosophy at Canterbury University College in Christchurch in 1946 succeeding Karl Popper. He became a full professor in 1952. He left New Zealand permanently for England in 1959, first taking a chair in philosophy at Manchester University, and then becoming a (...) fellow of Balliol College, Oxford, in 1966. Prior died on 6 October 1969 in Trondheim, Norway. After Prior’s death, many logicians and philosophers have analysed and discussed his approach to formal and philosophical logic. In particular, his contributions to modal logic, tense-logic and deontic logic have been studied. -/- In 1957, A.N. Prior proposed the three-valued modal logic Q as a ‘correct’ modal logic from his philosophical motivations, see Prior (1957). Prior developed Q in order to offer a logic for contingent beings, in which one could intelligibly and rationally state that some beings are contingent and some are necessary, see Akama & Nagata (2005). According to Akama & Nagata (2005), Q has a natural semantics. In other words, from the philosophical point of view, Q can be regarded as an ‘actualist’ modal logic. -/- This review article is a developed description of, and discussion on, ‘The System Q’ that is the fifth chapter of Prior (1957). In addition, in his logical analysis of ‘Time & Existence’ (that is the eights chapter of Prior (1967)), Prior has worked on system Q. Thus, Prior (1967) has also been very useful for this article. This article analyses the logical structure of system Q in order to provide a more understandable description as well as logical analysis for today’s logicians, philosophers, and information-computer scientists. In the paper, the Polish notations are translated into modern notations in order to be more comprehensible and to support the developed formal descriptions as well as semantic analysis. (shrink)
The idea that democracy is under threat, after being largely dormant for at least 40 years, is looming increasingly large in public discourse. Complex systems theory offers a range of powerful new tools to analyse the stability of social institutions in general, and democracy in particular. What makes a democracy stable? And which processes potentially lead to instability of a democratic system? This paper offers a complex systems perspective on this question, informed by areas of the mathematical, natural, and social (...) sciences. We explain the meaning of the term 'stability' in different disciplines and discuss how laws, rules, and regulations, but also norms, conventions, and expectations are decisive for the stability of a social institution such as democracy. (shrink)
In this essay I propose to facilitate a dialogue between the thoughts of conceptual artist and philosopher, Daya Krishna, and the work of literary artist, Vikas Swarup. The central concept that will be “interrogated” in this dialogue is that of knowledge. I will apply my understanding of Daya Krishna’s conceptualization of the knowledge enterprise on to Vikas Swarup’s attitude toward knowledge as embodied in his 2005 novel, Q & A. This exercise serves to create a context in which conceptions of (...) knowledge from diverse fields can be in dialogue with one another, and thereby enhance meaning. Daya Krishna observes that the loss of certainty and proof in our postmodern age erodes the concept of knowledge. He alternately suggests new indicators with which to define knowledge, indicators which factor in chance and probability, and take into account inherent moral qualities of knowledge. I argue that this alternative model of knowledge finds an expression in Swarup’s novel. (shrink)
Disease prioritarianism is a principle that is often implicitly or explicitly employed in the realm of healthcare prioritization. This principle states that the healthcare system ought to prioritize the treatment of disease before any other problem. This article argues that disease prioritarianism ought to be rejected. Instead, we should adopt ‘the problem-oriented heuristic’ when making prioritizations in the healthcare system. According to this idea, we ought to focus on specific problems and whether or not it is possible and efficient to (...) address them with medical means. This has radical implications for the extension of the healthcare system. First, getting rid of the binary disease/no-disease dichotomy implicit in disease prioritarianism would improve the ability of the healthcare system to address chronic conditions and disabilities that often defy easy classification. Second, the problem-oriented heuristic could empower medical practitioners to address social problems without the need to pathologize these conditions. Third, the problem-oriented heuristic clearly states that what we choose to treat is a normative consideration. Under this assumption, we can engage in a discussion on de-medicalization without distorting preconceptions. Fourth, this pragmatic and de-compartmentalizing approach should allow us to reconsider the term ‘efficiency’. (shrink)
Reward and punishment sensitivity seem important traits in understanding behavior in general and psychopathology in particular. Though the definitions used for reward and punishment sensitivity differentiate between responsivity and motivation, the measures thus far used to assess these constructs do not. Further, specificity of the type of reward and punishment in questionnaires might result in measurement bias especially when examining the relationship with psychopathology. Therefore, we developed a stimulus-independent multidimensional questionnaire of reward and punishment sensitivity that differentiates between responsivity and (...) motivation. This study addresses the psychometric qualities of this newly developed reward and punishment responsivity and motivation questionnaire. On the basis of exploratory ordinal factor analysis that was used to examine the quality of the initial pool of 39 items, the number of items was reduced to 18. Confirmatory ordinal factor analysis on the remaining items in an independent sample supported a 18-item four-factor model, and showed acceptable to good internal reliability. The relationship between the subscales of the RPRM-Q and often used questionnaires was examined in the combined sample, which showed some first support for the ability of the new questionnaire to differentiate between responsivity and motivation to approach/avoid. The findings indicate that the RPRM-Q might be a helpful instrument to further test the relevance of punishment and reward sensitivity in psychopathology. (shrink)
