Results for 'R. Basha'

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  1.  56
    Lifespan profiles of Alzheimer's disease-associated genes and products in monkeys and mice.R. Dosunmu, J. Wu, L. Adwan, B. Maloney, M. R. Basha, C. A. McPherson, G. J. Harry, D. C. Rice, N. H. Zawia & D. K. Lahiri - 2009 - J Alzheimers Dis 18:211-30.
    Alzheimer's disease is characterized by plaques of amyloid-beta peptide, cleaved from amyloid-beta protein precursor . Our hypothesis is that lifespan profiles of AD-associated mRNA and protein levels in monkeys would differ from mice and that differential lifespan expression profiles would be useful to understand human AD pathogenesis. We compared profiles of AbetaPP mRNA, AbetaPP protein, and Abeta levels in rodents and primates. We also tracked a transcriptional regulator of the AbetaPP gene, specificity protein 1 , and the beta amyloid precursor (...)
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  2. Alzheimer's disease -like pathology in aged monkeys after infantile exposure to environmental metal lead : evidence for a developmental origin and environmental link for AD.J. Wu, M. R. Basha, B. Brock, D. P. Cox, F. Cardozo-Pelaez, C. A. McPherson, J. Harry, D. C. Rice, B. Maloney, D. Chen, D. K. Lahiri & N. H. Zawia - 2008 - J Neurosci 28:3-9.
    The sporadic nature of Alzheimer's disease argues for an environmental link that may drive AD pathogenesis; however, the triggering factors and the period of their action are unknown. Recent studies in rodents have shown that exposure to lead during brain development predetermined the expression and regulation of the amyloid precursor protein and its amyloidogenic beta-amyloid product in old age. Here, we report that the expression of AD-related genes [APP, BACE1 ] as well as their transcriptional regulator were elevated in aged (...)
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  3.  15
    Exposure to lead and the developmental origin of oxidative DNA damage in the aging brain.C. M. Bolin, R. Basha, D. Cox, N. H. Zawia, B. Maloney, D. K. Lahiri & F. Cardozo-Pelaez - 2006 - Faseb J 20:788-90.
    Oxidative damage to DNA has been associated with neurodegenerative diseases. Developmental exposure to lead has been shown to elevate the Alzheimer's disease related beta-amyloid peptide , which is known to generate reactive oxygen species in the aging brain. This study measures the lifetime cerebral 8-hydroxy-2'-deoxyguanosine levels and the activity of the DNA repair enzyme 8-oxoguanine DNA glycosylase in rats developmentally exposed to Pb. Oxo8dG was transiently modulated early in life , but was later elevated 20 months after exposure to Pb (...)
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  4.  21
    Co-localization and distribution of cerebral APP and SP1 and its relationship to amyloidogenesis.B. Brock, R. Basha, K. DiPalma, A. Anderson, G. J. Harry, D. C. Rice, B. Maloney, D. K. Lahiri & N. H. Zawia - 2008 - J Alzheimers Dis 13:71-80.
    Alzheimer's disease is characterized by amyloid-beta peptide -loaded plaques in the brain. Abeta is a cleavage fragment of amyloid-beta protein precursor and over production of APP may lead to amyloidogenesis. The regulatory region of the APP gene contains consensus sites recognized by the transcription factor, specificity protein 1 , which has been shown to be required for the regulation of APP and Abeta. To understand the role of SP1 in APP biogenesis, herein we have characterized the relative distribution and localization (...)
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  5.  60
    F. R. D. Goodyear: Tacitus. (Greece and Rome, New Surveys in the Classics, 4.) Pp. 44. Oxford: Clarendon Press, 1970. Paper, 35p.R. H. Martin - 1977 - The Classical Review 27 (1):117-117.
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  6.  93
    Theory and practice in education.R. F. Dearden - 1980 - Journal of Philosophy of Education 14 (1):17–29.
    R F Dearden; Theory and Practice in Education, Journal of Philosophy of Education, Volume 14, Issue 1, 30 May 2006, Pages 17–29, https://doi.org/10.1111/j.1467-.
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  7.  13
    The Ancient Concept of Progress: And Other Essays on Greek Literature and Belief.E. R. Dodds - 1973 - New York: Oxford University Press UK.
    This provocative collection of essays written by the influential Greek scholar E. R. Dodds between 1929 and 1971. represents the wide range of his literary and philosophical interests. Insightful and learned, the essays combine profound scholarship with the lucid humanity of a teacher awareof the special value of Greek studies in the modern world.
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  8.  73
    Sleeping Beauty: a simple solution.R. Weintraub - 2004 - Analysis 64 (1):8-10.
    I defend the suggestion that the rational probability in the Sleeping Beauty paradox is one third. The reasoning in its favour is familiar: for every heads-waking, there are two tails-wakings. To complete the defense, I rebut the reasoning which purports to justify the competing suggestion – that the correct probability is half – by undermining its premise, that no new information has been received.
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  9.  71
    Value, reasons and the structure of justification: how to avoid passing the buck.R. Crisp - 2005 - Analysis 65 (1):80-85.
  10. Professions and professionalism.R. S. Downie - 1990 - Journal of Philosophy of Education 24 (2):147–159.
    R S Downie; Professions and Professionalism, Journal of Philosophy of Education, Volume 24, Issue 2, 30 May 2006, Pages 147–159, https://doi.org/10.1111/j.1467-.
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  11.  16
    Towards an environmentally sensitive healthcare ethics: ten tasks and one model.Kristine Bærøe, Anand Singh Bhopal & TOrbjørn Gundersen - 2024 - Journal of Medical Ethics 50 (6):382-383.
    In the face of environmental crises such as climate change, pollution and biodiversity loss—which all adversely impact on health—Gils-Schmidt and Salloch explore whether physicians can be justified in taking climate issues into account in clinical care.1 While their approach centres on the ‘climate-sensitive’ decisions, physicians can carry out on the micro-level of clinical decision-making, they encourage further discussions on how climate-related issues can be included across different levels of decision-making in healthcare. We propose a list of tasks and a model (...)
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  12.  22
    Philosophy of Medicine: An Introduction.R. Paul Thompson & Ross Upshur - 2016 - New York: Routledge. Edited by Ross Upshur.
    What kind of knowledge is medical knowledge? Can medicine be explained scientifically? Is disease a scientific concept, or do explanations of disease depend on values? What is ‘evidence-based’ medicine? Are advances in neuroscience bringing us closer to a scientific understanding of the mind? The nature of medicine raises fundamental questions about explanation, causation, knowledge and ontology – questions that are central to philosophy as well as medicine. In this book Paul R. Thompson and Ross E. G. Upshur introduce the fundamental (...)
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  13.  36
    The generalized Sleeping Beauty problem: a challenge for thirders.R. White - 2006 - Analysis 66 (2):114-119.
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  14.  15
    Back to the 3 R’s: Rights, Responsibilities and Reasoning.Kenneth R. Westphal - 2016 - SATS 17 (1):21-60.
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  15. Tuḥfat al-abrār: sharḥ Ayyuhā al-walad al-muḥibb.Nūr al-Dīn Qūṭayṭ - 2010 - al-Munūfīyah, Miṣr: Ṣawt al-Qalam al-ʻArabī.
  16.  71
    Towards an axiology of knowledge.R. W. K. Paterson - 1979 - Journal of Philosophy of Education 13 (1):91–100.
    R W K Paterson; Towards an Axiology of Knowledge, Journal of Philosophy of Education, Volume 13, Issue 1, 30 May 2006, Pages 91–100, https://doi.org/10.1111/j.1.
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  17.  15
    In the Grip of Disease: Studies in the Greek Imagination.G. E. R. Lloyd - 2003 - Oxford University Press UK.
    This original and lively book explores Greek ideas about health and disease and their influence on Greek thought. Fundamental issues such as causation and responsibility, purification and pollution, mind-body relations and gender differences, authority and the expert and who can challenge them, reality and appearances, good government, happiness, and good and evil themselves are deeply implicated. Using the evidence not just from Greek medical theory and practice but also from epic, lyric, tragedy, historiography, philosophy, and religion, G. E. R. Lloyd (...)
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  18. Principii di logica reale: lezioni fatte nel secondo corso del R. liceo "Umberto I" di Roma.Nicolò R. D' Alfonso - 1894 - Torino: G. B. Paravia e c..
     
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  19.  11
    The Phaedo: Ed. with intro., notes, and app.R. D. Plato & Archer-Hind - 1973 - London,: Beaufort Books. Edited by Patrick Duncan.
  20.  14
    Professions and Professionalism.R. S. Downie - 1990 - Journal of Philosophy of Education 24 (2):147-159.
    R S Downie; Professions and Professionalism, Journal of Philosophy of Education, Volume 24, Issue 2, 30 May 2006, Pages 147–159, https://doi.org/10.1111/j.1467-.
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  21.  19
    Education, Love of One’s Subject, and the Love of Truth.R. K. Elliott - 1974 - Journal of Philosophy of Education 8 (1):135-153.
    R K Elliott; Education, Love of One’s Subject, and the Love of Truth, Journal of Philosophy of Education, Volume 8, Issue 1, 30 May 2006, Pages 135–153, https:/.
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  22.  42
    Education, love of one's subject, and the love of truth.R. K. Elliott - 1974 - Journal of Philosophy of Education 8 (1):135–153.
    R K Elliott; Education, Love of One’s Subject, and the Love of Truth, Journal of Philosophy of Education, Volume 8, Issue 1, 30 May 2006, Pages 135–153, https:/.
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  23.  27
    Versions of creativity.R. K. Elliott - 1971 - Journal of Philosophy of Education 5 (2):139–152.
    R K Elliott; Versions of Creativity, Journal of Philosophy of Education, Volume 5, Issue 2, 30 May 2006, Pages 139–152, https://doi.org/10.1111/j.1467-9752.1971.
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  24.  29
    Towards an Axiology of Knowledge.R. W. K. Paterson - 1979 - Journal of Philosophy of Education 13 (1):91-100.
    R W K Paterson; Towards an Axiology of Knowledge, Journal of Philosophy of Education, Volume 13, Issue 1, 30 May 2006, Pages 91–100, https://doi.org/10.1111/j.1.
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  25.  57
    Education and Justification.R. S. Peters - 1977 - Journal of Philosophy of Education 11 (1):28-38.
    R S Peters; Education and Justification, Journal of Philosophy of Education, Volume 11, Issue 1, 30 May 2006, Pages 28–38, https://doi.org/10.1111/j.1467-9752.1.
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  26.  9
    The Principles of History: And Other Writings in Philosophy of History.R. G. Collingwood (ed.) - 1999 - New York: Oxford University Press UK.
    Published here for the first time in paperback is much of a final and long-anticipated work on philosophy of history by the renowned Oxford philosopher, historian, and archaeologist R. G. Collingwood. The original text of this uncompleted work was only recently discovered in the archives of Oxford University Press. Also found there were two conclusions written by Collingwood for lectures which were eventually revised and published as The Idea of Nature, but which have relevance to his philosophy of history as (...)
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  27.  29
    Theory and Practice in Education.R. F. Dearden - 1980 - Journal of Philosophy of Education 14 (1):17-29.
    R F Dearden; Theory and Practice in Education, Journal of Philosophy of Education, Volume 14, Issue 1, 30 May 2006, Pages 17–29, https://doi.org/10.1111/j.1467-.
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  28.  19
    The Concept of Development: A Reply to Professor Hamlyn.R. K. Elliott - 1975 - Journal of Philosophy of Education 9 (1):40-48.
    R K Elliott; The Concept of Development: A Reply to Professor Hamlyn, Journal of Philosophy of Education, Volume 9, Issue 1, 30 May 2006, Pages 40–48, https://d.
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  29.  16
    The Concept of Development: A Reply to Professor Hamlyn.R. K. Elliott - 1975 - Journal of Philosophy of Education 9 (1):40-48.
    R K Elliott; The Concept of Development: A Reply to Professor Hamlyn, Journal of Philosophy of Education, Volume 9, Issue 1, 30 May 2006, Pages 40–48, https://d.
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  30.  14
    The concept of development: A reply to professor Hamlyn.R. K. Elliott - 1975 - Journal of Philosophy of Education 9 (1):40–48.
    R K Elliott; The Concept of Development: A Reply to Professor Hamlyn, Journal of Philosophy of Education, Volume 9, Issue 1, 30 May 2006, Pages 40–48, https://d.
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  31.  17
    Versions of Creativity.R. K. Elliott - 1971 - Journal of Philosophy of Education 5 (2):139-152.
    R K Elliott; Versions of Creativity, Journal of Philosophy of Education, Volume 5, Issue 2, 30 May 2006, Pages 139–152, https://doi.org/10.1111/j.1467-9752.1971.
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  32.  33
    Education and Justification.R. S. Peters - 1977 - Journal of Philosophy of Education 11 (1):28-38.
    R S Peters; Education and Justification, Journal of Philosophy of Education, Volume 11, Issue 1, 30 May 2006, Pages 28–38, https://doi.org/10.1111/j.1467-9752.1.
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  33.  56
    Explanation, Deliberation, and Reasons.R. Jay Wallace - 2003 - Philosophy and Phenomenological Research 67 (2):429-435.
    Jonathan Dancy’s Practical Reality defends a strikingly nonpsychologistic account of motivating reasons for action. When we explain what people do by citing their reasons, we are trying to isolate the considerations that were actually effective in moving them to act. But it is crucial, Dancy contends, that these considerations be understood in a way that preserves their connection to the normative contexts in which the concept of a reason also has a place. The considerations that move agents to act are (...)
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  34.  29
    The Bohr Atom, Models, and Realism.R. I. G. Hughes - 1990 - Philosophical Topics 18 (2):71-84.
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  35.  24
    Why favour simplicity?R. White - 2005 - Analysis 65 (3):205-210.
  36.  54
    Aristotelian and Stoic Conceptions of Necessity in the De Fato of Alexander of Aphrodisias.R. W. Sharples - 1975 - Phronesis 20 (3):247-274.
  37.  19
    'Because I say so!' Some limitations upon the rationalisation of authority.R. T. Allen - 1987 - Journal of Philosophy of Education 21 (1):15–24.
    R T Allen; ‘Because I Say So!’ Some Limitations Upon the Rationalisation of Authority, Journal of Philosophy of Education, Volume 21, Issue 1, 30 May 2006, Page.
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  38.  12
    ‘Because I Say So!’ Some Limitations Upon the Rationalisation of Authority.R. T. Allen - 1987 - Journal of Philosophy of Education 21 (1):15-24.
    R T Allen; ‘Because I Say So!’ Some Limitations Upon the Rationalisation of Authority, Journal of Philosophy of Education, Volume 21, Issue 1, 30 May 2006, Page.
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  39.  39
    The concept of physical education.R. Carlisle - 1969 - Journal of Philosophy of Education 3 (1):5–22.
    R Carlisle; The Concept of Physical Education, Journal of Philosophy of Education, Volume 3, Issue 1, 30 May 2006, Pages 5–22, https://doi.org/10.1111/j.1467-97.
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  40.  15
    Happiness and Education.R. F. Dearden - 1968 - Journal of Philosophy of Education 2 (1):17-29.
    R F Dearden; Happiness and Education, Journal of Philosophy of Education, Volume 2, Issue 1, 30 May 2006, Pages 17–29, https://doi.org/10.1111/j.1467-9752.1968.
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  41.  48
    Aestheticism, imagination and schooling: A reply to Ruby Meager.R. K. Elliott - 1981 - Journal of Philosophy of Education 15 (1):33–42.
    R K Elliott; Aestheticism, Imagination and Schooling: a reply to Ruby Meager, Journal of Philosophy of Education, Volume 15, Issue 1, 30 May 2006, Pages 33–42.
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  42.  19
    Aestheticism, Imagination and Schooling: a reply to Ruby Meager.R. K. Elliott - 1981 - Journal of Philosophy of Education 15 (1):33-42.
    R K Elliott; Aestheticism, Imagination and Schooling: a reply to Ruby Meager, Journal of Philosophy of Education, Volume 15, Issue 1, 30 May 2006, Pages 33–42.
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  43.  27
    D. W. Hamlyn on knowledge and the beginnings of understanding.R. K. Elliott - 1980 - Journal of Philosophy of Education 14 (1):109–116.
    R K Elliott; D. W. Hamlyn on Knowledge and the Beginnings of Understanding, Journal of Philosophy of Education, Volume 14, Issue 1, 30 May 2006, Pages 109–116.
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  44.  10
    D. W. Hamlyn on Knowledge and the Beginnings of Understanding.R. K. Elliott - 1980 - Journal of Philosophy of Education 14 (1):109-116.
    R K Elliott; D. W. Hamlyn on Knowledge and the Beginnings of Understanding, Journal of Philosophy of Education, Volume 14, Issue 1, 30 May 2006, Pages 109–116.
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  45.  18
    A Reply to John Kleinig.R. S. Peters - 1973 - Journal of Philosophy of Education 7 (2):167-176.
    R S Peters; A Reply to John Kleinig, Journal of Philosophy of Education, Volume 7, Issue 2, 30 May 2006, Pages 167–176, https://doi.org/10.1111/j.1467-9752.1973.
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  46.  22
    Value Education in a Pluralist Society.R. M. Hare - 1976 - Journal of Philosophy of Education 10 (1):7-23.
    R M Hare; Value Education in a Pluralist Society, Journal of Philosophy of Education, Volume 10, Issue 1, 30 May 2006, Pages 7–23, https://doi.org/10.1111/j.146.
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  47.  23
    Public schools: Private privilege—a reply to Brenda Cohen.R. J. Royce - 1982 - Journal of Philosophy of Education 16 (1):105–113.
    R J Royce; Public Schools: private privilege—a reply to Brenda Cohen, Journal of Philosophy of Education, Volume 16, Issue 1, 30 May 2006, Pages 105–113, https.
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  48.  39
    The Place of the Philebus in Plato's Dialogues1.R. A. H. Waterfield - 1980 - Phronesis 25 (3):270-305.
  49.  46
    Two approaches to the study of the origin of life.R. Hengeveld - 2007 - Acta Biotheoretica 55 (2):97-131.
    This paper compares two approaches that attempt to explain the origin of life, or biogenesis. The more established approach is one based on chemical principles, whereas a new, yet not widely known approach begins from a physical perspective. According to the first approach, life would have begun with—often organic—compounds. After having developed to a certain level of complexity and mutual dependence within a non-compartmentalised organic soup, they would have assembled into a functioning cell. In contrast, the second, physical type of (...)
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  50.  2
    Postscript 2.R. S. Peters - 1973 - Journal of Philosophy of Education 7 (2):179-180.
    R S Peters; Postscript 2, Journal of Philosophy of Education, Volume 7, Issue 2, 30 May 2006, Pages 179–180, https://doi.org/10.1111/j.1467-9752.1973.tb00480.x.
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