Determinations of the ethical acceptability of genetic therapy have relied on several distinctions in attempts to separate ethically acceptable genetic therapy from those possible therapies that could lead to genetic modifications of future human beings. One distinction that has been proposed is that genetic modifications of human somatic cells is ethically acceptable but that Germ-Line genetics modifications would be ethically objectionable. This paper examines several serious difficulties which call into question the ethical relevance of a somatic/Germ-Line distinction. Keywords: double effect, (...) future generations, Germ-Line modification CiteULike Connotea Del.icio.us What's this? (shrink)

The American Journal of Bioethics, Volume 12, Issue 8, Page 19-20, August 2012.

Advances in understanding genetic disorders have been rapid in the last few years and with them the need and desire for genetic counselling have grown. Almost simultaneously, particularly in the USA, several large screening programmes have been initiated to screen large numbers of people who may be carriers of such deleterious genes as those of Tay-Sachs disease and sickle cell anaemia. The authors of this paper, clinical medical students at University College Hospital, London, spent some time studying the ethical issues (...) raised. The first part of their study, which is not published here, relates to the biochemistry of certain genetic disorders, so leading up to the aspect of the subject which must concern readers of this journal, genetic counselling. At present genetic counselling is generally the province of the medical practitioner working with clinical biochemists, and in this paper their function is described and how programmes of screening for carriers are designed. Whether the subjects of the screening tests are found to be 'innocent' or 'guilty' psychological problems confront them, and of these the genetic counsellor must be aware. In fact the range of ethical problems raised by such counselling is wide and can only be sketched in this article. (shrink)

Modern medicine has put a new twist on one of our most fundamental values: self-determination. Although advance directives may be used to request treatment, this volume limits its focus to their more common function--the refusal of treatment. Timely and comprehensive, it provides a stimulating overview of this relevant topic, addressing such questions as: What are the individual and societal benefits of advance directives? Does an advance directive tamper with the sanctity of life? Will normalizing directives have an adverse effect on (...) the practice of medicine? Should a patient specify treatments to be withheld within a directive? What legal sanctions should apply against those who ignore directives? and What is a physician's role in helping his patient formulate an appropriate directive? (shrink)

(2001). Family Physicians and the Family Covenant Model's Usefulness in Solving Genetic Testing Conflicts. The American Journal of Bioethics: Vol. 1, No. 3, pp. 28-29.

This article details the motives, processes, and historical context behind an improvised performance of a commedia dell'arte-style pantomime originally devised by Mozart and his friends during the Viennese Carnival season of 1783. The performers' efforts to reconstruct and interpret the fragmentary musical and literary materials that survive are framed by a consideration of the marginal position that musical improvisation occupies in the history of eighteenth-century music, and alternative historiographical and ethnographical methods are explored for the insights they can offer into (...) praxes of extemporized music making. Improvisatory traditions in the realms of jazz and the commedia dell'arte offer models for reconceiving Mozart's music as a dialogical and collaborative medium; they also suggest ways in which present-day performers can gain historical, phenomenological, and hermeneutical insights into eighteenth-century texts and performances by engaging with them as improvisers. (shrink)

Audrey Hepburn is one of cinema's most stylish and enduring icons, and has embodied an ideal of femininity for generations of women. Using textual analysis, archival research and audience accounts of ‘Doing the Hepburn Look’, I argue that Audrey Hepburn, as a star clearly addressing a female audience, offered a flexible image which was enabling to young women through dress in relation to exigencies of gender, class and national identity. The paper draws on research conducted as part of a larger (...) project investigating Hepburn's ongoing appeal for young British women from the 1950s to the 1990s. (shrink)

We share Jaswal & Akhtar's concerns about the unintended repercussions of assumed social disinterest in autism. We expand consideration of these consequences with discussion of the literature and our own work on loneliness, mental ill-health, and self-representation, which is a cornerstone to social and emotional health. Further study is needed with expansive, mixed methodologies and involvement of the autistic community.

This essay introduces a Common Knowledge symposium on the relationship between texts (for instance, musical scores or dramatic scripts) and performance in the arts by drawing out its implications for the interpretation of publicly consequential texts (such as constitutions, legal statutes, and canon law). Arguing that judges and clerics could learn much from studying the work of Philip Gossett and other practitioners of textual criticism in the arts, the essay suggests that a wider array of choices exists for legal interpretation (...) than the usual alternative between originalism or literalism, on the one hand, and intuitionism, on the other hand. Contributions to the symposium (titled “Between Text and Performance”) emphasize what Roger Moseley calls “improvisatory fluency in historical idioms,” and this introduction recommends that jurists develop for the law the kind of “ear” that musicians must have when a score invites or demands improvisation. (shrink)