BackgroundIn the Canadian Alliance for Healthy Hearts and Minds cohort, participants underwent magnetic resonance imaging of the brain, heart, and abdomen, that generated incidental findings. The approach to managing these unexpected results remain a complex issue. Our objectives were to describe the CAHHM policy for the management of IFs, to understand the impact of disclosing IFs to healthy research participants, and to reflect on the ethical obligations of researchers in future MRI studies.MethodsBetween 2013 and 2019, 8252 participants were recruited with (...) a follow-up questionnaire administered to 909 participants at 1-year. The CAHHM policy followed a restricted approach, whereby routine feedback on IFs was not provided. Only IFs of severe structural abnormalities were reported.ResultsSevere structural abnormalities occurred in 8.3% of participants, with the highest proportions found in the brain and abdomen. The majority of participants informed of an IF reported no change in quality of life, with 3% of participants reporting that the knowledge of an IF negatively impacted their quality of life. Furthermore, 50% reported increased stress in learning about an IF, and in 95%, the discovery of an IF did not adversely impact his/her life insurance policy. Most participants would enrol in the study again and perceived the MRI scan to be beneficial, regardless of whether they were informed of IFs. While the implications of a restricted approach to IF management was perceived to be mostly positive, a degree of diagnostic misconception was present amongst participants, indicating the importance of a more thorough consent process to support participant autonomy.ConclusionThe management of IFs from research MRI scans remain a challenging issue, as participants may experience stress and a reduced quality of life when IFs are disclosed. The restricted approach to IF management in CAHHM demonstrated a fair fulfillment of the overarching ethical principles of respect for autonomy, concern for wellbeing, and justice. The approach outlined in the CAHHM policy may serve as a framework for future research studies.Clinical trial registrationhttps://clinicaltrials.gov/ct2/show/nct02220582. (shrink)

R. S. Peters on Education and Ethics reissues seven titles from Peters' life's work. Taking an interdisciplinary approach, the books are concerned with the philosophy of education and ethics. Topics include moral education and learning, authority and responsibility, psychology and ethical development and ideas on motivation amongst others. The books discuss more traditional theories and philosophical thinkers as well as exploring later ideas in a way which makes the subjects they discuss still relevant today.

Elliot R. Wolfson is Professor of Religious Studies and the Marsha and Jay Glazer Chair of Jewish Studies at the University of California, Santa Barbara.

صدر عن المركز العربي للأبحاث ودراسة السياسات كتاب الكشف والبيان عن أوصاف خصال شرار أهل الزمان الذي ألّفه محمد الحافظ بن حسين الصيداوي النجار وحقّقه مهند مبيضين. ويُعدّ هذا الكتاب من أدب المواعظ والأخلاق والتاريخ، وقد جمع فيه صاحبه ثقافة أدبية ودينية واسعة مكّنته من صوغ النص بلغة محكمة منضبطة، وبطريقة منظمة. يأخذنا المؤلف في كتابه إلى دمشق خلال النصف الأول من القرن الثامن عشر، ويصلنا بها حتى عام 1172هـ (1758م). ويُعدّ كلٌّ من الناس والمدينة مدارَ التأليف في هذا الكتاب (...) الذي يبحث فيه مؤلفه عن المجتمع الأمثل والزمان الخالي من الفساد. لكنّ البحث عن شكل أفضل للمجتمع ليس دافع التأليف الوحيد بالنسبة إلى المؤلف؛ فدمشق تستحق زمانًا أفضل مما كانت عليه في عصره الذي جعل الناس سبب سوئه، وهي عنده الظرف والناس هم المظروف، فإنْ صلح المظروف صلح زمان المدينة؛ لذلك نجده يذكّر بدمشق وفضلها وفضائلها. (shrink)

A longish (12 page) discussion of Richard Sorabji's excellent book, with a further discussion of what it means for a theory of emotions to be a cognitive theory.