BackgroundIn the Canadian Alliance for Healthy Hearts and Minds (CAHHM) cohort, participants underwent magnetic resonance imaging (MRI) of the brain, heart, and abdomen, that generated incidental findings (IFs). The approach to managing these unexpected results remain a complex issue. Our objectives were to describe the CAHHM policy for the management of IFs, to understand the impact of disclosing IFs to healthy research participants, and to reflect on the ethical obligations of researchers in future MRI studies.MethodsBetween 2013 and 2019, 8252 participants (...) (mean age 58 ± 9 years, 54% women) were recruited with a follow-up questionnaire administered to 909 participants (40% response rate) at 1-year. The CAHHM policy followed a restricted approach, whereby routine feedback on IFs was not provided. Only IFs of severe structural abnormalities were reported.ResultsSevere structural abnormalities occurred in 8.3% (95% confidence interval 7.7–8.9%) of participants, with the highest proportions found in the brain (4.2%) and abdomen (3.1%). The majority of participants (97%) informed of an IF reported no change in quality of life, with 3% of participants reporting that the knowledge of an IF negatively impacted their quality of life. Furthermore, 50% reported increased stress in learning about an IF, and in 95%, the discovery of an IF did not adversely impact his/her life insurance policy. Most participants (90%) would enrol in the study again and perceived the MRI scan to be beneficial, regardless of whether they were informed of IFs. While the implications of a restricted approach to IF management was perceived to be mostly positive, a degree of diagnostic misconception was present amongst participants, indicating the importance of a more thorough consent process to support participant autonomy.ConclusionThe management of IFs from research MRI scans remain a challenging issue, as participants may experience stress and a reduced quality of life when IFs are disclosed. The restricted approach to IF management in CAHHM demonstrated a fair fulfillment of the overarching ethical principles of respect for autonomy, concern for wellbeing, and justice. The approach outlined in the CAHHM policy may serve as a framework for future research studies.Clinical trial registrationhttps://clinicaltrials.gov/ct2/show/nct02220582. (shrink)

The article studies two related issues. First, it introduces the notion of the contraposition of quantifiers which is a “dual” notion of symmetry and has similar relations to co-intersectivity as symmetry has to intersectivity. Second, it shows how symmetry and contraposition can be generalised to higher order type quantifiers, while preserving their relations with other notions from generalized quantifiers theory.

An algebraic semantics, based on factor algebras, for one-way and two-way implicative verbs is proposed. Implicative verbs denote elements of filters or of ideals generated by identity functions in factor algebras. This semantics explains in particular the problem of implicational equivalence raised by two-way implicative verbs, and shows that the negation necessary to establish the implicativity of these verbs is the negation which preserves the presuppositions of sentences with implicative verbs. In addition, it follows from the proposed semantics that any (...) two implicative verbs denoting in the same algebra but belonging to different categories, are semantically related. (shrink)

The notion of anaphoric conservativity, that is a property of specific functions taking sets and binary relations as arguments is studied. Such functions are denotations of anaphoric determiners forming nominal anaphors. It is shown that anaphoric conservativity is strictly stronger that ordinary conservativity of this type of functions. In consequence some novel semantic descriptions of reflexive and reciprocal pronouns are provided and a semantic universal stating that reflexive and reciprocal non-possessive determiners denote anaphorically conservative functions is proposed.

We provide necessary and sufficient conditions determining how monotonicity of some classes of reducible quantifiers depends on the monotonicity of simpler quantifiers of iterations to which they are equivalent.

This paper explores a pair of puzzling and controversial topics in the history of late nineteenth-century philosophy: the psychologism debates, and the nature of neo-Kantianism. Each is sufficientl...

I investigate the consequences of Nietzsche's perspectivism for notions of truth and objectivity, and show how the metaphor of visual perspective motivates an epistemology that avoids self-referential difficulties. Perspectivism's claim that every view is only one view, applied to itself, is often supposed to preclude the perspectivist's ability to offer reasons for her epistemology. Nietzsche's arguments for perspectivism depend on “internal reasons”, which have force not only in their own perspective, but also within the standards of alternative perspectives. Internal reasons (...) allow a perspectivist argument against dogmatism without presupposing aperspectival criteria for theory choice. Nietzsche also offers “internal” conceptions of truth and objectivity which reduce them to a matter of meeting our epistemic standards. This view has pluralistic implications, which conflict with common sense, but it is nevertheless consistent and plausible. Nietzsche's position is similar to Putnam's recent internalism, and this is due to their common Kantian heritage. (shrink)

I defend Kant’s definition of analyticity in terms of concept “containment”, which has engendered widespread scepticism. Kant deployed a clear, technical notion of containment based on ideas standard within traditional logic, notably genus/species hierarchies formed via logical division. Kant’s analytic/synthetic distinction thereby undermines the logico-metaphysical system of Christian Wolff, showing that the Wolffian paradigm lacks the expressive power even to represent essential knowledge, including elementary mathematics, and so cannot provide an adequate system of philosophy. The results clarify the extent to (...) which analyticity sensu Kant can illuminate the problem of a priori knowledge generally. (shrink)

Aristotle’s theory of spontaneous generation offers many puzzles to those who wish to understand his theory both within the context of his biology and within the context of his more general philosophy of nature. In this paper, I approach the difficult and vague elements of Aristotle’s account of spontaneous generation not as weaknesses, but as opportunities for an interesting glimpse into the thought of an early scientist struggling to reconcile evidence and theory. The paper has two goals: to give as (...) charitable and full an account as possible of what Aristotle’s theory of spontaneous generation was, and to examine some of its consequences; and to reflect on Aristotle as a scientist, and what his comments reveal about how he approached a difficult problem. In particular, I propose that the well-recognized problem of the incompatibility between Aristotle’s concept of spontaneity and his theory of spontaneous generation presents an opportunity for insight into his scientific methodology when approaching ill-understood phenomena. (shrink)

This distinction has sometimes been read as purely epistemic, resting not on things, but on our knowledge of them: there is one world, not two, though it may be apprehended in two ways. But this view is patently at odds with the text. Knowledge and opinion are δυνάμεις, "faculties," to be distinguished and defined by their objects, no less than by the state of mind they produce, and Plato clearly states that the fallibility and unclearness of opinion is rooted in (...) the relative unreality of opinables. (shrink)

This essay is one of ten contributions to a special editorial feature in The Journal of Nietzsche Studies 49.2, in which authors were invited to address the following questions: What is the future of Nietzsche studies? What are the most pressing questions its scholars should address? What texts and issues demand our urgent attention? And as we turn to these issues, what methodological and interpretive principles should guide us? The editorship hopes this collection will provide a starting point for discussions (...) about the most fruitful directions for Nietzsche scholarship to take and the most promising avenues for building on the best recent work. (shrink)

Historical research on John Dalton has been dominated by an attempt to reconstruct the origins of his so-called "chemical atomic theory". I show that Dalton's theory is difficult to define in any concise manner, and that there has been no consensus as to its unique content among his contemporaries, later chemists, and modern historians. I propose an approach which, instead of attempting to work backward from Dalton's theory, works forward, by identifying the research questions that Dalton posed to himself and (...) attempting to understand how his hypotheses served as answers to these questions. I describe Dalton's scientific work as an evolving set of puzzles about natural phenomena. I show how an early interest in meteorology led Dalton to see the constitution of the atmosphere as a puzzle. In working on this great puzzle, he gradually turned his interest to specifically chemical questions. In the end, the web of puzzles that he worked on required him to create his own novel philosophy of chemistry for which he is known today. (shrink)

Comment l'intention apologétique de Blondel dans L’Action est-elle compatible avec le caractère philosophique de l’œuvre ? Comment éviter le soupçon de préjugé, de pétition de principes ? R. Virgoulay montre comment le projet mis en œuvre dans L’Action et défini dans la Lettre de 1896, ouvrait la philosophie à l'examen du problème religieux par la détermination a priori de la notion de surnaturel. Après avoir exposé « la méthode de L’Action » pour faire passer d'une conviction subjective, d'un témoignage vécu, (...) à une « science », c'est-à-dire à l'exposé qui conjugue nécessité et universalité, il s'attarde sur la cinquième partie de L’Action. Celle-ci, après l'élaboration des quatre autres parties, peut être alors une philosophie de la religion qui porte sur le contenu même du Christianisme, et pour laquelle la notion décisive est celle du surnaturel. Les questions que pose cette notion amènent l'auteur à comparer la problématique blondélienne à celle de Laberthonnière, comparaison qui manifeste la différence entre la démarche théologique de ce dernier et celle, philosophique, de Blondel. Alors que laberthonnière tente de justifier théologiquement l'entreprise philosophique de Blondel, la Lettre distingue rigoureusement la théologie de la philosophie. How is the apologetic intention of Blondel in Action compatible with the philosophical character of the work ? How can one avoid the suspicion of prejudice, of begging the question ? R. Virgoulay shows how the project put to work in Action and defined in the Lettre of 1896, opened philosophy to the examination of the religious problem by the a priori determination of the notion of the supernatural. After discussing « the method of Action » in order to move from a subjective conviction, from a lived witnessing, to a « science », that is to say, to an analyses that conjugate necessity and universality, the author concentrates on the fifth part of Action. This latter, after, the elaboration of the four other parts, could be, then, a philosophy of religion that carries to the very content of Christianity, and for which the decisive notion is that of the supernatural. The questions that this idea brings up led the author to compare Blondel’s field of inquiry to that of Laberthonnière, a comparison that, manifests the difference between a theological approach of the latter and that, philosophical, of Blondel. While Laberthonnière tries theologically to justify the philosophical enterprise of Blondel, the Lettre rigorously distinguishes theology from philosophy. (shrink)

You would be hard-pressed to find someone who categorically opposes protecting the environment, yet most people would agree that the environmentalist movement has been ineffectual and even misguided. Some argue that its agenda is misplaced, oppressive, and misanthropic—a precursor to intrusive government, regulatory bungles, and economic stagnation. Others point out that its alarmist rhetoric and preservationist solutions are outdated and insufficient to the task of galvanizing support for true reform. In this impassioned and judicious work, R. Bruce Hull argues that (...) environmentalism will never achieve its goals unless it sheds its fundamentalist logic. The movement is too bound up in polarizing ideologies that pit humans against nature, conservation against development, and government regulation against economic growth. Only when we acknowledge the infinite perspectives on how people should relate to nature will we forge solutions that are respectful to both humanity and the environment. Infinite Nature explores some of these myriad perspectives, from the scientific understandings proffered by anthropology, evolution, and ecology, to the promise of environmental responsibility offered by technology and economics, to the designs of nature envisioned in philosophy, law, and religion. Along the way, Hull maintains that the idea of nature is social: in order to reach the common ground where sustainable and thriving communities are possible, we must accept that many natures can and do exist. Incisive, heartfelt, and brimming with practical solutions, Infinite Nature brings a much-needed and refreshing voice to the table of environmental reform. (shrink)

In Rabinowicz & Rønnow-Rasmussen, we defended the following claims: Not only states of affairs, or facts, but also concrete objects, such as things or persons, may have final value ; The final value of a concrete object need not be intrinsic, i.e., it need not be exclusively based on the internal properties of its bearer; The final value of a concrete object is not reducible to the value of some states of affairs that involve the object in question. Our arguments (...) for – have been challenged. This paper is an attempt to respond to some of these challenges, viz. those that concern the reducibility issue. The discussion presupposes a Brentano-inspired account of value in terms of fitting responses to value bearers. Attention is given to a yet another type of reduction proposal, according to which the ultimate bearers of final value are abstract particulars rather than abstract states or facts. While the proposal is attractive, it confronts serious difficulties. To recognise tropes as potential bearers of final value, along with other objects, is one thing; but to reduce the final value of concrete objects to the final value of tropes is another matter. (shrink)

The crux of the dispute between formalism and intuitionism, it is held, is not whether certain entities exist or not, but how the term function shall be used in mathematics. The identification of effective definition with general recursion fails because an undefined function lies concealed beneath the requirement of a finite number of substitutions, and a fresh characterization of effective definition is sought in terms of a hierarchy of ordinal recursions.A correspondence exists between primitive recursive properties and direct proofs, of (...) irrationality and transcendence for instance, and between general recursive properties and indirect proofs.Mathematics is a concept creating activity and the distinction between a formal mathematics devoid of meaning, at one level, and a meaningful metamathematics at the next is considered to be untenable.RésuméLa controverse entre les formalistes et les intuitionistes ne repose pas, considére‐t‐on, sur l'existence ou la non‐existence de certaines entités, mail sur l'usage du terme fonction en mathématiques. L'identification de la définition effective avec la récursion générate n'est pas valable parce qu'une fonction indéfinié est dissimulée sous la nécessité d'un nombre fini de substitutions, et une nouvelle caractérisation de définition effective est recherchée sous forme de hiérarchie de récursions ordinates.II existe, d'une part, une correspondance entre les propriétés primitives récursives et les preuves directes, d'irrationalité et de transcendance par exemple, et, d'autre part, entre les propriétés récursives générates et les preuves par l'absurde.Les mathématiques sont une activité créatrice de concepts, et la distinction entre les mathématiques formelles dépourvues de sens et, sur le plan supérieur, une méta‐mathématique chargée de sens, ne semble pas justifiée. (shrink)

This paper examines the life and work of T. C. Chamberlin, a prominent glacial geologist who developed an interest in interdisciplinary earth science. His work on the geological agency of the atmosphere informed his understanding of climate change and other terrestrial phenomena and led him to propose a new theory of the formation of the Earth and the solar system.Chamberlin's graduate seminar at the University of Chicago in 1896 contained all the themes that informed his research programme over the next (...) three decades. These included the carbon dioxide theory of climate change in its relationship to diastrophism and oceanic circulation, the role of water vapour feedbacks in the climate system, and the relationship between multiple glaciations, the climate system, and the formation of the planet. (shrink)