Bidirectional deep brain stimulation platforms have enabled a surge in hours of recordings in naturalistic environments, allowing further insight into neurological and psychiatric disease states. However, high amplitude, high frequency stimulation generates artifacts that contaminate neural signals and hinder our ability to interpret the data. This is especially true in psychiatric disorders, for which high amplitude stimulation is commonly applied to deep brain structures where the native neural activity is miniscule in comparison. Here, we characterized artifact sources in recordings from (...) a bidirectional DBS platform, the Medtronic Summit RC + S, with the goal of optimizing recording configurations to improve signal to noise ratio. Data were collected from three subjects in a clinical trial of DBS for obsessive-compulsive disorder. Stimulation was provided bilaterally to the ventral capsule/ventral striatum using two independent implantable neurostimulators. We first manipulated DBS amplitude within safe limits to characterize the impact of stimulation artifacts on neural recordings. We found that high amplitude stimulation produces slew overflow, defined as exceeding the rate of change that the analog to digital converter can accurately measure. Overflow led to expanded spectral distortion of the stimulation artifact, with a six fold increase in the bandwidth of the 150.6 Hz stimulation artifact from 147–153 to 140–180 Hz. By increasing sense blank values during high amplitude stimulation, we reduced overflow by as much as 30% and improved artifact distortion, reducing the bandwidth from 140–180 Hz artifact to 147–153 Hz. We also identified artifacts that shifted in frequency through modulation of telemetry parameters. We found that telemetry ratio changes led to predictable shifts in the center-frequencies of the associated artifacts, allowing us to proactively shift the artifacts outside of our frequency range of interest. Overall, the artifact characterization methods and results described here enable increased data interpretability and unconstrained biomarker exploration using data collected from bidirectional DBS devices. (shrink)
A obra aqui analisada pertence ao professor, ensaísta e filósofo Ollivier Pourriol, conferencista francês, cujas temáticas dos seus projetos circundam a relação entre filosofia e cinema. Esta obra, em específico, aborda o desejo no cinema. Dialogando as narrativas cinematográficas que abordam o desejo e pontuando entre filosofia e cinema os conceitos que se expressam nas imagens.
A obra "O racional e o místico em Wittgenstein" é uma das obras do professor Urbano Zilles, da PUC-RS, que tem a finalidade de mostrar um panorama da filosofia de Ludwig Wittgenstein com leitura e análise de suas principais obras: Tractatus Lógicus-philosophicus e Investigações Filosóficas.