Expression and transposition of the Suppressor‐mutator (Spm) transposon of maize are controlled by interacting epigenetic and autoregulatory mechanisms. Methylation of critical element sequences prevents both transcription and transposition, heritably inactivating the element. The promoter, comprising the terminal 0.2 kb of the element, and a 0.35‐kb, highly GC‐rich, downstream sequence are the methylation target sequences. The element encodes two proteins necessary for transposition, TnpA and TnpD. There are multiple TnpA binding sites, both in the 5′ terminal promoter region and at the (...) element's 3′ end. In addition to its role in transposition, TnpA is both a positive and a negative regulator of transcription. TnpA represses the element's promoter when it is not methylated. When the element is inactive and its promoter methylated, TnpA activates the methylated promoter and facilitates both its transient and heritable demethylation. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:610 Feminist Studies 43, no. 3. © 2017 by Raina J. León Pandora’s Box Opens and Terence Crutcher Dies Raina J. León Fresh from the bath, my husband comes nude, beard trimmed, still glistening and pinked. He shares the fullness of his skin, freckles and moles in their constellations. What little fat on his lank jiggles, begs for pinch as he turns to the closet to dig. (...) I am encapsulated by covers. No sleep for hours since I woke to watch the video I couldn’t with him awake. How I watched it, over and over, and knew this might be how I die: a broken-down car, my hands up, helicopters above with a man saying, a real bad dude, must be, and then shot, because Terence is me, like Sandy and Aisha... because just that day, earlier, I was transformed into child, questioned on the body of my work, made invisible and hypervisible, bleeding shadow for another’s feet. One leads to another in a mass of entangled links. Now, he moves. He does not feel the cold I dread out there where reality gnashes. Raina J. León 611 Inside the cocoon, the smell of last night’s tremble sweat, I can imagine entrance into another dreaming, breathe in and out our twining. He slips on boxers, then soft cotton shirt, then jeans. All black, his style. In my mourning, I call him close, and he comes to bed. With his body, he creates another womb as suddenly the weeping starts, says, when you are ready, tell me, because he doesn’t know how the world turns, yet in that moment, there is a hope.... (shrink)

Thriving is a psychological state in which individuals experience a sense of vitality and a sense of learning. Thriving come from relational connections with others, and is deeply rooted in social systems. Theoretical literature suggests that thriving occurs in the presence of decision-making discretion, broad information sharing, and a climate of trust. However, no study has investigated these environmental factors empirically. Using a multiple-studies approach, we established valid and reliable scale for each of these environmental factors using experimental vignettes, confirmed (...) the association of decision-making discretion, broad information sharing and climate of trust with thriving, and identified the role of self-determination theory in determining these relationships. Our analysis was based on data collected from 512 Indian management students across five studies. The results indicate significant difference in thriving for high vs. low level for decision-making discretion, broad information sharing and climate of trust. The relationship of these environmental factors with thriving is mainly due to the fulfillment of the need for competence. Competence partially mediates the relationship of decision-making discretion with thriving, and fully mediates the relationship of broad information sharing and climate of trust with thriving. Autonomy, although positively related with the environmental factors, does not lead to thriving. Practical implications, limitations and research avenues are discussed. (shrink)

Modern linguistics usually differentiates between content or syncategorematic words and function or categorematic words.

Study of classical commentary on Sāṅkhyakārikā of Īśvarakr̥ṣṇa, work on the fundamentals of Sankhya philosophy.

This baseline study was conducted to find out the knowledge, attitudes and practices of medical ethics among the undergraduate medical interns who did not have structured ethics curriculum in their course. A descriptive, cross-sectional study was carried out using a self-administered structured questionnaire among the medical undergraduate interns of Maharajgunj Medical Campus, the pioneer medical college of Nepal which enrols 60 students in a year. A total of 46 interns participated in the study. The most common source of knowledge on (...) ethics was lectures/seminars (35.7%) followed by experience at work (24.5%), training (21.4%) and own reading (17.3%). The main contents of Hippocratic Oath were known to 98.8% while 60.9% knew the main contents of Nepal Medical Council (NMC) code of ethics. Great majority (91.3%) regard ethics as very important in medical profession. “Doctors know the best irrespective of patients’ opinion” was disagreed by only 39.1% indicating the paternalistic attitude. However, 78.3% were in favour of adhering to the patient’s wish. None of the participant agreed to abandon confidentiality. Only about one-fourth (26.1%) claim to encounter ethical dilemma every day while the highest number (43.5%) had once in a month. To deal with the situation of ethical dilemma, majority approached to immediate supervisor followed by head of the department and colleagues. Eighty-seven percent of participating interns were involved in research activities involving human subjects. Only one of the participants had encountered the ethical issue on end-of-life and it was do-not-resuscitate consent in a terminally ill patient. On implementation of the curriculum on medical ethics focus should be - principles of biomedical ethics, sensitive ethical dilemmas like end-of-life care and practical experiences with participation in deliberations of the ethics committee. (shrink)

Non-dualistic Vedanta insists on the importance of knowledge rather than action for attaining liberation. Knowledge is regarded as the direct and immediate means of liberation. The cause of the bondage is ignorance and the latter can be removed by knowledge. Non-dualistic Vedānta advocates that the individual is ignorant of the truth that his Self is none other than the Brahman and gets involved in the chain of transmigration. Knowledge of the Self leads to liberation. However, this position leads to a (...) debate between Non-dualistic Vedānta and Mīmāmsā School of thought with reference to understanding whether knowledge itself is a mental action. The objective of the present paper is to examine whether knowledge can be regarded as a mental action. (shrink)

This book deals with the philosophy of Daya Krishna, an Indian philosopher of the twentieth century. It discusses the central issues in Daya Krishna’s early philosophy as a synthesis of the Indian and Western philosophical methods. It presents problems of the past and the present in a holistic frame of creative philosophizing. It provides a glimpse into the issues human beings face in all vital areas of human civilization. It discusses the nature of philosophy and the philosophical method in Daya (...) Krishna’s syncretic philosophy. Issues such as self and freedom and ethics and religion are explored in the chapters. It is of interest to those who are engaged with Indian philosophy and Indian philosophers of the twentieth century and especially to those whose interest lies in understanding the cultural East and its philosophical responses to the cultural West. (shrink)

We share Nair-Collins and Joffe's (2023) concern with the accuracy of the “whole brain-death” diagnosis, which fails to take into account current understandings of residual brain function (neurohor...

The chromosomes undergo a condensation‐decondensation cycle within the life cycle of mammalian cells. Chromosome condensation is a complex and critical event that is necessary for the equal distribution of genetic material between the two daughter cells. Although chromosome condensation‐decondensation and segregation is mechanistically complex, it proceeds with high fidelity during the eukaryotic cell division cycle. Cell fusion studies have indicated the presence of chromosome condensation factors in mammalian cells during mitosis. If extracts from mitotic cells are injected into immature oocytes (...) of Xenopus laevis, they induce meiotic maturation (i.e. germinal vesicle breakdown and chromosome condensation) within 2–3 hours. Recently, we showed that the maturation‐promoting activity of the mitotic cell extracts is inactivated by certain protein factors present in cells during the G1 period. The activity of the G1 factors coincides with the process of chromosome decondensation that begins at telophase and continues throughout the G1 period. These studies have revealed that the mitotic factors and the G1 factors play a pivotal role in the regulation of condensation and decondensation of chromosomes. Furthermore, our studies strongly suggest that nonhistone protein phosphorylation and dephosphorylation may mediate chromosome condensation and decondensation, respectively. (shrink)

Study of Vivekacūḍāmaṇi of Śaṅkarācārya, work on Vedanta philosophy.

Day-to-day lives are affected globally by the epidemic coronavirus 2019. With an increasing number of positive cases, India has now become a highly affected country. Chronic diseases affect individuals with no time identification and impose a huge disease burden on society. In this article, an Efficient Recurrent Neural Network with Ensemble Classifier is built using VGG-16 and Alexnet with weighted model to predict disease and its level. The dataset is partitioned randomly into small subsets by utilizing mean-based splitting method. Various (...) models of classifier create a homogeneous ensemble by utilizing an accuracy-based weighted aging classifier ensemble, which is a weighted model’s modification. Two state of art methods such as Graph Sequence Recurrent Neural Network and Hybrid Rough-Block-Based Neural Network are used for comparison with respect to some parameters such as accuracy, precision, recall, f1-score, and relative absolute error. As a result, it is found that the proposed ERNN-EC method accomplishes accuracy of 95.2%, precision of 91%, recall of 85%, F1-score of 83.4%, and RAE of 41.6%. (shrink)

The phenomenon of dreamless sleep and its philosophical consequences, particularly deep sleep's relevance to such issues as Self, Consciousness, Personal Identity, Unity of Subject, and Disembodied Life, are explored through a discussion, in varying detail, of certain noted doctrines and views--for example of Advaita Vedānta, Hegel, and H. D. Lewis. Finally, with a cue from Leibniz and McTaggart, the suggestion is made that at no stage during sleep is the self without some perceptions, however indeterminate. Support for this hypothesis is (...) claimed from the current psychoanalytic opinion that mental activity does not cease during any part of sleep and that human beings continue to dream even in the so-called dreamless state. (shrink)

Long‐range correlation is a general class of coordination pattern found to be common to the intrinsic dynamics of complex systems, including human behavior. Balasubramaniam, Hove, and Médé investigate intrinsic dynamics in repeated finger movements, and they find that different measures of movement dynamics yield different long‐range correlations. Results shed light on the way that coordination patterns are expressed as a function of measurement context.

As part of the special issue on “The United Nations at Seventy-Five: Looking Back to Look Forward,” this essay connects the past of the United Nations to its future from the perspective of the Global South. When the UN was created, most developing countries were colonies that played no role in writing the rules and designing the architecture of the post-1945 UN-centric global multilateral order. Today, countries in the Global South command a majority of the UN membership, but still mostly (...) function as norm takers and are severely underrepresented in the UN Security Council—which functions as the geopolitical cockpit—and also in the senior ranks of the UN system, in the key posts in the Secretariat, and in the UN's funds and agencies. Gradually, however, these countries are using their numerical strength to give voice to their distinctive preferences, priorities, and values. This essay provides a broad-brush sketch of the changing nature of the North-South partnership on the UN's four overarching normative mandates of security, development, environment, and human rights. It includes a brief comment on the coronavirus pandemic within the framework of its main narrative of the continuing need for a UN-centric North-South partnership. (shrink)

Current EEG research emphasizes gamma band coherence as a signature of functional integration, that is, the solution to the binding problem. We note that spatial patterns of coherent neural activity are also observed at other EEG frequencies. If these oscillations reflect Nunez's resonant modes, they offer a solution to the binding problem that emerges naturally from the architecture of cortical connections.

Background The aim of the study is to assess the knowledge, attitudes and practices among healthcare professionals in Barbados in relation to healthcare ethics and law in an attempt to assist in guiding their professional conduct and aid in curriculum development. Methods A self-administered structured questionnaire about knowledge of healthcare ethics, law and the role of an Ethics Committee in the healthcare system was devised, tested and distributed to all levels of staff at the Queen Elizabeth Hospital in Barbados (a (...) tertiary care teaching hospital) during April and May 2003. Results The paper analyses 159 responses from doctors and nurses comprising junior doctors, consultants, staff nurses and sisters-in-charge. The frequency with which the respondents encountered ethical or legal problems varied widely from 'daily' to 'yearly'. 52% of senior medical staff and 20% of senior nursing staff knew little of the law pertinent to their work. 11% of the doctors did not know the contents of the Hippocratic Oath whilst a quarter of nurses did not know the Nurses Code. Nuremberg Code and Helsinki Code were known only to a few individuals. 29% of doctors and 37% of nurses had no knowledge of an existing hospital ethics committee. Physicians had a stronger opinion than nurses regarding practice of ethics such as adherence to patients' wishes, confidentiality, paternalism, consent for procedures and treating violent/non-compliant patients (p = 0.01) Conclusion The study highlights the need to identify professionals in the workforce who appear to be indifferent to ethical and legal issues, to devise means to sensitize them to these issues and appropriately training them. (shrink)

Grush has proposed a fairly comprehensive version of the idea of internal models within the framework of the emulation theory of representation. However, the formulation suffers from assumptions that render such models biologically infeasible. Here I present some problems from physiological principles of human movement production to illustrate why. Some alternative views to emulation are presented.

It is proposed here that Webb's ideas about robots as possible models of animals need some rethinking. In our view, even though widely used biorobotics strategies are fairly successful at reproducing the macroscopic behavior of biological systems, there are still several problems unresolved on the side of robotics as well as biology. Both mathematical and hardware-like robotics models should be feasible physiologically. Control principles elaborated in robotics are not necessarily applied to biological control systems. Although observations of flying birds inspired (...) aerodynamics and thus modern airplanes, little knowledge has been added to the neurophysiological principles underlying flight in birds. Chess playing computers might outperform most chess players, but they cannot be considered as physiologically feasible models of human thinking. (shrink)

Speech perception has been a very productive and important area in psycholinguistics. In this review easy, I discuss Cutler's new book on native language listening. Cutler argues for a theory of speech perception, where all speech perception is accomplished by competence in native speech. I review this book and attempt to situate its main contributions in the broader context of cognitive science.

Philosophical Psychology, Volume 24, Issue 3, Page 427-435, 01Jun2011.

We agree with Nielsen Busch and Mjaaland’s (2023) assessment that the Dead Donor Rule (DDR) should be viewed as an essential requirement of the organ donation process, and that the essence of the r...

Purpose The Hon’ble Supreme Court of India, in a landmark judgment, scrapped a draconian law [Section 66 ] that gave the police absolute power to put behind bars anybody who was found posting offensive or annoying comments online. This paper aims to examine the take of people on the “Free Speech via Social Media” issue and their attitude towards the way sensitive messages/information are posted, shared and forwarded on social media, especially, Facebook. Design/methodology/approach The research was carried out on a (...) sample of 200 social media users, all picked up randomly, from five Indian states/Union Territories. Data were collected through a questionnaire, and users were contacted through e-mail. Data collected were analyzed through the Kolmogorov–Smirnov Z test. Findings The findings indicate that hate posts/messages are on the rise, and more and more users are joining in. Besides, prosecution happens only when the aggrieved party is influential or powerful. Practical implications The findings of this research give a strong insight into the social media behaviour of users in relation to hate contents/posts. The study establishes the fact that Indian people are in favour of free speech, but with a sense of restraint and responsibility. The work could form the basis for future research on various aspects of hate speech on social media. Researchers could study the trials and prosecutions that have happened over the past few years and whether punishment has acted as a deterrent. Originality/value The research is likely to be important for those involved in work on freedom of speech or hate speech through social media. Social networking sites such as Facebook would also get some insights into users’ perception towards free and hate speech mechanism on social media. (shrink)

Deep and universal spirituality is evident in the life and teachings of all the founders of great world faiths. Over time, however, it gets clouded under the institutional and doctrinal structure of the religion that surrounds it. This book, Interfaith Spirituality: Toward Universal Faith beyond Dogmas, by Ramesh N. Patel, stands out by emphasizing and articulating the noble and inspirational spirituality of world faiths, Eastern and Western. The faiths chosen for narration are Judaism, Christianity, Islam, Taoism, Confucianism, Buddhism and (...) Hinduism. -/- The book goes farther than bringing out the spirituality of Eastern and Western faiths. For, it offers intellectually sound thinking toward relieving the age-old tensions between faiths, such as the numinous and the mystical, monotheism and non-dualism, privileging of believers against open-ended tolerance of differences and so on. -/- A further standout feature of the book is its diving deep to pick out pearls of spiritual wisdom from the world faiths and weaving them into thoughtful necklaces which it calls thought experiments in world spirituality. To top it all is offered an optimal universal spirituality that is comprehensive in scope and universal in application. It manifests a flower with spiritual outlines in four petals of work, faith, concept and contemplation. Spiritual seekers from diverse dimensions of life will find this useful and supportive. -/- The book, Interfaith Spirituality, thus is not just innovative. It offers a message of healing and calming moderation for a world that is torn by polarizing conflicts of various sorts. (shrink)

Mahatma Gandhi is regarded as an apostle of nonviolence. But his own thought prioritized truth as the final goal and nonviolence only as the preferred means to achieve the goal. Hence, it is of utmost importance to understand clearly what Gandhi meant by “truth.” Gandhi himself did not offer great help in communicating his concept of truth. He claimed, though, that it was easier for him to grasp truth as he conceived it and that he struggled to grasp nonviolence. Kishorlal (...) Mashruwala, an intellectually inclined close associate and follower of Gandhi wrote a book called Gandhi Vichar Dohan or Quintessence of Gandhi’s Thought in Gujarati. Mashruwala was a clear and systematic thinker and Gandhi approved of the book as accurate depiction of his own, Gandhi’s, thinking. The book has never been translated in English. The present work, Mahatma Gandhi’s Thought: Philosophy of Truth and Nonviolence, by Professor Ramesh N. Patel, is first in publishing relevant parts of that book. It clarifies the dual concept of truth that Gandhi developed and worked with. The concept sports highly original and innovative thinking that, at the same time, reflects an ethic that would challenge anyone to the extreme. Greatness of Gandhi is made obvious when it is realized that he lived this original concept of extremely challenging truth ethic fully through his life. The present work goes ahead to show how Gandhi’s concept of truth logically works as the prime source from which nonviolence and other Gandhian concepts are derived. It also presents Gandhi’s overall thought in a philosophically systematized manner. This is its unique feature compared to the enormous literature available on Gandhi which keeps painting him just as an apostle of nonviolence, focusing on his politically dramatic years. (shrink)

Adi Shankara is regarded as the greatest philosopher and spiritual leader in the very long history of India and one of the most influential thought leaders in world history. Estimates vary as to when he lived, with scholars placing it at 788-820 C.E. According to Shankara, there is only One Being, which is beyond language and thought because it is ultimate, infinite and all-pervasive. Being spiritual, this One Being is pure consciousness, unlike our normal consciousness which always requires subject-object duality. (...) The One Being is non-dual, being one without a second. Shankara’s concept of One Being strikes intuitively true to many, though it sounds narcissistic to a few. Shankara presents a strong rationale in its support and outlines a whole life path to reach the One Being in actual experience. As a concept One Being is a rational alternative to the traditional idea of God viewed as a divine person. Its spirituality is a constructive alternative to the atheist’s mere denial of God. This book, One Being, by Ramesh N. Patel, describes and explores Adi Shankara’s spiritual path and its supporting philosophy in an accessible and intelligible way for the serious modern reader interested in this challenging but highly rewarding subject. The reader is taken step by step through Shankara’s life, work, nature of knowledge, reality, life ethics, karma and details of the spiritual path of knowledge. In today's strife torn and bipolarized times, One Being is all the more relevant for its obvious potential as a spiritual healer bringing a harmonious message of unity in diversity. Ramesh N. Patel was Professor of Philosophy and Religion at Antioch College where he taught for twenty-five years, retiring in 2002. Since then he has been teaching voluntary classes in Bhagavad-gita, Upanishads, Vedic philosophy and Spiritual Studies. He is the author of Philosophy of the Gita and of Hinduism for Today. (shrink)

The book called "Philosophy of the Gita," by Prof. Ramesh N. Patel, is a striking philosophical study of the celebrated Sanskrit text called the Bhagavad-gita which is known simply as the Gita. Patel's book proposes and develops a new hermeneutic called archaic coherentism and applies it to the Gita to distill and decode a comprehensive metaphysic and philosophy of action embedded in the text. A new conceptual translation of the Sanskrit text brings out this philosophy in clear detail. Philosophical (...) essays preceding the translation include analysis of the often-neglected background of war and morality, discussion of action, freedom and self-identity, delineation of a new synoptic philosophy of Hinduism, and unearthing of a strikingly original and innovative metaphysics of existence, energy and triple individuation. The translation of the Gita is followed by two critical essays called "Emerging Philosophy" and "Coherence and Exegesis." Patel's translation focuses on the conceptual rendering of every term, with no Sanskrit word left untranslated, even including the tough ones like guna and Brahman. The essay called "Emerging Philosophy" does away with all Sanskrit terms, to facilitate the understanding of the newly decoded Gita's philosophy as a whole. The essay called "Coherence and Exegesis" critically examines several scholarly standpoints on the Gita with Patel's sound philosophical reasoning. The innovative philosophy of the Gita that emerges through the book's analysis includes an original theory of individuation revealing a Platonic-type Form of individuation evolving at three levels: essential, actional and physical. The book is written for professional philosophers and Sanskritist Indologists. It generally assumes familiarity with logical problems of philosophy and with Sanskrit terms in Indian philosophy. The author has a rare dual training in Sanskrit and philosophy. He skillfully exploits both in this book to achieve an unusual outcome that should be of great interest and challenge to both professional philosophers as well as scholars of Indology. (shrink)