36 found
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  1.  81
    What is a Gene?Raphael Falk - 1986 - Studies in History and Philosophy of Science Part A 17 (2):133-173.
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  2.  5
    Linkage: From Particulate to Interactive Genetics. [REVIEW]Raphael Falk - 2003 - Journal of the History of Biology 36 (1):87 - 117.
    Genetics was established on a strict particulate conception of heredity. Genetic linkage, the deviation from independent segregation of Mendelian factors, was conceived as a function of the material allocation of the factors to the chromosomes, rather than to the multiple effects (pleiotropy) of discrete factors. Although linkage maps were abstractions they provided strong support for the chromosomal theory of inheritance. Direct Cytogenetic evidence was scarce until X-ray induced major chromosomal rearrangements allowed direct correlation of genetic and cytological rearrangements. Only with (...)
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  3.  2
    Zionism and the Biology of the Jews.Raphael Falk - 1998 - Science in Context 11 (3-4).
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  4.  29
    Long Live the Genome! So Should the Gene.Raphael Falk - 2004 - History and Philosophy of the Life Sciences 26 (1):105 - 121.
    Developments in the sequencing of whole genomes and in simultaneously surveying many thousands of transcription and translation products of specific cells have ushered in a conceptual revolution in genetics that rationally introduces top-down, holistic analyses. This emphasized the futility of attempts to reduce genes to structurally discrete entities along the genome, and the need to return to Johannsen's definition of a gene as 'something' that refers to an invariant entity of inheritance and development. We may view genes either as generic (...)
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  5.  21
    The Dominance of Traits in Genetic Analysis.Raphael Falk - 1991 - Journal of the History of Biology 24 (3):457-484.
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  6.  29
    The Real Objective of Mendel's Paper: A Response to Monaghan and Corcos. [REVIEW]Raphael Falk & Sahotra Sarkar - 1991 - Biology and Philosophy 6 (4):447-451.
    Mendel's work in hybridization is ipso facto a study in inheritance. He is explicit in his interest to formulate universal generalizations, and at least in the case of the independent segregation of traits, he formulated his conclusions in the form of a law. Mendel did not discern, however, the inheritance of traits from that of the potential for traits. Choosing to study discrete non-overlapping traits, this did not hamper his efforts.
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  7.  42
    Evolutionary Epistemology: What Phenotype is Selected and Which Genotype Evolves?Raphael Falk - 1993 - Biology and Philosophy 8 (2):153-172.
    In 1941/42 Konrad Lorenz suggested that Kant's transcendental categories ofa priori knowledge could be given an empirical interpretation in Darwinian material evolutionary terms: a priori propositional knowledge was an organ subject to natural selection for adaptation to its specific environments. D. Campbell extended the conception, and termed evolution a process of knowledge. The philosophical problem of what knowledge is became a descriptive one of how knowledge developed, the normative semantic questions have been sidestepped, as if the descriptive insights would automatically (...)
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  8.  89
    Issues in Evolutionary Epistemology.Raphael Falk - 1994 - Philosophia 23 (1-4):333-343.
  9.  34
    Species as Individuals.Raphael Falk - 1988 - Biology and Philosophy 3 (4):455-462.
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  10.  3
    Genetic Analysis.Raphael Falk - 2007 - In Mohan Matthen & Christopher Stephens (eds.), Philosophy of Biology. Elsevier. pp. 3--249.
  11.  28
    The Rise and Fall of Dominance.Raphael Falk - 2001 - Biology and Philosophy 16 (3):285-323.
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  12.  32
    What is a Gene?—Revisited.Raphael Falk - 2010 - Studies in History and Philosophy of Science Part C 41 (4):396-406.
    The dialectic discourse of the ‘gene’ as the unit of heredity deduced from the phenotype, whether an intervening variable or a hypothetical construct, appeared to be settled with the presentation of the molecular model of DNA: the gene was reduced to a sequence of DNA that is transcribed into RNA that is translated into a polypeptide; the polypeptides may fold into proteins that are involved in cellular metabolism and structure, and hence function. This path turned out to be more bewildering (...)
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  13.  8
    The Struggle of Genetics for Independence.Raphael Falk - 1995 - Journal of the History of Biology 28 (2):219-246.
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  14.  40
    M. Ruse (Ed.). (2009). Thomas Henry Huxley: Evolution & Ethics.Raphael Falk - 2010 - Philosophia 38 (2):417-428.
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  15.  39
    On Causality, Heritability and Fitness.Lia Ettinger, Eva Jablonka & Raphael Falk - 1991 - Biology and Philosophy 6 (1):27-29.
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  16.  11
    Mendel's Impact.Raphael Falk - 2006 - Science in Context 19 (2):215.
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  17.  17
    Evolutionary Epistemology as a Philosophy of Nature. [REVIEW]Raphael Falk - 1987 - History and Philosophy of the Life Sciences 9 (2):339 - 346.
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  18.  29
    How Many Chromosomes?Raphael Falk - 2003 - Biology and Philosophy 18 (4):619-619.
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  19. What is a Gene?Raphael Falk - 1986 - Studies in History and Philosophy of Science 17 (2):133.
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  20.  1
    On the Nature of the Gene. [REVIEW]Raphael Falk - 2013 - Studies in History and Philosophy of Science Part C 44 (4a):623-625.
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  21.  14
    Between Beanbag Genetics and Natural Selection.Raphael Falk - 1990 - Biology and Philosophy 5 (3):313-325.
    The encounter between the Darwinian theory of evolution and Mendelism could be resolved only when reductionist tools could be applied to the analysis of complex systems. The instrumental reductionist interpretation of the hereditary basis of continuously varying traits provided mathematical tools which eventually allowed the construction of the Modern Synthesis of the theory of evolution.When genotypic as well as environmental variance allow the isolation of parts of the system, it is possible to apply Mendelian reductionism, that is , to treat (...)
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  22.  9
    Critical Studies.Kenneth J. Perszyk, Raphael Falk & David Shatz - 1987 - Philosophia 17 (3):355-364.
  23.  4
    Final Discussion: Issues and Challenges for the Future.Rony Armon, Ulrich Charpa, Eric Davidson, Ute Deichmann, Raphael Falk, John Glass, Shimon Glick, Manfred Laubichler, Michel Morange, Isaac, Addy Pross, Siegfried Roth & Varda Shoshan-Barmatz - 2012 - Perspectives in Biology and Medicine 55 (4):608-611.
  24.  2
    Logic and Philosophy of Science: Review ofGenetics and Philosophy: An IntroductionPaul Griffiths and Karola Stotz,Genetics and Philosophy: An Introduction. New York: Cambridge University Press , 270 Pp., $29.99. [REVIEW]Raphael Falk - 2014 - Philosophy of Science 81 (3):470-475.
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  25.  2
    Review of Genetics and Philosophy: An Introduction. [REVIEW]Raphael Falk - 2014 - Philosophy of Science 81 (3):470-475,.
  26.  1
    What is a Gene?—Revisited.Raphael Falk - 2010 - Studies in History and Philosophy of Science Part C: Studies in History and Philosophy of Biological and Biomedical Sciences 41 (4):396-406.
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  27.  2
    On the Nature of the Gene , Creating a Physical Biology: The Three-Man Paper and Early Molecular Biology). [REVIEW]Raphael Falk - 2013 - Studies in History and Philosophy of Science Part C: Studies in History and Philosophy of Biological and Biomedical Sciences 44 (4):623-625.
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  28.  1
    Final Discussion: Issues and Challenges for the Future.Rony Armon, Ulrich Charpa, Eric Davidson, Ute Deichmann, Raphael Falk, John Glass, Shimon Glick, Manfred Laubichler, Michel Morange & Isaac Yanni Nevo - 2012 - Perspectives in Biology and Medicine 55 (4):608-611.
  29.  1
    Molecular Genetics: Increasing the Resolving Power of Genetic Analysis.Raphael Falk - 2008 - History and Philosophy of the Life Sciences 30 (1):43 - 52.
    Contrary to Mendel, who introduced hybridization as a methodology for the study of selected discrete traits, de Vries conceived of organisms to be composed of discrete traits. This introduced into genetic research the dialectics of reductive analysis of genes as instrumental variables versus that of genes as the material atoms of heredity. The latter conception gained support with the analysis of mutations and eventually with high resolution analysis at the genetic and biochemical levels, as achieved in fungi and later in (...)
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  30.  1
    Foreword.Raphael Falk, Diane B. Paul & Garland Allen - 1998 - Science in Context 11 (3-4).
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  31.  59
    The Concept of the Gene in Development and Evolution: Historical and Epistemological Perspectives.Peter J. Beurton, Raphael Falk & Hans-Jörg Rheinberger (eds.) - 2000 - Cambridge University Press.
    Advances in molecular biological research in the latter half of the twentieth century have made the story of the gene vastly complicated: the more we learn about genes, the less sure we are of what a gene really is. Knowledge about the structure and functioning of genes abounds, but the gene has also become curiously intangible. This collection of essays renews the question: what are genes? Philosophers, historians and working scientists re-evaluate the question in this volume, treating the gene as (...)
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  32. Constructivism could do without destructivism.Raphael Falk - 1995 - Ethik Und Sozialwissenschaften 6 (3):318.
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  33. Don't Throw the Baby out with the Bathwater.Raphael Falk - 1993 - Ethik Und Sozialwissenschaften 4 (1):24.
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  34. Genetic Analysis: A History of Genetic Thinking.Raphael Falk - 2009 - Cambridge University Press.
    There is a paradox lying at the heart of the study of heredity. To understand the ways in which features are passed down from one generation to the next, we have to dig deeper and deeper into the ultimate nature of things - from organisms, to genes, to molecules. And yet as we do this, increasingly we find we are out of focus with our subjects. What has any of this to do with the living, breathing organisms with which we (...)
     
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  35. The Concept of the Gene in Development and Evolution.Raphael Falk & Hans-Jorg Rheinberger - 2001 - Journal of the History of Biology 34 (2):406-407.
     
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  36. Wilhelm Johannsen: A Rebel or a Diehard.Raphael Falk - 2008 - In Oren Harman & Michael Dietrich (eds.), Rebels, Mavericks, and Heretics in Biology. Yale University Press.
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