The molecular aspects of the microtubule system is a research area that has developed very rapidly during the past decade. Research on the assembly mechanisms and chemistry of tubulin and the molecular biology of microtubules have advanced our understanding of microtubule formation and its regulation. The emerging view of tubulin is of a macromolecule containing spatially discrete sequences that constitute functionally different domains with respect to self‐association, interactions with microtubule associated proteins (MAPs) and specific ligands. Recent studies point to the (...) role of the carboxyl‐terminal moiety of tubulin subunits in regulating its assembly into microtubules. These investigations combined with further studies on the spatial relationships between tubulin domains should provide new insights into the detailed structural basis of microtubule assembly. (shrink)

Resumen La argumentación es una forma de discurso en la que un hablante defiende una postura en una discusión. El presente trabajo se enfoca en la complejidad argumentativa y los recursos evaluativos y evidenciales que caracterizan las disputas de niños de diverso nivel socioeconómico. Se analizaron 94 disputas entre niños de 4 años y otros niños (5 a 10 años) en situaciones de juego espontáneo registradas en hogares de sectores socioeconómicos medio y bajo. El análisis identificó diferencias marginales en la (...) complejidad argumentativa entre los grupos. Por su parte se hallaron diferencias significativas en recursos de evaluativos de emocionalidad y en los evidenciales deónticos y exclamativos a favor de los sectores de nivel socioeconómico bajo. Los sectores medios registraron un mayor empleo de expresiones de causalidad y conectores. Los resultados se discuten a la luz de los hallazgos de investigaciones previas. Abstract Argumentation is a type of discourse in which a speaker defends a claim in a discussion. The present work focuses on the argumentative complexity and the evaluative and evidential resources that characterize the disputes of children of different socioeconomic levels. We analyzed 94 disputes between 4-year-old children and other children (5 to 10 years old) in situations of spontaneous play registered in homes of middle and low socioeconomic status (SES). The analysis identified marginal differences in argumentative complexity between the groups. On the other hand, significant differences were found in evaluative expressions of emotion and in deontic and exclamatory evidential markers, more frequently used by the low SES group. The mid SES group tends to use a higher number of expressions of causality and connectors. The results are discussed with reference to the findings of previous research. (shrink)

This is a collective study, in nine new essays, of the close connection between theology and cosmology in Stoic philosophy.

In this chapter, Ricardo Silvestre and Alan Herbert offer a reconstruction of the Gītā’s concept of God with a focus on the relationship between God and the world. They try to explain the claim that the Gītā is panentheistic. This is done with the help of some key notions of contemporary metaphysics (such as ontological dependence and fundamentality) along with the Indic notion of prakṛti, considered as a metaphysical primitive denoting the intimate relationship that exists between matter and conscious (...) living beings on the one hand, and God on the other. (shrink)

In this article, I present the structural consequences generated by the continuous and systematic epistemic injustices carried out in certain communities or institutions. These injustices contribute to building a structure of silencing, denial of epistemic authority, cover-up and impunity. The importance of the normative aspect that guides the reflections about these injustices will be exposed in two senses: on the one hand, insofar as it is necessary to have criteria that allow establishing the truth in the background of evaluation of (...) epistemic injustices and, on the other, in the sense of specifying how systematically attempting against it produces almost irreversible epistemic damage and guarantees the perpetuation of the structure. It will be shown how this happens within the framework of a powerful institution such as the Catholic Church, which has exhibited a pattern of testimonial injustices and the cover-up of abuses within it for decades. (shrink)

The use of new paradigms of false belief tasks allowed to reduce the age of children who pass the test from the previous 4 years in the standard version to only 15 months or even a striking 6 months in the nonverbal modification. These results are often taken as evidence that infants already possess an—at least implicit—theory of mind. We criticize this inferential leap on the grounds that inferring a ToM from the predictive success on a false belief task requires (...) to assume as premise that a belief reasoning is a necessary condition for correct action prediction. It is argued that the FBT does not satisfactorily constrain the predictive means, leaving room for the use of belief-independent inferences. These heuristics, when applied to the FBT, can achieve the same predictive success of a belief-based inference because information provided by the test stimulus allows the recognition of particular situations that can be subsumed by their ‘laws’. Instead of solving this issue by designing a single experimentum crucis that would render unfeasible the use of non-representational inferences, we suggest the application of a set of tests in which, although individually they can support inferences dissociated from a ToM, only an inference that makes use of false beliefs is able to correctly predict all the outcomes. (shrink)

En un contexto de transformaciones profundas en la sociedad boliviana, el autor plantea que más que una nueva teoría de la sociedad boliviana se requiere desarrollar otra mirada. En esta dirección, el presente artículo busca plantear un esquema renovado sobre las referencias desde las cuales deben encuadrar el debate los bolivianos y bolivianas. El texto aborda la construcción de matrices culturales, explicitando la moderna y la andina, y conecta matriz cultural con institucionalidad, para proponer una institucionalidad andina.

In this essay, I focus on Lugones’s relatively lesser explored notion of playfulness. I weigh in on the debate about whether playfulness is necessary for what Lugones calls “world-traveling,” which enables one to recognize another person as a full subject. I argue that although the attribute of playfulness may not be necessary for world-traveling, it is necessary for collaborative world-making––creating a new, shared world that is opened through the activity of play.

Is it possible to combine different logics into a coherent system with the goal of applying it to specific problems so that it sheds some light on foundational aspects of those logics? These are two of the most basic issues of combining logics. Paranormal modal logic is a combination of paraconsistent logic and modal logic. In this paper, I propose two further combinatory developments, focusing on each one of these two issues. On the foundational side, I combine paranormal modal logic (...) with normal modal logic, resulting into a paraconsistent and paracomplete multimodal logic dealing with the notions of plausibility and certainty. On the application side, I combine this logic with Reiter’s default logic, resulting into an inductive and consequently nonmonotonic paraconsistent and paracomplete logic able to represent some key inductive principles. (shrink)

¿Ciencias sociales o ciencias de la sociedad? -- La adquisición e intercambio de conocimiento -- La formación y evolución del lenguaje -- La formación de valores, moral y costumbre -- Bases metodológicas para el estudio histórico de los fenómenos sociales -- Cooperación social y gobierno.

Anchors and ghosts -- Making sense -- The anxiety of evidence -- The wheat and the chaff -- Sedation or seduction?.

Any plausibly just market exchange must balance two conflicting moral considerations: non-worseness (Wertheimer, 1999) and euvoluntariness (true voluntariness; Munger, 2011). We propose an analytical theory of just market exchange that partly resolves this conflict.

Este trabajo describe la vida y escritos de L. Polo hasta 1996. A los 25 años descubrió su método de pensamiento: el abandono del limite mental. Vivió en Madrid, Roma, Granada y Pamplona. Amante de la verdad y de la libertad personal. Entre sus obras más profundas se encuentran las que componen su Curso de teoría del conocimiento y su Antropología trascendental.

We uncover fundamental dimensions of the process through which organizations embed the practice of fraternity through embarking on an organizational journey in the direction of the common good. Building on the latest encyclical of Pope Francis, _Fratelli Tutti_, about fraternal and social friendship, we offer insight into the understanding of what it means to become a fraternal organization and reflect on the key ethical and paradoxical challenges for organizations aiming at collectively contributing to the common good. We add to previous (...) work by characterizing this journey as a process involving unique ethical challenges that emerge from the paradoxes associated with this process and how this might change the nature of the relationships between organizations and others within the organizational landscape. (shrink)

This collection of new essays by an international group of scholars closely examine the works of Aristotle's Organon. The Organon is the general title given to the collection of Aristotle's logical works: Categories, De Interpretatione, Prior Analytics, Posterior Analytics, Topics and Sophistical Refutations. This extremely influential collection gave Aristotle the reputation of being the founder of logic, and has helped shaped the development of logic for over two millennia. The chapters in this volume cover topics pertaining to each of the (...) six works traditionally included in the Organon as well as its manuscript tradition. In addition, a comprehensive introduction by the editors discusses Aristotle and logic, the composition and order of the Organon, and the authenticity, title, and chronology of the treatises that make up these works New Essays on Aristotle's Organon offers a valuable insight into this collection for students and scholars working on Aristotle, the works of the Organon, or the philosophy of logic more broadly. (shrink)

El concepto de acción -- Teoría y lógica de las normas -- Los predicados jurídicos y su base empírica -- La identificación del fenómeno jurídico -- Lagunas y criterios de decisión -- La revolución informático-jurídica -- Secuencias y niveles en el sistema normativo -- Ciencia jurídica e irracionalismo.

From Homeric heroes, Lucifer and Faust to the phenomenology of individual and social emotions, this book unfolds historical dimensions, literary recreations and philosophical analyses of the most ambivalent emotion of pride, from worst of sins to noblest feeling.

La integración de la tecnología en el ámbito del derecho penal plantea desafíos significativos debido a la falta de regulación de la inteligencia artificial (IA), lo que podría comprometer los derechos fundamentales. Este estudio se centra en abordar estos desafíos y proponer soluciones mediante un análisis exhaustivo de la situación actual y las posibles implicaciones de la IA en el sistema jurídico penal. El objetivo principal de esta investigación es analizar los problemas, desafíos y oportunidades que surgen con la implementación (...) de la inteligencia artificial en el ámbito penal. Se busca identificar la necesidad de una regulación específica para la IA en el derecho penal, con el fin de proteger los derechos fundamentales de las personas y garantizar un sistema jurídico justo y equitativo. Para abordar esta problemática, se adoptó un enfoque metodológico cualitativo. Se llevó a cabo una revisión bibliográfica detallada para examinar los antecedentes, problemas y desafíos asociados con la IA en los sistemas jurídicos, especialmente en el ámbito penal. Además, se realizaron análisis de criterios y opiniones de expertos en derecho para obtener una comprensión más profunda de la situación y las posibles soluciones. Los resultados de este estudio revelan la necesidad urgente de establecer una normativa específica para regular la aplicación de la inteligencia artificial en el ámbito penal. Se destaca que la falta de regulación representa un riesgo significativo para los derechos fundamentales, especialmente en lo que respecta a la configuración de delitos con el apoyo de la IA. Además, se identifican diferentes dimensiones que deben abordarse en la regulación, incluyendo principios y reglas básicas del derecho, supervisión humana de los sistemas de IA y la promoción de la innovación responsable en este campo. Este artículo subraya la importancia de establecer una regulación efectiva para la inteligencia artificial en el ámbito penal. Esta regulación no solo protegerá los derechos fundamentales de las personas, sino que también promoverá un uso responsable y progresivo de la IA como una herramienta valiosa para los profesionales del derecho. Es crucial que la regulación sea integral y adaptable para garantizar un sistema jurídico justo y equitativo en la era digital. (shrink)

In this paper I present a formalization of the theory of ideal concepts applied to the concept of God. It is done within a version of the Simplest Quantified Modal Logic (SQML) and attempts to solve three meta-problems related to the concept of God: the unicity of extension problem, the homogeneity/heterogeneity problem and the problem of conceptual unity.

El paciente en estado crítico reviste una especial importancia al desarrollar investigaciones, debido a que ha perdido o visto reducida su autonomía. El objetivo del presente estudio fue identificar el uso de los principios éticos de Ezequiel J. Emanuel, como guía en el desarrollo de investigaciones en pacientes críticos. Se realizó una revisión integrativa en las bases de datos WoS, PUBMED, SCOPUS y SciELO, y se encontraron 545 artículos de los cuales ocho cumplieron con los criterios previamente definidos. En estos (...) se identificó la descripción de los ocho principios de Emanuel, los cuales demostraron constituir un marco integral y sistemático de utilidad para orientar la conducta ética en la población analizada, siendo la ‘validez científica’ el principio más descrito en la investigación del paciente crítico, seguido del principio de ‘consentimiento informado’. (shrink)

El presente texto es una indagación del concepto de utopía propuesto por el filósofo colombiano Darío Botero Uribe, en relación con el concepto de disenso expuesto por el filósofo francés Jacques Ranciére. El pensamiento político de los dos autores toma como centro de las transformaciones políticas el movimiento individual ético en forma de acción política en vía de trasformación de diferentes formas de dominación presentes en las sociedades actuales. La intención entonces se centra en la estética como disputa de la (...) reformulación del campo social, económico y político, que coloca lo político en permanente contingencia y devenir, por lo que nunca existe un proyecto político último o ‘verdadero’ esencial, a manera de los grandes movimientos del siglo XX, sino que en eco de la propuesta foucaultiana los dos autores sostienen una forma de estética de la existencia en cuanto acción política. (shrink)

RESUMEN Se analiza la relación entre las memorias inscritas en el cuerpo, el trauma y los recursos corporizados subjetivos y colectivos con los que cuentan las mujeres víctimas de violencia para reconstruir y resignificarse como personas dignas de credibilidad y agentes de cambio. Se refieren casos específicos de violencia sexual en Colombia y se expone la importancia de la creación de comunidades de confianza que propicien espaclos para la narración y escucha de los testimonlos de víctimas, la tramitación de conflictos (...) y nuevas vías de afrontamiento, a partir de los recursos que brinda la reinvención de hábitos corporizados en el arte. ABSTRACT The article analyzes the relation among memories inscribed in the body, trauma, and the subjective and collective embodied resources available to women victims of violence in order to reconstruct and resignify themselves as persons worthy of credibility and as agents of change. It discusses specific cases of sexual violence in Colombia and the importance of creating communities of trust that foster spaces for narrating and listening to the testimonies of victims, as well as for handling conflicts and exploring new ways of coping, on the basis of the resources provided by the reinvention of habits embodied in art. (shrink)

BackgroundThe effect of orgasm on the development and shaping of partner preferences may involve a catalysis of the neurochemical mechanisms of bonding. Therefore, understanding such process is relevant for neuroscience and psychology.MethodsA systematic review was carried out using the terms Orgasm, Sexual Reward, Partner Preference, Pair Bonding, Brain, Learning, Sex, Copulation.ResultsIn humans, concentrations of arousing neurotransmitters and potential bonding neurotransmitters increase during orgasm in the cerebrospinal fluid and the bloodstream. Similarly, studies in animals indicate that those neurotransmitters and others modulate (...) the appetitive and consummatory phases of sexual behavior and reward. This suggests a link between the experience of orgasm/sexual reward and the neurochemical mechanisms of pair bonding. Orgasm/reward functions as an unconditioned stimulus. Some areas in the nervous system function as UCS-dete... (shrink)

Partner preferences are expressed by many social species, including humans. They are commonly observed as selective contacts with an individual, more time spent together, and directed courtship behavior that leads to selective copulation. This review discusses the effect of conditioning on the development of heterosexual and homosexual partner preferences in rodents. Learned preferences may develop when a conditioned stimulus (CS) is associated in contingency with an unconditioned stimulus (UCS) that functions as a reinforcer. Consequently, an individual may display preference for (...) a partner that bears a CS. Some UCS may be more or less reinforcing, depending on when they are experienced, and may be different for males and females. For example, it could be that, only during periods of early development, that stimuli associated with nurture and juvenile play become conditioned. In adulthood, other stimuli such as sexual reward, cohabitation, mild stress, or even pharmacological manipulations may function as reinforcers to condition partner preferences. Evolutionary biologists and psychologists must take into consideration the idea that an individual’s experience with reward (i.e. sexual and pharmacological) can override presumably ‘innate’ mate choices (e.g. assortativeness and orientation) or mate strategies (e.g. monogamy or polygamy) by means of Pavlovian and operant contingencies. In fact, it is likely as innate to learn about the environment in ways that maximize reward and minimize aversive outcomes, making so-called ‘proximate’ causes (e.g. pleasure) ultimately more powerful predictors of social behavior and choice than so-called ‘ultimate’ causes (e.g. genetic or reproductive fitness). Keywords: pavlovian; operant; learning; sex; copulation (Published: 15 March 2012) Citation: Socioaffective Neuroscience & Psychology 2012, 2 : 17340 - DOI: 10.3402/snp.v2i0.17340. (shrink)

Mathematics is a critical part of much scientific research. Physics in particular weaves math extensively into its instruction beginning in high school. Despite much research on the learning of both physics and math, the problem of how to effectively include math in physics in a way that reaches most students remains unsolved. In this paper, we suggest that a fundamental issue has received insufficient exploration: the fact that in science, we don’t just use math, we make meaning with it in (...) a different way than mathematicians do. In this reflective essay, we explore math as a language and consider the language of math in physics through the lens of cognitive linguistics. We begin by offering a number of examples that show how the use of math in physics differs from the use of math as typically found in math classes. We then explore basic concepts in cognitive semantics to show how humans make meaning with language in general. The critical elements are the roles of embodied cognition and interpretation in context. Then, we show how a theoretical framework commonly used in physics education research, resources, is coherent with and extends the ideas of cognitive semantics by connecting embodiment to phenomenological primitives and contextual interpretation to the dynamics of meaning-making with conceptual resources, epistemological resources, and affect. We present these ideas with illustrative case studies of students working on physics problems with math and demonstrate the dynamical nature of student reasoning with math in physics. We conclude with some thoughts about the implications for instruction. (shrink)