The purpose of this essay is to reflect on the Carolingian age and on the assumptions that have governed the study of this important segment of the early Middle Ages. I am concerned with two issues: what happened during the Carolingian period, and where the period should be located in the larger historical context. That is to say, the discussion is both historical and historiographical. It is intended not only for Carolingian specialists, but also for others who have reason to (...) consider the origins and development of medieval history. (shrink)

Efforts by governments, firms, and patients to deliver pioneering drugs for critical health needs face a challenge of diminishing efficiency in developing those medicines. While multi-sectoral collaborations involving firms, researchers, patients, and policymakers are widely recognized as crucial for countering this decline, existing incentives to engage in drug development predominantly target drug manufacturers and thereby do little to stimulate collaborative innovation. In this mini review, we consider the unexplored potential within pharmaceutical regulations to create novel incentives to encourage a diverse (...) set of actors from the public and private spheres to engage in the kind of collaborative knowledge exchange requisite for fostering enhanced innovation in early drug development. (shrink)

Across a wide range of legal contexts, E. Thomas Sullivan and Richard S. Frase identify three basic ways that government measures and private remedies have been ...

This work helps highlights how the innovations in Flathman's thought have shaped the field of political theory and will be of interest to students and scholars alike.

Given that university faculty members and supervisors practicing in the community have been involved in at least one research supervisor-graduate student relationship, it is surprising that so little attention has been paid to the ethical issues involved in such relationships. Indeed, as a student and her or his graduate research supervisor may be involved in a close working relationship for many years, it is understandable that several opportunities can arise that could be considered dual or multiple relationships. Examples of such (...) relationship issues discussed in this article include authorship matters, favoritism or inequitable treatment of students, and sexual relationships. Depending on the nature of the relationship, the impact on students can be quite severe; although, the effects on students have not been adequately studied. Existing ethical guidelines do not provide enough guidance in this area where students are in a position of diminished power with respect to the supervisor. Following the discussion of relationship issues, we suggest extensions of current guidelines to deal with these issues. (shrink)

The fitness of any evolutionary unit can be understood in terms of its two basic components: fecundity (reproduction) and viability (survival). Trade-offs between these fitness components drive the evolution of life-history traits in extant multicellular organisms. We argue that these trade-offs gain special significance during the transition from unicellular to multicellular life. In particular, the evolution of germ–soma specialization and the emergence of individuality at the cell group (or organism) level are also consequences of trade-offs between the two basic fitness (...) components, or so we argue using a multilevel selection approach. During the origin of multicellularity, we study how the group trade-offs between viability and fecundity are initially determined by the cell level trade-offs, but as the transition proceeds, the fitness trade-offs at the group level depart from those at the cell level. We predict that these trade-offs begin with concave curvature in single-celled organisms but become increasingly convex as group size increases in multicellular organisms. We argue that the increasingly convex curvature of the trade-off function is driven by the cost of reproduction which increases as group size increases. We consider aspects of the biology of the volvocine green algae – which contain both unicellular and multicellular members – to illustrate the principles and conclusions discussed. (shrink)

H.P. Grice is known principally for his influential contributions to the philosophy of language, but his work also includes treatises on the philosophy of mind, ethics, and metaphysics--much of which is unpublished to date. This collection of original essays by such philosophers as Nancy Cartwright, Donald Davidson, Gilbert Harman, and P.F. Strawson demonstrates the unified and powerful character of Grice's thoughts on being, mind, meaning, and morals. An introductory essay by the editors provides the first overview of Grice's work.

This chapter combines formal models of how the fitness of a collective can become decoupled from the fitness with more empirical work on the volvocine algae. It uses the Volvox clade as a model system. It describes the evolution of altruism in the volvocine green algae. This chapter suggests that altruism may evolve from genes involved in life-history trade-offs. It shows the several cooperation, conflict, and conflict mediation cycles in the volvocine green algae. This cycle of cooperation, conflict, and conflict (...) mediation drives evolutionary transitions in individuality. (shrink)

Reviews evidence which suggests that there may be little or no direct introspective access to higher order cognitive processes. Ss are sometimes unaware of the existence of a stimulus that importantly influenced a response, unaware of the existence of the response, and unaware that the stimulus has affected the response. It is proposed that when people attempt to report on their cognitive processes, that is, on the processes mediating the effects of a stimulus on a response, they do not do (...) so on the basis of any true introspection. Instead, their reports are based on a priori, implicit causal theories, or judgments about the extent to which a particular stimulus is a plausible cause of a given response. This suggests that though people may not be able to observe directly their cognitive processes, they will sometimes be able to report accurately about them. Accurate reports will occur when influential stimuli are salient and are plausible causes of the responses they produce, and will not occur when stimuli are not salient or are not plausible causes. (shrink)

A long-standing challenge to evolutionary theory has been whether it can explain the origin of complex organismal features. We examined this issue using digital organisms—computer programs that self-replicate, mutate, compete and evolve. Populations of digital organisms often evolved the ability to perform complex logic functions requiring the coordinated execution of many genomic instructions. Complex functions evolved by building on simpler functions that had evolved earlier, provided that these were also selectively favoured. However, no particular intermediate stage was essential for evolving (...) complex functions. The first genotypes able to perform complex functions differed from their non-performing parents by only one or two mutations, but differed from the ancestor by many mutations that were also crucial to the new functions. In some cases, mutations that were deleterious when they appeared served as stepping-stones in the evolution of complex features. These findings show how complex functions can originate by random mutation and natural selection. (shrink)

Articles: Smart, "Quine's Philosophy of science"; Harman, "An Introduction to 'Translation and Meaning', Chapter Two of Word and Object"; Stenius, "Beginning with Ordinary Things"; Chomsky, "Quine's Empirical Assumptions"; Hintikka, "Behavioral Criteria of Radical Translation"; Stroud, "Conventionalism and the Indeterminacy of Translation"; Strawson, "Singular Terms and Predication"; Grice, "Vacuous Names"; Geach, "Quine's Syntactical Insights"; Davidson, "On Saying That"; Follesdal, "Quine on Modality"; Sellars, "Some Problems about Belief"; Kaplan, "Quantifying In"; Berry, "Logic with Platonism"; Jensen, "On the Consistency of a Slight (?) (...) Modification in Quine's New Foundations"; Quine, "Replies"; Publications of W. V. Quine. (shrink)

As its subtitle 'Skepticism, Individuality and Chastened Politics' indicates, this book is an exploration of and a largely favorable engagement with salient elements in the thinking of a theorist who is widely regarded as the greatest Anglophone political thinker and among the top rank of philosophical writers generally. In emphazing Hobbes's skepticism, Richard Flathman goes against the grain of much of the literature concerning Hobbes. The theme of individuality is more familiar, particularly from the celebrated writings on Hobbes by (...) Michael Oakeshott, but the idea of a chastened politics challenges the widely influential view that Hobbes was not only an authoritarian but an incipient or proto-totalitarian. (shrink)

Why is it that some business managers appear to behave differently in private and at work? How, if at all, are the decisions managers make affected by the nature of their organisations? What impact do organisational values have on the moral autonomy of managers? A research project into these questions is now under way in three disparate Australian business firms and this paper sets out the premise underlying it. For purposes of research the general premise is that the moral character (...) of a business influences the moral judgements and actions of its members. More specifically, it is suggested that the economic paradigm renders a business organisation amoral rather than moral or immoral, and as a result moral responsibility comes to be assigned to individual members. However, the socio-cultural nature of such firms interferes with the ability of managers to exercise moral autonomy. Governed as it is by the market or laws of economics, the amoral organisation is likely to transform its members into individuals without moral standards. (shrink)

Charles Foster and Jonathan Herring are to be congratulated on their useful presentation of the roles played by concepts of personhood and identity in English medical law. 1 However, I fear that the project they have undertaken here is misconceived. It is an interesting and important misconception, which is widely shared in the literature on medical law and ethics; but a misconception it remains. The problem is this. What we call ‘the Law’ is in fact a complex assemblage of institutions, (...) rules, accredited persons, practices and systems. What it is not is a self-sufficient, integrated and self-interpreting system of doctrine. As such it does not have a clear structure which we can excavate and the idea that we can find concepts which explain and unify that structure at some deep level is thus quixotic. To approach ‘the Law’ in that way is to pursue a chimaera. We should instead... (shrink)

BRENTANO'S CLAIMS ABOUT INTENTIONALITY DO NOT BEAR SOLELY\nON A CONCERN WITH THE POSITIVE NATURE OF MENTAL STATES.\nTHEY ALSO HAVE NO BEARING ON THE PROBLEM OF MENTAL/MATERIAL\nIDENTITY. PART OF THEIR POINT IS JUST TO OPPOSE A CERTAIN\nVIEW ABOUT THE PROPER OBJECTS OF AWARENESS, NAMELY THAT\nINSOFAR AS WE ARE AWARE OF OBJECTS THEY HAVE AN EXISTENCE\n"IN THE MIND." BOTH HUME AND DESCARTES HELD SUCH A VIEW. AN\nEXAMINATION OF THE NOTIONS OF "IDEA" AND "OBJECTIVE\nREALITY" SHOWS THE INACCURACY OF REGARDING DESCARTES AS A\n"REPRESENTATIVE REALIST." (...) WHAT REPRESENTS EXTERNAL NATURES\nIN THE MIND IS JUST THOSE NATURES THEMSELVES INSOFAR AS\nTHEY EXIST IN THE MIND. (shrink)

The German volume Gadamer Lesebuch [A Gadamer Reader], selected and edited by Jean Grondin in consultation with Hans-Georg Gadamer himself, contains a set of essays that present a cross section of writings by one of the twentieth century's greatest philosophers. The volume begins with an autobiographical sketch and culminates in a conversation with Jean Grondin that looks back over a lifetime of productive philosophical work. The essays not already available in English have here been translated by Richard E. Palmer, (...) a respected translator of Gadamer's writings. The sixteen essays contained in the Lesebuch are augmented here by three other essays: Gadamer's last essay on Derrida, "Hermeneutics Tracking the Trace" and two essays on practical philosophy. The Gadamer Reader: A Bouquet of the Later Writings richly conveys the scope and depth of Gadamer's thought, covering the range of his work in hermeneutics, aesthetics, practical philosophy, and essays on Plato, Hegel, and Heidegger. In addition, Palmer offers introductory remarks before each essay that explain its importance in the context of Gadamer's writings and define its key terms. Throughout, in both his translation and commentary, his aim is to make this critically important philosopher as clear and accessible as possible to an English-speaking audience. (shrink)