The authors of the numerous medieval and early modern Sanskrit-medium commentaries on the various recensions and sub-recensions of the Vālmīkirāmāyaṇa frequently found themselves in a somewhat awkward hermeneutical position. The epic itself, like many Indic texts, is highly revered both as a religious text, one of the earliest and most influential Vaiṣṇava texts, and as a literary work that is not only a great poem but indeed the very first poem and the fons et origo of all subsequent poetry. Moreover, (...) like Vyāsa, the author of the Rāmāyaṇa’s sister epic, the Mahābhārata, Vālmīki was regarded not merely as an inspired poet and sage, but as a ṛṣi, that is to say an inerrant seer whose speech, in his case inspired directly by the creator divinity Brahmā and the god’s gift of a divine vision, must therefore be accepted as absolutely true and authoritative. The problem facing the work’s commentators is that Vālmīki’s text portrays its hero, Rāma, as not only a god in the form of a man, but as one who, ignorant of his own divinity, suffers all of the mental, emotional, and physical pain to which ordinary mortals are prey. In this Rāma differs sharply from the subsequent Vaiṣṇava avatāra and central figure of the Mahābhārata, Kṛṣṇa, who, fully aware of his godhood, rarely suffers in any way mentally or physically. But the Rāmāyaṇa’s commentators are living and writing in a world in which the development of the medieval bhakti movements has led poets and theologians to conceive of and write about Rāma as an omnipotent and omniscient figure very much like Kṛṣṇa. The present essay discusses the lexical, grammatical, and hermaneutical strategies the commentors adopted to negotiate the tension between Vālmīki’s apparent depiction of the suffering of his hero and a proposed deeper meaning in which the avatāra conforms more fully to what became the medieval and modern theology of god on earth. (shrink)

Albert Einstein's Quest as a Scientist and as a Jew to Replace a Forsaken God.

The marketing of health care services raises the prospect that an ethic of strangers will govern relations between providers and patients. A fiduciary model that emphasizes honesty and public accountability, as well as the patient's good and avoiding unnecessary services, can keep marketing consistent with the ethical tradition of medicine.

Graphical AbstractIn article 2000078, Alison Patteson et al. review the various functions of filamentous and non-filamentous vimentin. While the mechanical and intracellular roles of vimentin – such as providing protection of the nucleus and elasticity to the cytoskeleton – are well documented, recent studies point towards additional, non-mechanical functions for vimentin. These functions include signaling roles in wound healing, lipogenesis and sterol processing as well as a role in pathogen infection.

Intermediate filaments (IFs) formed by vimentin are less understood than their cytoskeletal partners, microtubules and F‐actin, but the unique physical properties of IFs, especially their resistance to large deformations, initially suggest a mechanical function. Indeed, vimentin IFs help regulate cell mechanics and contractility, and in crowded 3D environments they protect the nucleus during cell migration. Recently, a multitude of studies, often using genetic or proteomic screenings show that vimentin has many non‐mechanical functions within and outside of cells. These include signaling (...) roles in wound healing, lipogenesis, sterol processing, and various functions related to extracellular and cell surface vimentin. Extracellular vimentin is implicated in marking circulating tumor cells, promoting neural repair, and mediating the invasion of host cells by viruses, including SARS‐CoV, or bacteria such as Listeria and Streptococcus. These findings underscore the fundamental role of vimentin in not only cell mechanics but also a range of physiological functions. Also see the video abstract here https://youtu.be/YPfoddqvz-g. (shrink)