: Protection of human subjects from investigators' conflicts of interest is critical to the integrity of clinical investigation. Personal financial conflicts of interest are addressed by university policies, professional society guidelines, publication standards, and government regulation, but "intrinsic conflicts of interest"—conflicts of interest inherent in all clinical research—have received relatively less attention. Such conflicts arise in all clinical research endeavors as a result of the tension among professionals' responsibilities to their research and to their patients and both academic and financial (...) incentives. These conflicts should be disclosed to research subjects and managed as assiduously as are financial conflicts of interest. (shrink)

The God Dialogues is an intriguing and extensive philosophical debate about the existence of God. Engaging and accessible, it covers all the main arguments for and against God's existence, from traditional philosophical "proofs" to arguments that involve the latest developments in biology and physics.

This study contributes to the burgeoning research on corporate social responsibility (CSR) at the individual level of analysis, in a hitherto largely neglected developing country context. Using survey information collected from 297 employees in public and private enterprises in Kosovo, this study examines how and to what extent employees’ perceptions of their employer's CSR activities are associated with their intention to emigrate. Applying a needs‐based framework, this research provides evidence that employees’ perceptions of CSR are positively related to the meaningfulness (...) of their work and job satisfaction and negatively related to intention to emigrate. Additionally, results confirm that the association between CSR perceptions and emigration intention is mediated by the meaningfulness of work and job satisfaction. From a practical point of view, this research should encourage private and public enterprises in developing countries to enhance and extend their CSR engagement. (shrink)

Narrowing the focus of his Soundings in St. Augustine's Imagination (1994) O'Connell (philosophy, Fordham U.) analyzes three decisive conversions portrayed in the Confessions: the youthful reading of Cicero, that sparked by the platonist books, and the final capitulation in the Milanese garden. He also compares the conversion imagery with that in the Dialogues of Cassicciacum to shed light on the question of two Augustines. Annotation copyrighted by Book News, Inc., Portland, OR.

A great thinker once said that "all philosophy is merely footnotes to Plato."Through Plato, Father O'Connell provides us here with an introduction to all philosophy. Designed for beginning students in philosophy, Plato on the Human Paradox examines and confronts human nature and the eternal questions concerning human nature through the dialogues of Plato, focusing on the Apology, Phaedo, Books III-VI of the Republic, Meno, Symposium, and O'Connell presents us here with an introduction to Plato through the philosopher's quest to define (...) "human excellence" or arete in terms of defining what "human being" is body and soul, focusing on Plato's preoccupations with the questions of how and what it means to have a "good life" in relation to or as opposed to a "moral life.". (shrink)

Many mammals use scent marks to advertise territory ownership, but only recently have we started to understand the complexity of these scent signals and the types of information that they convey. Whilst attention has generally focused on volatile odorants as the main information molecules in scents, studies of the house mouse have now defined a role for a family of proteins termed major urinary proteins (MUPs) which are, of course, involatile. MUPs bind male signalling volatiles and control their release from (...) scent marks. These proteins are also highly polymorphic and the pattern of polymorphic variants provides a stable ownership signal that communicates genome‐derived information on the individual identity of the scent owner. Here we review the interaction between the chemical basis of mouse scents and the dynamics of their competitive scent marking behaviour, demonstrating how it is possible to provide reliable signals of the competitive ability and identity of individual males. BioEssays 26:1288–1298, 2004. © 2004 Wiley Periodicals, Inc. (shrink)

This is a study of an under-developed topic in philosophy of language, namely first-person plural pronouns (‘we’, ‘us’, etc.) Richard Vallée has made very important progress by identifying crucial desiderata and putting forward an ingenious proposal about ‘we’ which addresses them. We contend that, despite this impressive progress, he makes some missteps, both omissions and errors; furthermore, his proposal appears implausible as a personal-level psychological story. We thus sketch an alternative approach to the semantics of the first-person plural indexical which, (...) though it builds on Vallée’s important work, departs substantially from it. (shrink)

This volume comprises systematic as well as historical essays, including contributions intended to give comprehensive overviews of such areas as genetic phenomenology, transcendental phenomenology, philosophy and history of logic and mathematics, Kant, hermeneutics, Hegel, and philosophy of language. The book is addressed to phenomenologists, particularly those who are interested in some or all of the areas mentioned. In his introduction Joseph J. Kockelmans indicates that these diverse areas enter into dialogue in the work of Thomas M. Seebohm, whom the editors (...) and authors wish to honor, and the systematic papers mirror the state of the art of research in the above-mentioned disciplines. (shrink)

The prenylated proteins represent a newly discovered class of post‐translationally modified proteins. The known prenylated proteins include the oncogene product p21ras and other low molecular weight GTP‐binding proteins, the nuclear lamins, and the γ subunit of the heterotrimeric G proteins. The modification involves the covalent attachment of a 15‐carbon (farnesyl) or 20‐carbon (geranylgeranyl) isoprenoid moiety in a thioether linkage to a carboxyl terminal cysteine. The nature of the attached substituent is dependent on specific sequence information in the carboxyl terminus of (...) the protein. In addition, prenylation entrains other post‐translational modifications forming a reaction pathway. In this article, we review our current understanding of the biochemical reactions involved in prenylation and discuss the possible role of this modification in the control of cellular functions such as protein maturation and cell growth. (shrink)

This volume contributes to the remarkable resurgence in interest for American pragmatism and its proponents by focusing on the influence of British empiricism, ...

"In an age of bewildering change and frightening insecurity, the meaning of person is crucial to an understanding of man's nature, not only in terms of his individual essentiality, but also as his nature bears upon, and is affected by, his constantly changing environment and the communal relationships which exist between persons. The present volume focuses upon this important question and offers answers from a variety of philosophical traditions which will enhance our understanding of man and person. Among the philosophical (...) issues raised are those involved in epistemology, social change, community, psychoanalysis, religion, moral commitment, political theory, peace, immorality, and technology. The essays constitute a dialogue, as it were, with the problems raised by Kant, Freud, Dewey, Whitehead, Skinner, Lonergan, Rahner, Macmurray, Rawls, and others. Many argue that man as a person what he is, and can be understood as such, only in terms of changing conditions and interpersonal relationships: Person and Community will contribute greatly to the insight and enjoyment of anyone concerned with this contention."-Publisher. (shrink)

James's ethical thought could frequently be consequentialist, but it could also on occasion show a deontological side, or "streak," as I contended in "William James on the Courage to Believe". This shows up when he speaks of the "strenuous" as against the "easy-going" moral mood, in "The Moral Philosopher and the Moral Life," and it preserves the precursive intervention of our "passional natures" in "The Will to Believe" from lapsing into "wishful thinking." Toned down slightly, perhaps, in "Varieties of Religious (...) Experience", it reasserts itself in "Pragmatism", and, it could be shown, in James's succeeding works as well. (shrink)

Models of scientific explanation derived from the physical sciences are often poorly suited to the historical sciences—to the fields William Whewell called the palaetiological sciences. A listing of 27 titles that explore the nature of narrative understanding across a range of scientific disciplines—from cosmology to paleontology to economics—attests to the importance of narrative epistemology in the sciences.