: Protection of human subjects from investigators' conflicts of interest is critical to the integrity of clinical investigation. Personal financial conflicts of interest are addressed by university policies, professional society guidelines, publication standards, and government regulation, but "intrinsic conflicts of interest"—conflicts of interest inherent in all clinical research—have received relatively less attention. Such conflicts arise in all clinical research endeavors as a result of the tension among professionals' responsibilities to their research and to their patients and both academic and financial (...) incentives. These conflicts should be disclosed to research subjects and managed as assiduously as are financial conflicts of interest. (shrink)
The traditional problem of evil is set forth, by no means for the first time, in Part X of Hume's Dialogues Concerning Natural Religion in these familiar words: ‘Is [God] willing to prevent evil, but not able? then he is impotent. Is he able, but not willing? then he is malevolent. Is he both able and willing? whence then is evil?’ This formulation of the problem of evil obviously suggests an argument to the effect that the existence of evil in (...) the world demonstrates that God does not exist. The purpose of this paper is to examine this argument, with a view to showing that while it is not a conclusive argument, it is much stronger than some apologists for traditional theism allow. (shrink)
The seventeen seminal essays by Robert J. Gordon collected here, including three previously unpublished works, offer sharply etched views on the principal topics of macroeconomics - growth, inflation, and unemployment. The author re-examines their salient points in a uniquely creative, accessible introduction that serves on its own as an introduction to modern macroeconomics. Each of the four parts into which the essays are grouped also offers a new introduction. The papers in Part I explore different key aspects of the (...) history, theory, and measurement of productivity growth. The essays in Part II investigate the sources of business cycles and productivity fluctuations. Those in Part III cover the effects of supply shocks in macroeconomics. The final group presents empirical studies of the dynamics of inflation in the United States. The foreword by Nobel Laureate Robert M. Solow comments on the abiding importance of these essays drawn from 1968 to the present. (shrink)
Introduction -- Knowing at the level of sympathy -- The drama of schooling/the schooling of drama -- The challenging world of educational leadership -- Cultivating a perspective on learning -- Building an ethical school -- Working within the geography of human development -- Foundational qualities of an ethical person -- The moral dimension of human resource development -- The ethics of teaching -- Cultivating a mature community -- The complexity of ethical living and learning.
Whilst Edward Gibbon's Memoirs of My Life comprise a notoriously complex document of autobiographical artifice, there is no reason to question the honesty of its revelation of his attitudes to geography and its relationship to the historian's craft. Writing of his boyhood before going up to Oxford, Gibbon commented that his vague and multifarious reading could not teach me to think, to write, or to act; and the only principle, that darted a ray of light into the indigested chaos, was (...) an early and rational application of the order of time and place. The maps of Cellarius and Wells imprinted in my mind the picture of ancient geography: from Stranchius I imbibed the elements of chronology: the Tables of Helvicus and Anderson, the Annals of Usher [ sic ] and Prideaux, distinguished the connection of events. . . This seems a fairly direct comment on Gibbon's attitude to geography as a historian in that it is confirmed by various of his working documents and commonplace book comments not aimed at posterity and by the practice embodied in his great work that was thus targeted, the Decline and Fall. Taking Gibbon's private documents, the first manuscript we have in his English Essays, for example, is a tabulated chronology from circa 1751 when Gibbon was fourteen years old, which begins with the creation of the world in 6000 BC and runs up to 1590 BC, this being exactly the sort of material which could be commonplaced from the likes of Ussher and Prideaux. Matching this attention to chronology is a concern with geography, and indeed the two are coupled together as in his comment in the Memoirs. Thus in his Index Expurgatoris, Gibbon berates Sallust as “no very correct historian” on the grounds that his chronology is not credible and that “notwithstanding his laboured description of Africa, nothing can be more confused than his Geography without either division of provinces or fixing of towns”. In this regard, Gibbon the author of the Decline and Fall was a “correct” historian, in that he was careful to frame each arena in which historical events were narrated in the light of a prefatory description of the geography of the location under discussion. This is most readily apparent in the second half of the opening chapter of the work, where Gibbon proceeds on what his “Table of Contents” calls a “View of the Provinces of the Roman Empire”, starting in the West with Spain and then proceeding clockwise to reach Africa on the other side of the Pillars of Hercules, a pattern of geographical description directly mirroring ancient practice in Strabo's Geography and Pomponius Mela's De Situ Orbis. But this practice of prefacing a historical account with geographical description repeats itself at various points in the work, as when, approaching the end of his grand narrative, Gibbon reaches the impact of “Mahomet, with sword in one hand and the Koran in the other” on “the causes of the decline and fall of the Eastern empire”. Before discussing the birth of Islam, Gibbon treats his readers to a discussion of the geography of Arabia, beginning with its size and shape before moving on to its soils, climate and physical–geographic subdivisions. (shrink)
"All art should become science and all science art; poetry and philosophy should be made one." Friedrich Schlegel's words perfectly capture the project of the German Romantics, who believed that the aesthetic approaches of art and literature could reveal patterns and meaning in nature that couldn't be uncovered through rationalistic philosophy and science alone. In this wide-ranging work, Robert J. Richards shows how the Romantic conception of the world influenced (and was influenced by) both the lives of the people (...) who held it and the development of nineteenth-century science. Integrating Romantic literature, science, and philosophy with an intimate knowledge of the individuals involved—from Goethe and the brothers Schlegel to Humboldt and Friedrich and Caroline Schelling—Richards demonstrates how their tempestuous lives shaped their ideas as profoundly as their intellectual and cultural heritage. He focuses especially on how Romantic concepts of the self, as well as aesthetic and moral considerations—all tempered by personal relationships—altered scientific representations of nature. Although historians have long considered Romanticism at best a minor tributary to scientific thought, Richards moves it to the center of the main currents of nineteenth-century biology, culminating in the conception of nature that underlies Darwin's evolutionary theory. Uniting the personal and poetic aspects of philosophy and science in a way that the German Romantics themselves would have honored, The Romantic Conception of Life alters how we look at Romanticism and nineteenth-century biology. (shrink)
Robert J. Howell offers a new account of the relationship between conscious experience and the physical world, based on a neo-Cartesian notion of the physical and careful consideration of three anti-materialist arguments. His theory of subjective physicalism reconciles the data of consciousness with the advantages of a monistic, physical ontology.
Discusses about selective engagement as the most desirable strategy for contemporary America, stating that it is the one that seeks to forestall dangers, not simply to react to them; that is politically viable; at home and abroad; and that protects US interests.
The risk of stroke for a child with SCD is many times greater than that of a healthy child without SCD or heart disease. There is a technique that allows the identification of the children with SCD who have high risk even within this relatively high-risk group. And there is a highly effective preventive treatment. While this would on the surface appear to be a straightforward medical decision, it is not. One must weigh the benefits of preventing permanent brain damage (...) against the risks of infection from transfused blood, iron overload, which is the result of the frequent transfusions, and rare transfusion reactions. (shrink)
Sickle cell anemia is a disease characterized by abnormal hemoglobin structure. There is a mutation in the beta-globin gene that changes the sixth amino acid from glutamic acid to valine causing the mutated hemoglobin to polymerize reversibly when deoxygenated to form a gelatinous network of fibrous polymers that stiffen and distort the red blood cell membrane. This leads to episodes of microvascular vasoocclusion and premature RBC destruction leading to hemolytic anemia. For reasons that are unclear, some children develop a large (...) artery vasculopathy involving the intracranial arteries supplying the brain.The risk of stroke for a child with SCD is many times greater than that of a healthy child without SCD or heart disease. There is a technique that allows the identification of the children with SCD who have high risk even within this relatively high-risk group. And there is a highly effective preventive treatment. (shrink)
The practice of manufacturers' payments of fees to retailers for the display and sale of their products has become a common practice. In the grocery retail business, the fees paid by manufacturers are called slotting fees, or a payment made for a slot on the shelf. The same practice is used now in the retail book industry. Large book chains command high fees from publishers for the prominent display of books. Entrepreneur's products are often precluded from stores and markets because (...) slotting fees are prohibitive. The fees are non-uniform and often paid in cash, creating an atmosphere that has already spawned illegal activity on the part of retail executives. This article examines the ethics of slotting fees. (shrink)
Taking Wittgenstein at His Word is an experiment in reading organized around a central question: What kind of interpretation of Wittgenstein's later philosophy emerges if we adhere strictly to his claims that he is not in the business of presenting and defending philosophical theses and that his only aim is to expose persistent conceptual misunderstandings that lead to deep philosophical perplexities? Robert Fogelin draws out the therapeutic aspects of Wittgenstein's later work by closely examining his account of rule-following and (...) how he applies the idea in the philosophy of mathematics.The first of the book's two parts focuses on rule-following, Wittgenstein's "paradox of interpretation," and his naturalistic response to this paradox, all of which are persistent and crucial features of his later philosophy. Fogelin offers a corrective to the frequent misunderstanding that the paradox of interpretation is a paradox about meaning, and he emphasizes the importance of Wittgenstein's often undervalued appeals to natural responses. The second half of the book examines how Wittgenstein applies his reflections on rule-following to the status of mathematical propositions, proofs, and objects, leading to remarkable, demystifying results.Taking Wittgenstein at His Word shows that what Wittgenstein claims to be doing and what he actually does are much closer than is often recognized. In doing so, the book underscores fundamental--but frequently underappreciated--insights about Wittgenstein's later philosophy. (shrink)
What distinguishes full-on stating a proposition from merely communicating it? For instance, what distinguishes claiming/asserting/saying that one has never smoked crack cocaine from merely implying/conveying/hinting this? The enormous literature on ‘assertion’ provides many approaches to distinguishing stating from, say, asking and commanding: only the former aims at truth; only the former expresses one's belief; etc. But this leaves my question unanswered, since in merely communicating a proposition one also aims at truth, expresses a belief, etc. My aim is not to (...) criticize extant accounts of the state-versus-merely-convey contrast, but rather to draw on clues from Dummett, functional linguistics and moral theory, to offer a novel one. The main idea is that full-on stating is distinctively conventionalized in a way that conversationally implicating, hinting, giving to understand, etc., are not. Specifically, full-on stating is constitutively tied to a particular conventional, linguistic, function-bearing device, the declarative sentence. To full-on state that p is to hit that ‘target speech act’ which owes its existence to that special-purpose device. It is therefore also to make one's action lie-prone. Nonetheless, once that sui generis target is there to be aimed for, a person may reach it without using the special-purpose tool—e.g. one may full-on state using a mere word or phrase, or coded hand signals, or semaphore. I end by considering several philosophical implications of this means of capturing the contrast. (shrink)
Human beings are both supremely rational and deeply superstitious, capable of believing just about anything and of questioning just about everything. Indeed, just as our reason demands that we know the truth, our skepticism leads to doubts we can ever really do so. In Walking the Tightrope of Reason, Robert J. Fogelin guides readers through a contradiction that lies at the very heart of philosophical inquiry. Fogelin argues that our rational faculties insist on a purely rational account of the (...) universe, yet at the same time, the inherent limitations of these faculties ensure that we will never fully satisfy that demand. As a result of being driven to this point of paradox, we either comfort ourselves with what Kant called "metaphysical illusions" or adopt a stance of radical skepticism. No middle ground seems possible and, as Fogelin shows, skepticism, even though a healthy dose of it is essential for living a rational life, "has an inherent tendency to become unlimited in its scope, with the result that the edifice of rationality is destroyed." In much Postmodernist thought, for example, skepticism takes the extreme form of absolute relativism, denying the basis for any value distinctions and treating all truth-claims as equally groundless. How reason avoids disgracing itself, walking a fine line between dogmatic belief and self-defeating doubt, is the question Fogelin seeks to answer. Reflecting upon the ancient Greek skeptics as well as such thinkers as Hume, Kant, Wittgenstein, Nietzsche, and Whitman, this book takes readers into--and through--some of philosophy's most troubling paradoxes. (shrink)
