This article is the lead piece in a special report that presents the results of a bioethical investigation into chimeric research, which involves the insertion of human cells into nonhuman animals and nonhuman animal embryos, including into their brains. Rapid scientific developments in this field may advance knowledge and could lead to new therapies for humans. They also reveal the conceptual, ethical, and procedural limitations of existing ethics guidance for human‐nonhuman chimeric research. Led by bioethics researchers working closely with an (...) interdisciplinary work group, the investigation focused on generating conceptual clarity and identifying improvements to governance approaches, with the goal of helping scholars, funders, scientists, institutional leaders, and oversight bodies (embryonic stem cell research oversight [ESCRO] committees and institutional animal care and use committees [IACUCs]) deliver principled and trustworthy oversight of this area of science. The article, which focuses on human‐nonhuman animal chimeric research that is stem cell based, identifies key ethical issues in and offers ten recommendations regarding the ethics and oversight of this research. Turning from bioethics’ previous focus on human‐centered questions about the ethics of “humanization” and this research's potential impact on concepts like human dignity, this article emphasizes the importance of nonhuman animal welfare concerns in chimeric research and argues for less‐siloed governance and oversight and more‐comprehensive public communication. (shrink)

In this conversation, four experts in animal research oversight—Christopher Stodgell, Lori Hill, Robert Kesterson, and Angelika Rehrig—discuss the complexities of stem cell-based chimeric animal experiments, especially in relation to traditional animal welfare practices. Each expert shares their experiences and suggestions for how best to conduct chimeric animal research, including discussing the importance of communication and collaboration between experts in animal behavior and welfare and the investigators conducting or proposing chimeric research studies.

This title provides a synoptic overview of the current state of interdisciplinary research, education, administration and management, and problem solving - knowledge that spans the disciplines and interdisciplinary fields and crosses the space between the academic community and society at large.

This book provides a comprehensive and critical account of Gadamer's hermeneutical philosophy. Robert J. Dostal shows that at the heart of Gadamer's enterprise is the thesis that "being that can be understood is language.".

In this Element, we extend our earlier treatment of biology's first law. The law says that in any evolutionary system in which there is variation and heredity, there is a tendency for diversity and complexity to increase. The law plays the same role in biology that Newton's first law plays in physics, explaining what biological systems are expected to do when no forces act, in other words, what happens when nothing happens. Here we offer a deeper explanation of certain features (...) of the law, develop a quantitative version of it, and explore its consequences for our understanding of diversity and complexity. (shrink)

This is the most important book on Hegel to have appeared in the past ten years. The author offers a completely new interpretation of Hegel's idealism that focuses on Hegel's appropriation and development of Kant's theoretical project. Hegel is presented neither as a pre-critical metaphysician nor as a social theorist, but as a critical philosopher whose disagreements with Kant, especially on the issue of intuitions, enrich the idealist arguments against empiricism, realism, and naturalism. In the face of the dismissal of (...) absolute idealism as either unintelligible or implausible, Pippin explains and defends an original account of the philosophical basis for Hegel's claims about the historical and social nature of self-consciousness and of knowledge itself. (shrink)

Human beings, like other organisms, are the products of evolution. Like other organisms, we exhibit traits that are the product of natural selection. Our psychological capacities are evolved traits as much as are our gait and posture. This much few would dispute. Evolutionary psychology goes further than this, claiming that our psychological traits -- including a wide variety of traits, from mate preference and jealousy to language and reason -- can be understood as specific adaptations to ancestral Pleistocene conditions. In (...) Evolutionary Psychology as Maladapted Psychology, Robert Richardson takes a critical look at evolutionary psychology by subjecting its ambitious and controversial claims to the same sorts of methodological and evidential constraints that are broadly accepted within evolutionary biology. The claims of evolutionary psychology may pass muster as psychology; but what are their evolutionary credentials? Richardson considers three ways adaptive hypotheses can be evaluated, using examples from the biological literature to illustrate what sorts of evidence and methodology would be necessary to establish specific evolutionary and adaptive explanations of human psychological traits. He shows that existing explanations within evolutionary psychology fall woefully short of accepted biological standards. The theories offered by evolutionary psychologists may identify traits that are, or were, beneficial to humans. But gauged by biological standards, there is inadequate evidence: evolutionary psychologists are largely silent on the evolutionary evidence relevant to assessing their claims, including such matters as variation in ancestral populations, heritability, and the advantage offered to our ancestors. As evolutionary claims they are unsubstantiated. Evolutionary psychology, Richardson concludes, may offer a program of research, but it lacks the kind of evidence that is generally expected within evolutionary biology. It is speculation rather than sound science -- and we should treat its claims with skepticism. (shrink)

The target article outlines a Future-State-Maximization approach whose focus on “rewarding” actions that lead to increased action possibilities serves as an alternative to standard value-….

The value ofPatriarcha as a historical document consists primarily inits revelation of the strength and persistence in Europeanculture of the patriarchal ...

Metaphysics, geometry, and the problems with diagrams -- The Pythagorean theorem: Euclid I.47 and VI.31 -- Thales and geometry: Egypt, Miletus, and beyond -- Pythagoras and the famous theorems -- From the Pythagorean theorem to the construction of the cosmos out of right triangles.

In the last 60,000 years humans have expanded across the globe and now occupy a wider range than any other terrestrial species. Our ability to successfully adapt to such a diverse range of habitats is often explained in terms of our cognitive ability. Humans have relatively bigger brains and more computing power than other animals and this allows us to figure out how to live in a wide range of environments. Here we argue that humans may be smarter than other (...) creatures, but none of us is nearly smart enough to acquire all of the information necessary to survive in any single habitat. In even the simplest foraging societies, people depend on a vast array of tools, detailed bodies of local knowledge, and complex social arrangements, and often do not understand why these tools, beliefs, and behaviors are adaptive. We owe our success to our uniquely-developed ability to learn from others. This capacity enables humans to gradually accumulate information across generations, and develop well-adapted tools, beliefs, and practices that are too complex for any single individual to invent during their lifetime. (shrink)

This book sets the record straight about the greater influence of Dilthey than Husserl in Heidegger’s initial formulation of his conception of phenomenology. Scharff shows how, in Heidegger’s early lecture courses, phenomenology is presented as a genuine philosophical alternative, and explores our own current need for a phenomenological philosophy.

L’auteur analyse la réglementation économique à travers ses effets allocatifs et redistributifs. Il met en évidence l’apparition de rentes découlant de l’adoption de la réglementation. La destination finale de ces rentes caractérise l’essentiel des effets redistributifs envisagés. Selon l’auteur, l’évaluation éthique d’une réglementation doit reposer sur le bien-fondé des effets redistributifs qui en découlent. La question centrale consistant à voir si la réglementation a pour effet de détourner les rentes d’une large majorité au profit d’un nombre restreint d’individus. L’article met (...) en évidence la manière dont on peut envisager une éthique de la réglementation comme un problème d’appropriation de rentes économiques du grand nombre vers un nombre plus restreint d’individus. (shrink)

This book seeks to reframe our understanding of the lawyer's work by exploring how Martin Luther King, Jr built his advocacy on a coherent set of moral claims regarding the demands of love and justice in light of human nature. King never shirked from staking out challenging claims of moral truth, even while remaining open to working with those who rejected those truths. His example should inspire the legal profession as a reminder that truth-telling, even in a society that often (...) appears morally balkanized, has the capacity to move hearts and minds. At the same time, his example should give the profession pause, for King's success would have been impossible without his substantive views about human nature and the ends of justice. This book is an effort to reframe our conception of morality's relevance to professionalism through the lens provided by the public and prophetic advocacy of Dr King. (shrink)

The fact that simplicity has been linked with induction by many philosophers of science, some of whom have proposed or supported criteria of “inductive simplicity,” means that the problem must be given some serious attention. I take “inductive simplicity” as a title, however, only by way of concession to these historical treatments, since it is precisely the burden of my paper to show that there is no such thing. So much for the conclusion. I shall spend the remainder of my (...) time arguing for it. (shrink)

Our thoughts about the world are clearly influenced by such things as point of view, temperament, past experience and culture. However, some thinkers go much further and argue that everything that exists depends on us, arguing that 'even reality is relative'. Can we accept such a claim in the face of events such as floods and other natural disasters or events seemingly beyond our control? 'Realists' argue that reality is independent of out thinking. 'Relativists' disagree, arguing that what there is (...) depends on our point of view. Which is right? Robert Kirk provides a crystal clear account of this debate from the Greek philosophers to Wittgenstein and Rorty. Along the way, he unpacks some of the more complicated issues surrounding ideas of objectivity, subjectivity, pragmatism and realism essential for those beginning any study of philosphy. (shrink)

In the decades since his death, Adorno's thinking has lost none of its capacity to unsettle the settled, and has proved hugely influential in social and cultural thought. To most people, the entertainment provided by television, radio, film, newspapers, astrology charts and CD players seem harmless enough. For Adorno, however, the culture industry that produces them is ultimately toxic in its effect on the social process. Here, Robert Witkin unpacks Adorno's notoriously difficult critique of popular culture in an engaging (...) and accessible style, looking first at the development of the overarching theories of authority, commodification and negative dialectics within which Adorno's work needs to be seen. This book is an essential guide for understanding one of the key thinkers of our time. (shrink)

Mourir pour la France, faire la guerre, tomber au champ d'honneur... Les jeunes générations y songent-elles encore? Il est vrai que la désacralisation de la chose militaire, propagée par l'hédonisme-pacifisme triomphant, a eu raison de cette aspiration traditionnelle. Le 14juillet des dernières décennies n'est-il pas devenu une fête pour la fête parmi tant d'autres, où les défilés militaires s'exposent au regard comme un spectacle de foire? L'Ecole a, elle-même, renoncé à exalter les vertus de la nation et de la patrie (...) tant glorifiées par la Révolution. Cette mise au ban du soldat comme de l'Histoire ne traduit-elle pas un déni de réalité caractérisé? Comme s'il suffisait de fermer les yeux sur les multiples motifs d'hostilité entre les Etats pour en neutraliser la bête noire : l'éternel retour de la guerre et de ses innombrables morts que l'esprit victimaire d'aujourd'hui récupère insidieusement. C'est oublier que la France ne serait pas la France sans ces guerres qui ont fait date, sans un choix décisif de société, sans un refus de se soumettre à la loi de l'Occupant. Bref, sans une certaine idée de la France... Les figures d'épouvantail successives sous lesquelles disparaît désormais le soldat - gendarme, bourreau, nazi, etc., - achèvent de brouiller le sens profond de son sacrifice. Où la part de sang versé et répandu, renforçant le lien de l'individu à la Nation, révèle aussi la part inconnue, transcendante, de l'homme face à la mort. Robert Redeker nous invite à explorer le gouffre d'incompréhension qui sépare le soldat de la société civile actuelle à la lumière d'un brillant arrière-plan philosophique et historique s'attachant à cerner l'essence de la guerre. (shrink)

'Nadeau and Kafatos supply plenty of food for thought: the apparently recondite concept of non-locality, they suggest, has consequences everywhere.'--Publisher's Weekly.

This book is a wide-ranging treatment of central topics in epistemology. It provides conceptions of belief and knowledge, offers a theory of how they are grounded in our experience and in the social context of testimony, and connects them with the will and with action, moral responsibility, and intellectual virtue.

I. the view that reasons cannot be causes. II. the view that the explanatory relevance of psychological states such as beliefs and intentions derives from their content, their explanatory role is not causal and we thus have no good reason to ascribe causal power to them. III. the idea that if the mental supervenes on the physical, then what really explains our actions is the physical properties determining our propositional attitudes, and not those attitudes themselves. IV. the thesis that since (...) there are no laws linking (intentional) mental states to actions, those states cannot be genuine causes of action. (shrink)

Darwin's theory of evolution by natural selection provided the first, and only, causal-mechanistic account of the existence of adaptations in nature. As such, it provided the first, and only, scientific alternative to the “argument from design”. That alone would account for its philosophical significance. But the theory also raises other philosophical questions not encountered in the study of the theories of physics. Unfortunately the concept of natural selection is intimately intertwined with the other basic concepts of evolutionary theory—such as the (...) concepts of fitness and adaptation —that are themselves philosophically controversial. Fortunately we can make considerable headway in getting clear on natural selection without solving all of those outstanding problems. (shrink)