13 found
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  1.  14
    Discovering.Robert Scott Root-Bernstein - 1989 - Bridgewater, NJ: Replica Books.
    Examines the processes of scientific creativity and discovery, and proposes a model of scientific development.
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  2.  23
    Age and Location in Severity of COVID‐19 Pathology: Do Lactoferrin and Pneumococcal Vaccination Explain Low Infant Mortality and Regional Differences?Robert Root-Bernstein - 2020 - Bioessays 42 (11):2000076.
    Two conundrums puzzle COVID‐19 investigators: 1) morbidity and mortality is rare among infants and young children and 2) rates of morbidity and mortality exhibit large variances across nations, locales, and even within cities. It is found that the higher the rate of pneumococcal vaccination in a nation (or city) the lower the COVID‐19 morbidity and mortality. Vaccination rates with Bacillus Calmette–Guerin, poliovirus, and other vaccines do not correlate with COVID‐19 risks, nor do COVID‐19 case or death rates correlate with number (...)
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  3.  19
    Autoimmunity and the microbiome: T‐cell receptor mimicry of “self” and microbial antigens mediates self tolerance in holobionts.Robert Root-Bernstein - 2016 - Bioessays 38 (11):1068-1083.
    I propose a T‐cell receptor (TcR)‐based mechanism by which immunity mediates both “genetic self” and “microbial self” thereby, connecting microbiome disease with autoimmunity. The hypothesis is based on simple principles. First, TcR are selected to avoid strong cross‐reactivity with “self,” resulting in selection for a TcR repertoire mimicking “genetic self.” Second, evolution has selected for a “microbial self” that mimics “genetic self” so as to share tolerance. In consequence, our TcR repertoire also mimics microbiome antigenicity, providing a novel mechanism for (...)
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  4.  65
    Aesthetic cognition.Robert S. Root-Bernstein - 2002 - International Studies in the Philosophy of Science 16 (1):61 – 77.
    The purpose of this article is to integrate two outstanding problems within the philosophy of science. The first concerns what role aesthetics plays in scientific thinking. The second is the problem of how logically testable ideas are generated (the so-called "psychology of research" versus "logic of (dis)proof" problem). I argue that aesthetic sensibility is the basis for what scientists often call intuition, and that intuition in turn embodies (in a literal physiological sense) ways of thinking that have their own meta-logic. (...)
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  5.  48
    Compositional complementarity and prebiotic ecology in the origin of life.Axel Hunding, Francois Kepes, Doron Lancet, Abraham Minsky, Vic Norris, Derek Raine, K. Sriram & Robert Root-Bernstein - 2006 - Bioessays 28 (4):399-412.
    We hypothesize that life began not with the first self‐reproducing molecule or metabolic network, but as a prebiotic ecology of co‐evolving populations of macromolecular aggregates (composomes). Each composome species had a particular molecular composition resulting from molecular complementarity among environmentally available prebiotic compounds. Natural selection acted on composomal species that varied in properties and functions such as stability, catalysis, fission, fusion and selective accumulation of molecules from solution. Fission permitted molecular replication based on composition rather than linear structure, while fusion (...)
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  6.  30
    Mendel and Methodology.Robert Scott Root-Bernstein - 1983 - History of Science 21 (3):275-295.
  7.  36
    The sciences and arts share a common creative aesthetic.Robert S. Root-Bernstein - 1996 - In Alfred I. Tauber (ed.), The elusive synthesis: aesthetics and science. Boston: Kluwer Academic Publishers. pp. 49--82.
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  8.  36
    How scientists really think.Robert S. Root-Bernstein - 1989 - Perspectives in Biology and Medicine 32 (4):472-488.
  9. Editorial. Special Issue on Integral Biomathics: Can Biology Create a Profoundly New Mathematics and Computation?Plamen L. Simeonov, Koichiro Matsuno & Robert S. Root-Bernstein - 2013 - J. Progress in Biophysics and Molecular Biology 113 (1):1-4.
    The idea behind this special theme journal issue was to continue the work we have started with the INBIOSA initiative (www.inbiosa.eu) and our small inter-disciplinary scientific community. The result of this EU funded project was a white paper (Simeonov et al., 2012a) defining a new direction for future research in theoretical biology we called Integral Biomathics and a volume (Simeonov et al., 2012b) with contributions from two workshops and our first international conference in this field in 2011. The initial impulse (...)
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  10.  19
    Simultaneous origin of homochirality, the genetic code and its directionality.Robert Root-Bernstein - 2007 - Bioessays 29 (7):689-698.
    The origin of homochirality in molecules characterizing living systems has remained a mystery since Pasteur's recognition of the problem some 150 years ago.2-5 Most theories also assume that homochirality emerged in one class of molecules (e.g. ribose) from which it was enriched in other molecules (e.g. amino acids) as well.2-5 I propose a novel, experimentally testable hypothesis describing a process by which selective chirality in amino acids and ribonucleotides emerged simultaneously and hand-in-hand with the origin and directionality of the genetic (...)
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  11.  18
    Macroevolution.Robert Root-Bernstein - 2009 - Bioessays 31 (2):253-254.
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  12.  20
    The development and dissemination of non-patentable therapies (NPTs).Robert S. Root-Bernstein - 1994 - Perspectives in Biology and Medicine 39 (1):110-117.
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  13.  10
    COVID‐19 coagulopathies: Human blood proteins mimic SARS‐CoV‐2 virus, vaccine proteins and bacterial co‐infections inducing autoimmunity. [REVIEW]Robert Root-Bernstein - 2021 - Bioessays 43 (12):2100158.
    Severe COVID‐19 is often accompanied by coagulopathies such as thrombocytopenia and abnormal clotting. Rarely, such complications follow SARS‐CoV‐2 vaccination. The cause of these coagulopathies is unknown. It is hypothesized that coagulopathies accompanying SARS‐CoV‐2 infections and vaccinations result from bacterial co‐infections that synergize with virus‐induced autoimmunity due to antigenic mimicry of blood proteins by both bacterial and viral antigens. Coagulopathies occur mainly in severe COVID‐19 characterized by bacterial co‐infections with Streptococci, Staphylococci, Klebsiella, Escherichia coli, and Acinetobacter baumannii. These bacteria express unusually (...)
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