PurposeTo use the power of knowledge acquisition and machine learning in the development of a collaborative computer classification system based on the features of age-related macular degeneration (AMD).MethodsA vocabulary was acquired from four AMD experts who examined 100 ophthalmoscopic images. The vocabulary was analyzed, hierarchically structured, and incorporated into a collaborative computer classification system called IDOCS. Using this system, three of the experts examined images from a second set of digital images compiled from more than 1000 patients with AMD. Images (...) were annotated, and features were identified and defined. Decision trees, a machine learning method, were trained on the data collected and used to extract patterns. Interrelationships between the data from the different clinicians were investigated.ResultsSix drusen classes in the structured vocabulary were largely sufficient to describe all the identified features. The decision trees classified the data with 76.86% to 88.5% accuracy and distilled patterns in the form of hierarchical trees composed of 5 to 15 nodes. Experts were largely consistent in their characterization of soft, and to a lesser extent, hard drusen, but diverge in definition of other drusen. Size and crystalline morphology were the main determinants of drusen type across all experts.ConclusionsMachine learning is a powerful tool for the characterization of disease phenotypes. The creation of a defined feature set for AMD will facilitate the development of an IDOCS-based classification system. (shrink)

Too often in economics the understanding of how things work by and large--not axiomatically or categorically--and the idea that we generally cannot know the economic system well enough to intervene into it beneficially are done less than justice. Yet they were Adam Smith's central messages for public policy, and they authorized a presumption of liberty, thus exceptions to liberty should be treated as exceptional and bear the burden of proof.In Knowledge and Coordination, Daniel Klein reexamines the elements of economic (...) liberalism. He interprets Friedrich Hayek's notion of spontaneous order from the aestheticized perspective of an allegorical Smithian spectator. Klein addresses issues economists have had surrounding the notion of coordination by distinguishing the concatenate coordination of Hayek, Ronald Coase, and Michael Polanyi from the mutual coordination of Thomas Schelling and game theory. Clarifying the meaning of "cooperation," he resolves debates over whether entrepreneurial innovation enhances or upsets coordination. Entrepreneurship is interpreted in terms of discovery, or new knowledge. He points out that beyond information, knowledge entails interpretation and judgment. Rejecting homo economicus, Klein offers a distinctive formulation of knowledge economics, entailing asymmetric interpretation, judgment, entrepreneurship, error and correction. This richness of knowledge joins agent and analyst, and meaningful theory depends on tacit affinities between the two, even common contacts with an allegorical spectator. Knowledge and Coordination illuminates the recurring connections to underlying purposes and sensibilities, of analysts as well as agents. Knowledge and Coordination is an imaginative and insightful take on how, by confessing the looseness of its judgments and the by-and-large status of its claims, laissez-faire liberalism makes its economic doctrines more robust and its presumption of liberty more viable. (shrink)

Adam Smith and Friedrich Hayek saw the liberty principle as focal and accorded it strong presumption, but their wisdom invokes how little we can know. In Knowledge and Coordination, Daniel Klein re-examines the elements of economic liberalism. He interprets Hayek's notion of spontaneous order from the aestheticized perspective of a Smithian spectator, real or imagined. Klein addresses issues economists have had surrounding the notion of coordination by distinguishing the concatenate coordination of Hayek, Ronald Coase, and Michael Polanyi (...) from the mutual coordination of Thomas Schelling and game theory. Clarifying the meaning of cooperation, he resolves debates over whether entrepreneurial innovation enhances or upsets coordination, and thus interprets entrepreneurship in terms of discovery or new knowledge. Beyond information, knowledge entails interpretation and judgment, emergent from tacit reaches of the "society of mind," itself embedded in actual society. Rejecting homo economicus in favor of the "deepself," Klein offers a distinctive formulation of knowledge economics, entailing asymmetric interpretation, judgment, entrepreneurship, error, and correction-and kinds of discovery-which all serve the cause of liberty. This richness of knowledge joins agent and analyst, and meaningful theory depends on tacit affinities between the two. Knowledge and Coordination highlights the recurring connections to underlying purposes and sensibilities, of analysts as well as agents. Behind economic talk of market communication and social error and correction lies Klein's Smithian allegory, with the allegorical spectator representing a conception of the social. Knowledge and Coordination instructs us to declare such allegory. Knowledge and Coordination is an authoritative take on how, by confessing the looseness of its judgments and the by-and-large status of its claims, laissez-faire liberalism makes its economic doctrines more robust and its presumption of liberty more viable. (shrink)

Science fiction is fast becoming reality as scientists and engineers seek to develop new ways of directly accessing and controlling our brains through brain-computer and even brain-to-brain interfaces. If such research is to receive continuing public approval and support—and not invite opposition—it must anticipate the special ethical challenges it creates. By pointing to some of the acute concerns raised by neural engineering technologies—around issues of identity, normality, authority, responsibility, privacy, and justice—Eran Klein and colleagues model and stimulate the kind (...) of reflection that will be needed as new brain technologies are developed. And yet, as I read their informative discussion, I find myself asking even more questions. One concerns the ethical novelty of these technologies. For example, in terms of questions of identity, normality, responsibility, and authority, how different is deep brain stimulation from the potent psychiatric drugs that have been administered for decades? How different in terms of issues of liability associated with malfunction or misuse are brain-computer interfaces from other complex devices now routinely in use? Neither ethics nor law will have to rethink things from scratch as new neural devices and capabilities are introduced: the groundwork for answering some of these questions has already been laid in a variety of fields from bioethics, to health and product liability law. Nevertheless, I conclude that there are new questions here. It is not simply the fact that neural technologies pose questions of identity, privacy, and the like but that they do so with a degree of intensity that creates qualitatively new challenges. (shrink)

This is the first publication of these ideas in book form. 'It is a rare treat--important, original philosophy that is also a pleasure to read.

This chapter contains section titled: Part I Part II Part III Part IV.

Der Hermann Heller der frühen Bundesrepublik : Wolfgang Abendroth zum 100. Geburtstag -- Richard Rorty und das Entzücken am Schock der Deflationierung -- "... and to define America, her athletic democracy" : im Andenken an Richard Rorty -- Wie die ethische Frage zu beantworten ist : Derrida und die Religion -- Derridas klärende Wirkung : ein letzter Gruss -- Ronald Dworkin : ein Solitär im Kreise der Rechtsgelehrten -- Ein avantgardischer Spürsinn für Relevanzen : die Rolle des Intellektuellen und (...) die Sache Europas -- Europa und sine Immigranten -- Europa in der Sackgasse : Plädoyer für eine Politik der abgestuften Integration -- Medien, Märkte und Konsumenten : die seriöse Presse als Rückgrat der politischen Öffentlichkeit -- Hat die Demokratie noch eine epistemische Dimension? : empirische Forschung und normative Theorie. (shrink)

Many people assume that the claims of scientists are objective truths. But historians, sociologists, and philosophers of science have long argued that scientific claims reflect the particular historical, cultural, and social context in which those claims were made. The nature of scientific knowledge is not absolute because it is influenced by the practice and perspective of human agents. Scientific Perspectivism argues that the acts of observing and theorizing are both perspectival, and this nature makes scientific knowledge contingent, as Thomas Kuhn (...) theorized forty years ago. Using the example of color vision in humans to illustrate how his theory of “perspectivism” works, Ronald N. Giere argues that colors do not actually exist in objects; rather, color is the result of an interaction between aspects of the world and the human visual system. Giere extends this argument into a general interpretation of human perception and, more controversially, to scientific observation, conjecturing that the output of scientific instruments is perspectival. Furthermore, complex scientific principles—such as Maxwell’s equations describing the behavior of both the electric and magnetic fields—make no claims about the world, but models based on those principles can be used to make claims about specific aspects of the world. Offering a solution to the most contentious debate in the philosophy of science over the past thirty years, Scientific Perspectivism will be of interest to anyone involved in the study of science. (shrink)

The underlying thesis of the research in ethical autonomy for lethal autonomous unmanned systems is that they will potentially be capable of performing more ethically on the battlefield than are human soldiers. In this article this hypothesis is supported by ongoing and foreseen technological advances and perhaps equally important by an assessment of the fundamental ability of human warfighters in today's battlespace. If this goal of better-than-human performance is achieved, even if still imperfect, it can result in a reduction in (...) noncombatant casualties and property damage consistent with adherence to the Laws of War as prescribed in international treaties and conventions, and is thus worth pursuing vigorously. (shrink)

In Dangerous Minds, Ronald Beiner traces the deeper philosophical roots of such far-right ideologues as Richard Spencer, Aleksandr Dugin, and Steve Bannon, to the writings of Nietzsche and Heidegger—and specifically to the aspects of their thought that express revulsion for the liberal-democratic view of life.

This paper examines the issue of what the self is by reviewing neuropsychological research,which converges on the idea that the self may be more complex and differentiated than previous treatments of the topic have suggested. Although some aspects of self-knowledge such as episodic recollection may be compromised in individuals, other aspects—for instance, semantic trait summaries—appear largely intact. Taken together, these findings support the idea that the self is not a single, unified entity. Rather, it is a set of interrelated, functionally (...) independent systems. Implications for understanding the self in various areas of psychological research—e.g., neuroimaging, autism, amnesia, Alzheimer’s disease, and mirror self-recognition—are discussed in brief. (shrink)

All these specialist aspects of one life are different facets of the intellectual diamond which scintillates in the huge quarry of The Bertrand Russell Archives at McMaster University, Hamilton, Ontario. This is the quintessential man, the bundle of contradictions passionately dedicated to intellect, at times carrying the rational argument to irrational extremes; the natural-born emotional adventurer forever hampered by orphaned youth and too-early marriage. This Russell in the round is greater than the sum of his constituent parts, a man of (...) epic proportions, struggling through a lifetime beset with frustration and near-disaster; in youth the constitutional sceptic, in old age the sometimes splendid figure with "courage never to submit or yield.". (shrink)

The allegedly alternative theories of Phyletic Gradualism and Punctuated Equilibria are examined as regards the nature of their differences. The explanatory value of both models is determined by establishing their actual connection with reality. It is concluded that they are to be considered complementary rather than mutually exclusive at all levels of infraspecific, specific, and supraspecific evolution. So, in order to be described comprehensively, the pathways of evolution require at least two distinct models, each based on a discrete range of (...) real phenomena. [Phyletic Gradualism; Punctuated Equilibria; evolutionary theories; divergence models; additive speciation; microevolution; macroevolution; anagenesis.]. (shrink)

Inner speech is commonly understood as the conscious experience of a voice within the mind. One recurrent theme in the scientific literature is that the phenomenon involves a representation of overt speech, for example, a representation of phonetic properties that result from a copy of speech instructions that were ultimately suppressed. I propose a larger picture that involves some embodied objects and their misperception. I call it “the Body Error Theory,” or BET for short. BET is a form of illusionism, (...) but the particular version I favor is a cross-modal illusion. Newly described here, my hypothesis is that the experience of inner speech arises from a mix of interoception and audition. Specifically, there is the detection of slight but well-confirmed activities in the speech musculature that occur during inner speech, which helps to transform representations of normal but quiet nonverbal sounds that inevitably occur during inner speech, from breathing to background noise, into a mistaken perception of inner speech. Simply put, activities in the speech musculature mix with sounds to create the appearance of speech sounds, which thus explains the “voice within the mind.” I also show how BET’s cross-modal system fits with standard information processing accounts for speech monitoring and how it accommodates the central insights of leading theories of inner speech. In addition, I show how BET is supported by data from experience-sampling surveys and how it can be empirically tested against its rivals. (shrink)

The part that the university plays is increasingly of external and economic value, ignoring the importance of the value of knowledge in itself. By analyzing the university's current relationship with knowledge, this book tackles the problem head-on. It considers how the concept of knowledge can be reclaimed in an era of post truth and alternative fact, provides conceptual tools for people to think and debate about knowledge and education in new ways and offers a clear focus for the future development (...) of academia. This fascinating book is recommended reading to anyone engaged with the idea of rethinking universities in the 21st century. (shrink)

Meaning and communication -- Mighty dead: Kant and Hegel -- Scorekeeping -- Sentence meaning, term meaning, Anaphora -- Empirical content and empirical knowledge -- Logical discourse -- Representation and communication -- Objectivity and phenomenalism about norms.

Forty years ago, Vaughn Ball demonstrated that the then received notion of conditional relevance served no useful purpose, as it would only come into effect if the probability of an element were 0.0. But, if the probability of an element were 0.0, a directed verdict would be in order and so once again conditional relevancy was doing no work. I extended that analysis to include the relationship between proffers of evidence and facts of consequence to demonstrate that the work that (...) conditional relevancy was supposedly doing was isomorphic to that done by relevancy in all significant ways, and yet the Federal Rules of Evidence provide different standards for the two situations to determine admissibility. I thus proposed an amendment to FRE 104(b) to provide for the same standard to be applied to ‘relevancy’ and ‘conditional relevancy’. In a recent article, Matthew Kotzen appears to subject this work to intense scrutiny and criticism, yet at the same time reaches, so far as I can tell, identical conclusions. This raises the question, which I examine, whether this is an example of cross-disciplinary difficulties in communication. (shrink)

In this paper I explore the extent to which a perspectival understanding of scientific knowledge supports forms of “scientific pluralism.” I will not initially attempt to formulate a general characterization of either perspectivism or scientific pluralism. I assume only that both are opposed to two extreme views. The one extreme is a (monistic) metaphysical realism according to which there is in principle one true and complete theory of everything. The other extreme is a constructivist relativism according to which scientific claims (...) about any reality beyond that of ordinary experience are merely social conventions. (shrink)

The trials of life can wear us down. Unexpected events force us to face a new reality and unanswered prayers lead us to a growing frustration about why God doesn't intervene. We wonder if anything good can come out of this painful, dark, winter season. Grace Wabuke Klein knows that there is purpose in our darkest days and seasons of waiting. In Flourish, Grace meets the reader in their heartache, disappointment, and pain and gives encouragement and a fresh perspective (...) on the winter seasons we all go through, as well as practical steps to not just survive but to find purpose in the unknown and unexpected. Drawing insight from her own winter seasons, Grace reveals the divine purpose in each season of our lives. She explains how: -Fall is a time of release-a necessary season of letting go of offenses, unhealthy relationships, hurts, bad habits, toxic friendships, pride, unforgiveness and other heart issues before we can ever move on to the next season -Winter is a time of unexpected challenges and unknown futures-yet lessons learned in life's storms are deep and full of growth to shape us and makes us stronger. -Spring is a time of new things that require us to be open to new experiences, people, ideas, and perspective-stepping out into the unknown and uncomfortable. -Summer is a time when everything is flourishing-we clearly see how each season cultivated a deeper level of faith and spiritual muscles, developing our character and perseverance. Grace discovered there is value and unseen gifts in each season, but only in the hard seasons and storms of life are vital spiritual disciplines developed. Flourish connects with the reader in the tension and storms of life to bring a word of hope. (shrink)

The Ethical, Legal, and Social Implications (ELSI) program of the Human Genome Project stands as a model for how to organize bioethical inquiry for a rapidly changing field. Neuroscience has experienced significant growth in recent years and there is increasing interest in organizing critical reflection on this field, as evidenced by the creation of “neuroethics.” A nascent framework for reflection on the implications of neuroscience is emerging but significant work remains, given the pace and scope of neuroscientific developments. The adoption (...) of an ELSI program, modeled on that of the ELSI program of the Human Genome Project, promises a way for neuroscience to meet important organizational, educational, and policy objectives. Review of recent criticisms of the HGP ELSI program suggests that an ELSI program for neuroscience would face certain obstacles. Those interested in a neuroscience ELSI program will need to develop appropriate resources to overcome these obstacles. (shrink)

Secularization has accelerated. From 1981 to 2007, most countries became more religious, but from 2007 to 2020, the overwhelming majority became less religious. For centuries, all major religions encouraged norms that limit women to producing as many children as possible and discourage any sexual behavior not linked with reproduction. These norms were needed when facing high infant mortality and low life expectancy but require suppressing strong drives, and are rapidly eroding. These norms are so strongly linked with religion that abandoning (...) them undermines religiosity. Religion became pervasive because it was conducive to survival, encouraged sharing when there was no social security system, and it is conducive to mental health and coping with insecure conditions. People need coherent belief systems, but religion is declining. What comes next? The Nordic countries have consistently been at the cutting edge of cultural change. Protestantism left an enduring imprint, but the 20th Century welfare added universal health coverage, high levels of state support for education, welfare spending, child care, pensions and an ethos of social solidarity. These countries are also characterized by rapidly declining religiosity. Does this portend corruption and nihilism? Apparently not. These countries lead the world on numerous indicators of a well-functioning society, including economic equality, gender equality, low homicide rates, subjective well-being, environmental protection and democracy. They have become less religious, but their people have high levels of interpersonal trust, tolerance, honesty, social solidarity and commitment to democratic norms. The decline of religiosity has far-reaching implications. This book explores what comes next. (shrink)

In this essay I argue that T. S. Kuhn, at least in his later works, can be regarded as a perspectival realist. This is a retrospective interpretation based mainly on the essays published posthumously under the title The Road Since Structure (Kuhn 2000). Among the strongest grounds for this interpretation is that Kuhn explicitly states that one must have a “lexicon” in place before raising questions about the truth or falsity of claims made using elements of the lexicon. This, in (...) a linguistic framework, can be understood as an affirmation of perspectival realism. The essay concludes with an examination of Donald Davidson’s famous paper, “On The Very Idea of a Conceptual Scheme,” arguing, along lines Kuhn himself suggested, that Davidson’s presentation is no threat to his notion of a conceptual scheme, or, I would add, a theoretical perspective. (shrink)

Adopting the stage metaphor suggested in Brown’s review, and treating Scientific perspectivism as a play in five acts, I respond to his review as a playwright might respond to a generally favorable review. Taking the reader behind the stage door, I discuss the playwright’s intentions for each act, paying special attention to the expected audience for the play as a whole. The result, therefore, supplements the review from the standpoint of the playwright. It also provides answers to some of the (...) reviewer’s questions.Keywords: Matthew Brown; Scientific perspectivism. (shrink)

Talk of a “genetic program” has become almost as common in cell and evolutionary biology as talk of “genetic information”. But what is a genetic program? I understand the claim that an organism’s genome contains a program to mean that its genes not only carry information about which proteins to make, but also about the conditions in which to make them. I argue that the program description, while accurate in some respects, is ultimately misleading and should be abandoned. After that, (...) I sketch an alternative framework which is better suited to capturing the full informational nature of genes. This framework is centered on the notion of a signaling game, as originally developed by David Lewis, but expanded upon considerably by Brian Skyrms in more recent years. On the view I develop, genes turn out to be the producers and consumers of regulatory or developmental information, rather than entities encoding such information. This finding has consequences that link up with a broader debate in the philosophy of biology concerning inheritance systems. I take this to be one form of theoretical payoff that results from applying the signaling games framework to genes. (shrink)

Although the dream narrative, of (bio)logical necessity, originates with the dreamer, s/he typically does not know this. For the dreamer, the dream world is the real world. In this article I argue that this nightly misattribution is best explained in terms of the concept of mental ownership (e.g., Albahari, 2006; Klein, 2015a; Lane, 2012). Specifically, the exogenous nature of the dream narrative is the result of an individual assuming perspectival, but not personal, ownership of content s/he authored (i.e., “The (...) content in my head is not mine. Therefore it must be peripherally perceived”). Situating explanation within a theoretical space designed to address questions pertaining to the experienced origins of conscious content has a number of salutatory consequences. For example, it promotes predictive fecundity by bringing to light empirical generalizations whose presence otherwise might have gone unnoticed (e.g., the severely limited role of mental time travel within the dream narrative). -/- . (shrink)

Kritische beschouwingen over wijsgerig-ethische kwesties.

Discussions about brain data and privacy, particularly those advocating for human rights frameworks, at times, have embodied problematic undercurrents of, if not overt appeals to, neuro-exceptional...

INTERVENTION AND REFLECTION: BASIC ISSUES IN BIOETHICS, 10th Edition offers students a compelling introduction to biomedical ethics by combining riveting human stories with clear explanations of cutting edge scientific research. A collaboration between a nationally-acclaimed bioethicist and a seasoned journalist, this textbook continues to be the most widely used bioethics textbook on the market. Each chapter includes crisp summaries of the relevant ethical theories as well as classic and contemporary articles on the most pressing topics in the field. This edition (...) features new chapters on "Medicine in a Pluralistic Society" and the "Challenge of Global Bioethics. The accessible presentation of the conceptual debate and human dimension of today's biomedical ethics captivates and engages students, whether they are philosophy, nursing or medical majors or have no philosophical or scientific training. (shrink)

Ist der menschliche Intellekt materiell? Oder können wir mit Verweis auf seine intentionalen Tätigkeiten wie allgemeine Erkenntnis oder Selbsterkenntnis zeigen, dass er immateriell ist? Besteht also ein Zusammenhang zwischen Intentionalität und Immaterialität? Mit Philosophie des Geistes im Spätmittelalter bietet Martin Klein eine umfassende Darstellung der Philosophie des Geistes von Johannes Buridan im Zusammenhang seiner Erkenntnistheorie, Metaphysik und Naturphilosophie. Vor dem Hintergrund neuester Editionen wird Buridan im Kontext der spätmittelalterlichen Debatte über die Natur des menschlichen Intellekts und seine kognitiven Vermögen (...) prätsentiert. In this volume, Martin Klein offers a comprehensive account of John Buridan's philosophy of mind in the context of the late medieval debate about the nature of the human intellect and how this influences its cognitive functioning. (shrink)

Scientific realism is a doctrine that was both in and out of fashion several times during the twentieth century. I begin by noting three presuppositions of a succinct characterization of scientific realism offered initially by the foremost critic in the latter part of the century, Bas van Fraassen. The first presupposition is that there is a fundamental distinction to be made between what is “empirical” and what is “theoretical”. The second presupposition is that a genuine scientific realism is committed to (...) their being “a literally true story of what the world is like”. The third presupposition is that there are methods for justifying a belief in the empirical adequacy of a theory which do not also suffice to justify beliefs in its literal truth. Each of these presuppositions raises a number of problems, some of which are quite old and others rather newer. In each case, I briefly review some of the old problems and then elaborate the newer problems. (shrink)

Julia Driver has argued that there is a class of virtues that are compatible with or even require that an agent be ignorant in some respect. In this paper I argue for an alternative conception of the relationship between ignorance and virtue. The dispositions constitutive of virtue must include sensitivity to human limitations and fallibility. In this way the virtues accommodate ignorance, rather than require or promote it. I develop my account by considering two virtues in particular: tolerance (the paradigm (...) for my account) and modesty (which Driver employs as the paradigm for her account). Although several philosophers have offered alternatives to Driver's account of modesty and others have discussed tolerance as a moral virtue, an adequate account of the role of ignorance in the specification of the virtues generally has yet to be provided. I believe that similarities between the two virtues are instructive for defining that role. (shrink)

This first book-length study of Paul Tillich's ethics is drawn from research in the Harvard Archives and fifty years of teaching Tillich's social-political thought. In Ronald H. Stone's fourth work on Tillich's philosophy the ethic is examined from the early ontological to socialist ethics to his own final principled-situationalist ethic in late life. Unique to this study is the in-depth inquiry into Tillich's courageous social action correlated with his own philosophical-theological ethic. The book moves from an early socialist rally (...) in Berlin, through the wars, dialogue with John Foster Dulles about post-war planning, debates about nuclear deterrence, to Buddhist Christian dialogue. The author's own preference for the late ethic of the philosopher informs the inquiries into the earlier radical Tillich. The conclusion provides a synthesis of the vast sources of Tillich's ethics and presents twelve themes summarizing sources and future resources for ethics from his life's work. (shrink)

The Effect: An Introduction to Research Design and Causality is about research design, specifically concerning research that uses observational data to make a causal inference. It is separated into two halves, each with different approaches to that subject. The first half goes through the concepts of causality, with very little in the way of estimation. It introduces the concept of identification thoroughly and clearly and discusses it as a process of trying to isolate variation that has a causal interpretation. Subjects (...) include heavy emphasis on data-generating processes and causal diagrams. Concepts are demonstrated with a heavy emphasis on graphical intuition and the question of what we do to data. When we "add a control variable" what does that actually do? (shrink)