The U.S. Food and Drug Administration's rationale for supporting the development and approval of BiDil for heart failure specifically in black patients was based on under-powered, post hoc subgroup analyses of two relatively old trials , which were further complicated by substantial covariate imbalances between racial groups. Indeed, the only statistically significant difference observed between black and white patients was found without any adjustment for potential confounders in samples that were unlikely to have been adequately randomized. Meanwhile, because the accepted (...) baseline therapy for heart failure has substantially improved since these trials took place, their results cannot be combined with data from the more recent trial amongst black patients alone. There is therefore little scientific evidence to support the approval of BiDil only for use in black patients, and the FDA's rationale fails to consider the ethical consequences of recognizing racial categories as valid markers of innate biological difference, and permitting the development of group-specific therapies that are subject to commercial incentives rather than scientific evidence or therapeutic imperatives. This paper reviews the limitations in the scientific evidence used to support the approval of BiDil only for use in black patients; calls for further analysis of the V-HeFT I and II data which might clarify whether responses to H-I vary by race; and evaluates the consequences of commercial incentives to develop racialized medicines. We recommend that the FDA revise the procedures they use to examine applications for race-based therapies to ensure that these are based on robust scientific claims and do not undermine the aims of the 1992 Revitalization Act. (shrink)

Brain-centered theories of consciousness seem to face insuperable difficulties. While some philosophers now doubt that the hard problem of consciousness will ever be solved, others call for radically new approaches to conscious experience. In this article I resurrect a largely forgotten approach to consciousness known as neorealism. According to neorealism, consciousness is merely a part, or cross-section, of the environment. Neorealism implies that all conscious experiences, veridical or otherwise, exist outside of the brain and are wholly independent of being perceived (...) or not; nonveridical perceptions of the environment over an arbitrarily short period of time are supposed to be objective constituents of the environment over a more extended time scale. I argue here that neorealism fares at least as well as brain-centered theories of consciousness on a number of fundamental issues. On one fundamental issue—the nature of the relation between veridical and nonveridical perceptions—neorealism outperforms its competitors. (shrink)

Of the philosophers in recent times who have striven to heal this rupture between head and heart perhaps none has caught the fancy or stirred the hopes of the American philosophical community as Alfred North Whitehead has. But since the master started this task too late in life, it was left to his disciples to complete his work. And of those disciples who have continued the master's healing in theology, perhaps none has been so energetic or resourceful as Professor (...) Charles Hartshorne. While Professor Hartshorne has usually practised this therapy alone and unaided, he has on one notable occasion enlisted the aid both of another contemporary theological therapist, Professor William L. Reese, and also of most of the great philosophers in history. The fruit of this collaboration, Philosophers Speak of God, while not adding anything essentially novel to Professor Hartshorne's earlier work, presents the physician not only as an isolated laboratory researcher but also, with Professor Reese's help, in the process of actually confronting and healing his patients. Hence this book is an especially interesting and valuable case study of one type of contemporary attempt to cure theological schizophrenia. Theological therapists are to be found among scientists as well as among philosophers, moreover, for even in science the intellect does not- succeed in quieting the restless heart until it finds the God for which that restless heart seeks. Going "through the world with a reverent attitude yet an almost total absence of doctrine or belief--with a religious heart and a skeptical head... is," as we are told in a recent book representing this theological therapy from the point of view of a scientist--a biologist and natural historian--Alexander F. Skutch's The Quest of the Divine, "a most unsatisfactory way to live.". (shrink)

The emphasis on more overt managerial actions by primary school head teachers is considered, in relation to the effects of this change on their work‐styles. Methods of studying managerial work are highlighted before the outcomes of North American and Australian research on elementary school principalship are offered. The lack of systematisation and the methodological weaknesses in the British research on primary headship are highlighted, while a survey of recent research reveals the limited knowledge. It is argued that systematic study (...) of head teacher activity could be a valuable tool in refining models for head teacher development. (shrink)

Determining how we use our body to support cognition represents an important part of understanding the embodied and embedded nature of cognition. In the present investigation, we pursue this question in the context of a common perceptual task. Specifically, we report a series of experiments investigating head tilt (i.e., external normalization) as a strategy in letter naming and reading stimuli that are upright or rotated. We demonstrate that the frequency of this natural behavior is modulated by the cost of (...) stimulus rotation on performance. In addition, we demonstrate that external normalization can benefit performance. All of the results are consistent with the notion that external normalization represents a form of cognitive offloading and that effort is an important factor in the decision to adopt an internal or external strategy. (shrink)

Different explanations of color vision favor different philosophical positions: Computational vision is more compatible with objectivism (the color is in the object), psychophysics and neurophysiology with subjectivism (the color is in the head). Comparative research suggests that an explanation of color must be both experientialist (unlike objectivism) and ecological (unlike subjectivism). Computational vision's emphasis on optimally prespecified features of the environment (i.e., distal properties, independent of the sensory-motor capacities of the animal) is unsatisfactory. Conceiving of visual perception instead as (...) the visual guidance of activity in an environment that is determined largely by that very activity suggests new directions for research. (shrink)

What makes us human? Why do people think, feel and act as they do? What is the essence of human nature? What is the basic relationship between the individual and society? These questions have fascinated both great thinkers and ordinary humans for centuries. Now, at last, there is a solid basis for answering them, in the form of accumulated efforts and studies by thousands of psychology researchers. We no longer have to rely on navel-gazing and speculation to understand why people (...) are the way they are - we can instead turn to solid, objective findings. This book, by an eminent social psychologist at the peak of his career, not only summarizes what we know about people - it also offers a coherent, easy-to-understand, though radical, explanation. Turning conventional wisdom on its head, the author argues that culture shaped human evolution. Contrary to theories that depict the individual's relation to society as one of victimization, endless malleability, or just a square peg in a round hole, he proposes that the individual human being is designed by nature to be part of society. Moreover, he argues that we need to briefly set aside the endless study of cultural differences to look at what most cultures have in common - because that holds the key to human nature. Culture is in our genes, although cultural differences may not be. This core theme is further developed by a powerful tour through the main dimension of human psychology. What do people want? How do people think? How do emotions operate? How do people behave? And how do they interact with each other? The answers are often surprising, and along the way the author explains how human desire, thought, feeling, and action are connected. (shrink)

All 24 secondary schools in a West Midlands local education authority were visited and a structured interview was conducted with the head or another senior teacher. An interview schedule was used to record details concerning the rule structure which had been established to control the conduct of the pupils. Information was also gathered about the sanctions and rewards used to maintain this behaviour and from most schools copies of the rules were available. It was found that almost all schools (...) had rule systems that were in written form and that these were made available to staff and students, chiefly through booklets or other material given to pupils when they first enrolled. All schools backed up their rules, whether written or not by a series of sanctions, most of which related to non?conforming behaviour. Some sanctions were applied to poor work but this was usually treated by special provision or special tutoring. Most also used rewards but these tended to be reserved for good performance. There were few cases where good behaviour was found to be rewarded systematically in any way. (shrink)

analogy, the similarity along with difference, among meanings, among sorts of thinking, and among realities. Analogy theory ori­ginated with *Aristotle in its three main parts: analogy of meaning, analogous thinking, and analogy of being. There were some ante­cedents in *Plato, where the names of Forms and of participating things are the same but differ in meaning, and the notion of ‘being’ is said to differ with what we are talking about, for example Forms versus physical things (Sophist). Systematic use of (...) the three elem­ents to unify philosophy and to resolve problems is, however, Aristotle's invention along with the idea that *metaphor is a species of analogy. Aristotle distinguished what were later called analogies of attribution, based on causation, signs, symptoms, and represen­tations (medical skill, medical supplies; hat/head cover, hat/in pic­ture), from analogy based on proportionality, A: B :: C : D; where the common implicit predicate is related in meaning (supplied food. (shrink)

Commenting on the passage in Revelation which says that the people would have the Father's name written on their foreheads, Chapman writes, "The pineal gland, situated about the middle of the head is the 'spiritual gland,' the gland which connects the focalization of the outer, human consciousness with Father-Consciousness."--R. F. T.

The “information age” is often thought in terms of the digital revolution that begins with Turing’s 1937 paper, “On computable numbers, with an application to the Entscheidungsproblem.” However, this can only be partially correct. There are two aspects to Turing’s work: one dealing with questions of computation that leads to computer science and another concerned with building computing machines that leads to computer engineering. Here, we emphasize the latter because it shows us a Turing connected with mechanisms of information flow (...) rather than solely with the mathematical and logical problems of computability for which he is better known. Our reasons for doing so will become clear in what follows. In fact, the 1937 paper just mentioned provides a general schematic for building a computing machine; this mechanical connection puts Turing on an historical continuum with others who discovered mechanisms to cope with information. Of those involved in this quest in the 19th Century, two people in particular, Edison and Bell, had explicit visions of an information age that would follow from their work. Because they were explicitly aware of what they were doing and partly brought it about long before 1937, they deserve substantial credit for the information age they set out to inaugurate. Regarding one purely mechanical and non-electronic technology, Edison noted ten uses for the phonograph, including not only the replication of sound, but also “connection with the telephone, so as to make that instrument an auxiliary in the transmission of permanent and invaluable records, instead of being the recipient of momentary and fleeting communication”. Even though the telephone was only two years old when Edison wrote of a network made up of mechanical hard storage systems and people connected by wire, the network vision was already clearly in his head. (shrink)

PART 9: GRAVITY'S ETHICSThis isn't a hospital! It's an insane asylum! And it's your fault! Shaking her head lightly, Doctor Van Tintelen leaves the room and softly closes the door. Empathy streaming through her veins, she never gets used to the unpolished grief of a patient she has to tell of inevitable death, never. She thinks, “There should be pipes to drain the tears in every room, or at least rinsing basins for grief. What a job.” The crying is (...) that of the sisters Barrio. Miranda and Monica are twins who always refer to themselves as M&M. Though Monica cries the hardest, it is Miranda who was just told that her breast cancer has spread into her liver. No more treatment available.“Don't cry, Monica, I took the risk purposely. We both knew breast cancer runs in our family. You had the test, I didn't.”“And now you see the result, Miranda, you are going to die. We aren't even fifty yet. Damn.” The irony is that the clock in the room doesn't work, its pointers silent and stiff.“Do you really think you are better off? I've never completely understood why you had the preventive double mastectomy.”“I have never felt less of a woman. You know that.”“I know, but some men felt differently about it.”The remark hurts Monica almost physically, and Miranda apologises immediately. “Sorry, sweetheart, I shouldn't have said that. The sisters embrace for the hundredth time.”“Maybe I was too much of a coward,” Miranda says, resigned, “or too proud of my breasts.” For a second she lifts the big breasts sadly with her hands. Cynically: “After all, they were my trumps in eroland.”“A coward? You? How about me?” Monica seems to calm down somewhat. “I was too afraid of the continual fear …. (shrink)

The author, who received his doctorate from Syracuse University and is head of the department of philosophy at Western Kentucky University, offers in this study "an interpretation of Augustine's doctrine of illumination that is significantly different from the ones proposed by scholars who belong to the Thomist tradition." Before addressing himself to the doctrine of illumination, he devotes more than half of the book to an overview of Augustine's epistemology. In these preliminary chapters he discusses the structure of St. (...) Augustine's theory of knowledge, and then Augustine's ideas on skepticism and truth, faith, sensation, and cogitation. The doctrine and texts covered in these chapters will be familiar to anyone who has devoted much time to the study of Augustine's thought. However, the author's treatment is noteworthy for its clear and succinct style. The sixth chapter broaches the question of man's knowledge of the rationes aeternae. Negatively, Augustine explicitly rejected some explanations of how man's mind can know the forms in the divine mind. Positively, "Augustine's theory of illumination includes at least three major points: God is light and illumines all men to different degrees; There are intelligible truths, the rationes aeternae, which God illumines; and the mind of man can know the divine truths only as God illumines him." The final two chapters are devoted to four interpretative theories of Augustine's notion of illumination. Three of these theories Dr. Nash rejects: that of St. Thomas which identifies the divine light and the agent intellect; the Franciscan theory which attributes the function of the agent intellect to God; the Formal approach, ascribed to Gilson and Copleston among others, which maintains that "the function of illumination... is not to give the human mind some definite content but simply to convey the quality of certainty and necessity to certain ideas." Arguing that all these theories are inadequate, the author then presents his own interpretation, a modified ontologism, which he feels provides a solution to the key paradoxes in Augustine's theory of illumination. Although one wishes that the author had discussed more fully man's knowledge of God, and although there may be need for a more careful scrutiny of Augustine's use of cogitatio, this book is to be recommended as a lucid discussion of a difficult subject. The index and notes are helpful, and the book well made.--H. F. (shrink)

I have never read the two great stanzas of Odes III. 3 without a feeling that the above phrase was rather inadequate, according to what I suppose to be the accepted translation. I base the word ‘accepted’ on Forcellini, and Lewis and Short, who give the reference under the head of propositum, ‘purpose,’ ‘intention,’ ‘resolution,’ ‘design.’ But the capacity of sticking to some particular purpose is not a very noble quality, and if we take the phrase in the wider (...) sense of general tenacity of purpose, I do not feel that we get the ‘iustus’ of the ode, though we may perhaps get a person who is likely to succeed in life. Taken in this way, ‘tenax propositi’ suggests the portrait of Henry VIII., with his gross face and striding legs, dominating the English Church and the High Table of Trinity. I shall perhaps be told that the context shows the meaning. It may no doubt prevent the phrase from being misleading, but it does not make it worthy of its setting. I may add that in the other two places, where I know of its occurring, it has no very lofty meaning. In Ovid Met. X. 415, ‘propositi tenax’ is used to describe the persistent efforts of Myrrha's nurse to find out what is the matter. In Quintilian XI. 1, 90, in a discourse on mild equivalents, we are told that the ‘pertinax’ may be spoken of as ‘ultra modum propositi tenax.’. (shrink)

Polls show that 45% of the American public believes that humans were created about 10,000 years ago and that evolution is a fictitious myth. Another 25% believes that changes in the natural world are directed by a supernatural being with a particular goal in mind. This thinking clashes head on with scientific findings from the past 150 years, and there is a dearth of public critical thinking about the natural world within a scientific framework. Evolution and Religious Creation Myths (...) seeks to educate and arm the public on the differences between myth and science, fiction and theory. The book begins with a whirlwind tour of creation stories from several religions. The authors then explore how certain forms of religious fundamentalism clash with the science of evolution. They review how creationists and intelligent design proponents misuse and misrepresent scientific terminology and conclusions to further their own agendas. How do scientists respond to this threat? Modern science, which includes a level of indeterminacy, or chance, cannot support the premise that a supernatural designer engineered nature for a particular purpose in a deterministic fashion. This holds true for the creation of the universe, the appearance of the first biological molecules, chemical evolution, and the evolution of life forms through mutation, natural selection, and genetic drift. Instead, human biological and cultural evolution is described within a genetic framework. Scientists use a barrage of genetic tests and DNA phylogenies to support the scientific basis for evolution. For anyone who has ever needed to argue why evolution and creationism are not both valid theories that deserve equal attention, this book clearly defines the difference between theory and myth. Scientists, teachers, and defenders of the truth should read this book in preparation for when they are called upon to respond. (shrink)

This paper points to the need in ape language research to shift from experimentation to ethnography. We cannot determine what goes on inside the head of an ape when it communicates with a human being, but we can learn about the nature and content of the communication that occurs in such face-to-face interaction. This information is fundamental for establishing a baseline for the abilities of an ape-human common ancestor.

Active networking is an exciting new paradigm in digital networking that has the potential to revolutionize the manner in which communication takes place. It is an emerging technology, one in which new ideas are constantly being formulated and new topics of research are springing up even as this book is being written. This technology is very likely to appeal to a broad spectrum of users from academia and industry. Therefore, this book was written in a way that enables all these (...) groups to understand the impact of active networking in their sphere of interest. Information services managers, network administrators, and e-commerce developers would like to know the potential benefits of the new technology to their businesses, networks, and applications. The book introduces the basic active networking paradigm and its potential impacts on the future of information handling in general and on communications in particular. This is useful for forward-looking businesses that wish to actively participate in the development of active networks and ensure a head start in the integration of the technology in their future products, be they applications or networks. Areas in which active networking is likely to make significant impact are identified, and the reader is pointed to any related ongoing research efforts in the area. The book also provides a deeper insight into the active networking model for students and researchers, who seek challenging topics that define or extend frontiers of the technology. It describes basic components of the model, explains some of the terms used by the active networking community, and provides the reader with taxonomy of the research being conducted at the time this book was written. Current efforts are classified based on typical research areas such as mobility, security, and management. The intent is to introduce the serious reader to the background regarding some of the models adopted by the community, to outline outstanding issues concerning active networking, and to provide a snapshot of the fast-changing landscape in active networking research. Management is a very important issue in active networks because of its open nature. The latter half of the book explains the architectural concepts of a model for managing active networks and the motivation for a reference model that addresses limitations of the current network management framework by leveraging the powerful features of active networking to develop an integrated framework. It also describes a novel application enabled by active network technology called the Active Virtual Network Management Prediction (AVNMP) algorithm. AVNMP is a proactive management system; in other words, it provides the ability to solve a potential problem before it impacts the system by modeling network devices within the network itself and running that model ahead of real time. (shrink)

Active networking is an exciting new paradigm in digital networking that has the potential to revolutionize the manner in which communication takes place. It is an emerging technology, one in which new ideas are constantly being formulated and new topics of research are springing up even as this book is being written. This technology is very likely to appeal to a broad spectrum of users from academia and industry. Therefore, this book was written in a way that enables all these (...) groups to understand the impact of active networking in their sphere of interest. Information services managers, network administrators, and e-commerce developers would like to know the potential benefits of the new technology to their businesses, networks, and applications. The book introduces the basic active networking paradigm and its potential impacts on the future of information handling in general and on communications in particular. This is useful for forward-looking businesses that wish to actively participate in the development of active networks and ensure a head start in the integration of the technology in their future products, be they applications or networks. Areas in which active networking is likely to make significant impact are identified, and the reader is pointed to any related ongoing research efforts in the area. The book also provides a deeper insight into the active networking model for students and researchers, who seek challenging topics that define or extend frontiers of the technology. It describes basic components of the model, explains some of the terms used by the active networking community, and provides the reader with taxonomy of the research being conducted at the time this book was written. Current efforts are classified based on typical research areas such as mobility, security, and management. The intent is to introduce the serious reader to the background regarding some of the models adopted by the community, to outline outstanding issues concerning active networking, and to provide a snapshot of the fast-changing landscape in active networking research. Management is a very important issue in active networks because of its open nature. The latter half of the book explains the architectural concepts of a model for managing active networks and the motivation for a reference model that addresses limitations of the current network management framework by leveraging the powerful features of active networking to develop an integrated framework. It also describes a novel application enabled by active network technology called the Active Virtual Network Management Prediction (AVNMP) algorithm. AVNMP is a proactive management system; in other words, it provides the ability to solve a potential problem before it impacts the system by modeling network devices within the network itself and running that model ahead of real time. (shrink)

Part 10: The very old man and the sea of tears‘There is no time to waste, then, is there?' ‘He needs to be treated.’‘But he is 79 years old.’Two doctors in conflict. As happens often. The subject of the conversation is Mr Tyson, admitted to the hospital because of an aneurysm in his abdomen. Sarah Walters said ‘treat’. ‘Nonsense, too old, too risky’ is the opinion of Dr Jones. The squabble continues.Sarah: ‘So what? Does old age exclude you from society? (...) Of course we have to treat him.’‘But the investment will only last for a few years, and think of the risks, he may die from the operation. He should go home and, well, live what there is to live.’She shakes her head, her hair giving her a red aura. ‘I think he ought to have the operation.’‘I think it would be best if he should accept that time is running out, that life is finite, the whole existential rigmarole, et cetera.’‘Quite presumptuous of you to think he has not accepted that. Why? Just because he is old and did not kill himself?’ Sarah is indignant. ‘If he had done just that, we would have lamented about how we do not take care of our elderly, that society doesn't care, and that certainly there is no right to die unless your situation is totally hopeless and you're in a lot of pain. It doesn't make sense; in public health one does everything to increase life expectancy. Countries are proudly comparing themselves on the life expectancy list: mine is longer than yours. We worry because people have these unhealthy lifestyles, they are obese, they smoke, they get no exercise and they live a couch potato life. And then, lo and behold, they do grow old, in fact, and we go: …. (shrink)