BackgroundSocial cognitive impairments adversely affect social functioning in patients with schizophrenia. Although pharmacological interventions have been suggested to provide some benefits on social cognition, little information is available on the comparative efficacy of pharmacotherapy. Thus, the aim of this planned systematic review and network meta-analysis is to perform a quantitative comparison of the effects of various psychotropic drugs, including supplements, on social cognition disturbances of schizophrenia.MethodsThe literature search will be carried out using the PubMed, Embase, Cochrane Central Register of Controlled (...) Trials, PsycINFO, ClinicalTrials.gov, and International Clinical Trials Registry Platform databases from inception onward. Randomized controlled trials that examined the efficacy of drugs in social cognitive disturbances will be included, based on the most recent studies and the broader literature than previously searched. This protocol defines a priori the methods that will be used for study selection, data collection, quality assessment, and statistical syntheses.DiscussionThe findings this work are expected to help promote the development of better therapeutics of social cognitive impairments in schizophrenia and related psychiatric conditions.Systematic Review Registration[www.crd.york.ac.uk/prospero], identifier [CRD42021293224]. (shrink)

BackgroundBoth impairment and sex differences in social cognition and neurocognition have been documented in schizophrenia. However, whether sex differences exist in the association between social cognition and neurocognition are not known. We aimed to investigate the contribution of areas of neurocognition to theory of mind and hostility bias, representing social cognition, according to sex in early course schizophrenia.MethodsIn this cross-sectional study, we assessed neurocognition using the Japanese version of the Brief Assessment of Cognition in Schizophrenia and assessed the ToM and (...) hostility bias subdomains of social cognition using the Social Cognition Screening Questionnaire in 131 participants diagnosed with schizophrenia within 5 years of onset. Sex differences were analyzed using t-tests. The associations of neurocognitive subdomains with ToM and hostility bias according to sex were analyzed using multiple regression analysis. Results were adjusted by age, estimated premorbid intelligence quotient, and symptomatology.ResultsNo sex differences were found in ToM or hostility bias. Higher verbal fluency was significantly associated with higher ToM in females, whereas higher executive function was significantly associated with higher ToM in males. Higher verbal fluency was significantly associated with lower hostility bias in females, whereas neurocognition and hostility bias were not significantly associated in males.ConclusionThe results suggest that neurocognition associated with social cognition differ according to sex. These differences should be considered for more effective treatment of social cognition. (shrink)

Genetic epidemiology is a rapidly advancing field due to the recent availability of large amounts of omics data. In recent years, it has become possible to obtain omics information at the single‐cell level, so genetic epidemiological models need to be updated to integrate with single‐cell expression data. In this perspective paper, we propose a cell population‐based framework for genetic epidemiology in the single‐cell era. In this framework, genetic diversity influences phenotypic diversity through the diversity of cell population profiles, which are (...) defined as high‐dimensional probability distributions of the state spaces of biomolecules of each omics layer. We discuss how biomolecular experimental measurement data can capture the different properties of this distribution. In particular, single‐cell data constitute a sample from this population distribution where only some coordinate values are observable. From a data analysis standpoint, we introduce methodology for feature extraction from cell population profiles. Finally, we discuss how this framework can be applied not only to genetic epidemiology but also to systems biology. (shrink)

One influential positive argument for moral realism is the Explanatory Indispensability Argument. A crucial premise of this argument is the explanatory relevance of moral properties. On this premise, moral properties, such as wrongness, rightness, courage, and cowardice, are explanatorily indispensable to some empirical phenomena. Although there has been a lively debate on this premise, one crucial challenge to this thesis, what I call the Scientific Standard Challenge, has not been properly discussed. After explaining this challenge and a related concern, I (...) argue that in response to this central challenge, the proponents of the argument should take what I call the localist turn to defend the explanatory indispensability of moral properties. The localist turn encourages the defenders of moral explanations to be more sensitive to the nature of each moral explanation. For instance, some moral explanations are explanations of social matters, so the standards they need to meet are provided by relevant branches of the social sciences. On the other hand, some other moral explanations are about our psychology, so the theoretical standards those explanations need to meet should come from psychology. I illustrate how this localist project can be conducted in the case of the moral explanation that appeals to injustice. I argue that the field of comparative politics provides the theoretical standards moral explanations of institutional change need to meet. I shall then illustrate how a sophisticated moral explanation can meet those theoretical standards and how this moral explanation can be strong evidence of injustice’s explanatory indispensability. (shrink)

近世の儒者・熊沢蕃山(一六一九~九一)の一つ一つの著作の思想構造の解明をめざし、さらにそれぞれの著作を比較することで、蕃山の思想の変化に注目し、その変化の意味を問う。また中江藤樹『翁問答』や池田光政の 藩政改革をとりあげて、岡山藩における蕃山の政治体験の意味を解明し、それらの考察から多様な蕃山の思想を立体的に浮かび上がらせる。.

『哲学探究』以後、最晩期に独立した地位を与える。ウィトゲンシュタインの知識の哲学。.

Abstract“The wrongness of Albert's action causally explains why Jane judged that his action was wrong”. This type of causal moral explanation has been extensively discussed in the recent metaethical literature. This paper motivates the following claims about this type of moral explanation. First, a typical defence of this type of moral explanation suggested in the literature does not work because it predicts inaccurate modal information. Second, focusing on different aspects of the ways moral judgements are generated provides better chances for (...) the defender of this type of moral explanation. Third, the strategy mentioned in the previous point leads us to the following alternative evaluative explanation: The property of being a harmful action explains a recognisable pattern of moral judgements observed in the relevant empirical studies. One crucial implication the paper alludes to is a localist approach to the debates concerning moral realism: We should consider each moral property's ontological genuineness separately, referring to specific empirical findings that are particularly relevant to the target moral property in question. Such a localist approach can provide solid resources for realists to respond to various anti‐realist challenges, such as an influential evolutionary debunking argument. (shrink)

In this paper, using Mark Schroeder’s (2008a) expressivist semantic framework for normative language as a case study, I will identify difficulties that even an expressivist semantic theory capable of addressing the Frege-Geach problem will encounter in handling the logical possibility of moral dilemmas. To this end, I will draw on a classical puzzle formulated by McConnell (1978) that the logical possibility of moral dilemmas conflicts with some of the prima facie plausible axioms of the standard deontic logic, which include obligation (...) implies permission. On the tentative assumption that proponents of ethical expressivism should be generally committed to securing the logical possibility of moral dilemmas in their semantic theories, I will explore whether and how expressivists can successfully invalidate obligation implies permission within the framework developed by Schroeder. The case study eventually reveals that this can indeed be a hard task for expressivists. Generalizing from the case study, I will suggest that the source of the difficulty ultimately lies in the mentalist assumption of the expressivist semantic project that the logico-semantic relations exhibited by normative sentences should be modeled in terms of the psychological attitudes that speakers express by uttering them. My final goal will be to show that the difficulty expressivists face in dealing with the logical possibility of moral dilemmas is a reflection of the more general problem that their commitment to the mentalist assumption prevents them from flexibly adopting or dropping axioms in their semantic theories to get the right technical results. (shrink)

進化論・国家有機体説から生命主義・歴史への回帰まで、デモクラシーと煩悶の時代における「国体」の地平.

世界的な貧困や格差を前に、私たちはどんな正義を構想できるのだろうか。民主主義的な実践に根ざした新しい政治理論がここに誕生。 グローバルな正義を机上の空論で終わらせないために近年主張されているのが、「実践によって媒介された関係」に基づく正義論、つまり実践依存アプローチだ。サンジョヴァンニやウォルツァーなどによるこの理論をさら にアップデートすべく、NGOや社会運動といった主体を取り入れ、「集合的主体による実践依存アプローチ」の正義論を構想する。.

「語の意味」とは何か?『類語大辞典』の編集・執筆に関わってきた著者が、「意味の本質」「同義・類義・多義」「意味記述の方法」「辞書と意味記述」の4部に渡って、これまで深めてきた考察を明らかにする、「こと ばの意味」の研究に大きく資する一冊。.

We develop intuitionistic public announcement logic over intuitionistic \({\textbf{K}}\), \({{\textbf{K}}}{{\textbf{T}}}\), \({{\textbf{K}}}{{\textbf{4}}}\), and \({{\textbf{S}}}{{\textbf{4}}}\) with distributed knowledge. We reveal that a recursion axiom for the distributed knowledge is _not_ valid for a frame class discussed in [ 12 ] but valid for the restricted frame class introduced in [ 20, 26 ]. The semantic completeness of the static logics for this restricted frame class is established via the concept of pseudo-model.

The most famous chapter of Montesquieu’s _ The Spirit of the Laws _ (1748), Book XI, Chapter 6, 'On the constitution of England,' was an important i nspiration to the creators of modern constitutions, to which they often referred. However, as a result of scholarly focus on the political institutions discussed in this book, Montesquieu’s economic analysis has been woefully neglected. In order to correct this scholarly imbalance, this paper will elucidate the essential significance of Montesquieu’s comparison between the constitution (...) of modern England and that of ancient Rome in Book XI of _ The Spirit of the Laws _ ; inextricable relationship between military and political institutions on the one hand, and the transfer and distribution of wealth on the other. To argue this point, this paper will focus on Montesquieu’s other writings in the same year and shortly after the publication of _ The Spirit of the Laws _ : the revised edition in 1748 of _ The Considerations on the Causes of the Greatness of t... _. (shrink)

U ovom radu, koristeći Mark Schroederov (2008a) semantički okvir za ekspresivistički normativni jezik kao studiju slučaja, identificirat ću poteškoće s kojima će se čak i ekspresivistička semantička teorija sposobna za rješavanje Frege-Geach problema susresti pri objašnjenju logičke mogućnosti moralnih dilema. U tu svrhu, oslonit ću se na klasičnu zagonetku koju je formulirao McConnell (1978)a pokazuje da se logička mogućnost moralnih dilema sukobljava s nekim od naizgled opravdanih aksioma standardne deontičke logike, među kojima je i aksiom da obaveza implicira dopuštenost. Na (...) temelju tentativne pretpostavke da zastupnici etičkog ekspresivizma trebaju općenito biti posvećeni osiguravanju logičke mogućnosti moralnih dilema u svojim semantičkim teorijama, istražit ću da li i kako ekspresivisti mogu uspješno opovrgnuti aksiom da obaveza implicira dopuštenje unutar okvira koji je razvio Schroeder. Studija slučaja konačno otkriva da to može biti zaista težak zadatak za ekspresiviste. Generalizirajući iz studije slučaja, sugerirat ću da izvor poteškoće leži u mentalističkoj pretpostavci ekspresivističkog semantičkog projekta da bi logičko-semantički odnosi prikazani normativnim rečenicama trebali biti modelirani pomoću psiholoških stavova koje govornici izražavaju izgovarajući ih. Moj konačni cilj će biti pokazati da je poteškoća s kojom se ekspresivisti susreću u suočavanju s logičkom mogućnosti moralnih dilema odraz općeg problema da njihova predanost mentalističkoj pretpostavci sprječava fleksibilno usvajanje ili odbacivanje aksioma u njihovim semantičkim teorijama kako bi dobili ispravne tehničke rezultate. (shrink)