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Sapfo Lignou
Oxford University
Sapfo Lignou
University College London
  1.  10
    Co-Production: An Ethical Model for Mental Health Research?Sapfo Lignou, Liliana Capitao, Julia Madeleine Hamer-Hunt & Ilina Singh - 2019 - American Journal of Bioethics 19 (8):49-51.
    Volume 19, Issue 8, August 2019, Page 49-51.
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  2.  16
    Informed Consent in Cluster Randomised Trials: New and Common Ethical Challenges.Sapfo Lignou - 2018 - Journal of Medical Ethics 44 (2):114-120.
    Cluster randomised trials are an increasingly important methodological tool in health research but they present challenges to the informed consent requirement. In the relatively limited literature on the ethics of cluster research there is not much clarity about the reasons for which seeking informed consent in cluster randomised trials may be morally challenging. In this paper, I distinguish between the cases where informed consent in cluster trials may be problematic due to the distinct features of ‘population-based’ interventions, which have not (...)
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  3.  20
    Manipulation of Information in Medical Research: Can It Be Morally Justified?Sapfo Lignou & Sarah Jl Edwards - 2012 - Research Ethics 8 (1):9-23.
    The aim of this article is to examine whether informational manipulation, used intentionally by the researcher to increase recruitment in the research study, can be morally acceptable. We argue that this question is better answered by following a non-normative account, according to which the ethical justifiability of informational manipulation should not be relevant to its definition. The most appropriate criterion by which informational manipulation should be considered as morally acceptable or not is the researcher’s special moral duties towards their subjects. (...)
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  4.  18
    Evidence of Efficacy and Human Right to Health.Sarah J. L. Edwards, Sapfo Lignou & Elizabeth Oduwo - 2012 - American Journal of Bioethics 12 (6):35-37.
    The American Journal of Bioethics, Volume 12, Issue 6, Page 35-37, June 2012.
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  5.  71
    The 'Standard of Care' Debate and Global Justice in Research.Sapfo Lignou - 2011 - Research Ethics 7 (1):5-12.
    In this essay the ethical issues related to the ‘standard of care’ are discussed together with the implications for the treatment of the control group in transnational clinical trials. It is argued that the human right to health and the duty of justice formulate the moral basis on which this case should be debated.
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  6. Why Research Ethics Should Add Retrospective Review.Angus Dawson, Sapfo Lignou, Chesmal Siriwardhana & Dónal P. O’Mathúna - 2019 - BMC Medical Ethics 20 (1):1-8.
    Research ethics is an integral part of research, especially that involving human subjects. However, concerns have been expressed that research ethics has come to be seen as a procedural concern focused on a few well-established ethical issues that researchers need to address to obtain ethical approval to begin their research. While such prospective review of research is important, we argue that it is not sufficient to address all aspects of research ethics. We propose retrospective review as an important complement to (...)
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  7. Reconstructing Communities in Cluster Trials?Sapfo Lignou, Sushmita Das, Jigna Mistry, Glyn Alcock, Neena Shah More, David Osrin & Sarah Edwards - 2016 - Trials 17 (166):1-11.
    BACKGROUND: There is growing interest in the ethics of cluster trials, but no literature on the uncertainties in defining communities in relation to the scientific notion of the cluster in collaborative biomedical research. METHODS: The views of participants in a community-based cluster randomised trial (CRT) in Mumbai, India, were solicited regarding their understanding and views on community. We conducted two focus group discussions with local residents and 20 semi-structured interviews with different respondent groups. On average, ten participants took part in (...)
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