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Sebastian Schleidgen
University of Philosophy and Theology Vallendar
  1.  33
    What is Personalized Medicine: Sharpening a Vague Term Based on a Systematic Literature Review.Sebastian Schleidgen, Corinna Klingler, Teresa Bertram, Wolf H. Rogowski & Georg Marckmann - 2013 - BMC Medical Ethics 14 (1):55.
    Recently, individualized or personalized medicine (PM) has become a buzz word in the academic as well as public debate surrounding health care. However, PM lacks a clear definition and is open to interpretation. This conceptual vagueness complicates public discourse on chances, risks and limits of PM. Furthermore, stakeholders might use it to further their respective interests and preferences. For these reasons it is important to have a shared understanding of PM. In this paper, we present a sufficiently precise as well (...)
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  2.  18
    Alter Wein in Neuen Schläuchen? Ethische Implikationen der Individualisierten MedizinOld Wine in New Bottles? Ethical Implications of Individualized Medicine.Sebastian Schleidgen & Georg Marckmann - 2013 - Ethik in der Medizin 25 (3):223-231.
    Die sogenannte individualisierte Medizin (IM) ist in den letzten Jahren zu einem Schlagwort in Wissenschaft, Politik und Öffentlichkeit geworden. Wie jede technologische Neuentwicklung hat sie jedoch (potentielle) ethische Implikationen, die es zu berücksichtigen gilt, um eine angemessene Entwicklung und Anwendung individualisierter Präventions- und Therapiemaßnahmen zu ermöglichen. Allerdings steht eine ethische Bewertung der IM vor verschiedenen methodischen Herausforderungen, die sich insbesondere aus der Heterogenität des Problembereichs, begrifflicher Unklarheit sowie dem Frühstadium ihrer Entwicklung ergeben. Der vorliegende Beitrag spezifiziert zunächst den Begriff der (...)
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  3.  96
    Re-Focusing the Ethical Discourse on Personalized Medicine: A Qualitative Interview Study with Stakeholders in the German Healthcare System.Sebastian Schleidgen & Georg Marckmann - 2013 - BMC Medical Ethics 14 (1):20.
    In recent years, personalized medicine (PM) has become a highly regarded line of development in medicine. Yet, it is still a relatively new field. As a consequence, the discussion of its future developments, in particular of its ethical implications, in most cases can only be anticipative. Such anticipative discussions, however, pose several challenges. Nevertheless, they play a crucial role for shaping PM’s further developments. Therefore, it is vital to understand how the ethical discourse on PM is conducted, i.e. on what (...)
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  4.  5
    Prozess Oder Resultat? Der Begriff der Genetischen Veränderung in der Debatte Um Humane KeimbahninterventionenProcess or Result? The Concept of Genetic Modification in the Debate on Human Germline Interventions.Sebastian Schleidgen & Susan Sgodda - forthcoming - Ethik in der Medizin.
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  5.  4
    Prozess oder Resultat? Der Begriff der genetischen Veränderung in der Debatte um humane Keimbahninterventionen.Sebastian Schleidgen & Susan Sgodda - forthcoming - Ethik in der Medizin:1-16.
    ZusammenfassungIn der ethischen und rechtlichen Debatte um den möglichen Einsatz neuer Techniken zur Genomeditierung spielt der Begriff der genetischen Veränderung eine zentrale Rolle. Während im Bereich der grünen Gentechnik intensive Debatten um seine Bedeutung geführt werden, wird dieser Umstand im Kontext gentechnischer Interventionen am Menschen weitgehend ausgeblendet. Der Aufsatz expliziert drei mögliche Bedeutungen genetischer Veränderung, namentlich: ein prozessuales, ein diachrones sowie ein klassenbezogenes Verständnis. Anhand zweier Szenarien zukünftig erwartbarer Keimbahninterventionen wird anschließend exemplarisch gezeigt, welche Konsequenzen die Begriffe für die Kennzeichnung (...)
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  6.  55
    Mission: Impossible? On Empirical-Normative Collaboration in Ethical Reasoning.Sebastian Schleidgen, Michael C. Jungert & Robert H. Bauer - 2010 - Ethical Theory and Moral Practice 13 (1):59-71.
    During the 1980s, empirical social sciences and normative theory seemingly converged within ethical debates. This tendency kindled new debates about the limits and possibilities of empirical-normative collaboration. The article asks for adequate ways of collaboration by taking a closer look at the philosophy of science of empirical social sciences as well as normative theory development and its logical groundings. As a result, three possible modes of cooperation are characterized: first, the empirical assessment of conditions that actually necessitate the translation of (...)
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  7.  3
    Between Minimal and Greater Than Minimal Risk: How Research Participants and Oncologists Assess Data-Sharing and the Risk of Re-Identification in Genomic Research.Sebastian Schleidgen, Alma Husedzinovic, Dominik Ose, Christoph Schickhardt, Christof Kalle & Eva Winkler - 2019 - Philosophy and Technology 32 (1):39-55.
    Data-sharing among genomic researchers is promoted for its potential to accelerate our understanding of the molecular basis of cancer. However, with genomic data sharing the risks of re-identifying study participants, revealing personal genomic information and data misuse might increase. This study aims at exploring perceptions of patients and physicians in Oncology regarding their assessment of the informational risks resulting from participating in whole genomic research studies in order to improve the informed consent process. For this purpose, we conducted a qualitative (...)
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  8.  6
    Zur Rolle und Verantwortung von Ärzten und Forschern in systemmedizinischen Kontexten: Ergebnisse einer qualitativen Interviewstudie.Sandra Fernau, Sebastian Schleidgen, Christoph Schickhardt, Ann-Kristin Oßa & Eva C. Winkler - 2018 - Ethik in der Medizin 30 (4):307-324.
    ZusammenfassungSystemmedizinische Ansätze zeichnen sich durch die Integration großer Datenmengen aus vielfältigen Datenquellen aus und führen systembiologische und medizinische Forschungsansätze mit informationswissenschaftlichen Methoden und prädiktiven Verfahren mathematischer Modellierung zusammen. Hieraus resultiert eine enge Kooperation von Ärzten und Naturwissenschaftlern, wobei insbesondere die Expertise nicht-ärztlicher Forscher zunehmend an Bedeutung für die Datenaufbereitung und -interpretation gewinnt. Aus ethischer Perspektive wirft diese Entwicklung Fragen nach der konkreten Gestaltung einer systemmedizinischen Zusammenarbeit sowie möglichen Rollenveränderungen und neuen Verantwortungszuschreibungen an Ärzte und nicht-ärztliche Forscher auf. Um diese Fragen (...)
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  9.  11
    Between Minimal and Greater Than Minimal Risk: How Research Participants and Oncologists Assess Data-Sharing and the Risk of Re-Identification in Genomic Research.Sebastian Schleidgen, Alma Husedzinovic, Dominik Ose, Christoph Schickhardt, Christof von Kalle & Eva C. Winkler - 2019 - Philosophy and Technology 32 (1):39-55.
    Data-sharing among genomic researchers is promoted for its potential to accelerate our understanding of the molecular basis of cancer. However, with genomic data sharing the risks of re-identifying study participants, revealing personal genomic information and data misuse might increase. This study aims at exploring perceptions of patients and physicians in Oncology regarding their assessment of the informational risks resulting from participating in whole genomic research studies in order to improve the informed consent process. For this purpose, we conducted a qualitative (...)
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  10.  23
    Sustainable Development and Bioethics.Sebastian Schleidgen - 2008 - Proceedings of the Xxii World Congress of Philosophy 3:83-88.
    The so-called Brundtland-Report defines Sustainable Development as a conception of intra- and intergenerational justice, which is to be realized by a globally just distribution of possibilities for satisfying human basic needs as well as assuring such possibilities for future generations. Hence, any political and/orsocietal decision is addressed by the ethical demands of Sustainable Development insofar it affects possibilities for satisfying human basic needs. In particular, this concerns – contrary to the widespread opinion that Sustainable Development only has to deal with (...)
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  11.  17
    Sustainable Development and Bioethics – Ethical Thoughts on Decisions About Establishing Biobanks.Sebastian Schleidgen - 2008 - Proceedings of the Xxii World Congress of Philosophy 10:369-374.
    The so-called Brundtland-Report defines Sustainable Development as a conception of intra- and intergenerational justice, which is to be realized by a globally just distribution of possibilities for satisfying human basic needs as well as assuring such possibilities for future generations. Hence, any political and/or societal decision is addressed by the ethical demands of Sustainable Development insofar it affects possibilities for satisfying human basic needs. In particular, this concerns – contrary to the widespread opinion that Sustainable Development only has to deal (...)
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  12.  6
    Mission: Impossible? On Empirical-Normative Collaboration in Ethical Reasoning.Sebastian Schleidgen, Michael C. Jungert & Robert H. Bauer - 2010 - Ethical Theory and Moral Practice 13 (1):73-73.
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  13.  8
    Contractualism: History, Theories and Critiques.Sebastian Schleidgen - 2010 - In Richard Corrigan (ed.), Ethics: A University Guide. Progressive Frontiers Pubs.. pp. 109--134.
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  14. Old Wine in New Bottles? Ethical Implications of Individualized Medicine.Sebastian Schleidgen & Georg Marckmann - 2013 - Ethik in der Medizin 25 (3):223-231.
     
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