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Sebastian Schleidgen
Fernuniversität Hagen
  1.  44
    What is personalized medicine: sharpening a vague term based on a systematic literature review.Sebastian Schleidgen, Corinna Klingler, Teresa Bertram, Wolf H. Rogowski & Georg Marckmann - 2013 - BMC Medical Ethics 14 (1):55.
    Recently, individualized or personalized medicine (PM) has become a buzz word in the academic as well as public debate surrounding health care. However, PM lacks a clear definition and is open to interpretation. This conceptual vagueness complicates public discourse on chances, risks and limits of PM. Furthermore, stakeholders might use it to further their respective interests and preferences. For these reasons it is important to have a shared understanding of PM. In this paper, we present a sufficiently precise as well (...)
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  2. What is personalized medicine: sharpening a vague term based on a systematic literature review.Sebastian Schleidgen & Georg Marckmann - 2013 - BMC Medical Ethics 14 (1):20.
    In recent years, personalized medicine (PM) has become a highly regarded line of development in medicine. Yet, it is still a relatively new field. As a consequence, the discussion of its future developments, in particular of its ethical implications, in most cases can only be anticipative. Such anticipative discussions, however, pose several challenges. Nevertheless, they play a crucial role for shaping PM’s further developments. Therefore, it is vital to understand how the ethical discourse on PM is conducted, i.e. on what (...)
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  3.  2
    Empirical Research and Recommendations for Moral Action: A Plea for the Transparent Reporting of Bridge Principles in Public Health Research.Katja Kuehlmeyer, Marcel Mertz, Joschka Haltaufderheide, Alexander Kremling, Sebastian Schleidgen & Julia Inthorn - 2022 - Public Health Ethics 15 (2):147-159.
    Academic publications of empirical public health research often entail recommendations for moral action that address practitioners and policy makers. These recommendations are regularly based on implicit moral judgments with the underlying reasons not explicitly stated. In this paper, we elaborate on the moral relevance of such judgments and the need to explain them in order to account for academic argumentation. We argue for an explicit reporting of bridge principles to increase the transparency of the reporting of public health research. The (...)
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  4.  19
    Human germline editing in the era of CRISPR-Cas: risk and uncertainty, inter-generational responsibility, therapeutic legitimacy.Sebastian Schleidgen, Hans-Georg Dederer, Susan Sgodda, Stefan Cravcisin, Luca Lüneburg, Tobias Cantz & Thomas Heinemann - 2020 - BMC Medical Ethics 21 (1):1-12.
    BackgroundClustered Regularly Interspaced Short Palindromic Repeats-associated technology may allow for efficient and highly targeted gene editing in single-cell embryos. This possibility brings human germline editing into the focus of ethical and legal debates again.Main bodyAgainst this background, we explore essential ethical and legal questions of interventions into the human germline by means of CRISPR-Cas: How should issues of risk and uncertainty be handled? What responsibilities arise regarding future generations? Under which conditions can germline editing measures be therapeutically legitimized? For this (...)
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  5.  12
    Between Minimal and Greater Than Minimal Risk: How Research Participants and Oncologists Assess Data-Sharing and the Risk of Re-identification in Genomic Research.Sebastian Schleidgen, Alma Husedzinovic, Dominik Ose, Christoph Schickhardt, Christof Kalle & Eva Winkler - 2019 - Philosophy and Technology 32 (1):39-55.
    Data-sharing among genomic researchers is promoted for its potential to accelerate our understanding of the molecular basis of cancer. However, with genomic data sharing the risks of re-identifying study participants, revealing personal genomic information and data misuse might increase. This study aims at exploring perceptions of patients and physicians in Oncology regarding their assessment of the informational risks resulting from participating in whole genomic research studies in order to improve the informed consent process. For this purpose, we conducted a qualitative (...)
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  6.  17
    Between Minimal and Greater Than Minimal Risk: How Research Participants and Oncologists Assess Data-Sharing and the Risk of Re-identification in Genomic Research.Sebastian Schleidgen, Alma Husedzinovic, Dominik Ose, Christoph Schickhardt, Christof von Kalle & Eva C. Winkler - 2019 - Philosophy and Technology 32 (1):39-55.
    Data-sharing among genomic researchers is promoted for its potential to accelerate our understanding of the molecular basis of cancer. However, with genomic data sharing the risks of re-identifying study participants, revealing personal genomic information and data misuse might increase. This study aims at exploring perceptions of patients and physicians in Oncology regarding their assessment of the informational risks resulting from participating in whole genomic research studies in order to improve the informed consent process. For this purpose, we conducted a qualitative (...)
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  7.  20
    Old wine in new bottles? Ethical implications of individualized medicine.Sebastian Schleidgen & Georg Marckmann - 2013 - Ethik in der Medizin 25 (3):223-231.
    Die sogenannte individualisierte Medizin (IM) ist in den letzten Jahren zu einem Schlagwort in Wissenschaft, Politik und Öffentlichkeit geworden. Wie jede technologische Neuentwicklung hat sie jedoch (potentielle) ethische Implikationen, die es zu berücksichtigen gilt, um eine angemessene Entwicklung und Anwendung individualisierter Präventions- und Therapiemaßnahmen zu ermöglichen. Allerdings steht eine ethische Bewertung der IM vor verschiedenen methodischen Herausforderungen, die sich insbesondere aus der Heterogenität des Problembereichs, begrifflicher Unklarheit sowie dem Frühstadium ihrer Entwicklung ergeben. Der vorliegende Beitrag spezifiziert zunächst den Begriff der (...)
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  8.  61
    Mission: Impossible? On Empirical-Normative Collaboration in Ethical Reasoning.Sebastian Schleidgen, Michael C. Jungert & Robert H. Bauer - 2010 - Ethical Theory and Moral Practice 13 (1):59-71.
    During the 1980s, empirical social sciences and normative theory seemingly converged within ethical debates. This tendency kindled new debates about the limits and possibilities of empirical-normative collaboration. The article asks for adequate ways of collaboration by taking a closer look at the philosophy of science of empirical social sciences as well as normative theory development and its logical groundings. As a result, three possible modes of cooperation are characterized: first, the empirical assessment of conditions that actually necessitate the translation of (...)
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  9.  4
    On Humans and Machines.Johanna Seifert, Orsolya Friedrich & Sebastian Schleidgen - 2022 - Techné: Research in Philosophy and Technology 26 (2):207-231.
    In the present article we examine the anthropological implications of “intelligent” neurotechnologies (INTs). For this purpose, we first give an introduction to current developments of INTs by specifying their central characteristics. We then present and discuss traditional anthropological concepts such as the “homo faber,” the concept of humans as “deficient beings,” and the concept of the “cyborg,” questioning their descriptive relevance regarding current neurotechnological applications. To this end, we relate these anthropological concepts to the characteristics of INTs elaborated before. As (...)
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  10.  4
    Imitating the Human. New Human–Machine Interactions in Social Robots.Johanna Seifert, Orsolya Friedrich & Sebastian Schleidgen - 2022 - NanoEthics 16 (2):181-192.
    Social robots are designed to perform intelligent, emotional, and autonomous behavior in order to establish intimate relationships with humans, for instance, in the context of elderly care. However, the imitation of qualities usually assumed to be necessary for human reciprocal interaction may impact our understanding of social interaction. Against this background, we compare the technical operations based on which social robots imitate human-like behavior with the concepts of emotionality, intelligence, and autonomy as usually attached to humans. In doing so, we (...)
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  11.  2
    Joint Interaction and Mutual Understanding in Social Robotics.Sebastian Schleidgen & Orsolya Friedrich - 2022 - Science and Engineering Ethics 28 (6):1-20.
    Social robotics aims at designing robots capable of joint interaction with humans. On a conceptual level, sufficient mutual understanding is usually said to be a necessary condition for joint interaction. Against this background, the following questions remain open: in which sense is it legitimate to speak of human–robot joint interaction? What exactly does it mean to speak of humans and robots sufficiently understanding each other to account for human–robot joint interaction? Is such joint interaction effectively possible by reference, e.g., to (...)
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  12.  20
    Prozess oder Resultat? Der Begriff der genetischen Veränderung in der Debatte um humane Keimbahninterventionen.Sebastian Schleidgen & Susan Sgodda - 2020 - Ethik in der Medizin 32 (1):5-20.
    In der ethischen und rechtlichen Debatte um den möglichen Einsatz neuer Techniken zur Genomeditierung spielt der Begriff der genetischen Veränderung eine zentrale Rolle. Während im Bereich der grünen Gentechnik intensive Debatten um seine Bedeutung geführt werden, wird dieser Umstand im Kontext gentechnischer Interventionen am Menschen weitgehend ausgeblendet. Der Aufsatz expliziert drei mögliche Bedeutungen genetischer Veränderung, namentlich: ein prozessuales, ein diachrones sowie ein klassenbezogenes Verständnis. Anhand zweier Szenarien zukünftig erwartbarer Keimbahninterventionen wird anschließend exemplarisch gezeigt, welche Konsequenzen die Begriffe für die Kennzeichnung (...)
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  13.  27
    Sustainable Development and Bioethics: Ethical Thoughts on Decisions about Establishing Biobanks.Sebastian Schleidgen - 2008 - Proceedings of the Xxii World Congress of Philosophy 3:83-88.
    The so-called Brundtland-Report defines Sustainable Development as a conception of intra- and intergenerational justice, which is to be realized by a globally just distribution of possibilities for satisfying human basic needs as well as assuring such possibilities for future generations. Hence, any political and/orsocietal decision is addressed by the ethical demands of Sustainable Development insofar it affects possibilities for satisfying human basic needs. In particular, this concerns – contrary to the widespread opinion that Sustainable Development only has to deal with (...)
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  14.  20
    Sustainable Development and Bioethics – Ethical Thoughts on Decisions about Establishing Biobanks.Sebastian Schleidgen - 2008 - Proceedings of the Xxii World Congress of Philosophy 10:369-374.
    The so-called Brundtland-Report defines Sustainable Development as a conception of intra- and intergenerational justice, which is to be realized by a globally just distribution of possibilities for satisfying human basic needs as well as assuring such possibilities for future generations. Hence, any political and/or societal decision is addressed by the ethical demands of Sustainable Development insofar it affects possibilities for satisfying human basic needs. In particular, this concerns – contrary to the widespread opinion that Sustainable Development only has to deal (...)
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  15.  10
    Zur Rolle und Verantwortung von Ärzten und Forschern in systemmedizinischen Kontexten: Ergebnisse einer qualitativen Interviewstudie.Sandra Fernau, Sebastian Schleidgen, Christoph Schickhardt, Ann-Kristin Oßa & Eva C. Winkler - 2018 - Ethik in der Medizin 30 (4):307-324.
    ZusammenfassungSystemmedizinische Ansätze zeichnen sich durch die Integration großer Datenmengen aus vielfältigen Datenquellen aus und führen systembiologische und medizinische Forschungsansätze mit informationswissenschaftlichen Methoden und prädiktiven Verfahren mathematischer Modellierung zusammen. Hieraus resultiert eine enge Kooperation von Ärzten und Naturwissenschaftlern, wobei insbesondere die Expertise nicht-ärztlicher Forscher zunehmend an Bedeutung für die Datenaufbereitung und -interpretation gewinnt. Aus ethischer Perspektive wirft diese Entwicklung Fragen nach der konkreten Gestaltung einer systemmedizinischen Zusammenarbeit sowie möglichen Rollenveränderungen und neuen Verantwortungszuschreibungen an Ärzte und nicht-ärztliche Forscher auf. Um diese Fragen (...)
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  16.  14
    Mission: Impossible? On Empirical-Normative Collaboration in Ethical Reasoning.Sebastian Schleidgen, Michael C. Jungert & Robert H. Bauer - 2010 - Ethical Theory and Moral Practice 13 (1):73-73.
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  17.  1
    Old wine in new bottles? Ethical implications of individualized medicine.Sebastian Schleidgen & Georg Marckmann - 2013 - Ethik in der Medizin 25 (3):223-231.
    ZusammenfassungDie sogenannte individualisierte Medizin ist in den letzten Jahren zu einem Schlagwort in Wissenschaft, Politik und Öffentlichkeit geworden. Wie jede technologische Neuentwicklung hat sie jedoch ethische Implikationen, die es zu berücksichtigen gilt, um eine angemessene Entwicklung und Anwendung individualisierter Präventions- und Therapiemaßnahmen zu ermöglichen. Allerdings steht eine ethische Bewertung der IM vor verschiedenen methodischen Herausforderungen, die sich insbesondere aus der Heterogenität des Problembereichs, begrifflicher Unklarheit sowie dem Frühstadium ihrer Entwicklung ergeben. Der vorliegende Beitrag spezifiziert zunächst den Begriff der IM, um (...)
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  18.  9
    Contractualism: History, theories and critiques.Sebastian Schleidgen - 2010 - In Richard Corrigan (ed.), Ethics: A University Guide. Progressive Frontiers Pubs.. pp. 109--134.
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  19.  2
    How to derive ethically appropriate recommendations for action? A methodology for applied ethics.Sebastian Schleidgen, Alexander Kremling, Marcel Mertz, Katja Kuehlmeyer, Julia Inthorn & Joschka Haltaufderheide - forthcoming - Medicine, Health Care and Philosophy:1-10.
    Researchers in applied ethics, and some areas of bioethics particularly, aim to develop concrete and appropriate recommendations for action in morally relevant real-world situations. When proceeding from more abstract levels of ethical reasoning to such concrete recommendations, however, even with regard to the very same normative principle or norm, it seems possible to develop divergent or even contradictory recommendations for action regarding a certain situation. This may give the impression that such recommendations would be arbitrary and, hence, not well justified. (...)
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