Biomedical advances of the past 20 years have stimulated a renewed interest in medical ethics. Transplantation of multiple human organs, implantation of artificial devices, advances in genetics, and stem cell research are a few of the medical procedures and discoveries that have awakened in both professionals and the public an awareness that medical discoveries often raise important ethical and societal issues. Today, members of the medical profession face issues that did not seem so pressing to their predecessors, and physician conduct (...) in response to many of these issues involves decision-making based on ethical principles. Issues of informed consent, gifts from pharmaceutical companies, and patient rights to privacy were not of great concern to most physicians a generation ago. However, these and other topics that involve a physician's ethical conduct have become increasingly pertinent to the practice of medicine.A renewed emphasis on ethics has been voiced by leaders in the field of medicine. (shrink)

Biomedical advances of the past 20 years have stimulated a renewed interest in medical ethics. Transplantation of multiple human organs, implantation of artificial devices, advances in genetics, and stem cell research are a few of the medical procedures and discoveries that have awakened in both professionals and the public an awareness that medical discoveries often raise important ethical and societal issues. Today, members of the medical profession face issues that did not seem so pressing to their predecessors, and physician conduct (...) in response to many of these issues involves decision-making based on ethical principles. Issues of informed consent, gifts from pharmaceutical companies, and patient rights to privacy were not of great concern to most physicians a generation ago. However, these and other topics that involve a physician's ethical conduct have become increasingly pertinent to the practice of medicine.A renewed emphasis on ethics has been voiced by leaders in the field of medicine. (shrink)

Transplantation continues to push the frontiers of medicine into domains that summon forth troublesome ethical questions. Looming on the frontier today is human facial transplantation. We develop criteria that, we maintain, must be satisfied in order to ethically undertake this as-yet-untried transplant procedure. We draw on the criteria advanced by Dr. Francis Moore in the late 1980s for introducing innovative procedures in transplant surgery. In addition to these we also insist that human face transplantation must meet all the ethical requirements (...) usually applied to health care research. We summarize the achievements of transplant surgery to date, focusing in particular on the safety and efficacy of immunosuppressive medications. We also emphasize the importance of risk/benefit assessments that take into account the physical, aesthetic, psychological, and social dimensions of facial disfiguration, reconstruction, and transplantation. Finally, we maintain that the time has come to move facial transplantation research into the clinical phase. (shrink)

Main Response Topics ? Introduction ? Open display and public evaluation ? Publicity versus patient privacy ? Facial tissue donation ? Validity of Louisville Instrument for Risk Acceptance ? Patients' understanding of risk ? Face versus hand transplantation ? Rejection rates/risks ? Patient compliance ? Exit strategy ? Functional recovery ? Societietal implications ? Psychological implications ? Conclusion: Uncertainty likely to persist.

This chapter addresses the relationship between Rorty's pragmatist philosophy and his view of literature and literary writing. It begins by examining the relationship between philosophy and literature, construed by Rorty in terms of the opposition between “normal,” professionalized, argument‐centered philosophical discourse and the kind of cultural criticism which emphasizes human finitude and contingency, seeking through the use of irony and literary inventiveness to transform our prevalent visions of what it means to be human. This humanist side of Rorty's argument is (...) further developed through the discussion of the role that literature plays in intellectual self‐formation and moral edification, by educating moral sensibility and providing transformational shifts of conceptual perspective. These dynamics of literary innovation are then shown to dovetail nicely with Rorty's naturalistic, evolutionary conception of cultural development as well as his views regarding the indispensable role of the personal, the private, and the unshared in producing genuine cultural innovation. (shrink)

An important objection to signaling approaches to representation is that, if signaling behavior is driven by the maximization of usefulness, then signals will typically carry much more information about agent-dependent usefulness than about objective features of the world. This sort of considerations are sometimes taken to provide support for an anti-realist stance on representation itself. The author examines the game-theoretic version of this skeptical line of argument developed by Donald Hoffman and his colleagues. It is shown that their argument only (...) works under an extremely impoverished picture of the informational connections that hold between agent and world. In particular, it only works for cue-driven agents, in Kim Sterelny’s sense. In cases in which the agents’ understanding of what is useful results from combining pieces of information that reach them in different ways, and that complement one another, maximizing usefulness involves construing first a picture of agent-independent, objective matters of fact. (shrink)

Perhaps the most widely touted of GPT-4’s at-launch, zero-shot capabilities has been its reported 90th-percentile performance on the Uniform Bar Exam. This paper begins by investigating the methodological challenges in documenting and verifying the 90th-percentile claim, presenting four sets of findings that indicate that OpenAI’s estimates of GPT-4’s UBE percentile are overinflated. First, although GPT-4’s UBE score nears the 90th percentile when examining approximate conversions from February administrations of the Illinois Bar Exam, these estimates are heavily skewed towards repeat test-takers (...) who failed the July administration and score significantly lower than the general test-taking population. Second, data from a recent July administration of the same exam suggests GPT-4’s overall UBE percentile was below the 69th percentile, and $$\sim$$ ∼ 48th percentile on essays. Third, examining official NCBE data and using several conservative statistical assumptions, GPT-4’s performance against first-time test takers is estimated to be $$\sim$$ ∼ 62nd percentile, including $$\sim$$ ∼ 42nd percentile on essays. Fourth, when examining only those who passed the exam (i.e. licensed or license-pending attorneys), GPT-4’s performance is estimated to drop to $$\sim$$ ∼ 48th percentile overall, and $$\sim$$ ∼ 15th percentile on essays. In addition to investigating the validity of the percentile claim, the paper also investigates the validity of GPT-4’s reported scaled UBE score of 298. The paper successfully replicates the MBE score, but highlights several methodological issues in the grading of the MPT + MEE components of the exam, which call into question the validity of the reported essay score. Finally, the paper investigates the effect of different hyperparameter combinations on GPT-4’s MBE performance, finding no significant effect of adjusting temperature settings, and a significant effect of few-shot chain-of-thought prompting over basic zero-shot prompting. Taken together, these findings carry timely insights for the desirability and feasibility of outsourcing legally relevant tasks to AI models, as well as for the importance for AI developers to implement rigorous and transparent capabilities evaluations to help secure safe and trustworthy AI. (shrink)

Experimental balance is usually understood as the control for the value of the conditions, other than the one under study, which are liable to affect the result of a test. We discuss three different approaches to balance. ‘Millean balance’ requires identifying and equalizing ex ante the value of these conditions in order to conduct solid causal inferences. ‘Fisherian balance’ measures ex post the influence of uncontrolled conditions through the analysis of variance. In ‘efficiency balance’ the value of the antecedent conditions (...) is decided ex ante according to the efficiency they yield in the estimation of the treatment outcome. Against some old arguments by Worrall, we show that in both Fisherian and efficiency balance there are good reasons to randomize the allocation of treatments, in particular when there is no agreement among experimenters as to the antecedent conditions to be controlled for. (shrink)

Qui étaient les gnostiques? Simplement des hérétiques? Ou bien ont-ils, par leurs questionnements, contribué à la redéfinition de la religion monothéiste? Relevaient-ils du judaïsme, du christianisme, du mandéisme, du sabéisme, du manichéisme? Comment le mouvement gnostique a-t-il influencé le développement du christianisme dans l’Antiquité? L’Église a-t-elle rejeté ce mouvement? L’ouvrage de Serge Hutin répond à ces questions essentielles.

There has been much discussion of so-called teleosemantic approaches to the naturalization of content. Such discussion, though, has been largely confined to simple, innate mental states with contents such as ?There is a fly here.? Even assuming we can solve the issues that crop up at this stage, an account of the content of human mental states will not get too far without an account of productivity: the ability to entertain indefinitely many thoughts. The best-known teleosemantic theory, Millikan's biosemantics, offers (...) an account of productivity in thought. This paper raises a basic worry about this account: that the use of mapping functions in the theory is unacceptable from a naturalistic point of view. (shrink)

This article discusses the meaning of the notion of virtuality in modern physics. To this end, it develops considerations on the introduction and establishment in nuclear physics of two independent concepts at the turn of the 1920s and 1930s: that of the virtual state, used in the context of neutron scattering studies, and that of the virtual transition, useful for the theoretical understanding of strong nuclear forces, which forms the basis of what are now called virtual particles. Their comparative analysis (...) highlights the theoretical nature of virtual entities and processes in modern physics. It also shows how the virtual has been associated with various purely physical attributes, leading to a form of polysemy of the term, from the beginning of the application of these concepts. (shrink)

Sont ici rassemblés dix-sept textes qui reflètent un travail délibérément orienté sur plusieurs champs du savoir. Celui de la philosophie, ses œuvres et ses auteurs, antiques et modernes, comme Augustin, Leibniz, Spinoza, Kant ou Derrida. Celui de la littérature, et sa critique, comme Blanchot, Duras ou Deguy. Celui du religieux, comme l'exorcisme avec le Malleus maleficarum, la cruentation avec Ranchin, le miracle avec Augustin, ou la Bible et langue hébraïque avec Spinoza. Enfin celui du cinéma, avec les voix fantômes de (...) Duras, les spectres de Farocki, la question des genres d'Akerman, les utopies de Kluge, et la fin du monde de Bela Tarr. Tous ces textes sont philosophiques, dans leur effort de pensée, dans le but de faire l'expérience d'une écriture de la pensée, d'une invention d'un langage de la pensée ou du regard. Ils cherchent à penser le travail de la lettre, dans un livre, une croyance religieuse, un événement surnaturel, une pratique déviante, une voix narrative, la description d'un personnage, un plan-séquence, etc. Chacun d'eux se concentre sur un détail qui aurait pu passer inaperçu. En somme, ces textes proposent des argumentations précises, analysent des récrits et décryptent des séquences, dans le désir d'en poursuivre l'écriture par le seul jeu de la pensée."--Page 4 of cover. (shrink)

Various four- and three-valued modal propositional logics are studied. The basic systems are modal extensions BK and BS4 of Belnap and Dunn's four-valued logic of firstdegree entailment. Three-valued extensions of BK and BS4 are considered as well. These logics are introduced semantically by means of relational models with two distinct evaluation relations, one for verification and the other for falsification. Axiom systems are defined and shown to be sound and complete with respect to the relational semantics and with respect to (...) twist structures over modal algebras. Sound and complete tableau calculi are presented as well. Moreover, a number of constructive non-modal logics with strong negation are faithfully embedded into BS4, into its three-valued extension B3S4, or into temporal BS4, BtS4. These logics include David Nelson's three-valued logic N3, the four-valued logic N4 bottom, the connexive logic C, and several extensions of bi-intuitionistic logic by strong negation. (shrink)

A partir de los postulados de una concepción semántica de norma y su clasificación en reglas y principios, Robert Alexy ha enunciado una tesis fuerte de la separación, al concebir que entre ambos tipos de normas no solo existe una diferencia gradual, sino también cualitativa. En este contexto, los principios son descritos como mandatos de optimización, caracterizados por un cumplimiento gradual en atención a las posibilidades reales y jurídicas, y a través de la denominada técnica de la ponderación. A pesar (...) de las objeciones recibidas, la vigencia de esta tesis resulta incuestionable, sirviendo todavía de inspiración a las nuevas generaciones de juristas interesados en la Teoría del Derecho. En el presente capítulo se pretende exponer de manera sucinta pero precisa los postulados del principialismo alexyano, las críticas más recurrentes y sus posibles respuestas, para terminar con algunas notas interpretativas que persiguen contribuir a la continuación del camino trazado por el insigne profesor alemán. (shrink)

St. Thomas Aquinas never commented on the Song of Songs. The purpose of this book is to demonstrate, however, that he meditated on it and absorbed it, so that the words of the Song are for him a familiar repertoire and a theological source. His work contains numerous citations of the Song, not counting his borrowings of vocabulary and images from it. In total, there are 312 citations of the Song in Aquinas's corpus, along with citations of the Song that (...) are found in citations that Aquinas makes of other authors (as for example in the Catena aurea). Understanding the purpose and placement of these citations significantly enriches our understanding of Aquinas as a theologian, biblical exegete, and spiritual master. The book contains an Appendix listing and contextualizing each citation. The study of the citations of the Song especially illuminates Aquinas's spiritual doctrine. By citing the Song, Aquinas emphasizes the spiritual life's path of dynamic ascent, through an ever increasing participation in the mystery of the nuptial union of Christ and the Church through love. The Song also highlights the eschatological tension or yearning present in the spiritual life, which is ordered to the fullness of beatific vision. Although Aquinas's theology is highly "intellectual," by citing the Song he brings out the affective character of the spiritual life and conveys the centrality of love in the soul's journey toward Christ. He also draws together contemplation and preaching through his use of the Song. (shrink)

This paper proposes a five-part empirical typology of interconnections of race and class. We describe the mechanisms whereby (1) race is a form of class relation; (2) race relations and class relations reciprocally affect each other; (3) race acts as a sorting mechanism into class locations; (4) race acts as a mediating linkage to class locations; and (5) race interacts with class in determining other outcomes. Rather than insisting on one or another mechanism as the overarching framework for conceptualising the (...) interconnections between race and class, we propose a theoretical integration of all five within a functionalist model. The model reconciles the empirical effects of race variables with a class-functionalist explanation of race. Our typology of interconnections is useful for situating concrete empirical phenomena, and our theoretical integration of those interconnections offers a coherent explanatory system that captures the recursive causality of race and class. (shrink)

El Menón es un buen ejemplo del uso de la ironía socrática como forma de refutación. Específicamente, la forma lógica de reducción al absurdo constituye un dispositivo muy relacionado con la ironía socrática. En este artículo, se examinan analíticamente los cuatro elementos de la ironía que se presentan en el diálogo: 1. el conocimiento falso como una posición inicial asumida por los interlocutores de Sócrates; 2. la igno­ rancia socrática; 3. la reducción al absurdo del falso saber inicial; y 4. (...) el reconocimiento del error y la ignorancia. (shrink)

A far-reaching reinterpretation of Plato’s Timaeus and its engagement with time, eternity, body, and soul that in its original French edition profoundly influenced Derrida The Tomb of the Artisan God provides a radical rereading of Timaeus, Plato’s metaphysical text on time, eternity, and the relationship between soul and body. First published in French in 1995, the original edition of Serge Margel’s book included an extensive introductory essay by Jacques Derrida, who drew on Margel’s insights in developing his own concepts (...) of time, the promise, the world, and khōra. Now available in English with a new preface by Margel, this engagement with Platonic thought proceeds from two questions that span the history of philosophy: What is time? What is the body? Margel’s twinned interrogation centers around Plato’s concept of the demiurge (divine artisan or craftsman): its body, its anthropomorphic attributes, its productive capacities and regulatory functions in the ordering/organization/assembling of the world. He posits that this paradoxical figure is not merely a cosmological metaphor for the living body but also the site of its destruction, dissolution, and disappearance. Torn between the finite and the infinite, being and becoming, the concept of demiurge also poses metaphysical questions about time, time before time, and the end of time. The ontological status of the demiurge’s body, Margel argues, would become increasingly decisive in the history of philosophy, particularly in Christianity and the dogma of incarnation. (shrink)

We aim to map out the points of confluence between phronesis and emotion, as well as the nature of this confluence. We do so based on philosophical and psychological explanations of emotions and phronesis. Making sound decisions, which requires phronesis, is an important matter, but its relationship with emotions has only just begun to be studied. We propose that the interplay between phronesis and emotion is possible (rather than inevitable) because both have a cognitive-behavioural structure and because emotions are hierarchical. (...) In the case of emotion, there are no gaps between the cognitive and behavioural dimensions, while phronetic acts can only manifest if cognitive and behavioural aspects are activated simultaneously. The confluence we identify is bidirectional and involves mutual enrichment in this dual dimension. On the one hand, phronesis enriches emotion because it involves extra subjective knowledge and allows emotion to be directed towards higher goals. On the other hand, emotions enrich phronesis because phronesis makes decisions based on sensitive preferences and because emotions confirm correctness in the context of moral decision making. Methodologically, this study is theoretical and interdisciplinary, as our approach is both philosophical and psychological. Philosophy helps us to improve the conceptual foundation of the construct, while psychology provides an analysis of the emotional process, allowing philosophy to understand how emotional evaluation-assessment and motivation lead to decision making. (shrink)

Our limited a priori-reasoning skills open a gap between our finding a proposition conceivable and its metaphysical possibility. A prominent strategy for closing this gap is the postulation of ideal conceivers, who suffer from no such limitations. In this paper I argue that, under many, maybe all, plausible unpackings of the notion of ideal conceiver, it is false that ideal negative conceivability entails possibility.

While attention to research integrity has been growing over the past decades, the processes of signalling and denouncing cases of research misconduct remain largely unstudied. In this article, we develop a theoretically and empirically informed understanding of the causes and consequences of reporting research misconduct in terms of power relations. We study the reporting process based on a multinational survey at eight European universities. Using qualitative data that witnesses of research misconduct or of questionable research practices provided, we aim to (...) examine actors’ rationales for reporting and not reporting misconduct, how they report it and the perceived consequences of reporting. In particular we study how research seniority, the temporality of work appointments, and gender could impact the likelihood of cases being reported and of reporting leading to constructive organisational changes. Our findings suggest that these aspects of power relations play a role in the reporting of research misconduct. Our analysis contributes to a better understanding of research misconduct in an academic context. Specifically, we elucidate the processes that affect researchers’ ability and willingness to report research misconduct, and the likelihood of universities taking action. Based on our findings, we outline specific propositions that future research can test as well as provide recommendations for policy improvement. (shrink)

In recent years, the most widespread doctrine about the conflicts between fundamental (usually constitutional) legal rights could be summarized in the following three main theses: (1) The elements in conflict are legal principles, as opposed to legal rules; (2) Those conflicts are not consequences of the existence of inconsistencies or antinomies between the norms involved, but rather depend on the empirical circumstances of the case. In other words, the norms are logically consistent and the conflicts are not determinable a priori (...) or in abstracto , but only in concreto ; and (3) The classical criteria for solving conflicts between norms, such as lex superior , lex posterior and lex specialis , are not suitable to solve conflicts among fundamental legal rights. Indeed, they require a specific method known as ‘weighing and balancing’. Although all three theses could be (and indeed have been) regarded as problematic, in this paper I address mainly the second one. I try to show that there is room for a tertium genus between antinomies (deontic inconsistencies) and conflicts caused by strict empirical circumstances that I call ‘contextual antinomies’. There are situations in which the norms involved are not inconsistent but the conflict arises for logical reasons. My thesis is that many conflicts between fundamental legal rights fall in this category. I offer, in an appendix, a proposal of formalization of this kind of conflict and the elements involved in it. (shrink)

La crise écologique actuelle prend ses racines dans une histoire faite de possibles, parfois aboutis, d'échecs et de renoncements. Près de deux siècles de politiques environnementales que Serge Audier synthétise ici à la lumière des entraves et des infléchissements qui les ont forgées, les empêchant encore aujourd'hui de répondre efficacement à l'urgence toujours plus criante. Depuis la fin du XXe siècle, des signaux d'alarme écologiques ne cessent de retentir : réchauffement climatique toujours plus incontrôlable, destruction exponentielle et dramatique de (...) la biodiversité, déforestations accélérées, pollutions diverses, " plastification " des mers, etc. Pourtant, les défenseurs de la cause écologique peinent à véritablement convaincre l'ensemble de la société ainsi que les décideurs économiques et politiques de la nécessité d'un changement urgent de modèle. Pourquoi les forces politiques, de droite mais aussi de gauche, n'ont-elles pas su ou voulu prendre en charge le défi écologique? C'est à cette question que s'intéresse ce livre de Serge Audier, qui offre une ample fresque inédite sur les racines philosophiques, idéologiques et politiques de la crise actuelle. Au croisement de l'histoire et de la philosophie, cette généalogie intellectuelle examine les logiques doctrinales et politiques qui, depuis près de deux siècles, ont présidé aux prises de position et aux programmes en matière environnementale, à leurs réussites comme à leurs nombreux échecs. L'auteur montre notamment pourquoi, dans de nombreuses régions du monde, la logique socio-économique, politique et culturelle dominante est allée dans le sens d'un modèle productiviste qui a provoqué une destruction accélérée et sans précédent du milieu naturel. Parallèlement, il soulève la question des " possibles " non aboutis ou non réalisés, et invite à (re)découvrir des voies alternatives - entre anarchisme et socialisme - qui ont cherché à articuler critique sociale et critique écologique du capitalisme, dans l'horizon d'une " cité écologique " à venir. (shrink)

Alors que monte la prise de conscience du péril environnemental, les obstacles à une véritable mutation écologique des sociétés contemporaines restent massifs et les modèles alternatifs peinent à s'imposer. Les traditions intellectuelles de la gauche semblent souvent impuissantes à apporter des réponses. Pire, n'ont-elles pas contribué, par leur culte des "forces productives", à l'impasse actuelle? La généalogie intellectuelle proposée par Serge Audier revient sur des évidences trompeuses, notamment celle qui voudrait que les mouvements émancipateurs n'aient abordé que très tardivement (...) les enjeux écologiques. On redécouvre certes peu à peu des voix minoritaires qui, de Henry D. Thoreau à William Morris, avaient manifesté très tôt un souci inédit de la nature. Mais en les érigeant en héros solitaires, on contribue à occulter une nébuleuse beaucoup plus large et méconnue qui, entre socialisme et anarchisme, a esquissé les traits d'une "société écologique". L'objectif de ce livre est d'exhumer et de reconstituer une pensée sociale de la nature et de l'émancipation, construite aux marges du "grand récit" socialiste et républicain. De fait, cette tendance dissidente a été ignorée, marginalisée, voire combattue par les courants hégémoniques, qui ont souvent vu dans l'écologie un conservatisme traditionaliste ou un romantisme réactionnaire... Si les "ennemis" de la "société écologique" se trouvent bien entendu du côté des forces du capitalisme, il serait faux et dangereux d'oublier qu'ils font aussi partie de l'histoire même de la gauche et du socialisme dans ses orientations majoritaires, encore prégnantes."--Page 4 of cover. (shrink)

En 1517, il y a cinq cents ans, la réforme de Luther fracture l'Europe. La même année, les conquistadores espagnols s'en prennent au Mexique, qu'ils colonisent et christianisent. Ils y introduisent aussi notre façon d'écrire l'histoire. Les vainqueurs ignorent tout des sociétés indigènes. Or pour imposer leur loi, ils doivent impérativement connaître les coutumes et donc le passé des vaincus. Mais que sont l'histoire et le temps dans l'esprit des Indiens? Le temps n'est pas encore une valeur universelle. Comment les (...) Espagnols formatés dans une Europe chrétienne où l'histoire est chronologique et orientée auraient-ils pu concevoir et accepter la cosmologie méso-américaine? Civilisés contre barbares? En quelques décennies, la machine à remonter le temps des envahisseurs s'emploie à capturer les mémoires des sociétés amérindiennes pour leur fabriquer un passé qui puisse être rattaché au patrimoine antique de la chrétienté. Du côté des Indiens, le souvenir de leur monde au sein duquel les êtres, les choses et les dieux étaient liés se dilue avec le passage des générations même si, dans les codex ou dans les mystérieux cantares, subsistent quelques pans secrets de leur mémoire. Serge Gruzinski propose ici une exploration inédite des débuts de l'expansion coloniale et nous explique comment, sur le terrain, religieux et Indiens se mettent à écrire l'histoire du monde. (shrink)

Las 15 piezas que ahora lo conforman abrevan en la Historia, en confeciones personales y entrevistas, y mezclan la literatura y el periodismo de manera audaz y perfecta. Los protagonistas son hombres excepcionales y el momento que se ha elegido para contar son las visperas de sus muertes -tal vez el momento de mayor soledad y de mayor intimidad de un hombre. A traves de la magistral escritura de Tomas Eloy Martinez tenemos el privilegio de asistir a los ultimos (...) minutos de sus vidas, el momento previo a perderlo todo y cuando, resistiendo a la indiferencia del mundo, se suena con alguna inmortalidad. (shrink)