Through statistical analysis of datasets describing single cell shape following systematic gene depletion, we have found that the morphological landscapes explored by cells are composed of a small number of attractor states. We propose that the topology of these landscapes is in large part determined by cell‐intrinsic factors, such as biophysical constraints on cytoskeletal organization, and reflects different stable signaling and/or transcriptional states. Cell‐extrinsic factors act to determine how cells explore these landscapes, and the topology of the landscapes themselves. (...) Informational stimuli primarily drive transitions between stable states by engaging signaling networks, while mechanical stimuli tune, or even radically alter, the topology of these landscapes. As environments fluctuate, the topology of morphological landscapes explored by cells dynamically adapts to these fluctuations. Finally we hypothesize how complex cellular and tissue morphologies can be generated from a limited number of simple cell shapes. (shrink)

In a chronically migrant world, the academy is no exception. Academic migrants, who shift to another space and another world view, feature in the educational landscape of every continent. However, a global lens may not be useful in understanding their experiences, nor in seeking to support them in their endeavours. This dispatch discusses ways of understanding the intersections of space, movement and world view derived from Pacific thinking of various sources. The discussion is grounded in the activities of (...) Leadership Pacific (LP). This is not a program but a cause-based movement. It provides a safe space for storying as learning and leadership. LP has grown from a single group to become a fluid, welcoming and ever-morphing network of inter-locking clusters across the region. Responding to the need for a village-like web of caring and reciprocal relationships, LP fills the gap experienced by many Pacific-origin academic migrants when faced with academic practices and relationships. Through its people-centred storying pedagogy, LP provides an alternative space in which indigenous ways of knowing and being can be at home and the racism inherent in a mono-cultural understanding of academia is challenged. It welcomes both Pacific-origin academic migrants and those academics who seek alignment with a village-like people-centred approach to relationships. The LP experience, which now includes an international conference, provides a model of contextualised action that may be helpful in supporting academic migrants from other regions. Long-term, the influence of movements such as LP has the potential to shift deep-seated universal assumptions of what movement and space might mean for the academy, and of ethical forms of response to the needs and potentials of the academically migrant. (shrink)

Visual Perception of Shape, Space and Appearance Liliana Albertazzi. the sort I have in mind. What I am speaking of is the mandatory correlations between attributes of visual space (those of, e.g., surfaces, shape, distance, direction) and  ...

We analyze the points of total collision of the Newtonian gravitational system on shape space (the relational configuration space of the system). While the Newtonian equations of motion, formulated with respect to absolute space and time, are singular at the point of total collision due to the singularity of the Newton potential at that point, this need not be the case on shape space where absolute scale doesn’t exist. We investigate whether, adopting a relational (...) description of the system, the shape degrees of freedom, which are merely angles and their conjugate momenta, can be evolved through the points of total collision. Unfortunately, this is not the case. Even without scale, the equations of motion are singular at the points of total collision (and only there). This follows from the special behavior of the shape momenta. While this behavior induces the singularity, it at the same time provides a purely shape-dynamical description of total collisions. By help of this, we are able to discern total-collision solutions from non-collision solutions on shape space, that is, without reference to (external) scale. We can further use the shape-dynamical description to show that total-collision solutions form a set of measure zero among all solutions. (shrink)

We discuss the total collision singularities of the gravitational N-body problem on shape space. Shape space is the relational configuration space of the system obtained by quotienting ordinary configuration space with respect to the similarity group of total translations, rotations, and scalings. For the zero-energy gravitating N-body system, the dynamics on shape space can be constructed explicitly and the points of total collision, which are the points of central configuration and zero (...) class='Hi'>shape momenta, can be analyzed in detail. It turns out that, even on shape space where scale is not part of the description, the equations of motion diverge at (and only at) the points of total collision. We construct and study the stratified total-collision manifold and show that, at the points of total collision on shape space, the singularity is essential. There is, thus, no way to evolve the solutions through these points. This mirrors closely the big bang singularity of general relativity, where the homogeneous-but-not-isotropic cosmological model of Bianchi IX shows an essential singularity at the big bang. A simple modification of the general-relativistic model (the addition of a stiff matter field) changes the system into one whose shape-dynamical description allows for a deterministic evolution through the singularity. We suspect that, similarly, some modification of the dynamics would be required in order to regularize the total collision singularity of the N-body model. (shrink)

We discuss the total collision singularities of the gravitational N-body problem on shape space. Shape space is the relational configuration space of the system obtained by quotienting ordinary configuration space with respect to the similarity group of total translations, rotations, and scalings. For the zero-energy gravitating N-body system, the dynamics on shape space can be constructed explicitly and the points of total collision, which are the points of central configuration and zero (...) class='Hi'>shape momenta, can be analyzed in detail. It turns out that, even on shape space where scale is not part of the description, the equations of motion diverge at (and only at) the points of total collision. We construct and study the stratified total-collision manifold and show that, at the points of total collision on shape space, the singularity is essential. There is, thus, no way to evolve the solutions through these points. This mirrors closely the big bang singularity of general relativity, where the homogeneous-but-not-isotropic cosmological model of Bianchi IX shows an essential singularity at the big bang. A simple modification of the general-relativistic model (the addition of a stiff matter field) changes the system into one whose shape-dynamical description allows for a deterministic evolution through the singularity. We suspect that, similarly, some modification of the dynamics would be required in order to regularize the total collision singularity of the N-body model. (shrink)

One of the foremost goals of research in physics is to find the most basic and universal theories that describe our universe. Many theories assume the presence of absolute space and time in which the physical objects are located and physical processes take place. However, it is more fundamental to understand time as relative to the motion of another object, e.g., the number of swings of a pendulum, and the position of an object primarily relative to other objects. This (...) paper aims to explain how using the principle of relationalism, classical mechanics can be formulated on a most elementary space, which is freed from absolute entities: shape space. In shape space, only the relative orientation and length of subsystems are taken into account. A sufficient requirement for the validity of the principle of relationalism is that by changing a system’s scale variable, all the theory’s parameters that depend on the length, get changed accordingly. In particular, a direct implementation of the principle of relationalism introduces a proper transformation of the coupling constants of the interaction potentials in classical physics. This change leads consequently to a transformation in Planck’s measuring units, which enables us to derive a metric on shape space in a unique way. In order to find out the classical equations of motion on shape space, the method of “symplectic reduction of Hamiltonian systems” is extended to include scale transformations. In particular, we will give the derivation of the reduced Hamiltonian and symplectic form on shape space, and in this way, the reduction of a classical system with respect to the entire similarity group is achieved. (shrink)

This is a revised and updated edition of Graham Nerlich's classic book The Shape of Space. It develops a metaphysical account of space which treats it as a real and concrete entity. In particular, it shows that the shape of space plays a key explanatory role in space and spacetime theories. Arguing that geometrical explanation is very like causal explanation, Professor Nerlich prepares the ground for philosophical argument, and, using a number of novel examples, (...) investigates how different spaces would affect perception differently. This leads naturally to conventionalism as a non-realist metaphysics of space, an account which Professor Nerlich criticises, rejecting its Kantian and positivistic roots along with Reichenbach's famous claim that even the topology of space is conventional. He concludes that there is, in fact, no problem of underdetermination for this aspect of spacetime theories, and offers an extensive discussion of the relativity of motion. (shrink)

Height-pitch associations are claimed to be universal and independent of language, but this claim remains controversial. The present study sheds new light on this debate with a multimodal analysis of individual sound and melody descriptions obtained in an interactive communication paradigm with speakers of Dutch and Farsi. The findings reveal that, in contrast to Dutch speakers, Farsi speakers do not use a height-pitch metaphor consistently in speech. Both Dutch and Farsi speakers’ co-speech gestures did reveal a mapping of higher pitches (...) to higher space and lower pitches to lower space, and this gesture space-pitch mapping tended to co-occur with corresponding spatial words (high-low). However, this mapping was much weaker in Farsi speakers than Dutch speakers. This suggests that cross-linguistic differences shape the conceptualization of pitch and further calls into question the universality of height-pitch associations. (shrink)

Cognitive Science, Volume 46, Issue 2, February 2022.

The growing body of research on temporal and spatial experience lacks a comprehensive theoretical approach. Drawing on Giddens’ framework, we present time-space distanciation as a construct for theorizing the relations between culture, time, and space. TSD in a culture may be understood as the extent to which time and space are abstracted as separate dimensions and activities are extended and organized across time and space. After providing a historical account of its development, we outline a multi-level (...) conceptualization of TSD supported by research on cultural differences in the experience of time and space. We impact this conceptualization by examining two ethnographic case studies. We conclude by highlighting future research directions. TSD is an integrative, interdisciplinary, multi level construct with the potential to guide the burgeoning social science of time and space. (shrink)

There is an analogy between Timaeus's act of describing a world in words and the demiurge's task of making a world of matter. This analogy implies a parallel between language as a system of reproducing ideas in words, and the world, which reproduces reality in particular things. Authority lies in the creation of a likeness in words of the eternal Forms. The Forms serve as paradigms both for the physical world created by the demiurge, and for the world in discourse (...) created by Timaeus: his discourse gains its validity not from faithfulness to the way things appear, or the way particular things 'actually happened', but in virtue of its attempt to express in words a likeness of the perfect and eternal reality. There are implications for Plato's philosophy of language, and for the relation between words and things (words do not depict or name things but can be used to construct worlds in a parallel way to the manner in which things construct worlds, both worlds being modelled on one common world of ideas). The match between world and discourse is because of their common pictorial relation (likeness) to an independent model. (shrink)

What is special about all our living exchanges with our surroundings is that they occur within the ceaseless, intertwined flow of many unfolding strands of spontaneously responsive, living activity. This requires us to adopt a kind of fluid, process thinking, a shift from thinking of events as occurring between things and beings existing as separate entities prior to their inter-action, to events occurring within a continuously unfolding, holistic but stranded flow of events, with no clear, already existing boundaries to be (...) found anywhere (Mol & Law, 1994)—a flow of events within which we ourselves are also immersed. We thus become involved in activities within which we find things happening to us, as much as we make things happen in our surroundings—in other words, our surroundings are also agentive in that they can exert “calls” upon us to respond within them in appropriate ways. Consequently, what we can learn in such encounters is not just new facts or bits of information, but new ways of relating or orienting ourselves bodily to the others and othernesses in the world around us—although much can “stand in the way” of our doing this. My concern below is to explore events happening on the (inter)-subjective side of the Cartesian subject/object divide which “shape” our spontaneous ways of acting in, and reflecting on, the “worlds” within which we live out our lives. (shrink)

Semantic Scholar extracted view of "Space-Shaping Technologies and the Geographical Disembedding of Place" by Jonathan Smith.

In this contribution, we draw on findings from a non-formal, community music project to elaborate on the relationship between the concept ofeudaimonia, as defined by Seligman, the interactive dimensions of collective free improvisation, and the concept of collaborative creativity. The project revolves around The Ostend Street Orkestra (TOSO), a music ensemble within which homeless adults and individuals with a psychiatric or alcohol/drug related background engage in collective musical improvisation. Between 2017 and 2019 data was collected through open interviews and video (...) recordings of rehearsals and performances. Participant data was analyzed through inductive analysis based on the principles of grounded theory. One interesting finding was the discrepancy in the participant interviews between social relationships indicative of a negative affect about social group interaction versus strong feelings of group coherence and belonging. Video recordings of performances and rehearsals showed clear enjoyment and pleasure while playing music. Alongside verbal reflection through one-on-one interviews video recordings and analysis of moment-to moment observations should be used, in order to capture the complexity of community music projects with homeless people. The initial open coding was aligned with the five elements of the PERMA model. Overall, we observed more focus on Relationship (sense of belonging), Engagement (flow in rehearsals and performances) and Meaning (belonging to something greater than yourself) and less on Positive Emotion and Accomplishment (goal setting). (shrink)

This article proposes a new bi-directional way of understanding the convergence of biology and computing. It argues for a reciprocal interaction in which biology and computing have shaped and are currently reshaping each other. In so doing, we qualify both the view of a natural marriage and of a digital shaping of biology, which are common in the literature written by scientists, STS, and communication scholars. The DNA database is at the center of this interaction. We argue that DNA databases (...) are spaces of convergence for computing and biology that change in form, meaning, and function from the 1960s to the 2000s. The first part of the article shows how, in the 1980s, DNA sequencing shifted from passively incorporating computers to be increasingly modeled in digital coding and decoding. Information retrieval algorithms, reciprocally, were altered according to the peculiarities of DNA in the first sequence-storage databases. The second part of the article investigates the impact of these reciprocal interactions and globalization on the organization of research centers, ways of conducting big science, and scientific values. Through convergence and new technologies such as data mining, biology and computing were transformed technologically, institutionally, and culturally into a new bio-data enterprise called genomics. (shrink)

Space is a particular, the particular thing structuring our world. It has shape. And size. And reference to space and its properties is fundamental to physical explanation. This, in a nutshell, is Nerlich's position. Espousing it Nerlich marches against the tide of philosophical opinion which dominated the first half or more of this century.His arguments are laid out in a wholly enjoyable book: clearly and simply written, ‘meaty’ in argument and lucid in explanation. The book does not (...) have the same technical scope in theoretical physics as do its relevant companions. Rather, the book is a sustained argument aimed at establishing the theses with which I began and its content has been selected accordingly. But the clarity of presentation and consistency of argument recommend it as a major contribution to the field. It is especially to be recommended to the non-technical philosopher. And there is another important reason for commending it: much of the argumentation of the book is not to be found elsewhere, it fills an important gap in the field. I need hardly add that I find myself in sympathy with Nerlich's position. (shrink)

Efforts from diverse disciplines, including evolutionary studies and biomechanical experiments, have yielded new insights into the genetic, signaling, and mechanical control of tooth formation and functions. Evidence from fossils and non‐model organisms has revealed that a common set of genes underlie tooth‐forming potential of epithelia, and changes in signaling environments subsequently result in specialized dentitions, maintenance of dental stem cells, and other phenotypic adaptations. In addition to chemical signaling, tissue forces generated through epithelial contraction, differential growth, and skeletal constraints act (...) in parallel to shape the tooth throughout development. Here recent advances in understanding dental development from these studies are reviewed and important gaps that can be filled through continued application of evolutionary and biomechanical approaches are discussed. (shrink)

Spaces can make certain forms of philosophical activity more likely or more fruitful among the people who occupy them, and many public philosophers aim to promote one or another form of fruitful philosophical activity. It's helpful to distinguish four ways in which spaces can facilitate philosophical reflection and interaction: domain‐general cognitive facilitation, domain‐specific cognitive facilitation, affective facilitation, and relational facilitation. This chapter shows how philosophical spaces shape the activity of their occupants in ways of interest to public philosophers. Groups (...) can be unjustly excluded from philosophical communities for any number of reasons, but some of that exclusion is territorial. There are a number of challenges facing the would‐be designer of a philosophical space. The chapter presents three such challenges and offers some suggestions for how designers of philosophical spaces might address them. These include: the problem of rapport, the problem of urban social psychology, and the problem of the outsider. (shrink)

Empathy is an integral aspect of human existence. Without at least a basic ability to access others’ affective life, social interactions would be well-nigh impossible. Yet, recent studies seem to show that the means we have acquired to access others’ emotional life no longer function well in what has become our everyday business – technologically mediated interactions in digital spaces. If this is correct, there are two important questions: (1) What makes empathy for frequent internet users so difficult? and (2) (...) What can we do to alleviate the negative consequences? Correspondingly, the aim of this paper is twofold. First, we identify structural differences between offline and technologically mediated interactions that can explain why digital empathy is harder to achieve. Second, drawing on the literature on ‘situated affectivity,’ we consider the idea of modifying digital spaces in ways specifically designed to ‘scaffold’ empathy where our evolved mechanisms fail. Section 2 argues that empathy is requires interpreting the behavior of embodied subjects. Section 3 identifies three factors that are crucial for this interpretative endeavor: the empathizer’s affective repertoire, their perceptual input, and their background knowledge. Section 4 argues that technologically mediated interactions differ from face-to-face interactions with regard to these factors in ways which render our evolved empathy mechanisms less effective in the digital world. Section 5 introduces the idea that situational factors can serve as ‘empathic scaffolds,’ i.e., as ‘tools’ that can ‘shape’ people’s empathic reactions. Section 6 wraps up the main line of reasoning, responds to objections and invites further scholarship. (shrink)

The author suggests to view the architectural planning of the human environment as „directing” the phenomena and events that occur in human surroundings. In her reflections on human existence she juxtaposes the concepts “environment” and “space”, which both accentuate different aspects of the human environment. The author views “environment” as the objective existence of human surroundings, and “space” as the effect of environmental envisionment and experiencing the environment by means of rationality and valuation.The author also focuses on interactions (...) between the paradigm of thought and the paradigm of the order which humans bring into the space they design, and describes related examples. She notes that the links between architecture and the “how” and “what” of our thinking are visible not only in accounts of bygone eras, but also in the influence on architecture of two contemporary thought trends—post-modernism and ecologism. She goes on to suggest that ecological architecture should be understood as spatial design patterned on the structure of eco-systems. Thus understood, ecological architecture is neither structuralistic, nor “atomic”, nor collectivistic. The author also sees the difference between post-modern and ecological architecture in the ability of making use of the opportunities provided by difference. (shrink)