We investigate two constants cT and rT, introduced by Chaitin and Raatikainen respectively, defined for each recursively axiomatizable consistent theory T and universal Turing machine used to determine Kolmogorov complexity. Raatikainen argued that cT does not represent the complexity of T and found that for two theories S and T, one can always find a universal Turing machine such that equation image. We prove the following are equivalent: equation image for some universal Turing machine, equation image for some universal Turing (...) machine, and T proves some Π1-sentence which S cannnot prove. © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. (shrink)

Der Begriff der Person wird häufig im Bereich der biomedizinischen Ethik angewandt, wie vor allem in der Abtreibungsdebatte. Es wird immer noch kontrovers darüber diskutiert, ob ein Embryo als Person anzusehen ist.Dieses Buch zeigt einerseits auf, dass der Begriff der Person keinen Beitrag zur Antwort nach dem moralischen Status eines menschlichen Wesens am Lebensbeginn leisten kann. Andererseits wird jedoch deutlich, dass dieser Begriff für den Respekt gegenüber menschlichen Wesen am Lebensende hilfreich ist. Was bedeutet Respekt vor der Autonomie von Personen (...) bei der Sterbehilfe und was bedeutet Respekt gegenüber dementen Personen, die nicht mehr autonom sind? Bei der Beantwortung dieser Fragen spielt der Begriff der Person eine entscheidende Rolle. Dieses Buch soll einen Beitrag zur Verdeutlichung der Grenzen und Gültigkeit des Begriffs der Person in der biomedizinischen Ethik leisten. (shrink)

In biomedical ethics, the concept of person plays a major role in the discussion of ethically appropriate relationships with early human beings. The debate over abortion is one such case. There is still a heated debate over whether a fetus is already a person. However, because of the structure of the argument, the debate over the moral status of the fetus quickly becomes all-or-nothing. Against this background, I would like to address the question of to what extent the concept of (...) person can be helpful in biomedical ethics. I argue that this concept is not useful for ethically appropriate interactions with early human beings, but it is useful for ethically appropriate interactions with human beings at the end of life. I demonstrate my thesis with reference to the argument about euthanasia. The concept of person plays a crucial role in understanding what it means to respect the autonomy of a person who desires euthanasia. (shrink)

This study examines the neural substrate of the understanding of human relationships in verbal communication with Japanese honorific sentences as experimental materials. We manipulated two types of Japanese verbs specifically used to represent respect for others, i.e., exalted and humble verbs, which represent respect for the person in the subject and the person in the object, respectively. We visually presented appropriate and anomalous sentences containing the two types of verbs and analyzed the electroencephalogram elicited by the verbs. We observed significant (...) parietal negativity at a latency of approximately 400 ms for anomalous verbs compared with appropriate verbs. This parietal negativity could be a manifestation of the pragmatic process used to integrate the linguistic forms with the human relationships represented in the sentences. The topographies of these event-related potentials corresponded well with those of ERPs for two second-person pronouns in Chinese. This correspondence suggests that the pragmatic integration process in honorific expressions is cross-linguistically common in part. Furthermore, we assessed the source localization by means of independent component analysis and dipole fitting and observed a significant difference in ERP between the honorific and control sentences in the IC cluster centered in the precentral gyrus and in the cluster centered in the medial part of the occipital lobe, which corresponded well with the functional magnetic resonance imaging findings for Japanese honorification. We also found several significant differences in the time-frequency analyses for the medial occipital cluster. These significant differences in the medial occipital cluster suggested that the circuit of the theory of mind was involved in the processing of Japanese honorification. Our results suggest that pragmatic and syntactic processing are performed in parallel because the person to be respected must fulfill the grammatical function appropriate for the honorific verb. (shrink)

1-kan. Geijutsuteki rōdō no shakaigaku -- 2-kan. Geijutsuteki sōzō no riron.

There are different ways of defining science, but I should like to examine it primarily as one of the forms of mental labor. In this connection it is appropriate to recall Marx's words: "A distinction must be made between universal labor and cooperative labor. Each plays its own role in the process of production. They overlap, but there is also a distinction between them. Every scientific work, every discovery, every invention is universal labor. It is made possible partly by cooperation (...) among contemporaries and partly by making use of the work of those who have gone before. Joint labor presumes direct cooperation among individuals." What is subsumed here under "cooperative labor," according to Marx, is "directly associated labor," which, to put it in other terms, is "direct labor.". (shrink)

Refusal is considered a face-threatening act, since it contradicts the inviter’s expectations. In the case of Japanese, native speakers are known to prefer to leave sentences unfinished for a conventional indirect refusal. Successful comprehension of this indirect refusal depends on whether the addressee is fully conventionalized to the preference for syntactic unfinishedness so that they can identify the true intention of the refusal. Then, non-native speakers who are not fully accustomed to the convention may be confused by the indirect style. (...) In the present study, we used event-related potentials of electroencephalography in an attempt to differentiate the neural substrates for perceiving unfinished sentences in a conventionalized indirect refusal as an FTA between NS and NNS, in terms of the unfinishedness and indirectness of the critical sentence. In addition, we examined the effects of individual differences in mentalization, or the theory of mind, which refers to the ability to infer the mental states of others. We found several different ERP effects for these refusals between NS and NNS. NNS induced stronger P600 effects for the unfinishedness of the refusal sentences, suggesting their perceived syntactic anomaly. This was not evoked in NS. NNS also revealed the effects of N400 and P300 for the indirectness of refusal sentences, which can be interpreted as their increased processing load for pragmatic processing in the inexperienced contextual flow. We further found that the NNS’s individual mentalizing ability correlates with the effect of N400 mentioned above, indicating that lower mentalizers evoke higher N400 for indirect refusal. NS, on the contrary, did not yield these effects reflecting the increased pragmatic processing load. Instead, they evoked earlier ERPs of early posterior negativity and P200, both of which are known as indices of emotional processing, for finished sentences of refusal than for unfinished ones. We interpreted these effects as a NS’s dispreference for finished sentences to realize an FTA, given that unfinished sentences are considered more polite and more conventionalized in Japanese social encounters. Overall, these findings provide evidence that a syntactic anomaly inherent in a cultural convention as well as individual mentalizing ability plays an important role in understanding an indirect speech act of face-threatening refusal. (shrink)

We examined amygdala subregion volumes in patients with a first episode of major depression and in healthy subjects. Covariate-adjusted linear regression was performed to compare the MD and healthy groups, and adjustments for age, gender, and total estimated intracranial volume showed no differences in amygdala subregion volumes between the healthy and MD groups. Within the MD group, we examined the association between amygdala subregion volume and the 17-item Hamilton Rating Scale for Depression score and the HAMD subscale score, and found (...) no association in the left amygdala. In the right amygdala, however, there was an inverse linear association between the HAMD total and the HAMD core and lateral nucleus and anterior-amygdaloid-regions. Furthermore, an inverse linear association was seen between the HAMD psychic and the lateral nucleus, anterior-amygdaloid-regions, transition, and whole amygdala. The findings of this study suggest that the severity of MD and some symptoms of MD are associated with right amygdala volume. There have been few reports on the relationship between MD and amygdala subregional volume, and further research is needed to accumulate more data for further validation. (shrink)

Cancer chemotherapy has been the most common cancer treatment. However, it has side effects that kill both tumor cells and immune cells, which can ravage the patient’s immune system. Chemotherapy should be administered depending on the patient’s immunity as well as the level of cancer cells. Thus, we need to design an efficient treatment protocol. In this work, we study a feedback control problem of tumor-immune system to design an optimal chemotherapy strategy. For this, we first propose a mathematical model (...) of tumor-immune interactions and conduct stability analysis of two equilibria. Next, the feedback control is found by solving the Hamilton–Jacobi–Bellman equation. Here, we use an upwind finite-difference method for a numerical approximate solution of the HJB equation. Numerical simulations show that the feedback control can help determine the treatment protocol of chemotherapy for tumor and immune cells depending on the side effects. (shrink)