Results for 'Signaling'

963 found
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  1. Virtue signalling is virtuous.Neil Levy - 2020 - Synthese 198 (10):9545-9562.
    The accusation of virtue signalling is typically understood as a serious charge. Those accused usually respond by attempting to show that they are doing no such thing. In this paper, I argue that we ought to embrace the charge, rather than angrily reject it. I argue that this response can draw support from cognitive science, on the one hand, and from social epistemology on the other. I claim that we may appropriately concede that what we are doing is virtue signalling, (...)
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  2.  27
    Signalling, commitment, and strategic absurdities.Daniel Williams - 2022 - Mind and Language 37 (5):1011-1029.
    Why do well‐functioning psychological systems sometimes give rise to absurd beliefs that are radically misaligned with reality? Drawing on signalling theory, I develop and explore the hypothesis that groups often embrace beliefs that are viewed as absurd by outsiders as a means of signalling ingroup commitment. I clarify the game‐theoretic and psychological underpinnings of this hypothesis, I contrast it with similar proposals about the signalling functions of beliefs, and I motivate several psychological and sociological predictions that could be used to (...)
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  3. Virtue signalling and the Condorcet Jury theorem.Scott Hill & Renaud-Philippe Garner - 2021 - Synthese 199 (5-6):14821-14841.
    One might think that if the majority of virtue signallers judge that a proposition is true, then there is significant evidence for the truth of that proposition. Given the Condorcet Jury Theorem, individual virtue signallers need not be very reliable for the majority judgment to be very likely to be correct. Thus, even people who are skeptical of the judgments of individual virtue signallers should think that if a majority of them judge that a proposition is true, then that provides (...)
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  4.  50
    Hedgehog signalling as an antagonist of ageing and its associated diseases.Monireh Dashti, Maikel P. Peppelenbosch & Farhad Rezaee - 2012 - Bioessays 34 (10):849-856.
    Hedgehog is an important morphogenic signal that directs pattern formation during embryogenesis, but its activity also remains present through adult life. It is now becoming increasingly clear that during the reproductive phase of life and beyond it continues to direct cell renewal (which is essential to combat the chronic environmental stress to which the body is constantly exposed) and counteracts vascular, osteolytic and sometimes oncological insults to the body. Conversely, down‐regulation of hedgehog signalling is associated with ageing‐related diseases such as (...)
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  5.  34
    Signalling games, sociolinguistic variation and the construction of style.Heather Burnett - 2019 - Linguistics and Philosophy 42 (5):419-450.
    This paper develops a formal model of the subtle meaning differences that exist between grammatical alternatives in socially conditioned variation and how these variants can be used by speakers as resources for constructing personal linguistic styles. More specifically, this paper introduces a new formal system, called social meaning games, which allows for the unification of variationist sociolinguistics and game-theoretic pragmatics, two fields that have had very little interaction in the past. Although remarks have been made concerning the possible usefulness of (...)
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  6.  24
    Signalling under Uncertainty: Interpretative Alignment without a Common Prior.Thomas Brochhagen - 2020 - British Journal for the Philosophy of Science 71 (2):471-496.
    Communication involves a great deal of uncertainty. Prima facie, it is therefore surprising that biological communication systems—from cellular to human—exhibit a high degree of ambiguity and often leave its resolution to contextual cues. This puzzle deepens once we consider that contextual information may diverge between individuals. In the following we lay out a model of ambiguous communication in iterated interactions between subjectively rational agents lacking a common contextual prior. We argue ambiguity’s justification to lie in endowing interlocutors with means to (...)
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  7.  7
    Electrical signalling in prokaryotes and its convergence with quorum sensing in Bacillus.Abhirame Bavaharan & Christopher Skilbeck - 2022 - Bioessays 44 (4):2100193.
    The importance of electrical signalling in bacteria is an emerging paradigm. Bacillus subtilis biofilms exhibit electrical communication that regulates metabolic activity and biofilm growth. Starving cells initiate oscillatory extracellular potassium signals that help even the distribution of nutrients within the biofilm and thus help regulate biofilm development. Quorum sensing also regulates biofilm growth and crucially there is convergence between electrical and quorum sensing signalling axes. This makes B. subtilis an interesting model for cell signalling research. SpoOF is predicted to act (...)
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  8.  22
    CREB signalling in neural stem/progenitor cells: Recent developments and the implications for brain tumour biology.Theo Mantamadiotis, Nikos Papalexis & Sebastian Dworkin - 2012 - Bioessays 34 (4):293-300.
    This paper discusses the evidence for the role of CREB in neural stem/progenitor cell (NSPC) function and oncogenesis and how these functions may be important for the development and growth of brain tumours. The cyclic‐AMP response element binding (CREB) protein has many roles in neurons, ranging from neuronal survival to higher order brain functions such as memory and drug addiction behaviours. Recent studies have revealed that CREB also has a role in NSPC survival, differentiation and proliferation. Recent work has shown (...)
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  9. Propositional Content in Signalling Systems.Jonathan Birch - 2014 - Philosophical Studies 171 (3):493-512.
    Skyrms, building on the work of Dretske, has recently developed a novel information-theoretic account of propositional content in simple signalling systems. Information-theoretic accounts of content traditionally struggle to accommodate the possibility of misrepresentation, and I show that Skyrms’s account is no exception. I proceed to argue, however, that a modified version of Skyrms’s account can overcome this problem. On my proposed account, the propositional content of a signal is determined not by the information that it actually carries, but by the (...)
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  10.  52
    Costly signalling: A work in progress.Stewart Saunders - 2009 - Biology and Philosophy 24 (3):405-416.
    The Evolution of Animal Communication is a detailed examination of a wide variety of animal signalling systems. The main focus of the book is explaining how such signalling systems remain reliable when there is apparent evolutionary pressure to deceive. The principle strategy is to appeal to signal costs: signals remain reliable because the potential benefits of deceit are outweighed by the costs of producing the deceptive signal. In this review I show just how difficult this idea is to test, even (...)
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  11.  26
    Signalling pathways and the host‐parasite relationship: Putative targets for control interventions against schistosomiasis.Hong You, Geoffrey N. Gobert, Malcolm K. Jones, Wenbao Zhang & Donald P. McManus - 2011 - Bioessays 33 (3):203-214.
    A better understanding of how schistosomes exploit host nutrients, neuro‐endocrine hormones and signalling pathways for growth, development and maturation may provide new insights for improved interventions in the control of schistosomiasis. This paper describes recent advances in the identification and characterisation of schistosome tyrosine kinase and signalling pathways. It discusses the potential intervention value of insulin signalling, which may play an important role in glucose uptake and carbohydrate metabolism in schistosomes, providing the nutrients essential for parasite growth, development and, notably, (...)
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  12.  20
    Wnt signalling: a theme with nuclear variations.Colin Sharpe, Nicola Lawrence & Alfonso Martinez Arias - 2001 - Bioessays 23 (4):311-318.
    Wnt proteins are involved in a large number of events during development and disease. The crucial element in the transduction of the signal elicited by Wnt is the state and activity of β-catenin. There are two pools of β-catenin, one associated with cadherins at the cell surface and a soluble one in the cytolasm, whose state and concentration are critical for Wnt signalling. In the absence of Wnt, the cytoplasmic pool is low due to targetted degradation of β-catenin. Upon Wnt (...)
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  13.  26
    Signalling via testosterone: Communicating health and vigour.Alejandro Kacelnik & Sasha Norris - 1998 - Behavioral and Brain Sciences 21 (3):378-378.
    Our commentary summarises the current understanding of how testosterone can be used as a mechanism to link quality to external traits potentially used in sexual signalling, particularly female choice. Testosterone-dependent traits may reveal male's status to rivals and immunocompetence to females. We highlight some interesting unanswered questions and suggest that cross-disciplinary collaboration would help solve them.
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  14.  68
    Costly signalling theories: beyond the handicap principle.Ben Fraser - 2012 - Biology and Philosophy 27 (2):263-278.
    Two recent overviews of costly signalling theory—Maynard-Smith and Harper ( 2003 ) and Searcy and Nowicki ( 2005 )—both refuse to count signals kept honest by punishment of dishonesty, as costly signals, because (1) honest signals must be costly in cases of costly signalling, and (2) punishment of dishonesty itself requires explanation. I argue that both pairs of researchers are mistaken: (2) is not a reason to discount signals kept honest by punishment of dishonesty as cases of costly signalling, and (...)
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  15.  76
    Conventional Semantic Meaning in Signalling Games with Conflicting Interests.Elliott O. Wagner - 2015 - British Journal for the Philosophy of Science 66 (4):751-773.
    Lewis signalling games are often used to explain how it is possible for simple agents to develop systems of conventional semantic meaning. In these games, all players obtain identical payoffs in every outcome. This is an unrealistic payoff structure, but it is often employed because it is thought that semantic meaning will not emerge if interests conflict. Here it is shown that not only is conventional meaning possible when interests conflict, but it is the most likely outcome in a finite (...)
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  16. Signalling games select horn strategies.Robert van Rooy - 2004 - Linguistics and Philosophy 27 (4):493-527.
    In this paper I will discuss why (un) marked expressionstypically get an (un)marked interpretation: Horn''sdivision of pragmatic labor. It is argued that it is aconventional fact that we use language this way.This convention will be explained in terms ofthe equilibria of signalling games introduced byLewis (1969), but now in an evolutionary setting. Iwill also relate this signalling game analysis withParikh''s (1991, 2000, 2001) game-theoretical analysis ofsuccessful communication, which in turn is compared withBlutner''s: 2000) bi-directional optimality theory.
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  17.  20
    Purinergic signalling: Its unpopular beginning, its acceptance and its exciting future.Geoffrey Burnstock - 2012 - Bioessays 34 (3):218-225.
    Adenosine 5′-triphosphate (ATP) was identified in 1970 as the transmitter responsible for non-adrenergic, non-cholinergic neurotransmission in the gut and bladder and the term ‘purinergic’ was coined. Purinergic cotransmission was proposed in 1976 and ATP is now recognized as a cotransmitter in all nerves in the peripheral and central nervous systems. P1 (adenosine) and P2 (ATP) receptors were distinguished in 1978. Cloning of these receptors in the early 1990s was a turning point in the acceptance of the purinergic signalling hypothesis. There (...)
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  18.  58
    Virtue Signalling to Signal Trustworthiness, Avoid Distrust, and Scaffold Self-Trust.William Tuckwell - forthcoming - Social Epistemology.
    ABSTRACT Justin Tosi and Brandon Warmke argue that virtue signalling – saying things in order to improve or protect your moral reputation – has a range of bad consequences and that as such there is a strong moral presumption against engaging in it. I argue that virtue signalling also has a range of good consequences, and that as such there is no default presumption either for or against engaging in it. Following from this, I argue that given that virtue signalling (...)
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  19.  10
    Signalling mechanisms regulating axonal branching in vivo.Hannes Schmidt & Fritz G. Rathjen - 2010 - Bioessays 32 (11):977-985.
    Identification of the molecular mechanisms underlying axonal branching in vivo has begun in several neuronal systems, notably the projections formed by dorsal root ganglion (DRG) neurons or retinal ganglion cells (RGC). cGMP signalling is essential for sensory axon bifurcation at the spinal cord, whereas brain‐derived neurotrophic factor (BDNF) and ephrinA signalling establish position‐dependent branching of RGC axons. In the latter system, the degradation of specific signalling components, via the ubiquitin‐proteasome system, may provide an additional mechanism involved in axon branching of (...)
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  20.  46
    Signalling under Uncertainty: Interpretative Alignment without a Common Prior.Thomas Brochhagen - 2017 - British Journal for the Philosophy of Science:axx058.
    Communication involves a great deal of uncertainty. Prima facie, it is therefore surprising that biological communication systems—from cellular to human—exhibit a high degree of ambiguity and often leave its resolution to contextual cues. This puzzle deepens once we consider that contextual information may diverge between individuals. In the following we lay out a model of ambiguous communication in iterated interactions between subjectively rational agents lacking a common contextual prior. We argue ambiguity’s justification to lie in endowing interlocutors with means to (...)
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  21. Content in Simple Signalling Systems.Nicholas Shea, Peter Godfrey-Smith & Rosa Cao - 2018 - British Journal for the Philosophy of Science 69 (4):1009-1035.
    Our understanding of communication and its evolution has advanced significantly through the study of simple models involving interacting senders and receivers of signals. Many theorists have thought that the resources of mathematical information theory are all that are needed to capture the meaning or content that is being communicated in these systems. However, the way theorists routinely talk about the models implicitly draws on a conception of content that is richer than bare informational content, especially in contexts where false content (...)
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  22.  7
    Wnt signalling goes nuclear.Michael Kühl & Doris Wedlich - 1997 - Bioessays 19 (2):101-104.
    The Wnt signalling cascade is a highly conserved signalling pathway throughout the animal kingdom. In Xenopus, Wnt signalling functions in mesodermal dorsoventral patterning. Earlier work on deciphering the components of the wnt signalling cascade left a gap between cytosolic β‐catenin, the final member of the cascade, and the nuclear target genes. Several recent papers now reveal how the Wnt signal is transmitted into the nucleus. Surprisingly, β‐catenin directly interacts with the transcription factor LEF‐1/XTCF‐3, and thereby is not only translocated into (...)
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  23.  20
    Calcium signalling and cell proliferation.Michael J. Berridge - 1995 - Bioessays 17 (6):491-500.
    The orderly sequence of events that constitutes the cell cycle is carefully regulated. A part of this regulation depends upon the ubiquitous calcium signalling system. Many growth factors utilize the messenger inositol trisphosphate (InsP3) to set up prolonged calcium signals, often organized in an oscillatory pattern. These repetitive calcium spikes require both the entry of external calcium and its release from internal stores. One function of this calcium signal is to activate the immediate early genes responsible for inducing resting cells (...)
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  24.  9
    BMP signalling in early Xenopus development.Leslie Dale & C. Michael Jones - 1999 - Bioessays 21 (9):751-760.
    Bone morphogenetic proteins (BMPs) are typically members of the transforming growth factor β (TGF-β) family with diverse roles in embryonic development. At least five genes with homology to BMPs are expressed during Xenopus development, along with their receptors and intracellular signalling pathways. The evidence suggests that BMPs have roles to play in both mesoderm induction and dorsoventral patterning. Studies in Xenopus have also identified a number of inhibitory binding proteins for the classical BMPs, encoded by genes such as chordin and (...)
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  25. A stag hunt with signalling and mutual beliefs.Jelle de Boer - 2013 - Biology and Philosophy 28 (4):559-576.
    The problem of cooperation for rational actors comprises two sub problems: the problem of the intentional object (under what description does each actor perceive the situation?) and the problem of common knowledge for finite minds (how much belief iteration is required?). I will argue that subdoxastic signalling can solve the problem of the intentional object as long as this is confined to a simple coordination problem. In a more complex environment like an assurance game signals may become unreliable. Mutual beliefs (...)
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  26.  33
    Signalling in independence-friendly logic.F. Barbero & G. Sandu - 2014 - Logic Journal of the IGPL 22 (4):638-664.
  27.  33
    Modelling Religious Signalling.Carl Brusse - 2019 - Dissertation, Australian National University
    The origins of human social cooperation confound simple evolutionary explanation. But from Darwin and Durkheim onward, theorists (anthropologists and sociologists especially) have posited a potential link with another curious and distinctively human social trait that cries out for explanation: religion. This dissertation explores one contemporary theory of the co-evolution of religion and human social cooperation: the signalling theory of religion, or religious signalling theory (RST). According to the signalling theory, participation in social religion (and its associated rituals and sanctions) acts (...)
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  28. Neural signalling of probabilistic vectors.Nicholas Shea - 2014 - Philosophy of Science 81 (5):902-913.
    Recent work combining cognitive neuroscience with computational modelling suggests that distributed patterns of neural firing may represent probability distributions. This paper asks: what makes it the case that distributed patterns of firing, as well as carrying information about (correlating with) probability distributions over worldly parameters, represent such distributions? In examples of probabilistic population coding, it is the way information is used in downstream processing so as to lead to successful behaviour. In these cases content depends on factors beyond bare information, (...)
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  29.  59
    Signalling signalhood and the emergence of communication.Thomas C. Scott-Phillips, Simon Kirby & Graham R. S. Ritchie - 2009 - Cognition 113 (2):226-233.
  30.  23
    Wnt‐Notch signalling: An integrated mechanism regulating transitions between cell states.Silvia Muñoz-Descalzo, Joaquin de Navascues & Alfonso Martinez Arias - 2012 - Bioessays 34 (2):110-118.
    The activity of Wnt and Notch signalling is central to many cell fate decisions during development and to the maintenance and differentiation of stem cell populations in homeostasis. While classical views refer to these pathways as independent signal transduction devices that co‐operate in different systems, recent work has revealed intricate connections between their components. These observations suggest that rather than operating as two separate pathways, elements of Wnt and Notch signalling configure an integrated molecular device whose main function is to (...)
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  31.  69
    Signalling In Languages With Imperfect Information.Gabriel Sandu - 2001 - Synthese 127 (1-2):21-34.
    This paper is a short survey of different languageswith imperfect information introduced in (Hintikka and Sandu 1989).The imperfect information concerns both quantifiers and connectives.At the end, I will sketch a connection between these languages and linearlogic.
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  32.  28
    Superluminal signalling.Steven Weinstein - unknown
    Special relativity is said to prohibit faster-than-light (superluminal) signalling, yet controversy regularly arises as to whether this or that physical phenomenon violates the prohibition. I argue that the controversy is a result of a lack of clarity as to what it means to `signal', and I propose a criterion. I show that although we have no reason to think that one can send signals faster than light, this is not prohibited by special relativity.
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  33.  10
    Credible signalling and social bonds: Ultimately drawing on the same idea.Patrick Kennedy & Andrew N. Radford - 2021 - Behavioral and Brain Sciences 44.
    The hypotheses in both target articles rely implicitly on much the same logic. For a “social-bonding” device to make sense, there must be an underlying reason why an otherwise-arbitrary behaviour sustains alliances – namely, credible signals of one's value to partners. To illustrate our points, we draw on the parallels with supposed bonding behaviours in nonhuman animals.
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  34.  8
    Signalling molecules and the regulation of intracellular transport.Nicholas T. Ktistakis - 1998 - Bioessays 20 (6):495-504.
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  35. We Should Move on from Signalling-Based Analyses of Biological Deception.Vladimir Krstic - forthcoming - Erkenntnis:1-21.
    This paper argues that extant signalling-based analyses cannot explain a range of cases of biological (and psychological) deception, such as those in which the deceiver does not send a signal at all, but that Artiga and Paternotte’s (Philos Stud 175:579–600, 2018) functional and my (Krstić in The analysis of self-deception: rehabilitating the traditionalist account. PhD Dissertation, University of Auckland, 2018: §3; Krstić and Saville in Australas J Philos 97:830–835, 2019) manipulativist analyses can. Therefore, the latter views should be given preference. (...)
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  36.  57
    Vagueness and Imprecise Imitation in Signalling Games.Michael Franke & José Pedro Correia - 2018 - British Journal for the Philosophy of Science 69 (4):1037-1067.
    Signalling games are popular models for studying the evolution of meaning, but typical approaches do not incorporate vagueness as a feature of successful signalling. Complementing recent like-minded models, we describe an aggregate population-level dynamic that describes a process of imitation of successful behaviour under imprecise perception and realization of similar stimuli. Applying this new dynamic to a generalization of Lewis’s signalling games, we show that stochastic imprecision leads to vague, yet by-and-large efficient signal use, and, moreover, that it unifies evolutionary (...)
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  37.  13
    Animal Signalling.Carl Brusse - 2018 - In Todd K. Shackelford & Viviana A. Weekes-Shackelford (eds.), Encyclopedia of Evolutionary Psychological Science. Springer Verlag. pp. 1--4.
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  38.  16
    Biology of purinergic signalling: Its ancient evolutionary roots, its omnipresence and its multiple functional significance.Alexei Verkhratsky & Geoffrey Burnstock - 2014 - Bioessays 36 (7):697-705.
    The purinergic signalling system, which utilises ATP, related nucleotides and adenosine as transmitter molecules, appeared very early in evolution: release mechanisms and ATP‐degrading enzymes are operative in bacteria, and the first specific receptors are present in single cell eukaryotic protozoa and algae. Further evolution of the purinergic signalling system resulted in the development of multiple classes of purinoceptors, several pathways for release of nucleotides and adenosine, and a system of ectonucleotidases controlling extracellular levels of purinergic transmitters. The purinergic signalling system (...)
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  39.  5
    Grounding and its Signalling: Evidence from Short News Texts.Esam N. Khalil - 2001 - Discourse Studies 3 (1):97-118.
    This article is an inquiry into the discourse phenomenon of grounding, viz. the foreground-background structure. It explains the place of the phenomenon in the structure of discourse and provides evidence of grounding from short news items. Focusing on the surface structure level of discourse organization, the article examines variant marking of the FG-BG articulation at sentence-initial position. Using English and Arabic news data, the article explicates the grounding-signalling function of entities that appear in that position and shows that Arabic news (...)
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  40.  12
    Linking the unfolded protein response to bioactive lipid metabolism and signalling in the cell non‐autonomous extracellular communication of ER stress.Nicole T. Watt, Anna McGrane & Lee D. Roberts - 2023 - Bioessays 45 (8):2300029.
    The endoplasmic reticulum (ER) organelle is the key intracellular site of both protein and lipid biosynthesis. ER dysfunction, termed ER stress, can result in protein accretion within the ER and cell death; a pathophysiological process contributing to a range of metabolic diseases and cancers. ER stress leads to the activation of a protective signalling cascade termed the Unfolded Protein Response (UPR). However, chronic UPR activation can ultimately result in cellular apoptosis. Emerging evidence suggests that cells undergoing ER stress and UPR (...)
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  41.  71
    Addiction, Self‐Signalling and the Deep Self.Richard Holton - 2016 - Mind and Language 31 (3):300-313.
    Addicts may simply deny that they are addicted; or they may use self-signalling to try to provide evidence that giving up is not worthwhile. I provide an account that shows how easy it is to provide apparent evidence either that the addiction is so bad that it cannot be escaped; or that there is no real addiction, and hence nothing to escape. I suggest that the most effective way of avoiding this is to avoid self-signalling altogether.
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  42.  29
    Signalling pathways and the host‐parasite relationship: Putative targets for control interventions against schistosomiasis: Signalling pathways and future anti‐schistosome therapies.Hong You, Geoffrey N. Gobert, Malcolm K. Jones, Wenbao Zhang & Donald P. McManus - 2011 - Bioessays 33 (7):556-556.
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  43.  41
    Nonlocal Quantum Information Transfer Without Superluminal Signalling and Communication.Jan Walleczek & Gerhard Grössing - 2016 - Foundations of Physics 46 (9):1208-1228.
    It is a frequent assumption that—via superluminal information transfers—superluminal signals capable of enabling communication are necessarily exchanged in any quantum theory that posits hidden superluminal influences. However, does the presence of hidden superluminal influences automatically imply superluminal signalling and communication? The non-signalling theorem mediates the apparent conflict between quantum mechanics and the theory of special relativity. However, as a ‘no-go’ theorem there exist two opposing interpretations of the non-signalling constraint: foundational and operational. Concerning Bell’s theorem, we argue that Bell employed (...)
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  44.  26
    Not by signalling alone: Music's mosaicism undermines the search for a proper function.Anton Killin, Carl Brusse, Adrian Currie & Ronald J. Planer - 2021 - Behavioral and Brain Sciences 44.
    Mehr et al. seek to explain music's evolution in terms of a unitary proper function – signalling cooperative intent – which they cash out in two guises, coalition signalling and parental attention signalling. Although we recognize the role signalling almost certainly played in the evolution of music, we reject “ultimate” causal explanations which focus on a unidirectional, narrow range of causal factors.
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  45.  22
    The IRS‐signalling system during insulin and cytokine action.Lynne Yenush & Morris F. White - 1997 - Bioessays 19 (6):491-500.
    The discovery of the first intracellular substrate for insulin, IRS‐1, redirected the field of diabetes research and has led to many important advances in our understanding of insulin action. Detailed analysis of IRS‐1 demonstrates structure/function relationships for this modular docking molecule, including mechanisms of substrate recognition and signal propagation. Recent work has also identified other structurally similar molecules, including IRS‐2, the Drosophila protein, DOS, and the Grb2‐binding protein, Gab1, suggesting that this intracellular signalling strategy is conserved evolutionarily and is utilized (...)
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  46.  44
    Synapse signalling complexes and networks: machines underlying cognition.Seth G. N. Grant - 2003 - Bioessays 25 (12):1229-1235.
  47. Signalling and Social Norms.Duxbury Neil - 2001 - Oxford Journal of Legal Studies 21 (4).
     
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  48.  5
    Signalling to p53: where does it all start?Michael B. Kastan - 1996 - Bioessays 18 (8):617-619.
    Alterations in the p53 gene product appear to be a major factor in human tumorigenesis and may influence the responses of many human tumors to therapy. Much effort has focused on understanding the signals which normally initiate p53 growth‐suppressive functions. Though it has been known that DNA damage can induce p53, a recent publication reports data which suggest that p53 can be induced by depletion of ribonucleotide pools, even in the absence of detectable DNA damage(1). These observations provide new ideas (...)
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  49.  25
    The assembly of signalling complexes by receptor tyrosine kinases.George Panayotou & Michael D. Waterfield - 1993 - Bioessays 15 (3):171-177.
    Cell proliferation in response to growth factors is mediated by specific high affinity receptors. Ligand‐binding by receptors of the protein tyrosine kinase family results in the stimulation of several intracellular signal transduction pathways. Key signalling enzymes are recruited to the plasma membrane through the formation of stable complexes with activated receptors. These interactions are mediated by the conserved, non‐catalytic SH2 domains present in the signalling molecules, which bind with high affinity and specificity to tyrosine‐phosphorylated sequences on the receptors. The assembly (...)
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  50. Representation without Informative Signalling.Gerardo Alberto Viera - forthcoming - British Journal for the Philosophy of Science.
    Various writers have attempted to use the sender-receiver formalism to account for the representational capacities of biological systems. This paper has two goals. First, I argue that the sender-receiver approach to representation cannot be complete. The mammalian circadian system represents the time of day, yet it does not control circadian behaviours by producing signals with time of day content. Informative signalling need not be the basis of our most basic representational capacities. Second, I argue that representational capacities are primarily about (...)
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