Primary progressive aphasia is a clinical syndrome in which patients progressively lose speech and language abilities. Three variants are recognized: logopenic, associated with phonology and/or short-term verbal memory deficits accompanied by left temporo-parietal atrophy; semantic, associated with semantic deficits and anterior temporal lobe atrophy; non-fluent associated with grammar and/or speech-motor deficits and inferior frontal gyrus atrophy. Here, we set out to investigate whether the three variants of PPA can be dissociated based on error patterns in a single language task. We (...) recruited 21 lvPPA, 28 svPPA, and 24 nfvPPA patients, together with 31 healthy controls, and analyzed their performance on an auditory noun-to-verb generation task, which requires auditory analysis of the input, access to and selection of relevant lexical and semantic knowledge, as well as preparation and execution of speech. Task accuracy differed across the three variants and controls, with lvPPA and nfvPPA having the lowest and highest accuracy, respectively. Critically, machine learning analysis of the different error types yielded above-chance classification of patients into their corresponding group. An analysis of the error types revealed clear variant-specific effects: lvPPA patients produced the highest percentage of “not-a-verb” responses and the highest number of semantically related nouns ; in contrast, svPPA patients produced the highest percentage of “unrelated verb” responses and the highest number of light verbs. Taken together, our findings indicate that error patterns in an auditory verb generation task are associated with the breakdown of different neurocognitive mechanisms across PPA variants. Specifically, they corroborate the link between temporo-parietal regions with lexical processing, as well as ATL with semantic processes. These findings illustrate how the analysis of pattern of responses can help PPA phenotyping and heighten diagnostic sensitivity, while providing insights on the neural correlates of different components of language. (shrink)

The robotics industry is growing rapidly, and to a large extent the development of this market sector is due to the area of social robotics – the production of robots that are designed to enter the space of human social interaction, both physically and semantically. Since social robots present a new type of social agent, they have been aptly classified as a disruptive technology, i.e. the sort of technology which affects the core of our current social practices and might lead (...) to profound cultural and social change. -/- Due to its disruptive and innovative potential, social robotics raises not only questions about utility, ethics, and legal aspects, but calls for “robo-philosophy” – the comprehensive philosophical reflection from the perspectives of all philosophical disciplines. This book presents the proceedings of the first conference in this new area, “Robo-Philosophy 2014 – Sociable Robots and the Future of Social Relations", held in Aarhus, Denmark, in August 2014. The short papers and abstracts collected here address questions of social robotics from the perspectives of philosophy of mind, social ontology, ethics, meta-ethics, political philosophy, aesthetics, intercultural philosophy, and metaphilosophy. -/- Social robotics is still in its early stages, but it is precisely now that we need to reflect its possible cultural repercussions. This book is accessible to a wide readership and will be of interest to everyone involved in the development and use of social robotics applications, from social roboticists to policy makers. (shrink)