Sots-art, the mock use of the Soviet ideological clichés of mass culture, originated in Soviet nonconformist art of the early 1970s. An original and provocative guide, Endquote: Sots-Art Literature and Soviet Grand Style examines the conceptual aspect of sots-art, sots-art poetry, and sots-art prose, and discusses where these still-vital intellectual currents may lead.

The versatile clustered regularly interspaced short palindromic repeats (CRISPR)/Cas system has emerged as a promising technology for therapy and molecular diagnosis. It is especially suited for overcoming viral infections outbreaks, since their effective control relies on an efficient treatment, but also on a fast diagnosis to prevent disease dissemination. The CRISPR toolbox offers DNA‐ and RNA‐targeting nucleases that constitute dual weapons against viruses. They allow both the manipulation of viral and host genomes for therapeutic purposes and the detection of viral (...) nucleic acids in “Point of Care” sensor devices. Here, we thoroughly review recent advances in the use of the CRISPR/Cas system for the treatment and diagnosis of viral deleterious infections such as HIV or SARS‐CoV‐2, examining their strengths and limitations. We describe the main points to consider when designing CRISPR antiviral strategies and the scientific efforts to develop more sensitive CRISPR‐based viral detectors. Finally, we discuss future prospects to improve both applications. Also see the video abstract here: https://www.youtube.com/watch?v=C0z1dLpJWl4. (shrink)

This article discusses the role of representative strategies in twentieth-century Russian culture. Just as Russia interacted with Europe in the Marquis de Custine’s time via discourse and representation, in the twentieth century Russia re-entered European consciousness by simulating ‘socialism’. In the post-Soviet era, the nation aspired to be admitted to the ‘European house’ by simulating a ‘market economy’, ‘democracy’, and ‘postmodernism’. But in reality Russia remains the same country as before, torn between the reality of its own helplessness and poverty, (...) and the messianic myth of its own greatness. Post-Soviet culture is a product of Stalinist culture. ‘Russian postmodernism’ was created less by artists, writers, poets, and film makers, than by theorists and critics. At the beginning of the 1990s, a need to describe contemporary Russian culture emerged. In this way, ‘Russian postmodernism’ arose from the desire to ‘sell’ projects in the West—from the simple obligation to describe socialist experience in concrete, transferable terms that Westerners could grasp. The nostalgia experienced by the post-Soviet era creates its own simulated postmodernism , in which the matrices of the construction and functioning of culture cease to be connected with specifically Russian (Soviet) history, and instead reproduce Western models almost exactly. We are facing yet another attempt at radical cultural modernization. If the first attempt (revolutionary culture) was the most original and fruitful, and the second (Stalinist culture, Socialist Realism) was less productive but still original, then the third, post-Soviet, attempt (rich in individuality, but lacking in original ideas or style) is for the moment the least productive and original. If we exclude sots-art (conceptualism) from ‘Russian postmodernism’, there would be nothing left. Clearly, an original cultural model in post-Soviet Russia will not take shape until original strategies for processing the country’s cultural past are developed. In their turn, these strategies can only result from a radical transformation of post-Soviet identity into a new, genuinely Russian one. (shrink)

This article discusses the role of representative strategies in twentieth-century Russian culture. Just as Russia interacted with Europe in the Marquis de Custine’s time via discourse and representation, in the twentieth century Russia re-entered European consciousness by simulating ‘socialism’. In the post-Soviet era, the nation aspired to be admitted to the ‘European house’ by simulating a ‘market economy’, ‘democracy’, and ‘postmodernism’. But in reality Russia remains the same country as before, torn between the reality of its own helplessness and poverty, (...) and the messianic myth of its own greatness. Post-Soviet culture is a product of Stalinist culture. ‘Russian postmodernism’ was created less by artists, writers, poets, and film makers, than by theorists and critics. At the beginning of the 1990s, a need to describe contemporary Russian culture emerged. In this way, ‘Russian postmodernism’ arose from the desire to ‘sell’ projects in the West—from the simple obligation to describe socialist experience in concrete, transferable terms that Westerners could grasp. The nostalgia experienced by the post-Soviet era creates its own simulated postmodernism , in which the matrices of the construction and functioning of culture cease to be connected with specifically Russian (Soviet) history, and instead reproduce Western models almost exactly. We are facing yet another attempt at radical cultural modernization. If the first attempt (revolutionary culture) was the most original and fruitful, and the second (Stalinist culture, Socialist Realism) was less productive but still original, then the third, post-Soviet, attempt (rich in individuality, but lacking in original ideas or style) is for the moment the least productive and original. If we exclude sots-art (conceptualism) from ‘Russian postmodernism’, there would be nothing left. Clearly, an original cultural model in post-Soviet Russia will not take shape until original strategies for processing the country’s cultural past are developed. In their turn, these strategies can only result from a radical transformation of post-Soviet identity into a new, genuinely Russian one. (shrink)

This essay analyzes the recent appearance in Russian letters of ultra-nationalist fantasies about the restoration of Russia’s imperial or totalitarian status. This new trend has its roots not only in the increasingly patriotic tone of Russian society and politics, but also in the dynamics of the literary field itself. ‘Imperialist writers’ such as Aleksandr Prokhanov and Pavel Krusanov have both revived and reacted against postmodern themes and motifs from earlier decades. Relying on the legacy of sots-art and stiob , (...) the ‘imperialists’ advance a new model in Russia’s postmodern tradition, one that is balanced on the very borderline between irony and ideological militancy. In playing the game of ambiguous fanaticism, these writers have been able to attract the attention of a broad and diverse public, and have moved from an intellectual periphery into the cultural mainstream. (shrink)

Business ethics courses have been launched with professors from business pulling on one oar, and professors of philosophy pulling on the other, but they lack a sense of direction. Let's begin with the basics: What is an ehtical decision? More fundamentally, why the interest in professional ethics in the first place?There are over 300 centers for the study of appIied ethics in this country-why? The events which face our society today are outside the business-oriented collection of shared beIiefs that set (...) our pubIic policy agenda. Cur beIiefs are too narrow, thus we see, understand, and control small slices of life.Business ethics should be the study of the structure and impact on us of what we call "business science," e.g., accounting, marketing, economics, law, etc., and the corresponding study of the process of what Carl Jung called individuation: learning to become one's own uniqueself in the face of these bodies of professional knowledge which have structured our lives and charted the direction for our sensibilities for too long. (shrink)

Business ethics courses have been launched with professors from business pulling on one oar, and professors of philosophy pulling on the other, but they lack a sense of direction. Let's begin with the basics: What is an ehtical decision? More fundamentally, why the interest in professional ethics in the first place?There are over 300 centers for the study of appIied ethics in this country-why? The events which face our society today are outside the business-oriented collection of shared beIiefs that set (...) our pubIic policy agenda. Cur beIiefs are too narrow, thus we see, understand, and control small slices of life.Business ethics should be the study of the structure and impact on us of what we call "business science," e.g., accounting, marketing, economics, law, etc., and the corresponding study of the process of what Carl Jung called individuation: learning to become one's own uniqueself in the face of these bodies of professional knowledge which have structured our lives and charted the direction for our sensibilities for too long. (shrink)

We explore themes in Nobel Prize–winning economist James M. Buchanan’s work and apply his Ethics and Economic Progress to problems facing individuals and firms. We focus on Buchanan’s analysis of the individual work ethic, his exhortations to “pay the preacher” of the “institutions of moral-ethical communication,” and his notion of law as “public capital.” We highlight several ways people with other-regarding preferences can contribute to social flourishing and some of the ways those who have “affected to trade for the public (...) good” might want to redirect their efforts. We show how Buchanan’s work has considerable implications for business ethics. Just as his economic analysis of politics changed how we understand government, we think his economic analysis of ethics can (and should) change how we understand business. (shrink)

Abstract…observations of skylfull pylotts is the onlye waye to bring it in rule; for it passeth the reach of naturall philosophy. – Michael Gabriel, 1576 (Collinson, 1867, p. 30)Abstract The tension between empirical data and formal theory pervades the entire history of geomagnetism, from the Middle Ages up to the present day. This paper explores its early-modern history (1500–1800), using a hybrid approach: it applies a methodological framework used in modern geophysics to interpret early-modern developments, exploring to what extent formal (...) conjectures shaped observation and vice versa. A range of pertinent case studies supports classification of this entire period as proto-scientific, characterised by the initial formation of theories being largely disconnected from observational constraints, and their subsequent evolution being advanced primarily by their empirical falsification, and not necessarily associated with the introduction of an alternative. The few exceptional instances of purely data-driven discovery were essentially due to an improved signal-to-noise ratio. (shrink)

NOT SAUSSURE: A CRITIQUE OF POST?SAUSSUREAN LITERARY THEORY by Raymond Tallis London: Macmillan, 1988. 273 pp., £33 (£10.95 paper).

The increasing availability of passively observed data has yielded a growing interest in “data fusion” methods, which involve merging data from observational and experimental sources to draw causal conclusions. Such methods often require a precarious tradeoff between the unknown bias in the observational dataset and the often-large variance in the experimental dataset. We propose an alternative approach, which avoids this tradeoff: rather than using observational data for inference, we use it to design a more efficient experiment. We consider the case (...) of a stratified experiment with a binary outcome and suppose pilot estimates for the stratum potential outcome variances can be obtained from the observational study. We extend existing results to generate confidence sets for these variances, while accounting for the possibility of unmeasured confounding. Then, we pose the experimental design problem as a regret minimization problem subject to the constraints imposed by our confidence sets. We show that this problem can be converted into a concave maximization and solved using conventional methods. Finally, we demonstrate the practical utility of our methods using data from the Women’s Health Initiative. (shrink)

Helps individual readers to overcome procrastination and build self-esteem Reveals how to create a culture of accountability, and how to hold someone accountable Gives leaders a step-by-step process for helping team members become more self-responsible Explains commitment reluctance and how to encourage self-responsibility among team members Uncovers why we blame others and shows how to defeat a blame culture Provides an easy read with no consultant-speak In recent years, HORN Training and Consulting was awarded the distinguished Gold Medal by the (...) Canadian Society for Training and Development for its leadership development program designed for one of the world’s largest international banks; and HORN is currently executing leadership development projects on a global scale for companies in the consumer packaged goods and pharmaceutical industries. (shrink)

A collection of photographs depicts life on Chicago's west side between 1949 and mid-1960s.