The cell is not only the structural, physiological, and developmental unit of life, but also the reproductive one. So far, however, this aspect of the cell has received little attention from historians and philosophers of biology. I will argue that cell theory had far-reaching consequences for how biologists conceptualized the reproductive relationships between germs and adult organisms. Cell theory, as formulated by Theodor Schwann in 1839, implied that this relationship was a specific and lawful one, that is, that germs of (...) a certain kind, all else being equal, would produce adult organisms of the same kind, and vice versa. Questions of preformation and epigenesis took on a new meaning under this presupposition. The question then became one of whether cells could be considered as autonomous agents producing adult organisms of a given species, or whether they were the product of external, organizing forces and thus only a stage in the development of the whole organism. This question became an important issue for nineteenth-century biology. As I will demonstrate, it was the view of cells as autonomous agents which helped both Charles Darwin and Gregor Mendel to think of inheritance as a lawful process. (shrink)

Prompted by recent recognitions of the omnipresence of horizontal gene transfer among microbial species and the associated emphasis on exchange, rather than isolation, as the driving force of evolution, this essay will reflect on hybridization as one of the central concerns of nineteenth-century biology. I will argue that an emphasis on horizontal exchange was already endorsed by ‘biology’ when it came into being around 1800 and was brought to full fruition with the emergence of genetics in 1900. The true revolution (...) in nineteenth-century life sciences, I maintain, consisted in a fundamental shift in ontology, which eroded the boundaries between individual and species, and allowed biologists to move up and down the scale of organic complexity. Life became a property extending both ‘downwards’, to the parts that organisms were composed of, as well as ‘upwards’, to the collective entities constituted by the relations of exchange and interaction that organisms engage in to reproduce. This mode of thinking was crystallized by Gregor Mendel and consolidated in the late nineteenth-century conjunction of biochemistry, microbiology and breeding in agro-industrial settings. This conjunction and its implications are especially exemplified by Wilhelm Johannsen’s and Martinus Beijerinck’s work on pure lines and cultures. An understanding of the subsequent constraints imposed by the evolutionary synthesis of the twentieth century on models of genetic systems may require us to rethink the history of biology and displace Darwin’s theory of natural selection from that history’s centre. (shrink)

Historians and philosophers of science have interpreted the taxonomic theory of Carl Linnaeus as an ‘essentialist’, ‘Aristotelian’, or even ‘scholastic’ one. This interpretation is flatly contradicted by what Linnaeus himself had to say about taxonomy in Systema naturae , Fundamenta botanica and Genera plantarum . This paper straightens out some of the more basic misinterpretations by showing that: Linnaeus’s species concept took account of reproductive relations among organisms and was therefore not metaphysical, but biological; Linnaeus did not favour classification by (...) logical division, but criticized it for necessarily failing to represent what he called ‘natural’ genera; Linnaeus’s definitions of ‘natural’ genera and species were not essentialist, but descriptive and polytypic; Linnaeus’s method in establishing ‘natural’ definitions was not deductive, but consisted in an inductive, bottom-up procedure of comparing concrete specimens. The conclusion will discuss the fragmentary and provisional nature of Linnaeus’s ‘natural method’. I will argue in particular that Linnaeus opted for inductive strategies not on abstract epistemological grounds, but in order to confer stability and continuity to the explorative practices of contemporary natural history. (shrink)

This paper presents and discusses a series of hybridization experiments carried out by Nils Herman Nilsson-Ehle between 1900 and 1907 at a plant breeding station in Svalöf, Sweden. Since the late 1880s, the Svalöf station had been renowned for its ‘scientific’ breeding methods, which basically consisted of an elaborate system of record-keeping through which the offspring of individual plants were traced over generations while being meticulously described. This record system corresponded to a certain breeding technique and certain theoretical convictions . (...) Inspired by Tschermack’s translation of Mendel’s Pisum-paper, Nilsson-Ehle began his experiments in 1900 and published a first, major synthesis of his findings in 1908. If one compares these experiments as documented in the breeding records, with their representations in print, one encounters discrepancies in terms of procedure and presentation of data. This can be explained by the fact that Nilsson-Ehle was obliged to follow the recording and breeding procedures institutionalised at Svalöf, and these procedures, grounded in a taxonomic discourse, left little room for Mendelian hybridisation experiments. The twists and turns that this story takes are analysed in terms of Bachelardian philosophy of science, where the ‘epistemological obstacle’ functions as a central, analytic category. In contrast to Bachelard, however, I will characterise these obstacles as being of an institutional, rather than mental, nature. Thus characterized, moreover, they turn out to have been prerequisites as much as barriers to scientific progress. (shrink)

Anthropologists, linguists, cultural historians, and literary scholars have long emphasized the value of examining writing as a material practice and have often invoked the list as a paradigmatic example thereof. This Focus section explores how lists can open up fresh possibilities for research in the history of science. Drawing on examples from the early modern period, the contributors argue that attention to practices of list making reveals important relations between mercantile, administrative, and scientific attempts to organize the contents of the (...) world. Early modern lists projected both spatial and temporal visions of nature: they inventoried objects in the process of exchange and collection; they projected possible trajectories for future endeavor; they publicized the social identities of scientific practitioners; and they became research tools that transformed understandings of the natural order. (shrink)

The cell is not only the structural, physiological, and developmental unit of life, but also the reproductive one. So far, however, this aspect of the cell has received little attention from historians and philosophers of biology. I will argue that cell theory had far-reaching consequences for how biologists conceptualized the reproductive relationships between germs and adult organisms. Cell theory, as formulated by Theodor Schwann in 1839, implied that this relationship was a specific and lawful one, that is, that germs of (...) a certain kind, all else being equal, would produce adult organisms of the same kind, and vice versa. Questions of preformation and epigenesis took on a new meaning under this presupposition. The question then became one of whether cells could be considered as autonomous agents producing adult organisms of a given species, or whether they were the product of external, organizing forces and thus only a stage in the development of the whole organism. This question became an important issue for nineteenth-century biology. As I will demonstrate, it was the view of cells as autonomous agents which helped both Charles Darwin and Gregor Mendel to think of inheritance as a lawful process. (shrink)

This paper provides a translation of the introduction, titled ‘Account of the work’ Ratio operis, to the first edition of Genera plantarum, published in 1737 by the Swedish botanist Carl Linnaeus. The text derives its significance from the fact that it is the only published text in which Linnaeus engaged in an explicit discussion of his taxonomic method. Most importantly, it shows that Linnaeus was clearly aware that a classification of what he called ‘natural genera’ could not be achieved by (...) a top-down approach of logical division, but had to rely on inductive, bottom-up procedures. The translation is supplemented by explanatory notes. (shrink)

This paper summarizes the results from the first European Advanced Seminar in the Philosophy of the Life Sciences, which was held at the Brocher Foundation in Hermance (Switzerland) 6-10 September 2011. The Advanced Seminar brought together philosophers of the life sciences to discuss the topic of "Causation and Disease." The search for causes of disease in the biomedical sciences, we argue on the basis of the contributions to this conference, has not resulted in a simplification and unification of biomedical knowledge, (...) as once hoped for by philosophers of science, but rather in its "complexification.". (shrink)

The Swedish naturalist Carl Linnaeus is famous for having turned botany into a systematic discipline, through his classification systems—most notably the sexual system—and his nomenclature. Throughout his life, Linnaeus experimented with various paper technologies designed to display information synoptically. The list took pride of place among these and is also the common element of more complex representations he produced, such as genera descriptions and his “natural system.” Taking clues from the anthropology of writing, this essay seeks to demonstrate that lists (...) can be considered as genuine research technologies. They possess a potential to generate research problems of their own but also pose limitations to inquiries that can be overcome only by the use of new media. (shrink)

Although the cell is commonly addressed as the unit of life, historians and philosophers have devoted relatively little attention to this concept in comparison to other fundamental concepts of biology such as the gene or species. As a partial remedy to this neglect, we introduce the cell as a major point of connection between various disciplinary approaches, epistemic strategies, technological vectors and overarching biological processes such as metabolism, growth, reproduction and evolution. We suggest that the role of the cell as (...) a nexus forms the basis for a new philosophical and historical appreciation of cell biology. This perspective focuses less on the cell as a well-defined, stable object and places more emphasis on its role as a mediator of fundamental biological processes. (shrink)

The prevalent reading of Darwin's achievements today is adaptationist. Darwin, so the usual story goes, succeeded in providing a naturalistic explanation of the fact that organisms are adapted to their environments, a fact that served and continues to serve, as a chief argument for creationism. This stands in a curious tension with Darwin's own fascination with phenomena whose adaptive value was problematic, like vicariance, ornaments, atavisms, and rudiments, as well as the various "contraptions" and "contrivances" by which organisms take advantage (...) of each other. I will explore this "dark side" of Darwin's evolutionism with respect to three themes that run through his work: heredity, which provided one of the corner stones of Darwin's theory and yet was defined as an essentially capricious, not necessarily adaptive force; mimicry, which for Darwin exemplified a general tendency of nature to produce deceiving semblances that turn actual relations on their head; and extinction, a phenomenon that pointed towards the redundancy of life, which for Darwin, in the double sense of that word, was both a fundamental condition and necessary consequence of evolution by natural selection. (shrink)

Eugenics: Then and now Content Type Journal Article DOI 10.1007/s11016-010-9477-1 Authors Staffan Müller-Wille, ESRC Centre for Genomics in Society, Byrne House, University of Exeter, Exeter, EX4 4PJ UK Journal Metascience Online ISSN 1467-9981 Print ISSN 0815-0796.