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Stephan Guttinger
London School of Economics
  1.  35
    Viruses as Living Processes.John Dupré & Stephan Guttinger - 2016 - Studies in History and Philosophy of Science Part C: Studies in History and Philosophy of Biological and Biomedical Sciences 59:109-116.
  2.  61
    Trust in Science: CRISPR–Cas9 and the Ban on Human Germline Editing.Stephan Guttinger - 2018 - Science and Engineering Ethics 24 (4):1077-1096.
    In 2015 scientists called for a partial ban on genome editing in human germline cells. This call was a response to the rapid development of the CRISPR–Cas9 system, a molecular tool that allows researchers to modify genomic DNA in living organisms with high precision and ease of use. Importantly, the ban was meant to be a trust-building exercise that promises a ‘prudent’ way forward. The goal of this paper is to analyse whether the ban can deliver on this promise. To (...)
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  3.  13
    The limits of replicability.Stephan Guttinger - 2020 - European Journal for Philosophy of Science 10 (2):1-17.
    Discussions about a replicability crisis in science have been driven by the normative claim that all of science should be replicable and the empirical claim that most of it isn’t. Recently, such crisis talk has been challenged by a new localism, which argues a) that serious problems with replicability are not a general occurrence in science and b) that replicability itself should not be treated as a universal standard. The goal of this article is to introduce this emerging strand of (...)
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  4.  20
    A New Account of Replication in the Experimental Life Sciences.Stephan Guttinger - 2019 - Philosophy of Science 86 (3):453-471.
    The life sciences are said to be in the midst of a replication crisis because a majority of published results are irreproducible, and scientists rarely replicate existing data. Here I argue that point 2 of this assessment is flawed because there is a hitherto unidentified form of replication in the experimental life sciences, which I call ‘microreplications’. Using a case study from biochemistry, I illustrate how MRs depend on a key element of experimentation, namely, experimental controls. I end by reflecting (...)
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  5.  35
    Creating Parts That Allow for Rational Design: Synthetic Biology and the Problem of Context-Sensitivity.Stephan Güttinger - 2013 - Studies in History and Philosophy of Biological and Biomedical Sciences 44 (2):199-207.
    The parts-based engineering approach in synthetic biology aims to create pre-characterised biological parts that can be used for the rational design of novel functional systems. Given the context-sensitivity of biological entities, a key question synthetic biologists have to address is what properties these parts should have so that they give a predictable output even when they are used in different contexts. In the first part of this paper I will analyse some of the answers that synthetic biologists have given to (...)
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  6.  11
    The Double-Stranded RNA Binding Domain of Human Dicer Functions as a Nuclear Localization Signal.Michael Doyle, Lukas Badertscher, Lukasz Jaskiewicz, Stephan Güttinger, Sabine Jurado, Tabea Hugenschmidt, Ulrike Kutay & Witold Filipowicz - unknown
    Dicer is a key player in microRNA (miRNA) and RNA interference (RNAi) pathways, processing miRNA precursors and doublestranded RNA into ~21-nt-long products ultimately triggering sequence-dependent gene silencing. Although processing of substrates in vertebrate cells occurs in the cytoplasm, there is growing evidence suggesting Dicer is also present and functional in the nucleus. To address this possibility, we searched for a nuclear localization signal (NLS) in human Dicer and identified its C-terminal double-stranded RNA binding domain (dsRBD) as harboring NLS activity. We (...)
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  7.  19
    Editing the Reactive Genome: Towards a Postgenomic Ethics of Germline Editing.Stephan Guttinger - 2020 - Journal of Applied Philosophy 37 (1):58-72.
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  8.  22
    Replications Everywhere.Stephan Güttinger - 2018 - Bioessays 40 (7):1800055.
    Why the replication crisis might be less severe than it seems at first.
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  9.  23
    Riding the Wave Into a Crisper Future?Stephan Guttinger - 2018 - Studies in History and Philosophy of Science Part C: Studies in History and Philosophy of Biological and Biomedical Sciences 67:32-35.
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