Cholinergic-rich grafts have been shown to be effective in restoring maze-learning deficits in rats with lesions of the forebrain cholinergic projection system. However, the relevance of those studies to developing novel therapies for Alzheimer's disease is questioned.

This latest in attempts to collect statements from living American philosophers presents thoughts and interests of those writing in the "middle decades," the fifty years from 1920 to 1970. The editor has restricted himself to America’s senior philosophers asking each to reflect on "the things that matter most," or "to share the motifs in their work and to present concerns about their world". Although some influential elders are missing from this collection, an interesting variety of viewpoints and styles of American (...) philosophizing are represented. Especially interesting are the reflections of Brand Blanshard, Edwin Burtt, Herbert Feigl, Charles Hartshorne, Stephen Pepper, Roy Wood Sellars, and Herbert Spiegelberg. Blanshard traces his development from the influences upon him of Bradley, and describes his own rationalist ethics and humanist religion. Herbert Feigl in an even more autobiographical vein relates how he came under the important influence of Moritz Schlick and to be a member of the Vienna Circle. Also included in his article is a summary of his views on the issues of induction, scientific explanation, the mind-body problem, determinism, and some matters of practical philosophy. Pepper explains how he originated the idea of world hypotheses, and how he believes these hypotheses themselves originate and function, and Spiegelberg sketches an intriguing "ethics for fellows in the fate of existence." In his essay Hartshorne mixes comments on pragmatism, idealism, and the "linguistic turn," with explanations of his own "neoclassical metaphysics."—B.M. (shrink)

A major problem in developing an effective gene therapy for the nervous system lies in understanding the principles that maintain or turn off the expression of genes following their transfer into the CNS.

This paper seeks to examine two conflicting strands in the United States Supreme Court's treatment of “freedom of association,” by exploring some aspects of the historical development of the doctrine. It suggests that there are two conceptions of “freedom of association,” an older, traditional one, that eschews forcing odious contact on members of associations, and a newer one which privileges antidiscrimination doctrines over “freedom from association.” These two conceptions still exist on the Court, resulting in irreconcilable decisions such as those (...) permitting the Boy Scouts to exclude gay scoutmasters, but forcing the Jaycees to accept women. The preference of one conception over the other is also evident in the work of different scholars, whose doctrinal approaches are similarly irreconcilable. The Supreme Court has explained the discontinuities in the doctrine by seeking to characterize it in terms of the First Amendment's “freedom of speech” clause, but the paper argues that it makes more sense, in the context of these two cases, to regard them as related to the First Amendment's “freedom of religion” clauses. (shrink)

In October 1984, Bruno Huisman stated with regards to Jean Cavaillès, ‘Let us be honest, or at least realistic: today, one can be a professor of philosophy without ever having read a single line of Cavaillès. Often invoked, sometimes quoted, the oeuvre of Cavaillès is little attended for itself’ (Huisman 1984). As for Albert Lautman, it would seem that the situation is even more extreme. In 1994, the publisher Hermann, under the impetus of Bruno Huisman and George Canguilhem, collected almost (...) the totality of the Jean Cavaillès papers in one volume (Oeuvres complètes de philosophie des sciences (Cavaillès 1994)). But, the Essai sur l’unité des mathématiques et divers écrits (Lautman 1977), published by the Union générale d’Éditions in 1977, had all but disappeared by the early 1980s and yet was never republished! This will remain one of the great indignities of French publishing, for as Jean Petitot rightly affirms: ‘Regarded as too speculative, in spite of his exceptional mathematical scholarship and his close connection with Hilbertian axiomatic structuralism, his mathematical philosophy has, until now, been devoid of any particular attention …. We would like to state clearly from the start, Albert Lautman represents, in our view, without exaggeration, one of the most inspired philosophers of this century’ (Petitot 1987, 79-80). (shrink)

[Stephen Makin] Aristotle draws two sets of distinctions in Metaphysics 9.2, first between non-rational and rational capacities, and second between one way and two way capacities. He then argues for three claims: [A] if a capacity is rational, then it is a two way capacity [B] if a capacity is non-rational, then it is a one way capacity [C] a two way capacity is not indifferently related to the opposed outcomes to which it can give rise I provide explanations (...) of Aristotle's terminology, and of how [A]-[C] should be understood. I then offer a set of arguments which are intended to show that the Aristotelian claims are plausible. \\\ [Nicholas Denyer] In De Caelo 1: 11-12 Aristotle argued that whatever is and always will be true is necessarily true. His argument works, once we grant him the highly plausible principle that if something is true, then it can be false if and only if it can come to be false. For example, assume it true that the sun is and always will be hot. No proposition of this form can ever come to be false. Hence this proposition cannot be false. Hence it is necessarily true, and so too is anything that follows from it. In particular, it is necessarily true that the sun is hot. Moreover, if the sun not only is and always will be hot, but also always has been, then it follows by similar reasoning that the sun not only cannot now fail to be hot, but also never could have failed. Anything everlastingly true is therefore, in the strictest sense of the term, necessarily true. (shrink)

Stephen Tracy's neat demonstration that IG I3 35—authorizing the building of a temple and appointment of a priestess for Athena Nike—was cut by the man responsible for the Promachos accounts at first seemed decisive for the traditional c. 448 B.C. against my radical down-dating. Ira Mark then argued that this decree provided for the naiskos and altar of his Stage III in the 440s: the marble temple belonged to Stage IV over twenty years later. Despite these two powerful interventions (...) the matter is not closed. David Gill has, I fancy, convincingly refuted Mark on archaeological and architectural grounds. And there is still more to be said from the epigraphic angle. IG I 36, cut on the back of the stele, looks like a delayed rider to 35. But just how delayed was it? It arranged for the regular payment of the priestess's salary by the kolakretai in office in the month Thargelion. On the traditional view the gap would be close to a quarter of a century, since 36 is firmly dated 424/3 B.C. This is quite extraordinary, though reasons have been found for it. More serious perhaps is some neglected epigraphic evidence. We have eighteen other examples in fifth-century Attic epigraphy where decrees are followed on the same stone by other texts; but virtually all the gaps are short, never more than a few years. The relevant texts are IG I 4, 11/12, 41, 42/43, 52 A–B, 59, 61, 66, 68, 71, 72, 73, 89, 93, 101, 127/II1, 156, 1454. It is true that 42/43 are dated c. 445–442 and c. 435–427 B.C. in IG I, but this is quite arbitrary. (shrink)

Gold Stripe on a Jackass is a conceptually rich description of one naval officer's career journey. Author Stephen B. Sloane began his career in Annapolis, where the commandment of obedience holds sway, and finished in Berkeley, a place where questioning authority is woven deeply into the cultural fabric.