My aim in what follows is to sketch with a broad brush fundamental changes involving the concept of obligation in British ethics of the early modern period, as it developed in the direction of the view that obligatory force is a species of motivational force – an idea that deeply informs present thought. I shall also suggest, although I can hardly demonstrate it conclusively here, that one important source for this view was a doctrine which we associate with Kant, and (...) which it may seem surprising to find in British ethics, especially of the early modern period, viz., that rational agents are obligated by motives available through a form of practical thinking necessary for rational autonomy. (shrink)

Evidence from molecular genetics bolsters the claim that color is not a perceptuolinguistic and behavioral universal. Neurobiology continues to fill in many details about the flow of color information from photon reception to central processing in the brain. Humans have the most acute color vision in the biosphere because of natural selection and adaptation, not coincidence.

The result is nothing less than a fundamental reorientation of moral theory that enables it at last to account for morality's supreme authority--an account that ...

This book is a major work in the history of ethics, and provides the first study of early modern British philosophy in several decades. Professor Darwall discerns two distinct traditions feeding into the moral philosophy of the seventeenth and eighteenth centuries. On the one hand, there is the empirical, naturalist tradition, comprising Hobbes, Locke, Cumberland, Hutcheson, and Hume, which argues that obligation is the practical force that empirical discoveries acquire in the process of deliberation. On the other hand, there is (...) a group including Cudworth, Shaftesbury, Butler, and in some moments Locke, which views obligation as inconceivable without autonomy and which seeks to develop a theory of the will as self-determining. (shrink)

Why should we avoid doing moral wrong? After showing how attempts to vindicate morality have tended to fall back on non-moral values or first-person considerations, Stephen Darwall elaborates the interpersonal nature of moral obligations: their inherent link to our responsibilities to one another as members of the moral community.

A host of metabolic enzymes reversibly self‐assemble to form membrane‐less, intracellular filaments under normal physiological conditions and in response to stress. Often, these enzymes reside at metabolic control points, suggesting that filament formation affords an additional regulatory mechanism. Examples include cytidine‐5′‐triphosphate (CTP) synthase (CTPS), which catalyzes the rate‐limiting step for the de novo biosynthesis of CTP; inosine‐5′‐monophosphate dehydrogenase (IMPDH), which controls biosynthetic access to guanosine‐5′‐triphosphate (GTP); and ∆1‐pyrroline‐5‐carboxylate (P5C) synthase (P5CS) that catalyzes the formation of P5C, which links the Krebs (...) cycle, urea cycle, and proline metabolism. Intriguingly, CTPS can exist in co‐assemblies with IMPDH or P5CS. Since GTP is an allosteric activator of CTPS, the association of CTPS and IMPDH filaments accords with the need to coordinate pyrimidine and purine biosynthesis. Herein, a hypothesis is presented furnishing a biochemical connection underlying co‐assembly of CTPS and P5CS filaments – potent inhibition of CTPS by glutamate γ‐semialdehyde, the open‐chain form of P5C. (shrink)

In _The New Constitutionalism_, seven distinguished scholars develop an innovative perspective on the power of institutions to shape politics and political life. Believing that constitutionalism needs to go beyond the classical goal of limiting the arbitrary exercise of political power, the contributors argue that it should—and can—be designed to achieve economic efficiency, informed democratic control, and other valued political ends. More broadly, they believe that political and social theory needs to turn away from the negativism of critical theory to consider (...) how a good society should be "constituted" and to direct the work of designing institutions that can constitute a "good polity," in both the economic and civic senses. Stephen L. Elkin and Karol Edward Soltan begin with an overview of constitutionalist theory and a discussion of the new constitutionalism within the broader intellectual and historical context of political and social thought. Charles Anderson, James Ceaser, and the editors then offer different interpretations of the central issues regarding institutional design in a constitutionalist social science, consider various ways of performing the task, and discuss the inadequacy of recent political science to the job it ought to be doing. The book concludes with essays by Ted Lowi, Cass Sunstein and Edwin Haefele which apply these themes to the American regime. (shrink)

R. Abelson argues that the identity theory is false because it is possible to have an infinite number of thoughts (e.G. Of natural numbers) while the number of possible brain states is finite. The refutation fails because it conflates the logical possibility of having infinite thoughts with the actual ability to have them. The latter depends on many contingent facts, One of which may be the number of possible brain states.

What are ethical judgments about? And what is their relation to practice? How can ethical judgment aspire to objectivity? The past two decades have witnessed a resurgence of interest in metaethics, placing questions such as these about the nature and status of ethical judgment at the very center of contemporary moral philosophy. Moral Discourse and Practice: Some Philosophical Approaches is a unique anthology which collects important recent work, much of which is not easily available elsewhere, on core metaethical issues. Reinvigorated (...) naturalist moral realism and the various versions of moral realism, as well as irrealist, expressivist, and neo-Kantian constructivist theories are all represented in this fine collection, constituting a rich array of approaches to contemporary moral philosophy's most fundamental debates. An extensive introduction by Darwall, Gibbard, and Railton is also included, making this volume the most comprehensive and up-to-date work of its kind. Moral Discourse is ideally suited for use in courses in contemporary ethics, ethical theory, and metaethics. (shrink)

How we age and what we can do about it have been uppermost in human thought since antiquity. The many false starts have frustrated experimentalists and theoretical arguments pronouncing the inevitability of the process have created a nihilistic climate among scientists and the public. The identification of single gene alterations that substantially extend life span in nematodes and flies however, have begun to reinvigorate the field. Drosophila's long history of contributions to aging research, rich storehouse of genetic information, and powerful (...) molecular techniques make it an excellent system for studying the molecular mechanisms underlying the process of aging. In recent years, Drosophila has been used to test current theories on aging and explore new directions of potential importance to the biology of aging. One such example is the surprising finding that, as opposed to the commonly held assumption that adult life is a period of random passive decline in which all things are thought to fall apart, the molecular life of the adult fly appears to be a state of dynamic well‐regulated change. In the fly, the level of expression of many different genes changes in an invariant, often age‐dependent, manner. These as well as other molecular genetic studies and demographic analyses using the fly have begun to challenge widely held ideas about aging providing evidence that aging may be a much more dynamic and malleable process than anticipated. With the enormous success that Drosophila molecular genetics has demonstrated in helping understand complex biological phenomena such as development there is much optimism that similar approaches can be adapted to assist in understanding the process of aging. BioEssays 25:134–141, 2003. © 2003 Wiley Periodicals, Inc. (shrink)

Contemporary infectious disease surveillance systems aim to employ the speed and scope of big data in an attempt to provide global health security. Both shifts - the perception of health problems through the framework of global health security and the corresponding technological approaches – imply epistemological changes, methodological ambivalences as well as manifold societal effects. Bringing current findings from social sciences and public health praxis into a dialogue, this conversation style contribution points out several broader implications of changing disease surveillance. (...) The conversation covers epidemiological issues such as the shift from expert knowledge to algorithmic knowledge, the securitization of global health, and the construction of new kinds of threats. Those developments are detailed and discussed in their impacts for health provision in a broader sense. (shrink)

In these essays Stephen White examines the forms of psychological integration that give rise to self-knowable and self-conscious individuals who are responsible, concerned for the future, and capable of moral commitment. The essays cover a wide range of basic issues in philosophy of mind, metaphysics, moral psychology, and political philosophy, providing a coherent, sophisticated, and forcefully argued view of the nature of the self. Beginning with mental content and ending with Rawls and utilitarianism, each essay argues a distinctive line. (...) Together they are a unified and powerful philosophical position of considerable scope, one that provides a unique vision of the mind, consciousness, personhood, and morality. White argues that the unity of the self revealed in personal identity and moral responsibility is best understood in normative terms. Basic to such features of the self are the patterns of self-concern in which they are characteristically displayed and the internal justification that supports such concern. The treatment of intentionality and consciousness that grounds this account emphasizes privileged selfknowledge and practical rationality and their corresponding contributions to the unity of the self. A final source of unity emerges from the analysis of our fundamental commitments, an analysis that ensures a central place in moral theory for the notion of the self. (shrink)

We review the argument that latent image formation is a measurement in which the state vector collapses, requiring an enhanced noise parameter in objective reduction models. Tentative observation of a residual noise at this level, plus several experimental bounds, imply that the noise must be colored, and hence frame dependent and non-relativistic. Thus a relativistic objective reduction model, even if achievable in principle, would be incompatible with experiment; the best one can do is the non-relativistic CSL model. This negative conclusion (...) has a positive aspect, in that the non-relativistic CSL reduction model evades the argument leading to the Conway–Kochen “Free Will Theorem”. (shrink)

It has been a commonplace since the 2012 coup to hear how fragile the Malian democracy had become. Among the many causes is the political role that non-governmental organizations have played as a fourth branch of government. As deliberative democratic processes were replaced by a corrupt elite consensus during the past eight years, NGOs assumed an important place in this system. This included humanitarian NGOs. However, these same NGOs until recently were blind to the political impact they were having. This (...) essay suggests one explanation for this blindness and argues for the importance of a conception of humanitarian aid that balances moral responsibility with political responsibility. (shrink)

Coping with the Future: Theories and Practices of Divination in East Asia. Edited by Michael Lackner. Sinica Leidensia, vol. 138. Leiden: Brill, 2017. Pp. xvi + 586. €149, $172.

In this paper I distinguish three alternatives to the functionalist account of qualitative states such as pain. The physicalist-functionalist holds that (1) there could be subjects functionally equivalent to us whose mental states differed in their qualitative character from ours, (2) there could be subjects functionally equivalent to us whose mental states lacked qualitative character altogether and (3) there could not be subjects like us in all objective respects whose qualitative states differed from ours. The physicalist-functionalist holds (1) and (3) (...) but denies (2). The transcendentalist holds (1) and (2) and denies (3). I argue that both versions of physicalist-functionalism inherit the problem of property dualism which originally helped to motivate functionalist theories of mind. I also argue that neither version of physicalist-functionalism can distinguish in a principled way between those neurophysiological properties of a subject which are relevant to the qualitative character of that subject's mental states and those which are not. I conclude that the only alternative to a functionalist account of qualitative states is a transcendentalist account and that this alternative is not likely to appeal to the critics of functionalism. (shrink)

It has normally been assumed that whatever empirical and metaphysical problems it may raise, mind-body dualism would satisfy a number of deeply engrained intuitions about the mental for which nondualist theories have no plausible account. In what follows I shall argue that this is true only for a special class of dualist theories. I distinguish transcendental dualism from the other forms that dualist theories may take. And I argue that where the intuitions about subjectivity that have seemed to motivate and (...) support dualism are concerned, only transcendental dualism has an advantage over nondualist theories; nontranscendental versions of dualism are open to the same objections that have made nondualist accounts of the mind seem implausible. Moreover, I argue that the usual objections to transcendental dualism are inconclusive. I shall argue, however, that with regard to a crucial intuition concerning the subjective point of view - that we have a form of privileged access to our own qualitative mental states - transcendental dualism is at a disadvantage relative to some nondualist and nontranscendental theories. And I shall argue that if a theory fails to satisfy this intuition, its other advantages carry very little weight. Thus I claim that transcendental versions of dualism do not offer viable alternatives to nontranscendental theories of mind. (shrink)

The paper considers the Quinean heritage of the argument for the indeterminacy of translation. Beyond analyzing Quine’s notion of stimulus meaning, the paper discusses two Kripkean argument’s against the Quinean claim that dispositions can provide the basis for an account of meaning: the Normativity Argument and the Finiteness Argument. An analogy between Kripke’s arguments and Hume’s argument for epistemological skepticism about the external world will be drawn. The paper shows that the answer to Kripke’s rule-following skepticism is analogous to the (...) answer to Humean skepticism: our use of concepts is more basic than, and presupposed by, the statement of the skeptical problem itself. (shrink)

Purpose The purpose of this paper is to explore Turkish students’ perceived relevance of Facebook, the value of Facebook advertisements and the ethics of Facebook targeting users with advertisements. Design/methodology/approach Latent class cluster analysis is estimated to determine whether segments exist and whether covariates differ among segments. Findings Segments differ on Facebook relevance and advertisement targeting ethics and usefulness and the covariates gender, hours spent on Facebook during the week and personality. The segment that finds Facebook most relevant and uses (...) it the most disapproves of Facebook’s targeted advertisements. Facebook is an organization that relies heavily on advertising dollars for survival. This fact should be emphasized; otherwise, Facebook may not be able to sustain itself. Originality/value The paper provides an understanding of Facebook from a marketing perspective for a country at the crossroads of Europe and Asia. (shrink)

This paper describes a course on war and morality that involves a service-learning dimension. Motivated by the hypothetical imperative that if political philosophers have any special responsibility in a democratic society, then it is to acquaint citizens with political violence, the paper discusses the nature of political responsibility and political violence, the purpose of including a service requirement in a course on war and morality, and describes the content of just such a course. While reporting that service-learning students did not (...) seem to leave the course with a clearer understanding of the relationship between war and other varieties of political violence, they appeared to acquire a clearer understanding of the effects of the violence of war, thereby preparing them to make the former connection in the future. (shrink)