The Isis bibliography of the history of science has been published continuously since the first issue of the journal in 1913. This essay examines how information practices used to produce the bibliography have shaped, and were shaped by, the evolving discipline of the history of science. We first focus on the intellectual endeavors of George Sarton, who used the bibliography to help define and create a new academic field: the history of science. Next, we outline the administrative struggles of the (...) History of Science Society (HSS) as it tried to continue the project after Sarton’s retirement. Finally, we examine the technological aspects of producing a bibliography by focusing on the transition from analog to digital technologies over the last fifty years. In this overview, we show the central place the Isis bibliography played in the HSS community and argue that information practices surrounding the bibliography are an underutilized resource for studying the history of the discipline. (shrink)