Entrepreneurs with social goals face various challenges; insights into how these entrepreneurs experience and appreciate their work remain a black box though. Drawing on identity, conservation of resources, and person–organization fit theories, this study examines how entrepreneurs’ social value creation beliefs relate to their work-related well-being (job satisfaction, work engagement, and lack of work burnout), as well as how this process might be influenced by social concerns with respect to the common good. Using data from the German Public Value Atlas (...) 2015 and 2019 and the Swiss Public Value Atlas 2017, a three-study design analyzes three samples of entrepreneurs in Germany and Switzerland. Study 1 reveals that entrepreneurs report higher job satisfaction when they believe their organization creates social value. Study 2 indicates that these beliefs relate negatively to work burnout; entrepreneurs’ perceptions of having meaningful work mediate this relationship. Study 3 affirms and extends these results by showing that a sense of work meaningfulness mediates the relationship between social value creation beliefs and work engagement and that this mediating role is more prominent among entrepreneurs with strong social concerns. This investigation thus identifies a critical pathway—the extent to which entrepreneurs experience their work activities as important and personally meaningful—that connects social value creation beliefs with enhanced work-related well-being, as well as how this process might vary with a personal orientation that embraces the common good. (shrink)

The discipline area of physical education has historically struggled for legitimacy, sometimes being seen as a non-serious pursuit in educational terms compared to other subjects within the school curriculum. This book represents the first attempt in nearly 30 years to offer a coherent philosophical defence and conceptualisation of physical education and sport as subjects of educational value, and to provide a philosophically sound justification for their inclusion in the curriculum. The book argues that rather than relegating the body to ‘un-thinking’ (...) learning, a person’s essential being is not confined to their rationality but involves an embodied dimension. It traces the changing conceptions of the body, in philosophy and theology, that have influenced our understanding of physical education and sport, and investigates the important role that embodiment and movement play in learning about, through and in physical education. Physical education is defended as a vital and necessary part of education because the whole person goes to school, not just the mind, but the thinking, feeling and acting facets of a person. It is argued that physical education has the potential to provide a multitude of experiences and opportunities for students’ to become aware of their embodiment, explore alternative modes of awareness and to develop insights into and new modes of being not available elsewhere in the curriculum, and to influence moral character through the support of a moral community that is committed to that practice. Representing a sophisticated and spirited defence of the educational significance and philosophical value of physical education and sport, this book will be fascinating reading for any advanced student or researcher with an interest in physical education, the philosophy of sport, or the philosophy of education. (shrink)

A science is an intellectual activity defined by its mechanisms that prevent its scientists from always reaching the conclusions that they set out to reach. Such mechanisms are needed because, if scientists are given full control over what hypotheses they select, what data they discard, and what results they publish, they can communicate any conclusion that they desire. Synthesis, by setting a grand challenge, forces scientists across uncharted territory where they encounter and solve unscripted problems. When theory is inadequate, the (...) synthesis fails, and fails in a way that cannot be ignored. Therefore, synthesis drives discovery and paradigm change in ways that simple hypothesis testing cannot. Here, we describe the discoveries that emerged when synthetic biologists were challenged to create an alternative genetic system that has different molecular structures than DNA and RNA. In pursuit of this particular “grand challenge,” synthesis forced the recognition that the community did not know as much about the double helix as it had constructively assumed. In general, a field of science having access to synthesis as a research strategy can create knowledge even if its practitioners do not fit the ideal of a dispassionate, advocacy-free scientist. (shrink)

A philosophical conception of norms is developed and defended. Chapter I first examines the received view of norms in the social scientific and philosophical literature. On this view, norms are rule-like, an essentially subjective or internal conception. It will be argued, however, that norms are better described as patterns of behavior, an objective or external conception. The pattern view achieves a better fit with our intuitive understanding of norms, and is better suited to the role norms are to play in (...) social theory. The second chapter continues the appraisal of the pattern conception by looking at how norms perform in an applied theoretical context, namely, utilitarian moral theory. The third and fourth chapters attempt to reconcile the notion of conformity necessary to the pattern conception with the dictates of methodological individualism. The possibility of an individualistic grounding will be seen to depend on the types of individuals that are assumed to exist. As this study assumes the existence of moral motivation, as well as narrowly self-interested, rational motivation, an individualistic grounding will require a moral and a rational grounding for norms. Chapter III discusses the rational grounding and Chapter IV the moral. In addition, the analysis of the types of situations in which conformity is rational and moral will provide a superior typology of norms. (shrink)

Social order is regulated from above by the law but its foundation is built on norms and customs, informal social practices that enable people to make meaningful and productive uses of their time and resources. Despite the importance of these practices in keeping the social fabric together, very little of the jurisprudential literature has focused on a discussion of these norms and customs. In Social Norms in a Wired World Steven Hetcher argues that the traditional conception of norms as (...) rule-like linguistic entities is erroneous. Instead, norms must be understood as patterns of rationally governed behaviour maintained in groups by acts of conformity. Using informal game theory in the analysis of norms and customs, Hetcher applies his theory of norms to tort law and Internet privacy laws. This book will appeal to students and professionals in law, philosophy, and political and social theory. (shrink)

The gain of a selective advantage in cancer as well as the establishment of complex traits during evolution require multiple genetic alterations, but how these mutations accumulate over time is currently unclear. There is increasing evidence that a mutator phenotype perpetuates the development of many human cancers. While in some cases the increased mutation rate is the result of a genetic disruption of DNA repair and replication or environmental exposures, other evidence suggests that endogenous DNA damage induced by AID/APOBEC cytidine (...) deaminases can result in transient localized hypermutation generating simultaneous, closely spaced (i.e. “clustered”) multiple mutations. Here, we discuss mechanisms that lead to mutation cluster formation, the biological consequences of their formation in cancer and evidence suggesting that APOBEC mutagenesis can also occur genome‐wide. This raises the possibility that dysregulation of these enzymes may enable rapid malignant transformation by increasing mutation rates without the loss of fitness associated with permanent mutators. (shrink)

This article argues that psychological discourse fails miserably to provide an account of learning that can explain how humans come to understand, particularly understanding that has been grasped meaningfully. Part of the problem with psychological approaches to learning is that they are disconnected from the integral role embodiment plays in how I perceive myself, other persons and other things in the world. In this sense, it is argued that a central tenet of any educational learning involves being taught to perceive, (...) come to know ourselves and the world around us. This may seem like stating the obvious, but there is a general tendency to take the experience of perception for granted. Since phenomenology according to Merleau-Ponty recognises that perceptual experience is the basis of ‘all rationality’ makes it particularly apt for explaining the significant role embodiment plays in understanding what has been learned, and understanding that has been grasped meaningfully. What makes this account of embodied learning educationally significant is that the whole person is treated as a whole being, permitting the person to experience him or herself as a holistic and synthesised acting, feeling, thinking being-in-the-world, rather than as separate physical and mental qualities which bear no relation to each other. (shrink)

Somatic mutations arising in human skin cancers are heterogeneously distributed across the genome, meaning that certain genomic regions (e.g., heterochromatin or transcription factor binding sites) have much higher mutation densities than others. Regional variations in mutation rates are typically not a consequence of selection, as the vast majority of somatic mutations in skin cancers are passenger mutations that do not promote cell growth or transformation. Instead, variations in DNA repair activity, due to chromatin organization and transcription factor binding, have been (...) proposed to be a primary driver of mutational heterogeneity in melanoma. However, as discussed in this review here, recent studies indicate that chromatin organization and transcription factor binding also significantly modulate the rate at which UV lesions form in DNA. The authors propose that local variations in lesion susceptibility may be an important driver of mutational hotspots in melanoma and other skin cancers, particularly at binding sites for ETS transcription factors. (shrink)

We propose a causal model theory to explain asymmetries in judgments of the intentionality of a foreseen side-effect that is either negative or positive (Knobe, 2003). The theory is implemented as a Bayesian network relating types of mental states, actions, and consequences that integrates previous hypotheses. It appeals to two inferential routes to judgment about the intentionality of someone else's action: bottom-up from action to desire and top-down from character and disposition. Support for the theory comes from three experiments that (...) test the prediction that bottom-up inference should occur only when the actor's primary objective is known. The model fits intentionality judgments reasonably well with no free parameters. (shrink)

Somatic mutation plays a key role in transforming normal cells into cancerous cells. The analysis of cancer progression therefore requires the study of how point mutations and chromosomal mutations accumulate in cellular lineages. The spread of somatic mutations depends on the mutation rate, the number of cell divisions in the history of a cellular lineage, and the nature of competition between different cellular lineages. We consider how various aspects of tissue architecture and cellular competition affect the pace of mutation accumulation. (...) We also discuss the rise and fall of somatic mutation rates during cancer progression. BioEssays 26:291–299, 2004. © 2004 Wiley Periodicals, Inc. (shrink)

Recent sociological studies, like Robert Bellah’s Habits of the Heart, support the claim that Americans retain an ideal of isolated self-sufficiency. Yet the material conditions of our culture require ideals that shun exclusiveness and encourage associated living. The result of this dissonance is that Americans tend to approach their own and others’ values in a way that boils down to irrational personal preference. …Such is the cultural predicament that a theory of moral education must ultimately confront. In this essay I (...) articulate a Deweyan theory of moral understanding that makes our moral decisions and social commitments intelligible, enabling us to give empirically warranted, substantive justifications for our valuations. I argue that an emphasis on educating moral imagination could gradually lead our culture beyond its fossilized individualistic ideals. I further argue that any theory of moral education that ignores moral imagination is empirically irresponsible. (…). (shrink)

This study examines the logical coherence of the theological claim that Jesus was "truly man and truly God." The primary question dealt with is whether or not it is possible for one person to have all of the properties necessary for being fully divine and all of the properties necessary for being fully human. The philosophical approach is analytic, focusing upon alleged coherence problems generated by applying the Indiscernibility of Identicals to statements about Jesus. Two extended arguments against the coherence (...) of the doctrine of the incarnation are examined and rebutted. The bulk of the study is a presentation and evaluation of five modern philosophical approaches to solving the coherence problems generated by the Indiscernibility of Identicals. These are Relative Trinitarianism, the One-Nature view, the Reduplicative maneuver, kenoticism, and the Two-Minds view. Relative Trinitarianism is rejected because it denies the Indiscernibility of Identicals as a logical principle. The One-Nature view unnecessarily alters the concept of divinity and it, too, is rejected. Traditional kenoticism is judged an inadequate response to the incoherence challenge, but a revised kenoticism does show that many statements about Jesus can be coherently stated. This revised kenoticism eliminates coherence problems concerning many properties of Jesus, but not all. Some statements about Jesus, particularly modal statements, can be coherently stated as reduplicative statements. The problem is that some Steven A. Long incarnational property adjectives do not appear to be logically attributive, hence they cannot be predicated reduplicatively. Though the Two-Minds view is rejected, some features of it are used to show how incarnational property adjectives can be logically attributive and predicated reduplicatively. The conclusion is that there are no convincing arguments against the coherence of the incarnation and that a revised kenoticism and the Reduplicative maneuver together can be used to formulate a coherent interpretation of the doctrine of the incarnation that is possibly true. (shrink)

Public policy makers are calling for all university students to learn entrepreneurial competencies to prepare them to be productive citizens in an unpredictable future. Far more than simply starting up businesses, entrepreneurship is increasingly seen as a student-centric pedagogical technique (teaching through entrepreneurship) for helping students learn desperately needed foundational skills and attitudes such as curiosity, creativity, opportunity spotting, grit, resilience, proactivity, adaptability, empathy, self-efficacy, motivation, and tolerance for uncertainty and risk. This article describes generational trends that make this education (...) increasingly important and provides a Comprehensive Framework for Entrepreneurship Education (CFEE) to help implement best practices to achieve measurable Assurances of Learning (AoL) results at the institutional, degree program, and individual course levels. (shrink)

A normative framework for modeling causal and counterfactual reasoning has been proposed by Spirtes, Glymour, and Scheines. The framework takes as fundamental that reasoning from observation and intervention differ. Intervention includes actual manipulation as well as counterfactual manipulation of a model via thought. To represent intervention, Pearl employed the do operator that simplifies the structure of a causal model by disconnecting an intervened-on variable from its normal causes. Construing the do operator as a psychological function affords predictions about how people (...) reason when asked counterfactual questions about causal relations that we refer to as undoing, a family of effects that derive from the claim that intervened-on variables become independent of their normal causes. Six studies support the prediction for causal arguments but not consistently for parallel conditional ones. Two of the studies show that effects are treated as diagnostic when their values are observed but nondiagnostic when they are intervened on. These results cannot be explained by theories that do not distinguish interventions from other sorts of events. (shrink)

The presence of asymmetry in the human cerebral hemispheres is detectable at both the macroscopic and microscopic scales. The horizontal expansion of cortical surface during development (within individual brains), and across evolutionary time (between species), is largely due to the proliferation and spacing of the microscopic vertical columns of cells that form the cortex. In the asymmetric planum temporale (PT), minicolumn width asymmetry is associated with surface area asymmetry. Although the human minicolumn asymmetry is not large, it is estimated to (...) account for a surface area asymmetry of approximately 9% of the region’s size. Critically, this asymmetry of minicolumns is absent in the equivalent areas of the brains of other apes. The left-hemisphere dominance for processing speech is thought to depend, partly, on a bias for higher resolution processing across widely spaced minicolumns with less overlapping dendritic fields, whereas dense minicolumn spacing in the right hemisphere is associated with more overlapping, lower resolution, holistic processing. This concept refines the simple notion that a larger brain area is associated with dominance for a function and offers an alternative explanation associated with “processing type.” This account is mechanistic in the sense that it offers a mechanism whereby asymmetrical components of structure are related to specific functional biases yielding testable predictions, rather than the generalization that “bigger is better” for any given function. Face processing provides a test case – it is the opposite of language, being dominant in the right hemisphere. Consistent with the bias for holistic, configural processing of faces, the minicolumns in the right-hemisphere fusiform gyrus are thinner than in the left hemisphere, which is associated with featural processing. Again, this asymmetry is not found in chimpanzees. The difference between hemispheres may also be seen in terms of processing speed, facilitated by asymmetric myelination of white matter tracts ( Anderson et al., 1999 found that axons of the left posterior superior temporal lobe were more thickly myelinated). By cross-referencing the differences between the active fields of the two hemispheres, via tracts such as the corpus callosum, the relationship of local features to global features may be encoded. The emergent hierarchy of features within features is a recursive structure that may functionally contribute to generativity – the ability to perceive and express layers of structure and their relations to each other. The inference is that recursive generativity, an essential component of language, reflects an interaction between processing biases that may be traceable in the microstructure of the cerebral cortex. Minicolumn organization in the PT and the prefrontal cortex has been found to correlate with cognitive scores in humans. Altered minicolumn organization is also observed in neuropsychiatric disorders including autism and schizophrenia. Indeed, altered interhemispheric connections correlated with minicolumn asymmetry in schizophrenia may relate to language-processing anomalies that occur in the disorder. Schizophrenia is associated with over-interpretation of word meaning at the semantic level and over-interpretation of relevance at the level of pragmatic competence, whereas autism is associated with overly literal interpretation of word meaning and under-interpretation of social relevance at the pragmatic level. Both appear to emerge from a disruption of the ability to interpret layers of meaning and their relations to each other. This may be a consequence of disequilibrium in the processing of local and global features related to disorganization of minicolumnar units of processing. (shrink)

Comment on Dean Pettit, who replies in same issue.

The capacity to engage in systems thinking is often viewed as being a product of being able to understand complex systems due to one's facility in mastering systems theories, methods, and being able to adeptly reason. Relatively little attention is paid in the systems literature to the processes of learning from experience and creating knowledge as a direct consequence of individuals engaging systems thinking itself over time. In fact, the potential efficacy of systems thinking to improve performance normally seen as (...) only contingent on a priori knowledge, rather than knowledge created via learning from experience. Such newly create knowledge often results from engaging in modeling efforts and systemic forms of inquiry. This article proposes a model for creating new knowledge by coupling systems modeling with a pragmatic approach to knowledge-creation. This approach is based on a foundation of the pragmatic concepts first proposed by the American philosopher/scientist Charles Sanders Peirce over a century ago. This model offers systems practitioners a framework to engage in knowledge-intensive systems thinking (KIST) for addressing complex problematic issues. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Efficacious Grace and Free Will:Taking Aquinas at His WordSteven A. LongProfessor Steven Jensen, in his Nova et Vetera article "Efficacious Grace and Free Will: Six Inadequate Arguments," identifies arguments that he argues to be insufficient to show the compatibility of efficacious grace with free will.1 With respect to his analysis, I wish here to address only four conspicuous points: (1) whether in the discussion of efficacious grace "everyone" (...) agrees that the will is not determined by efficacious grace; (2) whether the fact that non-rational creatures are also contingent agents makes the specific contingency of choice that flows from the relation of the finite objects of the will to the intellectually specified formal object of the will (universal good) to be insufficient to constitute the nature of rational free choice; (3) whether Thomas's texts regarding the infallibility of divine premotion are "equivocal"; (4) whether the arguments being considered are properly identified principally as those of Réginald Garrigou-Lagrange, Taylor O'Neill, and Steven Long or are not better first identified in historico-doctrinal terms as the teaching of Aquinas, and second, of several centuries of renowned theologians and philosophers prior in time and in dignity to the aforementioned authors—so that principally identifying these arguments with them, is rather like crediting them with the real distinction of essence and existence?2 [End Page 1105]I. "Everyone" Agrees That the Will Is Not Determined by Efficacious Grace?As to the nature of Thomas's teaching—or even of the account identified historically by the Holy See as "Thomist" with respect to the Congregatio de Auxiliis and held since by a very great many Thomistic authors—Prof. Jensen seems somewhat to miscast the nature of the propositions under consideration.3 He argues on 119 that, "In any case, everyone involved seems to be in agreement that the will should not be determined by efficacious grace." But this is not the case. What there is agreement about is that the will is not determined by efficacious grace in such a way that it is not also and simultaneously freely determined by the will itself. Manifestly this is a contradiction in terms if we define freedom as including a liberty of indetermination with respect to divine providential causality. But Thomas does not do this, and there is no good reason why one should.4 Thus Thomas in De malo, q. 3, a. 2, ad 4: [End Page 1106]Now it is manifest that when something moves something else, it is not from the fact that it is moving said to be the first mover; wherefore it is not excluded that it be moved by another, from which likewise it has this very thing, that it moves. In the same way, when something moves itself, it is not excluded from being moved by another, from which it has this very thing that it moves itself: and thus it is not inconsistent with freedom that God is the cause of the act of free will.5 [End Page 1107]In the Oesterle translation of De malo—a wonderful translation—nonetheless this passage is erroneously rendered (betimes even Homer nods) as "hence it is not precluded that it is moved by another and from that other has the very ability to move."6 But the passage refers to God as cause of the very act of free will, not merely of the "ability": "et sic non repugnat libertati quod Deus est causa actus liberi arbitrii." When something moves itself, this does not imply that the thing is not moved by another "from which it has this very thing that it moves itself." And "thus it is not inconsistent with freedom that God is the cause of the act of free will." That is, God causes the free self-determination of the human will (even at the level of nature, prior to the consideration of grace), by moving the will from potency to act with respect to its own self-motion. Whether at the level of nature or at the level of grace, God moves the will with respect to its own self-determination in freedom, and this motion is not "indeterminate... (shrink)

Statements that share an explanation tend to lend inductive support to one another. For example, being told that Many furniture movers have a hard time financing a house increases the judged probability that Secretaries have a hard time financing a house. In contrast, statements with different explanations reduce one another s judged probability. Being told that Many furniture movers have bad backs decreases the judged probability that Secretaries have bad backs. I pose two questions concerning such discounting effects. First, does (...) the reduction depend on explanations being mutually incompatible or does it occur when explanations are deemed irrelevant to one another? I found that a small discounting effect occurred with statements that were blatantly unrelated. However, the discounting effect also depended on a factor external to the argument being judged; the composition of the argument set. Second, are explanation effects attributable to changes in the belief afforded statements or to response-specific changes resulting from misunderstanding of the probability rating task or response bias? The results implicate changes in belief. Prior belief influenced conditional probability more than argument strength judgements, as it would if participants understood the tasks in the same way as the experimenter. Also, conditional probability true and false judgements were complementary, suggesting no response bias. (shrink)

Plato's Euthyphro is a dialogue about the virtue of piety. It is also one of the aporetic dialogues, ending in apparent failure to discover what piety is. It is common to understand the dialogue as teaching lessons about other things, about definition, for instance, or about the logic of refutation. About piety, however, it is thought to teach us only negatively, showing a few of the many things which piety is not.My thesis, on the contrary, is that there is a (...) positive account of the nature of piety in the dialogue; it is, moreover, an account which cannot be separated from the other lessons which the dialogue teaches. I shall find it necessary to expose the structure of the logical lessons in order to develop my account of the holy. (shrink)

Future work is needed to establish that pure short-term memory is a coherent individual difference attribute that is separable from traditional compound short-term memory measures. Psychometric support for latent pure short-term memory capacity will provide an important starting point for future fine-grained analyses of the intrinsic factors that influence individual differences in math skills.

Jacob Böhme (1576-1624), the noted theosophist and mystic of the German Baroque, was possessed of a strong sense of the spiritual which pervades the many profound and lofty ideas of his thought. His philosophy is rooted in the belief that everything exists and becomes intelligible only through its opposite. This is sometimes considered the basis of philosophical systems akin to those of Hegel, Spinoza, and Schelling; and the sectarian Philadelphians were formed for the explication of his works. Here the hidden (...) meanings behind Böhme's mystical language are examined through his theory of theosophic-semantic elevation of the "phoneme" to codified "lexeme." This is the first organized and highly idiosyncratic linguistic grammar of the German Baroque, a grammar that emerges from behind the effect of words-in-context analysis. This is an invaluable study for both the literary historian and the student of linguistic history.--front jacket flat. (shrink)

In Australian end-of-life care, practicing euthanasia or physician-assisted suicide is illegal. Despite this, death hastening practices are common across medical settings. Practices can be clandestine or overt but in many instances physicians are forced to seek protection behind ambiguous medico-legal imperatives such as the Principle of Double Effect. Moreover, the way they conceptualise and experience such practices is inconsistent. To complement the available statistical data, the purpose of this study was to understand the reasoning behind how and why physicians in (...) Australia will hasten death. (shrink)