The replicator dynamics and Moran process are the main deterministic and stochastic models of evolutionary game theory. The models are connected by a mean-field relationship—the former describes the expected behavior of the latter. However, there are conditions under which their predictions diverge. I demonstrate that the divergence between their predictions is a function of standard techniques used in their analysis and of differences in the idealizations involved in each. My analysis reveals problems for stochastic stability analysis in (...) a broad class of games, demonstrates a novel domain of agreement between the dynamics, and indicates a broader moral for evolutionary modeling. (shrink)

This paper investigates the stochastically exponential stability of reaction-diffusion impulsive stochastic cellular neural networks. The reaction-diffusion pulse stochastic system model characterizes the complexity of practical engineering and brings about mathematical difficulties, too. However, the difficulties have been overcome by constructing a new contraction mapping and an appropriate distance on a product space which is guaranteed to be a complete space. This is the first time to employ the fixed point theorem to derive the stability criterion of (...) reaction-diffusion impulsive stochastic CNN with distributed time delays. Finally, an example is provided to illustrate the effectiveness of the proposed methods. (shrink)

Graphical AbstractCurrent differentiation therapies for cancer may not be effective because it might not be enough to only use molecules targeting chromatin remodelers. It may also be necessary to stabilize the re-expressed genes to convert malignant cells into benign ones.

This paper deals with stochastically globally exponential stability for stochastic impulsive differential systems with discrete delays and infinite distributed delays. By using vector Lyapunov function and average dwell-time condition, we investigate the unstable impulsive dynamics and stable impulsive dynamics of the suggested system, and some novel stability criteria are obtained for SIDSs with DDs and IDDs. Moreover, our results allow the discrete delay term to be coupled with the nondelay term, and the infinite distributed delay term to (...) be coupled with the nondelay term. Finally, two examples are given to verify the effectiveness of our theories. (shrink)

We prove almost sure exponential stability for the disease-free equilibrium of a stochastic differential equations model of an SIR epidemic with vaccination. The model allows for vertical transmission. The stochastic perturbation is associated with the force of infection and is such that the total population size remains constant in time. We prove almost sure positivity of solutions. The main result concerns especially the smaller values of the diffusion parameter, and describes the stability in terms of an (...) analogue $$\mathcal{R}_\sigma$$ of the basic reproduction number $$\mathcal{R}_0$$ of the underlying deterministic model, with $$\mathcal{R}_\sigma \le \mathcal{R}_0$$. We prove that the disease-free equilibrium is almost sure exponentially stable if $$\mathcal{R}_\sigma <1$$. (shrink)

This paper analyses the principles of stable cooperation for stochastic games. Starting from the non-cooperative version of a discounted, non zero-sum stochastic game, we build its cooperative form and find the cooperative solution. We then analyse the conditions under which this solution is stable. Principles of stability include subgame consistency, strategic stability and irrational behaviour proof of the cooperative solution. We finally discuss the existence of a stable cooperative solution, and consider a type of stochastic (...) games for which the cooperative solution is found and the principles of stable cooperation are checked. (shrink)

This paper addresses the robust stabilization problem for a class of stochastic Markovian jump systems with distributed delays. The systems under consideration involve Brownian motion, Markov chains, distributed delays, and parameter uncertainties. By an appropriate Lyapunov–Krasovskii functional, the novel delay-dependent stabilization criterion for the stochastic Markovian jump systems is derived in terms of linear matrix inequalities. When given linear matrix inequalities are feasible, an explicit expression of the desired state feedback controller is given. The designed controller, based on (...) the obtained criterion, ensures asymptotically stable in the mean square sense of the resulting closed-loop system. The convenience of the design is greatly enhanced due to the existence of an adjustable parameter in the controller. Finally, a numerical example is exploited to demonstrate the effectiveness of the developed theory. (shrink)

Despite the extensive literature describing the somatic genetic alterations in cancer cells, the precise origins of cancer cells remain controversial. In this article, I suggest that the etiology of cancer and the generation of genetic instability in cancer cells should be considered in the light of recent findings on both the stochastic nature of gene expression and its regulation at tissue level. By postulating that gene expression is intrinsically probabilistic and that stabilization of gene expression arises by cellular interactions (...) in “morphogenetic fields”, development and cellular differentiation can be rethought in an evolutionary perspective. In particular, this article proposes that disruptions of cellular interactions are the initial source of abnormal gene expression in cancer cells. Consequently, cancer phenotypes such as genetic and epigenetic instabilities, and also the presence of cells with stem cell‐like properties, may result from inaccurate and aberrant patterns of gene expression generated by microenvironmental alterations. Finally, the therapeutic implications of this view are discussed. BioEssays 27:1277–1285, 2005. © 2005 Wiley Periodicals, Inc. (shrink)

Age‐related and cancer‐related epigenomic modifications have been associated with enhanced cell‐to‐cell gene expression variability that characterizes increased cellular stochasticity. Since gene expression variability appears to be highly reduced by—and epigenetic and phenotypic stability acquired through—direct or long‐range cellular interactions during cell differentiation, we propose a common origin for aging and cancer in the failure to control cellular stochasticity by cell–cell interactions. Tissue‐disruption‐induced cellular stochasticity associated with epigenetic drift would be at the origin of organ dysfunction because of an increase (...) in phenotypic variation among cells, ultimately leading to cell death and organ failure through a loss of coordination in cellular functions, and eventually to cancerization. We propose mechanistic research perspectives to corroborate this hypothesis and explore its evolutionary consequences, highlighting a positive correlation between the median age of mass loss onset (a proxy for the onset of organ aging) and the median age at cancer diagnosis. (shrink)

More than thirty years ago, Amari and colleagues proposed a statistical framework for identifying structurally stable macrostates of neural networks from observations of their microstates. We compare their stochastic stability criterion with a deterministic stability criterion based on the ergodic theory of dynamical systems, recently proposed for the scheme of contextual emergence and applied to particular inter-level relations in neuroscience. Stochastic and deterministic..

An analysis is briefly presented of the possible causes of the failure of stochastic electrodynamics (SED) when applied to systems with nonlinear forces, on the basis that the main principles of the theory are correct. In light of this analysis, an alternative approach to the theory is discussed, whose postulates allow to establish contact with quantum mechanics in a natural way. The ensuing theory, linear SED, confirms the essential role of the vacuum–particle interaction as the source of quantum phenomena.

Are risk preferences stable over time? To address this question we elicit risk preferences from the same pool of subjects at two different moments in time. To interpret the results, we use a Fechner stochastic choice model in which the revealed preference of individuals is governed by some underlying preference, together with a random error. We take cumulative prospect theory as the underlying preference model (Kahneman and Tversky, Econometrica 47:263–292, 1979; Tversky and Kahneman, Journal of Risk and Uncertainty 5:297–323, (...) 1992). We observe that the aggregate pattern of preferences is very similar in both sessions, and it matches the results reported in the literature. Most subjects are risk averse for gains, and risk seeking for losses. However, the subjects that jointly agree with the reflection effect of prospect theory are around 50%. The percentage of individuals that change their responses across sessions is quite high, 63%. Estimating the stochastic choice model we find that 72% of the subjects have an underlying preference which agrees with the reflection effect of prospect theory. The remaining 28% are mainly classified as risk averse for both gains and losses. The results reinforce the empirical validity of the reflection effect. Deviations from the reflection effect can be attributed to noise, as well as to the existence of a fraction of risk averse subjects. (shrink)

Protein α-helices provide an ordered biological environment that is conducive to soliton-assisted energy transport. The nonlinear interaction between amide I excitons and phonon deformations induced in the hydrogen-bonded lattice of peptide groups leads to self-trapping of the amide I energy, thereby creating a localized quasiparticle (soliton) that persists at zero temperature. The presence of thermal noise, however, could destabilize the protein soliton and dissipate its energy within a finite lifetime. In this work, we have computationally solved the system of (...) class='Hi'>stochastic differential equations that govern the quantum dynamics of protein solitons at physiological temperature, T=310 K, for either a single isolated α-helix spine of hydrogen bonded peptide groups or the full protein α-helix comprised of three parallel α-helix spines. The simulated stochastic dynamics revealed that although the thermal noise is detrimental for the single isolated α-helix spine, the cooperative action of three amide I exciton quanta in the full protein α-helix ensures soliton lifetime of over 30 ps, during which the amide I energy could be transported along the entire extent of an 18-nm-long α-helix. Thus, macromolecular protein complexes, which are built up of protein α-helices could harness soliton-assisted energy transport at physiological temperature. Because the hydrolysis of a single adenosine triphosphate molecule is able to initiate three amide I exciton quanta, it is feasible that multiquantal protein solitons subserve a variety of specialized physiological functions in living systems. (shrink)

This study focuses on the static output feedback control of nonlinear Markov jump singularly perturbed systems within the framework of Takagi–Sugeno fuzzy approximation. From a practical point of view, the phenomenon of asynchronous switching between the plant and the controller is considered and characterized by a finite piecewise-homogenous Markov process. Particularly, for facilitating the controller synthesis, the closed-loop system is transformed into a fuzzy Markov jump singularly perturbed descriptor system by adopting descriptor representation. In order to fully accommodate the system (...) features, an appropriate stochastic Lyapunov function is constructed. Afterwards, by combining Finsler’s lemma, the mean square exponential admissibility of the system is analyzed. The conditions ensuring the existence of the predesigned controller are given and further solved by designing a brief search algorithm. Finally, a typical circuit system is used to demonstrate the application potential of the developed control technology and the effectiveness of the control strategy. (shrink)

ObjectiveNoisy galvanic vestibular stimulation (nGVS) is often used to improve postural stability in disorders, such as neurorehabilitation montage. For the safe use of nGVS, we investigated whether arterial pressure (AP) and heart rate vary during static supine and slow whole-body tilt with random nGVS (0.4 mA, 0.1–640 Hz, gaussian distribution) in a healthy elderly population.MethodsThis study was conducted with a double-blind, sham-controlled, cross-over design. Seventeen healthy older adults were recruited. They were asked to maintain a static supine position on (...) a bed for 10 min, and the bed was tilted up (TU) to 70 degrees within 30 s. After maintaining this position for 3 min, the bed was passively tilted down (TD) within 30 s. Real-nGVS or sham-nGVS was applied from 4 to 15 min. The time course of mean arterial pressure (MAP) and RR interval variability (RRIV) were analyzed to estimate the autonomic nervous activity.ResultnGVS and/or time, including pre-/post-event (nGVS-start, TU, and TD), had no impact on MAP and RRIV-related parameters. Further, there was no evidence supporting the argument that nGVS induces pain, vertigo/dizziness, and uncomfortable feeling.ConclusionnGVS may not affect the AP and RRIV during static position and whole-body tilting or cause pain, vertigo/dizziness, and discomfort in the elderly. (shrink)

A double delayed hybrid stochastic prey-predator bioeconomic system with Lévy jumps is established and analyzed, where commercial harvesting on prey and environmental stochasticity on population dynamics are considered. Two discrete time delays are utilized to represent the maturation delay of prey and gestation delay of predator, respectively. For a deterministic system, positivity of solutions and uniform persistence of system are discussed. Some sufficient conditions associated with double time delays are derived to discuss asymptotic stability of interior equilibrium. For (...) a stochastic system, existence and uniqueness of a global positive solution are studied. By using the invariant measure theory and singular boundary theory of diffusion process, existence of stochastic Hopf bifurcation and stochastic stability are investigated. By constructing appropriate Lyapunov functions, asymptotic dynamic behavior of the proposed hybrid stochastic system with double time delays and Lévy jumps is discussed. Numerical simulations are provided to show consistency with theoretical analysis. (shrink)

In this paper, we formulate and investigate a two-microorganism and single nutrient chemostat model with Monod-Haldane response function and random perturbation. First, for the corresponding deterministic system, we introduce the conditions of the stability of the equilibrium points. Then, using Lyapunov function and Itô’s formula, we investigate the existence and uniqueness of the global positive solution of the stochastic chemostat model. Furthermore, we explore and obtain the criterions of the extinction and the permanence for the stochastic model. (...) Finally, numerical simulations are carried out to illustrate our main results. (shrink)

In this paper, we investigate the dynamics of autonomous and nonautonomous stochastic toxin-producing phytoplankton–zooplankton system. For the autonomous system, we establish the sufficient conditions for the existence of the globally positive solution as well as the solution of population extinction and persistence in the mean. Furthermore, by constructing some suitable Lyapunov functions, we also prove that there exists a single stationary distribution which is ergodic, what is more important is that Lyapunov function does not depend on existence and (...) class='Hi'>stability of equilibrium. For the nonautonomous periodic system, we prove that there exists at least one nontrivial positive periodic solution according to the theory of Khasminskii. Finally, some numerical simulations are introduced to illustrate our theoretical results. The results show that weaker white noise and/or toxicity will strengthen the stability of system, while stronger white noise and/or toxicity will result in the extinction of one or two populations. (shrink)

This study concentrates on adaptive event-triggered control of complex dynamical networks with unpredictable coupling delays and stochastic deception attacks. The adaptive event-triggered mechanism is used to avoid the wasting of limited bandwidth. The probability of data communicated by the network is established by statistical properties and Bernoulli stochastic variables with an uncertain occurrence probability. Stability analysis based on Lyapunov–Krasovskii functional and the stability of the closed-loop system is guaranteed. Using the LMI technique, we obtain triggered parameters. (...) To demonstrate the feasibility and usefulness of the suggested methodology, two examples are shown. (shrink)

The output feedback controller is designed for a class of stochastic nonlinear systems that satisfy uncertain function growth conditions for the first time. The multivariate function growth condition has greatly relaxed the restrictions on the drift and diffusion terms in the original stochastic nonlinear system. Here, we cleverly handle the problem of uncertain functions in the scaling process through the function maxima theory so that the Ito differential system can achieve output stabilization through Lyapunov function design and the (...) solution of stochastic nonlinear system objects satisfies the existence of uniqueness, ensuring that the system is globally asymptotically stable in the sense of probability. Furthermore, it is concluded that the system is inversely optimally stable in the sense of probability. Finally, we apply the theoretical results to the practical subsea intelligent electroexecution robot control system and obtain good results. (shrink)

Solvency assessment is the core content of insurance supervision. In this paper, from the perspective of capital flow, the insurance company’s capital flow is regarded as a dynamic system, the stochastic differential equations model is established to describe its flow characteristics, and the existence of positive equilibrium point of the system is proved, as well as the conditions of stability at equilibrium point, that is, the requirements of the insurance company’s solvency. Furthermore, by using the numerical simulation method, (...) we get the strategy of insurance companies to deal with the solvency shortage when facing the change of external environment, and the strategy of insurance company to deal with solvency shortage is obtained. (shrink)

Mixed-strategy equilibria are typically rather unstable in evolutionary game theory. “Monocyclic” games, such as Rock–Paper–Scissors, have only mixed equilibria, some of which are “stable” in the sense that sequential best replies lead to them; yet, even these games are prone to stable cycles under discrete-time simultaneous best replies, giving an unusual equilibrium-selection problem. This article analyzes such games in a random-utility setting where changing strategies is costly, and the speed of the dynamic is, thus, endogenous. The stochastically stable outcome is (...) determined by the cost of switching strategies; when switching costs are high, mixed equilibria are selected, whereas when switching costs are low, cycles are selected. (shrink)

We introduce a dynamic model for evolutionary games played on a network where strategy changes are correlated according to degree of influence between players. Unlike the notion of stochastic stability, which assumes mutations are stochastically independent and identically distributed, our framework allows for the possibility that agents correlate their strategies with the strategies of those they trust, or those who have influence over them. We show that the dynamical properties of evolutionary games, where such influence neighborhoods appear, differ (...) dramatically from those where all mutations are stochastically independent, and establish some elementary convergence results relevant for the evolution of social institutions. (shrink)

This work is devoted to studying the stochastic stabilization of a class of neutral-type complex-valued neural networks with partly unknown Markov jump. Firstly, in order to reduce the conservation of our stability conditions, two integral inequalities are generalized to the complex-valued domain. Secondly, a state-feedback controller is designed to investigate the stability of the neutral-type CVNNs with H ∞ performance, making the stability problem a further extension, and then, the stabilization of the CVNNs with H ∞ (...) performance is investigated through a sampling-based event-triggered control for the first time that the transmission event is not triggered except when it violates the event-triggered condition. Finally, two examples are given to illustrate the validity and correctness of our obtained theorems. (shrink)

This paper considers observer design for discrete-time descriptor systems with packet losses. By taking packet loss into consideration, the error dynamic of the proposed observer becomes a stochastic switched system. Consequently, the proposed observer is synthesized in a stochastic switched system framework. Sufficient conditions for the stochastic stability with a prescribed robust performance of the error dynamic system are derived and converted into linear matrix inequalities. Not only can the proposed observer deal with packet losses, but (...) it also attenuates the effect of process disturbance and measurement noise. A numerical simulation of a truck-trailer is given to demonstrate the effectiveness of the proposed method. (shrink)

We introduce a dynamic model for evolutionary games played on a network where strategy changes are correlated according to degree of influence between players. Unlike the notion of stochastic stability, which assumes mutations are stochastically independent and identically distributed, our framework allows for the possibility that agents correlate their strategies with the strategies of those they trust, or those who have influence over them. We show that the dynamical properties of evolutionary games, where such influence neighborhoods appear, differ (...) dramatically from those where all mutations are stochastically independent, and establish some elementary convergence results relevant for the evolution of social institutions. (shrink)