BackgroundIn the Canadian Alliance for Healthy Hearts and Minds (CAHHM) cohort, participants underwent magnetic resonance imaging (MRI) of the brain, heart, and abdomen, that generated incidental findings (IFs). The approach to managing these unexpected results remain a complex issue. Our objectives were to describe the CAHHM policy for the management of IFs, to understand the impact of disclosing IFs to healthy research participants, and to reflect on the ethical obligations of researchers in future MRI studies.MethodsBetween 2013 and 2019, 8252 participants (...) (mean age 58 ± 9 years, 54% women) were recruited with a follow-up questionnaire administered to 909 participants (40% response rate) at 1-year. The CAHHM policy followed a restricted approach, whereby routine feedback on IFs was not provided. Only IFs of severe structural abnormalities were reported.ResultsSevere structural abnormalities occurred in 8.3% (95% confidence interval 7.7–8.9%) of participants, with the highest proportions found in the brain (4.2%) and abdomen (3.1%). The majority of participants (97%) informed of an IF reported no change in quality of life, with 3% of participants reporting that the knowledge of an IF negatively impacted their quality of life. Furthermore, 50% reported increased stress in learning about an IF, and in 95%, the discovery of an IF did not adversely impact his/her life insurance policy. Most participants (90%) would enrol in the study again and perceived the MRI scan to be beneficial, regardless of whether they were informed of IFs. While the implications of a restricted approach to IF management was perceived to be mostly positive, a degree of diagnostic misconception was present amongst participants, indicating the importance of a more thorough consent process to support participant autonomy.ConclusionThe management of IFs from research MRI scans remain a challenging issue, as participants may experience stress and a reduced quality of life when IFs are disclosed. The restricted approach to IF management in CAHHM demonstrated a fair fulfillment of the overarching ethical principles of respect for autonomy, concern for wellbeing, and justice. The approach outlined in the CAHHM policy may serve as a framework for future research studies.Clinical trial registrationhttps://clinicaltrials.gov/ct2/show/nct02220582. (shrink)

A collection of interviews with influential theorists working in philosophy of logic. The questions: Why were you initially drawn to the philosophy of logic? What are your main contributions to the philosophy of logic? What is the proper role of philosophy of logic in relation to other disciplines, and to other branches of philosophy? What have been the most significant advances in the philosophy of logic? What are the most important open problems in philosophy of logic, and what are the (...) prospects for progress? Interviews with JC Beall, John Lane Bell, Johan van Benthem, Patricia A. Blanchette, Otávio Bueno, James Cargile, Mark Colyvan, Newton Carneiro Affonso da Costa, Pascal Engel, Susan Haack, Jaakko J. Hintikka, Dale Jacquette, Penelope Maddy, Lawrence S. Moss, Catarina Dutilh Novaes, Ahti-Veikko Pietarinen, Graham Priest, Stephen Read, Nicholas Rescher, Stewart Shapiro, Peter Simons, Timothy Williamson, Jan Woleński. (shrink)

Normal narcissistic functioning has to do with the regulation of a coherent set of metarepresentations of the acting agent. That set of meta-representations has its own interior architecture and dynamics. Normal narcissistic functioning is an adaptive form of interpsychic processing which can be given a general account by integrating views of it drawn from the clinical traditions of psychoanalysis, empirical psychology, and contemporary cognitive and neurosciences. This is not to be confused with any form of organized psychopathology, though pathological forms (...) of narcissism are relevant to understanding normal narcissism. Neural correlates of normal narcissism, as also the characteristic emotions and pleasures/displeasures that accompany its operations, are also explored. It is proposed that this allostatic regulatory system plays a prominent role in a wide range of human behaviors. It also closes the gap between social norms governing such behaviors and the minds of the agents performing them. This integrative interpretation of the scientific material is offered as an exercise in “philosophy in cognitive science” and belongs to the tradition of naturalistic philosophical accounts of the human mind. (shrink)

My analysis of the constitutional foundations of judicial review has been criticized by Paul Craig; but his objections confuse the ‘constructive’ account of legislative intent I defend with the ‘literal’ conception (reflecting the views of individual legislators) I expressly repudiate. He thinks we must choose between legislative intent, literally conceived, and common law principle. This mistake exemplifies the peculiar character of Craig's ‘common law model’ of judicial review, in which the requirements of the rule of law, on one hand, and (...) the relevant statute, on the other, exist in separate mental worlds. That model is conceptually confused, rejecting the doctrine of ultra vires that (unqualified) legislative supremacy entails, and ultimately grounded in a wholly implausible view of the relationship between common law and statute. It subordinates both statutory text and purpose to common law doctrine, treated as largely self-contained and impervious to context. It ignores the interdependence of legislative and judicial power, impeding a genuine integration of statutory command and common law principle. (shrink)

An aspect of Pisistratus, which has not hitherto been utilized in this question , appears to justify another presentment of the evidence which connects him with the Homeric tradition. I shall endeavour to be brief and not to repeat what is common property or irrelevant. The literature and the bearing of the controversy are given with his usual clearness by P. Cauer, Grundfragen der Homerkritik,2 pp. 125 sqq. Cauer's private doctrine, that Homer was for the first time written down by (...) Pisistratus, I consider sufficiently refuted by C. Rothe, Die Was als Dichtung, pp. 5–13. Fantastic views lately promulgated in England are1 dealt with conclusively to my mind by Mr. A. Lang, The World of Homer, pp. 281 sqq., to whose account nothing for controversial purposes need be added. On looking back over the literature I find myself most in agreement with Hans Flach, whose treatise, Die litterarische Thdtigkeit des Peisistratos, 1885, has been unduly depreciated. I shall have to repeat my own views expressed in the Classical Review, 1901, p. 7; 1907, p. 18; and in the Classical Quarterly, 1909, p. 84. (shrink)

В книге собраны результаты исследований классической для эпистемологии проблемы истины. Для эпистемологов, методологов науки, а также для философов и ученых.

Consideration of the adaptive problems faced by our ancestors suggests functional reasons why people exhibit some biases in social judgment more than others. We present a taxonomy consisting of six domains of central social challenges. Each is associated with somewhat different motivations, and consequently different decision-rules. These decision-rules, in turn, make some biases inherently more likely to emerge than others.

Supercommentary on the inference (anumāna) part of Raghunātha Śiromaṇi's Tattvacintāmaṇidīdhiti, 16th century commentary on Gaṅgésa's Tattvacintāmaṇi, 13th century basic work of the neo-Nyaya school in Hindu philosophy.