Here we present and develop the hypothesis that the derepression of endogenous retrotransposable elements (RTEs) – “genomic parasites” – is an important and hitherto under‐unexplored molecular aging process that can potentially occur in most tissues. We further envision that the activation and continued presence of retrotransposition contribute to age‐associated tissue degeneration and pathology. Chromatin is a complex and dynamic structure that needs to be maintained in a functional state throughout our lifetime. Studies of diverse species have revealed that chromatin undergoes (...) extensive rearrangements during aging. Cellular senescence, an important component of mammalian aging, has recently been associated with decreased heterochromatinization of normally silenced regions of the genome. These changes lead to the expression of RTEs, culminating in their transposition. RTEs are common in all kingdoms of life, and comprise close to 50% of mammalian genomes. They are tightly controlled, as their activity is highly destabilizing and mutagenic to their resident genomes. (shrink)

The admissibility of Ackermann's rule? is one of the most important problems in relevant logic. While the?-admissibility of normal modal logics based on the relevant logic R has been previously discussed, the case for weaker relevant modal logics has not yet been considered. The method of normal models has often been used to prove the?-admissibility. This paper discusses which relevant modal logics admit? from the viewpoint of the method of normal models.

この世の悪は、一人ひとりがその行いを改めれば払拭できるものだろうか?自然災害に見舞われ、多くの人が苦しめられているとき、そこに悪の問題はないのだろうか?孔子や孟子、荘子、荀子などの中国古代の思想家たち も、悪という問題に直面し、格闘してきた。清代にいたるまでの、そうした悪をめぐる哲学的思考を辿りなおし、その可能性と限界を描き出す。悪にあらがい、その残酷さを引き受け、乗り越えるための方途を探る哲学の書 である。.

世界はいま危機に直面している.その危機に直面したときに試されているのが,我々の想像力であり,イメージの力なのである.その想像力を鍛えるのに最も重要なのは,批判(クリティーク)なのだ.いま最もアクチュア ルに活動している哲学者・中島隆博が紡ぐ,危機の時代の哲学の実践へ.

人類は深奥に潜む意識をいかに表現し思想としての普遍性を獲得してきたか。古今東西の表現者たちが格闘した言語経験を省察する。.

In motion-induced blindness , a target within rotating random dots is occasionally hidden from observers’ consciousness during observation. In the present study, a red ring-like cue was centered on a target and presented immediately after observers reported subjective disappearance of the target in MIB . The radius of the cue was systematically modulated. Observers quickly regained awareness of the disappeared object only after they were provided with a pinpoint cue of its location. We also found that a flickering cue at (...) 1 Hz hindered MIB when the radius of the cue was critically small . Furthermore, abrupt onset of a small square was enough to regain awareness of the target . Successful revival of the target with a small cue indicates that critical spatial distribution of visual attention determines what in the visual scene is included in visual awareness. (shrink)

帝国主義全盛の時代に武断的侵略的帝国主義に対し「倫理的帝国主義」を高唱。評価が分かれる稀代の自由主義思想家の実像に肉薄。.

This thesis describes a method to control rare events in non-equilibrium systems by applying physical forces to those systems but without relying on numerical simulation techniques, such as copying rare events. In order to study this method, the book draws on the mathematical structure of equilibrium statistical mechanics, which connects large deviation functions with experimentally measureable thermodynamic functions. Referring to this specific structure as the "phenomenological structure for the large deviation principle", the author subsequently extends it to time-series statistics that (...) can be used to describe non-equilibrium physics. The book features pedagogical explanations and also shows many open problems to which the proposed method can be applied only to a limited extent. Beyond highlighting these challenging problems as a point of departure, it especially offers an effective means of description for rare events, which could become the next paradigm of non-equilibrium statistical mechanics. (shrink)

Dysfunctional attentional control is observed in patients with mental disorders. However, there is no established neurophysiological method to assess attention in such patients. We showed a discrepancy in alpha-band power in the tasks that evoked internal and external attention event-related alpha-band power changes in healthy subjects during self-reflection and working memory tasks in a preliminary study. In this study, we aimed at elucidating event-related alpha-band power changes in healthy subjects during the tasks, addressing the shortcomings of the previous study. Sixteen (...) healthy volunteers were examined for the event-related power change during the tasks. The results demonstrated the discrepancy of alpha-band ERpow at 8, 10, and 12 Hz in the parieto-occipital area between the WM and SR tasks for a period between a target stimulus and a command stimulus, where a participant switched to internal attention from external attention according to the SR task and remained at external attention according to the WM task. The results suggest that alpha-band ERpow in this area is associated with the direction of attention in response to cognitive stimuli, indicating that the findings of ERpow during the two tasks would potentially aid in the clarification of the pathophysiology of the dysfunctional change in attention in patients with psychiatric disorders. (shrink)

Recently, several funding agencies have introduced the distribution of funds by a lottery system; however, its effects on the productivity of the research community are unclear. Simulation studies in philosophy of science have argued that a combination of peer review and lottery is an optimal method. However, these models overlook several important aspects of research activities, such as baseline funding through block grants. In this study, I constructed a general theoretical model that incorporates these aspects and argue that the conventional (...) combination of peer review and baseline funding outperforms the combination of peer review and lottery in many situations. (shrink)

The sense of agency refers to an experience in which one’s own action causes a change in environment. It is strongly modulated by both the contingency between action and its outcome and the consistency between predicted and actual action outcomes. Recent studies have suggested that the action outcome can retrospectively modulate action awareness. We suspect that the sense of agency can also be retrospectively modulated. This study examined whether the quantity of action outcome could influence the sense of agency. The (...) participants’ task was to trigger dot motion in a display and rate the extent to which they could control the initiation of dot motion. Independently of both the temporal contiguity between action and its outcome and the consistency between predicted and actual action outcomes, the speed of dot motion as an action’s outcome strongly influenced the sense of agency rating. The present study suggests that the sense of agency stems partly from the inference of action efficiency based on the quantitative aspect of action outcome. (shrink)

This paper aims to show that two eminent Marxists in the 1930s, the Italian Antonio Gramsci and the Japanese Tosaka Jun, shared three important characteristics of so-called Western Marxism: the methodological development of Marxism, the focus on the superstructure, and the pessimism about the impossibility of immediate revolution. Showing that Gramsci and Tosaka shared these characteristics enables us to revisit the framework of “Western Marxism,” which confusingly consists of both theoretical characteristics and geographical criteria. Looking at Gramsci and Tosaka on (...) the same plane allows us to revisit Marxist thought different from the orthodox Marxism in Soviet Russia, and not strictly as a Western, but as a part of potentially global movement of thought. (shrink)

Reinforcement learning has recently received much attention as a learning method for complicated systems, e.g., robot systems. It does not need prior knowledge and has higher capability of reactive and adaptive behaviors. However increase in dimensionality of the action-state space makes it diffcult to accomplish learning. The applicability of the existing reinforcement learning algorithms are effective for simple tasks with relatively small action-state space. In this paper, we propose a new reinforcement learning algorithm: “Q-learning with Dynamic Structuring of Exploration Space (...) Based on Genetic Algorithm ”. The algorithm is applicable to systems with high dimensional action and interior state spaces, for example a robot with many redundant degrees of freedom. To demonstrate the effectiveness of the proposed algorithm simulations of obstacle avoidance by a 50 links manipulator have been carried out. It is shown that effective behavior can be learned by using the proposed algorithm. (shrink)

十九世紀後半における英国唯美主義を支えた日本趣味の実態はどのようなものだったのか。ロセッティ、スウィンバーン、ペイター、ワイルド、ホイッスラーらの藝術について、さらに英国唯美主義の素地としてのギリシア のエピクーロス的世界、西脇順三郎を初めとする日本の詩人達とワイルド受容、ロセッティやペイターの系譜に連なる唯美主義者としてのハーンなど、両国の藝術の関わりを悠遠な視座から読み解く比較藝術論。図版多数。 .

死後の魂のヴィジョンと永遠回帰の宇宙論を語るこの破天荒な構想力、九鬼周造とはいったい何者か。.

40億年に及ぶとされる、地球における生命の歴史。共通の祖先から進化した生きものたちは、多様でありながら共通点もあわせ持っています。いのちとは何か?いのちはどのようにして生まれたのか?どのように考えられ てきたのか?その歴史をひもときながら、私たちの来た道と、これから行く道を、探ってみましょう。.

Reinforcement learning is very effective for robot learning. Because it does not need priori knowledge and has higher capability of reactive and adaptive behaviors. In our previous works, we proposed new reinforcement learning algorithm: “Q-learning with Dynamic Structuring of Exploration Space Based on Genetic Algorithm (QDSEGA)”. It is designed for complicated systems with large action-state space like a robot with many redundant degrees of freedom. And we applied it to 50 link manipulator and effective behavior is acquired. However optimality and (...) fault tolerance of the proposed algorithm were not considered and to demonstrate effectiveness of the proposed algorithm other applications are necessary. Acquiring of locomotion patterns by a multi-legged robot is a very interesting problem. As it has many redundant degrees of freedom, application of usual reinforcement learning is difficult and an optimal locomotion has not been acquired using previous reinforcement learning algorithm. And the redundancy of the robot is effective to the fault tolerance and various locomotion patterns can be acquired for adapting the faults of the legs. In this paper, we applied QDSEGA to acquiring of locomotion pattern by the multi-legged robot and considered the optimality and fault tolerance. Effective behavior has been obtained by using our proposed algorithm. (shrink)

Experiment with public deployment of the semantic service matchmaker to a UDDI registry for a year is described in this paper. UDDI is a standard registry for Web Services, but, its search functionality has been limited to a keyword search. Therefore, we propose an enhancement of UDDI, called Matchmaker, that supports semantic service capability discovery. Since September 2003, we have deployed the Matchmaker in one of four official UDDI registries operated by NTT-Communications. In this paper, we first introduce the Matchmaker, (...) and illustrate client tools which lower the threshold of use of semantics. Then, we evaluate this experiment by benchmarks in terms of its performance and functionality. Finally, we discuss user requirements obtained by two ways: questionnaire and observation of search behavior. (shrink)

General frames are often used in classical modal logic. Since they are duals of modal algebras, completeness follows automatically as with algebras but the intuitiveness of Kripke frames is also retained. This paper develops basics of general frames for relevant modal logics by showing that they share many important properties with general frames for classical modal logic.

Antonio Gramsci rigorously analysed the modern transformation of the Catholic Church and its strategy to spread its worldview to the Italian masses through secular means. His critique of the Church largely drew on his examination of the grounds that ensured Croce’s critique was doomed to failure. Despite its harshness, Croce’s critique failed because he did not grasp that the main target of the Church’s strategy was the common sense of the masses, while Croce pursued his critique in a highly idealist (...) manner, appealing only to his fellow intellectuals. He thereby, according to Gramsci, helped to reinforce the Church’s strategy by endorsing the rigid separation between the intellectuals and the masses. In contrast, unlike Croce and orthodox Marxism, Gramsci did not dismiss religion as a mere absurdity, recognising it as a source of people’s common sense that, albeit confusing in nature, informed their worldview. Gramsci considered that even the common sense of the masses constituted an appropriate grasp of the world, or ‘good sense’. In this sense, Gramsci’s critique of religion echoed his preoccupation with the longstanding division of Italian society between the intellectuals and the masses, which prevented mass participation in politics. (shrink)

Gramsci’s concept of the “ethical state” has been interpreted as a synonym for the “regulated society”—a future society in which everybody participates in governance following the rationalization o...

Face recognition is impaired in patients with prosopagnosia, which may occur as a side effect of neurosurgical procedures. Face selective regions on the ventral temporal cortex have been localized with electrical cortical stimulation, electrocorticography, and functional magnetic resonance imagining. This is the first group study using within-patient comparisons to validate face selective regions mapping, utilizing the aforementioned modalities. Five patients underwent surgical treatment of intractable epilepsy and joined the study. Subdural grid electrodes were implanted on their ventral temporal cortices to (...) localize seizure foci and face selective regions as part of the functional mapping protocol. Face selective regions were identified in all patients with fMRI, four patients with ECoG, and two patients with ECS. From 177 tested electrode locations in the region of interest, which is defined by the fusiform gyrus and the inferior temporal gyrus, 54 face locations were identified by at least one modality in all patients. fMRI mapping showed the highest detection rate, revealing 70.4% for face selective locations, whereas ECoG and ECS identified 64.8 and 31.5%, respectively. Thus, 28 face locations were co-localized by at least two modalities, with detection rates of 89.3% for fMRI, 85.7% for ECoG and 53.6 % for ECS. All five patients had no face recognition deficits after surgery, even though five of the face selective locations, one obtained by ECoG and the other four by fMRI, were within 10 mm to the resected volumes. Moreover, fMRI included a quite large volume artifact on the ventral temporal cortex in the ROI from the anatomical structures of the temporal base. In conclusion, ECS was not sensitive in several patients, whereas ECoG and fMRI even showed activation within 10 mm to the resected volumes. Considering the potential signal drop-out in fMRI makes ECoG the most reliable tool to identify face selective locations in this study. A multimodal approach can improve the specificity of ECoG and fMRI, while simultaneously minimizing the number of required ECS sessions. Hence, all modalities should be considered in a clinical mapping protocol entailing combined results of co-localized face selective locations. (shrink)

Kripke-completeness of every classical modal logic with Sahlqvist formulas is one of the basic general results on completeness of classical modal logics. This paper shows a Sahlqvist theorem for modal logic over the relevant logic Bin terms of Routley- Meyer semantics. It is shown that usual Sahlqvist theorem for classical modal logics can be obtained as a special case of our theorem.

Kripke-completeness of every classical modal logic with Sahlqvist formulas is one of the basic general results on completeness of classical modal logics. This paper shows a Sahlqvist theorem for modal logic over the relevant logic Bin terms of Routley-Meyer semantics. It is shown that usual Sahlqvist theorem for classical modal logics can be obtained as a special case of our theorem.

Previous studies have confirmed that the temporal attentional control created by the repetition of stimulus-response compatibility (SRC) tasks was transferred to shooting skills in lacrosse players. In the current study, we investigated whether combining motor imagery training with SRC tasks could enhance the scoring ability of lacrosse players. We grouped 33 male lacrosse players into three groups: an SRC task and motor imagery group (referred as to SRC+Image), an SRC task group, and a control group. Players in the first two (...) groups underwent five sessions of 200 SRC task trials. In addition, the SRC+Image group completed five sessions of motor imagery training. The control group underwent no training interventions. All three groups performed a lacrosse shooting test and a Simon task before and after training sessions to assess the magnitude of the interference effects of the various types of training they underwent. The results of the Simon task showed that repetition of 1,000 trials was enough to create a short-term representation with the incompatible special mapping being transferred to a dynamic activity like lacrosse shooting. Moreover, combination of a computer-based Type 2 task and motor-imagery training could effectively increase players’ scoring ability in a field of large spatial conflict. (shrink)