Taking advantage of the fact that they need not replicate their DNA, terminally differentiated neurons only repair their expressed genes and largely dispense with the burden of removing damage from most of their genome. However, they may pay a heavy price for this laxity if unforeseen circumstances, such as a pathological condition like Alzheimer's disease, cause them to re‐enter the cell cycle. The lifetime accumulation of unrepaired lesions in the silent genes of neurons is likely to be significant and may (...) result in aborting the mitotic process and triggering cell death if the cells attempt to express these dormant genes and resume DNA replication. BioEssays 25:168–173, 2003. © 2003 Wiley Periodicals, Inc. (shrink)

Le temps suspendu comme moment heureux est à juste titre considéré comme extrêmement précieux. Mais on peut se demander : par quoi donc peut-il bien être suspendu? L'hypothèse que l'auteur examine consiste dans l'idée que le temps est suspendu par le désir s'assouvissant. Ou que le temps suspendu n'est rien d'autre que du désir-temps : ni désir de temps, ni temps du désir ; il relève de leur unité profonde. Il s'agira d'élucider cette hypothèse notamment avec Rousseau, les épicuriens et (...) les stoïciens. (shrink)

Informed consent is the legal instrument that purports to protect an individual's autonomy and defends against medical arbitrariness. Informed Consent and Health highlights that possession of complete information about all relevant aspects of a proposed treatment is integral to the ability of a patient to make an informed choice. With patient choice at both legislative and judicial levels rising to greater levels of prominence, this timely book examines how the tensions between the rights of patients to make choices and the (...) duties of doctors to provide health care are managed.This illuminating book investigates our evolving understanding of informed consent from a range of comparative and international perspectives, demonstrating the diversity of its interpretations around the world. Chapters offer a nuanced analysis of the problems that impede the understanding and implementation of the concept of informed consent and explore the contemporary challenges that continue to hinder both the patient and the medical community.Containing an in-depth discussion on this fundamental right, this thought-provoking book will be of value to academics and practitioners alike. Providing fascinating insight into new solutions and interpretations, this book will also prove a key resource for clinicians and health care workers. (shrink)

The official model of explanation proposed by the logical empiricists, the covering law model, is subject to familiar objections. The goal of the present paper is to explore an unofficial view of explanation which logical empiricists have sometimes suggested, the view of explanation as unification. I try to show that this view can be developed so as to provide insight into major episodes in the history of science, and that it can overcome some of the most serious difficulties besetting the (...) covering law model. (shrink)

In this work, the prominent political philosopher Philip Pettit embarks on a massive undertaking to offers major new accounts of the foundations of the state and the nature of justice. In doing so Pettit builds a new theory of what the state is and what it ought to be, addresses the normative question of how justice serves as a measure of the success of a state, and the way it should operate in relation to its citizens and other people.

A person presented with adequate but not conclusive evidence for a proposition is in a position voluntarily to acquire a belief in that proposition, or to suspend judgment about it. The availability of doxastic options in such cases grounds a moderate form of doxastic voluntarism not based on practical motives, and therefore distinct from pragmatism. In such cases, belief-acquisition or suspension of judgment meets standard conditions on willing: it can express stable character traits of the agent, it can be responsive (...) to reasons, and it is compatible with a subjective awareness of the available options. (shrink)

How Galileo created the problem of consciousness -- Is there a ghost in the machine? -- Can physical science explain consciousness? -- How to solve the problem of consciousness -- Consciousness and the meaning of life.

Liang Shuming, considered to be the Last Confucian, was a Buddhist.

What's the Use of Philosophy? aims to answer the question posed in its title, whether the questioner intends to dismiss philosophy, or seeks a positive answer. The first three chapters explore the grounds for dismissal. Chapter 1 expresses skepticism about the value of much professional Anglophone philosophy, while recognizing virtues in work often viewed as peripheral. Chapter 2 studies a philosophical subfield, the philosophy of science, arguing that, while its condition may be better than the norm, it is far from (...) perfect. In Chapter 3, a more systematic critique is offered, in the form of a pathology report. Its diagnosis identifies six justifiable philosophical impulses that, when pursued obsessively, generate distortions and diseases: clarity becomes a fetish, formalism becomes obfuscation, "intuition" is given burdens it cannot bear, appeals to the a priori sprinkle fairy dust on controversial claims, ideas grabbed from other fields are used in cartoon forms, and questions no longer relevant are treated as if they were "timeless." Chapter 4 attempts to identify the legitimate goals of philosophy. It sees value in attempts to respond to questions arising from the difficulties of the age, in attempts to reform methods of inquiry, and, above all, in the construction of syntheses capable of helping people as they struggle to make sense of their lives. Philosophy is renewed when these traditional goals once again become central to its discussions. The final chapter responds to a frequently voiced worry in a letter to young philosophers who wonder how they can align their aspirations with the hyper-professionalism expected of them. (shrink)

An esteemed philosopher discusses his theory of universal freedom, describing how even those who are members of free societies may find their liberties curtailed and includes tests of freedom including the eyeball test and the tough-luck test.

This paper argues for a Husserlian account of phenomenal intentionality. Experience is intentional insofar as it presents a mind-independent, objective world. Its doing so is a matter of the way it hangs together, its having a certain structure. But in order for the intentionality in question to be properly understood as phenomenal intentionality, this structure must inhere in experience as a phenomenal feature. Husserl’s concept of horizon designates this intentionality-bestowing experiential structure, while his concept of motivation designates the unique phenomenal (...) character of this structure as it is experientially lived through. The way experience hangs together is itself a phenomenal feature of experience. (shrink)

Engineers are traditionally regarded as trustworthy professionals who meet exacting standards. In this chapter I begin by explicating our trust relationship towards engineers, arguing that it is a linear but indirect relationship in which engineers “stand behind” the artifacts and technological systems that we rely on directly. The chapter goes on to explain how this relationship has become more complex as engineers have taken on two additional aims: the aim of social engineering to create and steer trust between people, and (...) the aim of creating automated systems that take over human tasks and are meant to invite the trust of those who rely on and interact with them. (shrink)

Good reasoning can lead to success; bad reasoning can lead to catastrophe. Yet, it's not obvious how we reason, and why we make mistakes. This new book by one of the pioneers of the field, Philip Johnson-Laird, looks at the mental processes that underlie our reasoning. It provides the most accessible account yet of the science of reasoning.

This paper has two goals: (1) to defend a particular response to the problem of resultant moral luck and (2) to defend the claim that we are only responsible for what we could have avoided. Cases of overdetermination threaten to undermine the claim that we are only responsible for what we could have avoided. To deal with this issue, I will motivate a particular way of responding to the problem of resultant moral luck. I defend the view that one's degree (...) of responsibility is immune to moral luck but the scope of events for which one is responsible is subject to moral luck. I will then argue that this view allows us to explain away certain intuitions about responsibility and overdetermination (as well as similar intuitions regarding Frankfurt Cases). As a result, the claim that we are only responsible for what we could have avoided becomes significantly more plausible. (shrink)

Valorising the biocultural heritage of common goods could enable peasant farmers to achieve socially and economically inclusive sustainability. Increasingly appreciated by consumers, peasant heritage products offer small farmers promising opportunities for economic, social and territorial development. Identifying the obstacles and levers of this complex, multi-scale and multi-stakeholder objective requires an integrative framework. We applied the panarchy conceptual framework to two cases of participatory research with small quinoa producers: a local fair in Chile and quinoa export production in Bolivia. In both (...) cases, the “commoning” process was crucial both to bring stakeholders together inside their communities and to gain outside recognition for their production and thus achieve social and economic inclusion. Despite the differences in scale, the local fair and the export market shared a similar marketing strategy based on short value chains promoting quality products with high identity value. In these dynamics of biocultural heritage valorisation, the panarchical approach revealed the central place as well as the vulnerability of the community territory. As a place of both anchoring and opening, the community territory is the privileged space where autonomous and consensual control over the governance of common biocultural resources can be exercised. (shrink)

Cognitive neuropsychiatry (CN) is the explanation of psychiatric disorder by the methods of cognitive neuropsychology. Within CN there are, broadly speaking, two approaches to delusion. The first uses a one-stage model, in which delusions are explained as rationalizations of anomalous experiences via reasoning strategies that are not, in themselves, abnormal. Two-stage models invoke additional hypotheses about abnormalities of reasoning. In this paper, I examine what appears to be a very strong argument, developed within CN, in favor of a twostage explanation (...) of the difference in content between the Capgras and Cotard delusions. That explanation treats them as alternative rationalizations of essentially the same phenomenology. I show, however, that once we distinguish the phenomenology (and the neuroetiology), a one-stage model is adequate. In the final section I make some more general remarks on the oneand two-stage models. (shrink)

Comment Descartes a-t-il pu nier l'évidence de sa dette à l'égard du cogito d'Augustin, et Jacques Hadamard s'accuser, à l'inverse, de ne pas avoir découvert la relativité avant Einstein? Qu'est-ce qui pouvait bien justifier Lacan, lorsqu'il osait affirmer que l'inconscient n'est pas de Freud, mais de lui... De même, côté art : on se demande pourquoi Borges a voulu faire de Ménard l'auteur du Quichotte ou Duchamp devenir celui d'un urinoir. Thierry Marchaisse prouve ici que l'on peut devenir le (...) véritable auteur de l'idée d'un autre, et que ce paradoxe, avancé par Pascal voilà plus de trois siècles, est à la fois le verrou et la clé de la logique de la créativité. (shrink)

This root-and-branch reevaluation of Darwin's concept of sexual selection tackles the subject from historical, epistemological and theoretical perspectives. Contributions from a wealth of disciplines have been marshaled for this volume, with key figures in behavioural ecology, philosophy, and the history of science adding to its wide-ranging relevance. Updating the reader on the debate currently live in behavioural ecology itself on the centrality of sexual selection, and with coverage of developments in the field of animal aesthetics, the book details the current (...) state of play, while other chapters trace the history of sexual selection from Darwin to today and inquire into the neurobiological bases for partner choices and the comparisons between the hedonic brain in human and non-human animals. Welcome space is given to the social aspects of sexual selection, particularly where Darwin drew distinctions between eager males and coy females and rationalized this as evolutionary strategy. Also explored are the current definition of sexual selection (as opposed to natural selection) and its importance in today's biological research, and the impending critique of the theory from the nascent field of animal aesthetics. As a comprehensive assessment of the current health, or otherwise, of Darwin's theory, 140 years after the publication of his Descent of Man, the book offers a uniquely rounded view that asks whether 'sexual selection' is in itself a progressive or reactionary notion, even as it explores its theoretical relevance in the technical biological study of the twenty-first century. (shrink)

Ce livre cherche à montrer comment l'eau, à la fois réalité et symbole, nourrit la pensée de Platon. Quelle est l'origine de cette thématique et quelles en sont les finalités? A travers ces interrogations, il s'agit de mettre en lumière la fonction de cette matière particulière dont les aspects sont déclinés de manière originale dans l'ensemble de son oeuvre. En rassemblant la multiplicité des images de l'eau, l'auteur interroge la nature et la valeur des images en s'efforçant de montrer comment (...) Platon, écrivain et poète, met en oeuvre avec inventivité métaphores, allégories et mythes. De quoi alimenter un questionnement sur le réel, auquel l'eau donne un fil directeur. On y voit aussi se défaire une certaine idée du platonisme. Critique à l'égard de la rhétorique et des arts, Platon vise dans le miroir les effets illusoires de l'image et de l'imitation, mais Socrate utilise lui-même les images et les reflets tout au long des dialogues, et on en découvre avec étonnement toutes les variations. La métaphore hydrique conditionne l'univers de la parole et de la science, reflète le mouvement de la pensée et ses dérives. Dans les images métaphysiques et morales, ce sont les flux, les fleuves et le monde marin qui reflètent la nature et la qualité des âmes ; mythes et allégories déplient les symboles de la corruption, de l'oubli et de l'incontinence, où se jouent une idée de la matière et la valeur de l'existence. Sur le plan ontologique, l'eau dénoue les figures de l'instable qui mettent en oeuvre la réfutation des «liquides» - théoriciens du flux - et l'intelligibilité du devenir. Enfin, dans l'ordre politique, la critique de la thalassocratie, les mythes (l'Atlantide, la mer de la dissemblance) et les images nautiques suivent les lignes fluctuantes de l'histoire athénienne, mais tracent aussi les contours de la Cité juste et le visage du vrai gouvernant. Dans le scintillement des eaux, à la croisée du sensible et de l'intelligible, se construit l'iconologie platonicienne. L'eau figurée, transfigurée dans le fil liquide de la poésie, forme les multiples reflets de ce qu'il faut vraiment voir pour se libérer du spectacle des ombres et penser le chemin d'une sagesse, qui ne renonce jamais au monde. (shrink)

Wisdom is peculiarly abstract, ineffable, and yet perennial. It is also temporal, stretching forwards as well is backwards in time. Wisdom is often treated as the outcome of life experience, reflection, discipline, and equanimity. Capturing the Ineffable aims to establish wisdom as an area if inquiry within anthropology and an analytic account of wisdom and its role and focus in anthropology. In addition to developing theories for an anthropology (and excavation) of wisdom, this volume argues collectively that anthropology is especially (...) well suited to engage in questioning what it is that is called wisdom, and how wisdom, as a concept, and an enacted activity, functions in metaphysical and interpersonal experiences, values, and judgements. The contributors include many key US and UK thinkers. (shrink)

This is the first complete English translation of Gottlob Frege's Grundgesetze der Arithmetik, with introduction and annotation. The importance of Frege's ideas within contemporary philosophy would be hard to exaggerate. He was, to all intents and purposes, the inventor of mathematical logic, and the influence exerted on modern philosophy of language and logic, and indeed on general epistemology, by the philosophical framework.

The early nineteenth century saw the demise of the Italian-Atlantic tradition of republicanism and the rise of classical liberalism. A distinct Franco-German tradition of republicanism emerged from the time of Jean-Jacques Rousseau and Immanuel Kant, which differs from the older way of thinking associated with neo-republicanism. This chapter examines the key differences between the Italian-Atlantic and Franco-German traditions of republicanism and places them in a historical context. It first considers classical republicanism and how the ideological ideal of equal freedom as (...) nondomination differs from the twin institutional ideals of a mixed constitution and a contestatory citizenry. It then looks at the classical liberal opposition that arose in response to Italian-Atlantic republicanism. It also discusses the views of Kant and Rousseau about freedom and the role of the citizenry, as well as their theory of the constitution. The absolutist opposition in Jean Bodin and Thomas Hobbes to the institutional ideals of republicanism is also explored. (shrink)

This article builds upon previous discussion of social and technical determinisms as implicit positions in the biofuel debate. To ensure these debates are balanced, it has been suggested that they should be designed to contain a variety of deterministic positions. Whilst it is agreed that determinism does not feature strongly in contemporary academic literatures, it is found that they have generally been superseded by an absence of any substantive conceptualisation of how the social shaping of technology may be related to, (...) or occur alongside, an objective or autonomous reality. The problem of determinism emerges at an ontological level and must be resolved in situ. A critical realist approach to technology is presented which may provide a more appropriate framework for debate. In dialogue with previous discussion, the distribution of responsibility is revisited with reference to the role of scientists and engineers. (shrink)

Trusting someone in an intuitive, rich sense of the term involves not just relying on that person, but manifesting reliance on them in the expectation that this manifestation of reliance will increase their reason and motive to prove reliable. Can trust between people be formed on the basis of Internet contact alone? Forming the required expectation in regard to another person, and so trusting them on some matter, may be due to believing that they are trustworthy; to believing that they (...) seek es teem and will be rationally responsive to the good opinion communicated or promised by an act of trust; or to both factors at once. Neither mechanism can rationally command confidence, however, in the case where people are related only via the Internet. On the Internet everyone wears the ring of Gyges; everyone is invisible, in their personal identity, to others. (shrink)

This chapter contains section titled: Rawls's Anti‐Cosmopolitanism Rawls's Ontology of Peoples Reconstructing Rawls's Rejection of Cosmopolitanism Acknowledgments Notes.

Some industry and policy actors are concerned about public opposition to civil drones, in particular because of their association with military drones. However, very little is understood about public reactions to the technology. Strategies to ‘manage public acceptance’ have so far relied upon several untested assumptions. We conducted public engagement activities to explore citizens’ visions of civil drones. Several insights counteracted the prevailing assumptions. Rejecting the notion of blanket support for or opposition to civil drones, we found that citizens make (...) nuanced decisions about the acceptability of civil drones depending upon the purpose of the flight and the actors involved. The results are positioned in support for calls to strengthen the role of citizens in civil drone development and, in particular, to shift away from the current focus on citizens’ acceptance of civil drone development towards the development ofcivildrones that are acceptable to citizens. (shrink)

There has recently been a revival of interest in panpsychism as a theory of consciousness. The hope of the contemporary proponents of panpsychism is that the view enables us to integrate consciousness into our overall theory of reality in a way that avoids the deep difficulties that plague the more conventional options of physicalism on the one hand and dualism on the other. However, panpsychism comes in two forms — strong and weak emergentist — and there are arguments that seem (...) to show that weak emergentist panpsychism faces problems analogous to those of physicalism whilst strong emergentist panpsychism faces problems analogous to those of dualism. In this paper, I will develop a new hybrid of the strong and weak emergentist forms of panpsychism, a view according to which subjects of experience are strongly emergent but their phenomenal properties are weakly emergent. I will argue that this hybrid view manages to avoid the challenges facing both physicalism and dualism, and the analogues of those challenges that seem to undermine standard forms of panpsychism. (shrink)

Abstractionism, which is a development of Frege's original Logicism, is a recent and much debated position in the philosophy of mathematics. This volume contains 16 original papers by leading scholars on the philosophical and mathematical aspects of Abstractionism. After an extensive editors' introduction to the topic of abstractionism, the volume is split into 4 sections. The contributions within these sections explore the semantics and meta-ontology of Abstractionism, abstractionist epistemology, the mathematics of Abstractionis, and finally, Frege's application constraint within an abstractionist (...) setting. (shrink)

'The Matrix Project' comprises two contexts, namely photographic work of architect Thierry Lagrange and the self-reflective trajectory that he developed during his doctorate at KULeuven. Lagrange's practice-based research developed to an autonomous artistic project, in which he studied the signification and nature of observation within a creative process. Through his multifaceted practice as an architect, photographer and researcher, Lagrange developed 'The Matrix Method'; a method that stimulates creativity within different contexts and can be implemented for example in art education. (...) For the Matrix Project, 25 years' worth of photographs was entered into a context of research and presents a new perspective on different ways of seeing in our present visual culture. (shrink)

This essay explores some of the similarities and differences between the views of several Western and Chinese thinkers on the metaphysical status of moral qualities and how we come to perceive and appreciate them. It then uses this comparative analysis to identify and address some remaining problems in regard to these two issues. The essay offers a brief sketch of and introduction to the history of the study of moral qualities and moral perception in modern Western philosophy and takes the (...) views of John McDowell, W ang Yangming, and Mencius as the primary focus of its comparative component. It seeks to understand the views of these thinkers by a careful examination of the metaphors as well as the arguments they employ. (shrink)

It is intuitive that free action depends on consciousness in some way, since behavior that is unconsciously generated is widely regarded as un-free. But there is no clear consensus as to what such dependence comes to, in part because there is no clear consensus about either the cognitive role of consciousness or about the essential components of free action. I divide the space of possible views into four: the Constitution View (on which free actions metaphysically consist, at least in part, (...) in phenomenally conscious episodes of a special sort), the Causal-Dependence View (on which free actions are necessarily caused by conscious episodes), the Counterfactaul-Dependence View (on which free actions necessarily counterfactually dependent on conscious episodes of certain types), and the Independence View (on which there are no necessary dependence-relations that hold between free action and conscious episodes). After surveying recent empirical literature that purports to show that consciousness plays a smaller role in generating action than is usually supposed, I conclude that it is plausible that free action depends on consciousness in two ways. First, free action causally depends on consciousness control. Second, free action counterfactually depends on the agent's being responsive to certain reasons. (shrink)

Doing Right: A Practical Guide to Ethics for Medical Trainees and Physicians is a concise and practical guide to ethical decision-making in medicine. The text is aimed at second- and third-year one-semester ethics courses offered in medical schools, health sciences departments, and nursing programs. By taking an applied approach rather than a theoretical approach, this text serves the needs of medical and nursing students, residents, and practicing physicians by sorting through questions of moral principles relevant to the diverse and growing (...) number of healthcare professionals. The many topics covered include truth telling, refusal of treatment, assisted suicide, managing error, and reproductive choice. (shrink)