13 found
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  1.  30
    Rethinking the Role of the Nervous System: Lessons From the Hydra Holobiont.Alexander V. Klimovich & Thomas C. G. Bosch - 2018 - Bioessays 40 (9):1800060.
    Here we evaluate our current understanding of the function of the nervous system in Hydra, a non‐bilaterian animal which is among the first metazoans that contain neurons. We highlight growing evidence that the nervous system, with its rich repertoire of neuropeptides, is involved in controlling resident beneficial microbes. We also review observations that indicate that microbes affect the animal's behavior by directly interfering with neuronal receptors. These findings provide new insight into the original role of the nervous system, and suggest (...)
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  2.  53
    Why bacteria matter in animal development and evolution.Sebastian Fraune & Thomas C. G. Bosch - 2010 - Bioessays 32 (7):571-580.
    While largely studied because of their harmful effects on human health, there is growing appreciation that bacteria are important partners for invertebrates and vertebrates, including man. Epithelia in metazoans do not only select their microbiota; a coevolved consortium of microbes enables both invertebrates and vertebrates to expand the range of diet supply, to shape the complex immune system and to control pathogenic bacteria. Microbes in zebrafish and mice regulate gut epithelial homeostasis. In a squid, microbes control the development of the (...)
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  3.  17
    Multidisciplinary Approaches to Exploring Human–Microbiome Interactions.Thomas C. G. Bosch - 2019 - Bioessays 41 (10):1900130.
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  4.  31
    The Microbiome Mediates Environmental Effects on Aging.Brett B. Finlay, Sven Pettersson, Melissa K. Melby & Thomas C. G. Bosch - 2019 - Bioessays 41 (10):1800257.
    Humans’ indigenous microbes strongly influence organ functions in an age‐ and diet‐dependent manner, adding an important dimension to aging biology that remains poorly understood. Although age‐related differences in the gut microbiota composition correlate with age‐related loss of organ function and diseases, including inflammation and frailty, variation exists among the elderly, especially centenarians and people living in areas of extreme longevity. Studies using short‐lived as well as nonsenescent model organisms provide surprising functional insights into factors affecting aging and implicate attenuating effects (...)
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  5.  22
    Evolutionary “Experiments” in Symbiosis: The Study of Model Animals Provides Insights into the Mechanisms Underlying the Diversity of Host–Microbe Interactions.Thomas C. G. Bosch, Karen Guillemin & Margaret McFall-Ngai - 2019 - Bioessays 41 (10):1800256.
    Current work in experimental biology revolves around a handful of animal species. Studying only a few organisms limits science to the answers that those organisms can provide. Nature has given us an overwhelming diversity of animals to study, and recent technological advances have greatly accelerated the ability to generate genetic and genomic tools to develop model organisms for research on host–microbe interactions. With the help of such models the authors therefore hope to construct a more complete picture of the mechanisms (...)
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  6.  23
    Compagen, a comparative genomics platform for early branching metazoan animals, reveals early origins of genes regulating stem‐cell differentiation.Georg Hemmrich & Thomas C. G. Bosch - 2008 - Bioessays 30 (10):1010-1018.
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  7.  36
    Polyps, peptides and patterning.Thomas C. G. Bosch & Toshitaka Fujisawa - 2001 - Bioessays 23 (5):420-427.
    Peptides serve as important signalling molecules in development and differentiation in the simple metazoan Hydra. A systematic approach (The Hydra Peptide Project) has revealed that Hydra contains several hundreds of peptide signalling molecules, some of which are neuropeptides and others emanate from epithelial cells. These peptides control biological processes as diverse as muscle contraction, neuron differentiation, and the positional value gradient. Signal peptides cause changes in cell behaviour by controlling target genes such as matrix metalloproteases. The abundance of peptides in (...)
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  8.  36
    Understanding why we age and how: Evolutionary biology meets different model organisms and multi‐level omics.Eric Gilson & Thomas C. G. Bosch - 2016 - Bioessays 38 (6):494-497.
    The conference explored an extraordinary diversity of aging strategies in organisms ranging from short‐lived species to “immortal” animals and plants. Research on the biological processes of aging is at the brink of a revolution with respect to our understanding of its underlying mechanisms as well as our ability to prevent and cure a wide variety of age‐related pathologies.
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  9.  72
    How do environmental factors influence life cycles and development? An experimental framework for early‐diverging metazoans.Thomas C. G. Bosch, Maja Adamska, René Augustin, Tomislav Domazet-Loso, Sylvain Foret, Sebastian Fraune, Noriko Funayama, Juris Grasis, Mayuko Hamada, Masayuki Hatta, Bert Hobmayer, Kotoe Kawai, Alexander Klimovich, Michael Manuel, Chuya Shinzato, Uli Technau, Seungshic Yum & David J. Miller - 2014 - Bioessays 36 (12):1185-1194.
    Ecological developmental biology (eco‐devo) explores the mechanistic relationships between the processes of individual development and environmental factors. Recent studies imply that some of these relationships have deep evolutionary origins, and may even pre‐date the divergences of the simplest extant animals, including cnidarians and sponges. Development of these early diverging metazoans is often sensitive to environmental factors, and these interactions occur in the context of conserved signaling pathways and mechanisms of tissue homeostasis whose detailed molecular logic remain elusive. Efficient methods for (...)
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  10.  18
    (1 other version)BioEssays 4/2009.Thomas C. G. Bosch - 2009 - Bioessays 31 (4).
    Cover Photograph: Transgenic Hydra provide insights of general relevance into stem cell biology. The image shows a mass culture of transgenic Hydra expressing EGFP in all of their ectodermal epithelial cells. See article by Thomas C. G. Bosch pp. 478–486.
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  11.  13
    BioEssays 10∕2019.Thomas C. G. Bosch - 2019 - Bioessays 41 (10):1970101.
    Graphical AbstractCIFAR's Humans & the Microbiome program is a multidisciplinary group of biological, clinical, and social scientists who explore the links between microbiome biology and sociocultural, historical, evolutionary, and environmental aspects of human existence that may impact the microbiome or be impacted by it. In this focus issue, members of the program focus on topics ranging from decoding the link between nutrition, the microbiome and human developmental, metabolic, and immune health and aging, to understanding past changes in the environment and (...)
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  12.  27
    Control of asymmetric cell divisions: will cnidarians provide an answer?Thomas C. G. Bosch - 2004 - Bioessays 26 (9):929-931.
    Cells in the basal metazoan phylum Cnidaria are characterized by remarkable plasticity in their differentiation capacity. The mechanism controlling asymmetric cell divisions is not understood in cnidarians or in any other animal group. PIWI proteins recently have been shown to be involved in maintaining the self‐renewal capacity of stem cells in organisms as diverse as ciliates, flies, worms and mammals. Seipel et al.1 find that, in the cnidarian Podocoryne carnea, the Piwi homolog Cniwi is transcriptionally upregulated when the polyp generates (...)
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  13.  17
    Hydra and the hair follicle – An unconventional comparative biology approach to exploring the human holobiont.Marta B. Lousada, Tim Lachnit, Janin Edelkamp, Ralf Paus & Thomas C. G. Bosch - 2022 - Bioessays 44 (5):2100233.
    The microbiome of human hair follicles (HFs) has emerged as an important player in different HF and skin pathologies, yet awaits in‐depth exploration. This raises questions regarding the tightly linked interactions between host environment, nutrient dependency of host‐associated microbes, microbial metabolism, microbe‐microbe interactions and host immunity. The use of simple model systems facilitates addressing generally important questions and testing overarching, therapeutically relevant principles that likely transcend obvious interspecies differences. Here, we evaluate the potential of the freshwater polyp Hydra, to dissect (...)
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